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ZA898026B - Novel analogs of peptidase substrates - Google Patents

Novel analogs of peptidase substrates

Info

Publication number
ZA898026B
ZA898026B ZA898026A ZA898026A ZA898026B ZA 898026 B ZA898026 B ZA 898026B ZA 898026 A ZA898026 A ZA 898026A ZA 898026 A ZA898026 A ZA 898026A ZA 898026 B ZA898026 B ZA 898026B
Authority
ZA
South Africa
Prior art keywords
novel analogs
peptidase substrates
replaced
amide bond
novel
Prior art date
Application number
ZA898026A
Other languages
English (en)
Inventor
Daniel Schirlin
Schirlin Daniel
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA898026B publication Critical patent/ZA898026B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
  • Luminescent Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Radio Relay Systems (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ZA898026A 1988-10-28 1989-10-23 Novel analogs of peptidase substrates ZA898026B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP88402735A EP0371179A1 (fr) 1988-10-28 1988-10-28 Analogues des substrats de peptidases

Publications (1)

Publication Number Publication Date
ZA898026B true ZA898026B (en) 1990-07-25

Family

ID=8200435

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA898026A ZA898026B (en) 1988-10-28 1989-10-23 Novel analogs of peptidase substrates

Country Status (18)

Country Link
US (1) US5114927A (fr)
EP (2) EP0371179A1 (fr)
JP (1) JP2899327B2 (fr)
CN (1) CN1031880C (fr)
AT (1) ATE147405T1 (fr)
AU (1) AU622723B2 (fr)
CA (1) CA2001265C (fr)
DE (1) DE68927630T2 (fr)
DK (1) DK537589A (fr)
ES (1) ES2099072T3 (fr)
FI (1) FI95272C (fr)
GR (1) GR3023027T3 (fr)
HU (1) HU209311B (fr)
IL (1) IL92102A (fr)
NO (1) NO301074B1 (fr)
PH (1) PH27239A (fr)
PT (1) PT92140B (fr)
ZA (1) ZA898026B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0356595A1 (fr) * 1988-09-01 1990-03-07 Merrell Dow Pharmaceuticals Inc. Inhibiteurs des peptidases
CA2021660A1 (fr) * 1989-07-26 1991-01-27 Philippe Bey Inhibiteurs de la peptidose
IL95380A0 (en) * 1989-09-05 1991-06-30 Abbott Lab Peptidyl difluorodiol renin inhibitors
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
US5714470A (en) 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
EP0762887B1 (fr) * 1994-06-02 2001-09-26 Merrell Pharmaceuticals Inc. Derives enol acyle utilisables comme promedicaments pour des inhibiteurs de l'elastase
FI964789A0 (fi) * 1994-06-02 1996-11-29 Merrell Pharma Inc Elastaasin pefluorialkyyliketoni-inhibiittoreita ja menetelmiä niiden valmistamiseksi
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
JP4080541B2 (ja) * 1996-10-18 2008-04-23 バーテックス ファーマシューティカルズ インコーポレイテッド セリンプロテアーゼ、特にｃ型肝炎ウイルスｎｓ３プロテアーゼの阻害因子
TWI359147B (en) 2003-09-05 2012-03-01 Vertex Pharma Inhibitors of serine proteases, particularly hcv n
FR2914920B1 (fr) * 2007-04-11 2011-09-09 Clariant Specialty Fine Chem F Procede de deacetalisation d'alpha-aminoacetals.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
AU600226B2 (en) * 1985-02-04 1990-08-09 Merrell Pharmaceuticals Inc. Novel peptidase inhibitors
DE3674131D1 (de) * 1985-04-19 1990-10-18 Upjohn Co Substituierte dihalo-statin-reninhemmungsmittel.
EP0204571B1 (fr) * 1985-06-07 1992-01-22 Ici Americas Inc. Dérivés difluoro choisis
JPS63503380A (ja) * 1986-01-16 1988-12-08 アボット・ラボラトリーズ ペプチド類似体
DE3782191T2 (de) * 1986-06-05 1993-02-25 Ici America Inc Difluorketoverbindungen.
NZ223148A (en) * 1987-01-16 1989-10-27 Merrell Dow Pharma Peptide derivatives having peptidase inhibition activity

Also Published As

Publication number Publication date
IL92102A0 (en) 1990-07-12
PT92140B (pt) 1996-03-29
JP2899327B2 (ja) 1999-06-02
ES2099072T3 (es) 1997-05-16
HUT51649A (en) 1990-05-28
CN1043504A (zh) 1990-07-04
DE68927630D1 (de) 1997-02-20
EP0368719A2 (fr) 1990-05-16
PH27239A (en) 1993-05-04
EP0368719B1 (fr) 1997-01-08
EP0371179A1 (fr) 1990-06-06
JPH02172961A (ja) 1990-07-04
PT92140A (pt) 1990-04-30
AU622723B2 (en) 1992-04-16
NO301074B1 (no) 1997-09-08
US5114927A (en) 1992-05-19
HU209311B (en) 1994-04-28
CN1031880C (zh) 1996-05-29
ATE147405T1 (de) 1997-01-15
CA2001265A1 (fr) 1990-04-28
FI95272C (fi) 1996-01-10
CA2001265C (fr) 2001-05-01
EP0368719A3 (fr) 1991-10-02
DK537589A (da) 1990-04-29
HU895473D0 (en) 1990-01-28
IL92102A (en) 1994-07-31
DE68927630T2 (de) 1997-06-12
FI95272B (fi) 1995-09-29
DK537589D0 (da) 1989-10-27
NO894300D0 (no) 1989-10-27
FI895109A0 (fi) 1989-10-27
GR3023027T3 (en) 1997-07-30
NO894300L (no) 1990-04-30
AU4386789A (en) 1990-05-03

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