ZA92511B - Antigen-presenting chimaeric protein - Google Patents
Antigen-presenting chimaeric proteinInfo
- Publication number
- ZA92511B ZA92511B ZA92511A ZA92511A ZA92511B ZA 92511 B ZA92511 B ZA 92511B ZA 92511 A ZA92511 A ZA 92511A ZA 92511 A ZA92511 A ZA 92511A ZA 92511 B ZA92511 B ZA 92511B
- Authority
- ZA
- South Africa
- Prior art keywords
- pct
- protein
- antigen
- presenting
- sec
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 210000000234 capsid Anatomy 0.000 abstract 2
- 101710132601 Capsid protein Proteins 0.000 abstract 1
- 101710094648 Coat protein Proteins 0.000 abstract 1
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 abstract 1
- 101710125418 Major capsid protein Proteins 0.000 abstract 1
- 101710141454 Nucleoprotein Proteins 0.000 abstract 1
- 101710083689 Probable capsid protein Proteins 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Display Devices Of Pinball Game Machines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919101550A GB9101550D0 (en) | 1991-01-24 | 1991-01-24 | Antigen-presenting chimaeric protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA92511B true ZA92511B (en) | 1992-11-25 |
Family
ID=10688936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA92511A ZA92511B (en) | 1991-01-24 | 1992-01-24 | Antigen-presenting chimaeric protein |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5534257A (fr) |
| EP (1) | EP0572433B1 (fr) |
| JP (1) | JP3187832B2 (fr) |
| KR (1) | KR100197819B1 (fr) |
| AT (1) | ATE201449T1 (fr) |
| AU (1) | AU653387B2 (fr) |
| CA (1) | CA2101070C (fr) |
| DE (1) | DE69231837T8 (fr) |
| FI (1) | FI110615B (fr) |
| GB (2) | GB9101550D0 (fr) |
| IE (1) | IE920200A1 (fr) |
| NO (1) | NO313917B1 (fr) |
| NZ (1) | NZ241373A (fr) |
| WO (1) | WO1992013081A1 (fr) |
| ZA (1) | ZA92511B (fr) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9114003D0 (en) * | 1991-06-28 | 1991-08-14 | Mastico Robert A | Chimaeric protein |
| US5837268A (en) * | 1991-10-16 | 1998-11-17 | University Of Saskatchewan | GnRH-leukotoxin chimeras |
| WO1995005454A1 (fr) * | 1992-02-22 | 1995-02-23 | Cambridge Bacteriophage Technologies Ltd. | Bacteriophages mis au point par genie genetique et vaccins les contenant |
| GB9213601D0 (en) * | 1992-06-26 | 1992-08-12 | Mastico Robert A | Protein based delivery system |
| US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| US5559099A (en) * | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
| US6465253B1 (en) | 1994-09-08 | 2002-10-15 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
| US6127525A (en) * | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
| US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
| US6783980B2 (en) | 1995-06-15 | 2004-08-31 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| ES2190799T5 (es) | 1996-03-01 | 2008-08-16 | Novartis Ag | Inmunogenos peptidicos para vacunacion y tratamiento contra la alergia. |
| US5766905A (en) * | 1996-06-14 | 1998-06-16 | Associated Universities Inc. | Cytoplasmic bacteriophage display system |
| US20030017138A1 (en) | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
| AU5122499A (en) | 1998-07-27 | 2000-02-21 | Genentech Inc. | Improved transformation efficiency in phage display through modification of a coat protein |
| US6929946B1 (en) | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
| US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
| CA2393869A1 (fr) * | 1999-12-15 | 2001-06-21 | Genetech,Inc. | Balayage aveugle, procede combinatoire permettant la representation d'epitopes de proteines fonctionnelles |
| DE60138403D1 (de) | 2000-09-26 | 2009-05-28 | Crucell Holland Bv | Adenovirale vektoren für die übertragung von genen in zellen der skelettmuskulatur oder myoblasten |
| US7094409B2 (en) | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| US7128911B2 (en) | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| EP2196217A1 (fr) | 2001-09-14 | 2010-06-16 | Cytos Biotechnology AG | Emballage de substances immunostimulantes dans des particules similaires aux virus: procédés de production et utilisations |
| BR0213117A (pt) | 2001-10-05 | 2004-09-21 | Cytos Biotechnology Ag | Conjugados peptìdeo angiotensina-veìculo e seus usos |
| US7115266B2 (en) | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| CN100497639C (zh) | 2002-04-25 | 2009-06-10 | 克鲁塞尔荷兰公司 | 生产腺病毒载体的手段和方法 |
| WO2004009116A2 (fr) | 2002-07-18 | 2004-01-29 | Cytos Biotechnology Ag | Conjugues haptene-porteur et utilisations de ceux-ci |
| DE60336902D1 (de) | 2002-07-19 | 2011-06-09 | Cytos Biotechnology Ag | Impfstoffzusammensetzungen enthaltende amyloid beta 1-6 antigenarrays |
| US7537767B2 (en) | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
| NZ542323A (en) | 2003-03-26 | 2008-07-31 | Cytos Biotechnology Ag | Melan-A peptide analogue-virus-like-particle conjugates |
