ZA200903499B - Indoles which act as via receptor antagonists - Google Patents

Indoles which act as via receptor antagonists

Info

Publication number: ZA200903499B
Authority: ZA; South Africa
Prior art keywords: indoles; act; receptor antagonists; via receptor; antagonists
Prior art date: 2006-12-08

Application number

ZA200903499A

Other languages

English (en)

Inventor

Caterina Bissantz

Christophe Grundschober

Raffaello Masciadri

Hasane Ratni

Mark Rogers-Evans

Patrick Schnider

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-08

Filing date

2009-05-20

Publication date

2010-03-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38983746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200903499(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-05-20 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2010-03-31 Publication of ZA200903499B publication Critical patent/ZA200903499B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ZA200903499A 2006-12-08 2009-05-20 Indoles which act as via receptor antagonists ZA200903499B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP06125663		2006-12-08

Publications (1)

Publication Number	Publication Date
ZA200903499B true ZA200903499B (en)	2010-03-31

Family

ID=38983746

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200903499A ZA200903499B (en)	2006-12-08	2009-05-20	Indoles which act as via receptor antagonists

Country Status (21)

Country	Link
US (4)	US20080139618A1 (xx)
EP (1)	EP2089381B1 (xx)
JP (1)	JP2010511660A (xx)
KR (1)	KR101050558B1 (xx)
CN (1)	CN101541786A (xx)
AR (1)	AR064137A1 (xx)
AT (1)	ATE472544T1 (xx)
AU (1)	AU2007328994B2 (xx)
BR (1)	BRPI0720441A2 (xx)
CA (1)	CA2671324A1 (xx)
CL (1)	CL2007003503A1 (xx)
DE (1)	DE602007007512D1 (xx)
ES (1)	ES2345132T3 (xx)
IL (1)	IL198683A0 (xx)
MX (1)	MX2009005541A (xx)
NO (1)	NO20091832L (xx)
PE (1)	PE20081380A1 (xx)
RU (1)	RU2009120443A (xx)
TW (1)	TW200829570A (xx)
WO (1)	WO2008068184A1 (xx)
ZA (1)	ZA200903499B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20090078367A (ko) *	2006-12-08	2009-07-17	에프. 호프만-라 로슈 아게	인돌
WO2008068184A1 (en) *	2006-12-08	2008-06-12	F. Hoffmann-La Roche Ag	Indoles which act as via receptor antagonists
PE20081401A1 (es) *	2006-12-28	2008-10-24	Hoffmann La Roche	Derivados de indol como antagonistas de receptores vasopresina
US20100145805A1 (en) *	2008-12-08	2010-06-10	Electronics And Telecommunications Research Institute	Apparatus for providing digital contents using dmb channel and method thereof
EP2956441A4 (en) *	2013-02-18	2016-11-02	Scripps Research Inst	MODULATORS OF VASOPRESSIN RECEPTORS WITH THERAPEUTIC POTENTIAL
GB201521059D0 (en)	2015-11-30	2016-01-13	Isis Innovation	Inhibitors of metallo-beta-lactamases
US20230099441A1 (en) *	2019-04-26	2023-03-30	Generos Biopharma Ltd.	Heterocyclic compound, application thereof, and composition containing same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5924990B2 (ja) *	1979-11-21	1984-06-13	協和醗酵工業株式会社	新規なピペリジン誘導体
TW199153B (xx) *	1990-08-07	1993-02-01	Dtsuka Seiyaku Kk
CA2166975C (en) *	1993-07-16	2005-04-05	Mark G. Bock	Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists
CO5150201A1 (es)	1998-09-07	2002-04-29	Hoffmann La Roche	Derivados de piperidina
IL152177A0 (en)	2000-05-12	2003-05-29	Solvay Pharm Bv	Piperazine and piperidine compounds
WO2004035549A1 (en)	2002-10-17	2004-04-29	Amgen Inc.	Benzimidazole derivatives and their use as vanilloid receptor ligands
CA2615726C (en) *	2005-07-14	2014-05-27	Caterina Bissantz	Indol-3-yl-carbonyl-spiro-piperidine derivatives as v1a receptor antagonists
PL1912976T3 (pl)	2005-07-21	2009-04-30	Hoffmann La Roche	Pochodne indol-3-ilokarbonylopiperydynobenzoimidazolu jako antagoniści receptora V1a
ATE488519T1 (de)	2005-09-28	2010-12-15	Hoffmann La Roche	Indol-3-ylcarbonylazaspiroderivate als vasopressinrezeptorantagonisten
WO2008068184A1 (en) *	2006-12-08	2008-06-12	F. Hoffmann-La Roche Ag	Indoles which act as via receptor antagonists