| US20060292554A1 (en) * | 2004-05-18 | 2006-12-28 | Genentech, Inc. | Major coat protein variants for C-terminal and bi-terminal display |
| US7959928B2 (en) * | 2004-10-05 | 2011-06-14 | Cytos Biotechnology Ag | VLP-antigen conjugates and their uses as vaccines |
| US20110008831A1 (en) | 2005-05-26 | 2011-01-13 | Cytos Biotechnology Ag | Scalable fermentation process |
| EP1746165A1 (fr) * | 2005-07-21 | 2007-01-24 | Cytos Biotechnology AG | Procédé de fermentation échelonnable |
| EP1736538A1 (fr) | 2005-06-21 | 2006-12-27 | Cytos Biotechnology AG | Procédé pour la purification préparative de particules pseudo-virales (VLPs) |
| AU2006298767B2 (en) | 2005-09-28 | 2013-01-10 | Cytos Biotechnology Ag | Interleukin-1 conjugates and uses thereof |
| JP5484732B2 (ja) | 2005-12-14 | 2014-05-07 | サイトス バイオテクノロジー アーゲー | 過敏症の治療のための免疫賦活性核酸パッケージ粒子 |
| WO2007084568A2 (fr) | 2006-01-17 | 2007-07-26 | Health Research, Inc. | Bio-essai de suivi en hétéroduplex |
| PT2032592E (pt) | 2006-06-12 | 2013-08-28 | Cytos Biotechnology Ag | Processos para o empacotamento de oligonucleótidos em partículas semelhantes a vírus de bacteriófagos de arn |
| EP2554664A1 (fr) | 2011-08-02 | 2013-02-06 | Life Science Inkubator | Procédé de nettoyage de particules semblable à un virus (VLP) |
| RU2568872C1 (ru) * | 2014-10-15 | 2015-11-20 | Игорь Геннадьевич Сивов | Лекарственное средство для лечения вирусного гепатита с |
| FR3100819B1 (fr) * | 2019-09-18 | 2024-04-19 | Centre Nat Rech Scient | Production et fonctionnalisation de nanoparticules dérivées du phage T5 et utilisations thérapeutiques |
| WO2021215952A1 (fr) | 2020-04-24 | 2021-10-28 | Общество С Ограниченной Ответственностью "Индженик" | Procédé de production de particules de bactériophages de la famille levivirus |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989010967A1 (fr) * | 1988-05-05 | 1989-11-16 | Praxis Biologics, Inc. | Vaccins de flagelline recombinants |
| IT1226551B (it) * | 1988-07-29 | 1991-01-24 | Sclavo Spa | Peptide sintetico immunologicamente attivo capace di indurre la produzione di anticorpi con elevata specificita' verso l'alfa- fetoproteina e loro impiego in campo diagnostico |
| FI902151A7 (fi) * | 1988-08-30 | 1990-04-27 | Applied Res Systems Ars Holding | Yhdistelmä-DNA-fuusioproteiineja hormonierityksen muuttamiseksi |
| WO1990014355A1 (fr) * | 1989-05-17 | 1990-11-29 | Research Corporation Technologies, Inc. | Secretion induite par un retrovirus de produits de recombinaison |
-
1991
- 1991-01-24 GB GB919101550A patent/GB9101550D0/en active Pending
-
1992
- 1992-01-22 US US08/090,148 patent/US5534257A/en not_active Expired - Fee Related
- 1992-01-22 AT AT92903356T patent/ATE201449T1/de not_active IP Right Cessation
- 1992-01-22 GB GB9201372A patent/GB2253626B/en not_active Expired - Fee Related
- 1992-01-22 EP EP92903356A patent/EP0572433B1/fr not_active Expired - Lifetime
- 1992-01-22 JP JP50357692A patent/JP3187832B2/ja not_active Expired - Fee Related
- 1992-01-22 KR KR1019930702199A patent/KR100197819B1/ko not_active Expired - Fee Related
- 1992-01-22 AU AU11737/92A patent/AU653387B2/en not_active Ceased
- 1992-01-22 WO PCT/GB1992/000124 patent/WO1992013081A1/fr not_active Ceased
- 1992-01-22 CA CA002101070A patent/CA2101070C/fr not_active Expired - Fee Related
- 1992-01-22 DE DE69231837T patent/DE69231837T8/de not_active Expired - Fee Related
- 1992-01-23 NZ NZ241373A patent/NZ241373A/xx unknown
- 1992-01-23 IE IE020092A patent/IE920200A1/en not_active Application Discontinuation
- 1992-01-24 ZA ZA92511A patent/ZA92511B/xx unknown
-
1993
- 1993-07-22 NO NO19932644A patent/NO313917B1/no not_active IP Right Cessation
- 1993-07-23 FI FI933328A patent/FI110615B/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| NZ241373A (en) | 1993-04-28 |
| JP3187832B2 (ja) | 2001-07-16 |
| GB9101550D0 (en) | 1991-03-06 |
| AU1173792A (en) | 1992-08-27 |
| ATE201449T1 (de) | 2001-06-15 |
| WO1992013081A1 (fr) | 1992-08-06 |
| FI933328A0 (fi) | 1993-07-23 |
| EP0572433A1 (fr) | 1993-12-08 |
| CA2101070C (fr) | 2003-04-01 |
| AU653387B2 (en) | 1994-09-29 |
| KR100197819B1 (ko) | 1999-06-15 |
| GB9201372D0 (en) | 1992-03-11 |
| FI933328L (fi) | 1993-09-07 |
| GB2253626B (en) | 1995-02-08 |
| KR930703449A (ko) | 1993-11-30 |
| DE69231837D1 (de) | 2001-06-28 |
| CA2101070A1 (fr) | 1992-07-25 |
| EP0572433B1 (fr) | 2001-05-23 |
| NO932644L (no) | 1993-09-23 |
| JPH06504907A (ja) | 1994-06-09 |
| US5534257A (en) | 1996-07-09 |
| IE920200A1 (en) | 1992-07-29 |
| FI110615B (fi) | 2003-02-28 |
| NO932644D0 (no) | 1993-07-22 |
| DE69231837T8 (de) | 2004-08-12 |
| GB2253626A (en) | 1992-09-16 |
| NO313917B1 (no) | 2002-12-23 |
| DE69231837T2 (de) | 2001-10-18 |
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