2007
- 2007-11-29 WO PCT/EP2007/062984 patent/WO2008068184A1/en not_active Ceased
- 2007-11-29 US US11/947,195 patent/US20080139618A1/en not_active Abandoned
- 2007-11-29 US US11/947,146 patent/US8071622B2/en not_active Expired - Fee Related
- 2007-11-29 RU RU2009120443/04A patent/RU2009120443A/ru not_active Application Discontinuation
- 2007-11-29 MX MX2009005541A patent/MX2009005541A/es active IP Right Grant
- 2007-11-29 US US11/947,266 patent/US20080139617A1/en not_active Abandoned
- 2007-11-29 EP EP07847501A patent/EP2089381B1/en not_active Not-in-force
- 2007-11-29 AU AU2007328994A patent/AU2007328994B2/en not_active Ceased
- 2007-11-29 DE DE602007007512T patent/DE602007007512D1/de active Active
- 2007-11-29 ES ES07847501T patent/ES2345132T3/es active Active
- 2007-11-29 AT AT07847501T patent/ATE472544T1/de active
- 2007-11-29 US US11/998,371 patent/US7799923B2/en not_active Expired - Fee Related
- 2007-11-29 CN CNA2007800421348A patent/CN101541786A/zh active Pending
- 2007-11-29 JP JP2009539706A patent/JP2010511660A/ja active Pending
- 2007-11-29 CA CA002671324A patent/CA2671324A1/en not_active Abandoned
- 2007-11-29 KR KR1020097011629A patent/KR101050558B1/ko not_active Expired - Fee Related
- 2007-11-29 BR BRPI0720441-8A patent/BRPI0720441A2/pt not_active IP Right Cessation
- 2007-12-05 CL CL200703503A patent/CL2007003503A1/es unknown
- 2007-12-05 AR ARP070105428A patent/AR064137A1/es unknown
- 2007-12-06 TW TW096146544A patent/TW200829570A/zh unknown
- 2007-12-07 PE PE2007001745A patent/PE20081380A1/es not_active Application Discontinuation
2009
- 2009-05-11 IL IL198683A patent/IL198683A0/en unknown
- 2009-05-11 NO NO20091832A patent/NO20091832L/no not_active Application Discontinuation
- 2009-05-20 ZA ZA200903499A patent/ZA200903499B/xx unknown

Also Published As

Publication number	Publication date
AU2007328994A1 (en)	2008-06-12
DE602007007512D1 (de)	2010-08-12
KR101050558B1 (ko)	2011-07-19
CA2671324A1 (en)	2008-06-12
ES2345132T3 (es)	2010-09-15
ATE472544T1 (de)	2010-07-15
WO2008068184A1 (en)	2008-06-12
CN101541786A (zh)	2009-09-23
EP2089381B1 (en)	2010-06-30
US20080139617A1 (en)	2008-06-12
CL2007003503A1 (es)	2008-07-04
TW200829570A (en)	2008-07-16
AR064137A1 (es)	2009-03-18
JP2010511660A (ja)	2010-04-15
IL198683A0 (en)	2010-02-17
NO20091832L (no)	2009-07-07
BRPI0720441A2 (pt)	2014-01-07
US20080139548A1 (en)	2008-06-12
US7799923B2 (en)	2010-09-21
RU2009120443A (ru)	2011-01-20
AU2007328994B2 (en)	2012-03-08
US20080269290A1 (en)	2008-10-30
KR20090078368A (ko)	2009-07-17
US8071622B2 (en)	2011-12-06
EP2089381A1 (en)	2009-08-19
US20080139618A1 (en)	2008-06-12
MX2009005541A (es)	2009-06-05
PE20081380A1 (es)	2008-09-18

Publication	Publication Date	Title
PT1981902E (pt)	2015-11-02	Antagonistas dos recetores nogo
ZA200800320B (en)	2009-02-25	Indol-3-carbonyl-spiro-piperidine derivatives as Via receptor antagonists
EP2099454A4 (en)	2010-11-10	AMINOPYRROLIDINES AS CHEMOKINE RECEPTOR ANTAGONISTS
EP2058304A4 (en)	2012-10-10	P2X4 RECEPTOR ANTAGONIST
SI2094690T1 (sl)	2011-07-29	Derivati 2-aza-biciklo(3.1.0)heksana kot antagonisti receptorja za oreksin
IL187424A0 (en)	2008-02-09	C5a RECEPTOR ANTAGONISTS
ZA200904150B (en)	2010-11-24	Progesterone receptor antagonists
IL196056A0 (en)	2009-09-01	Il-8 receptor antagonists
EP2184278A4 (en)	2011-08-03	P2X4 RECEIVER ANTAGONIST
IL196587A0 (en)	2009-11-18	2-phenyl-indoles as prostaglandin d2 receptor antagonists
IL194811A0 (en)	2009-08-03	Il-8 receptor antagonists
ZA200705237B (en)	2009-06-24	C5A receptor antagonists
IL194700A0 (en)	2009-08-03	Il-8 receptor antagonists
EP2099300A4 (en)	2011-12-07	IL-8 RECEPTOR ANTAGONISTS
IL198542A0 (en)	2010-02-17	2-aminoquinolines as 5-ht(5a)receptor antagonists
ZA200806065B (en)	2009-07-29	Oxazoloisoquinoline derivatives as thrombin receptor antagonists
IL192693A0 (en)	2009-09-22	Urotensin ii receptor antagonists
EP2153736A4 (en)	2011-08-24	NEW LEUKOTRIEN RECEPTOR ANTAGONIST
ZA200903499B (en)	2010-03-31	Indoles which act as via receptor antagonists
ZA200904479B (en)	2010-09-29	Nitroderivatives as angiotensin II receptor antagonists
EP1874302A4 (en)	2009-12-16	ANTAGONISTS OF ANGIOTENSIN II RECEPTORS
IL196758A0 (en)	2009-11-18	Urotensin ii receptor antagonists
IL202454A0 (en)	2010-06-30	Urotensin ii receptor antagonists
ZA200802339B (en)	2009-10-28	Indol-3-yl-carbonyl-azaspiro derivatives as vasopressin receptor antagonists
ZA200903496B (en)	2010-03-31	Spiro-piperidine derivatives as via receptor antagonists