ZA200900019B - Tyrosine kinase inhibitors - Google Patents

Tyrosine kinase inhibitors

Info

Publication number: ZA200900019B
Authority: ZA; South Africa
Prior art keywords: tyrosine kinase; kinase inhibitors; inhibitors; tyrosine; kinase
Prior art date: 2006-07-10

Application number

ZA200900019A

Other languages

English (en)

Inventor

Christopher J Dinsmore

Matthew H Katcher

Alan B Northrup

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-10

Filing date

2009-01-05

Publication date

2009-11-25

2009-01-05 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2009-11-25 Publication of ZA200900019B publication Critical patent/ZA200900019B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Hematology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

ZA200900019A 2006-07-10 2009-01-05 Tyrosine kinase inhibitors ZA200900019B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US81976406P	2006-07-10	2006-07-10

Publications (1)

Publication Number	Publication Date
ZA200900019B true ZA200900019B (en)	2009-11-25

Family

ID=38923821

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200900019A ZA200900019B (en)	2006-07-10	2009-01-05	Tyrosine kinase inhibitors

Country Status (24)

Country	Link
US (2)	US8222269B2 (fr)
EP (1)	EP2049494B1 (fr)
JP (2)	JP4203121B1 (fr)
KR (1)	KR20090026187A (fr)
CN (1)	CN101535268B (fr)
AR (1)	AR061804A1 (fr)
AU (1)	AU2007273081B2 (fr)
BR (1)	BRPI0713941A2 (fr)
CA (1)	CA2656578C (fr)
CO (1)	CO6190518A2 (fr)
CR (1)	CR10560A (fr)
EC (1)	ECSP099051A (fr)
ES (1)	ES2497493T3 (fr)
GT (1)	GT200900004A (fr)
HN (1)	HN2009000018A (fr)
IL (1)	IL196337A0 (fr)
MA (1)	MA30631B1 (fr)
MX (1)	MX2009000410A (fr)
NO (1)	NO20090608L (fr)
PE (1)	PE20080275A1 (fr)
RU (1)	RU2009104303A (fr)
TW (1)	TW200813021A (fr)
WO (1)	WO2008008310A2 (fr)
ZA (1)	ZA200900019B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2408584C2 (ru)	2005-06-23	2011-01-10	Мерк Шарп Энд Домэ Корп.	Ингибиторы тирозинкиназы
US7893081B2 (en)	2007-12-20	2011-02-22	Merck & Co., Inc.	Tyrosine kinase inhibitors
WO2009141290A2 (fr) *	2008-05-21	2009-11-26	Basf Se	Pyridin-4-ylméthyl sulfonamides substitués
US8674105B2 (en)	2009-09-30	2014-03-18	Merck Sharp & Dohme Limited	Crystalline hydrochloride salts of c-Met kinase inhibitors
CA2772127A1 (fr) *	2009-09-30	2011-04-07	Merck Sharp & Dohme Ltd	Formulations pour des inhibiteurs de la kinase c-met
CN107674073B (zh)	2010-05-17	2021-09-10	印蔻真治疗公司	作为蛋白激酶调节剂的3,5-二取代-3h-咪唑(或[1,2,3]三唑)并[4,5-b] 吡啶化合物
WO2012003338A1 (fr)	2010-07-01	2012-01-05	Takeda Pharmaceutical Company Limited	Combinaison d'un inhibiteur de cmet et d'un anticorps dirigé contre hgf et/ou cmet
US9815831B2 (en)	2012-03-30	2017-11-14	Rhizen Pharmaceuticals Sa	3,5-disubstituted-3H-imidazo[4,5-B]pyridine and 3,5-disubstituted-3H-[1,2,3]triazolo[4,5-B] pyridine compounds as modulators of c-Met protein kinases
JP6280546B2 (ja)	2012-06-26	2018-02-14	デルマーファーマシューティカルズ	ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法
EP2983674A4 (fr)	2013-04-08	2017-05-10	Dennis M. Brown	Bénéfice thérapeutique de composés chimiques administrés de façon sous-optimale
US10875930B2 (en)	2013-07-30	2020-12-29	Blueprint Medicines Corporation	PIK3C2G fusions
WO2015017533A1 (fr) *	2013-07-30	2015-02-05	Blueprint Medicines Corporation	Fusions de ntrk2
EP3229836B1 (fr)	2014-12-09	2019-11-13	Institut National de la Sante et de la Recherche Medicale (INSERM)	Anticoprs monoclonaux contre 'axl'
WO2016135041A1 (fr)	2015-02-26	2016-09-01	INSERM (Institut National de la Santé et de la Recherche Médicale)	Protéines de fusion et anticorps les contenant pour favoriser l'apoptose
AU2017286128B2 (en) *	2016-06-17	2022-02-24	The Trustees Of The University Of Pennsylvania	Compounds, compositions and methods for prevention and/or treatment of cancer
KR20210142154A (ko)	2019-03-21	2021-11-24	옹쎄오	암 치료를 위한 키나제 억제제와 조합된 dbait 분자
CN114761006A (zh)	2019-11-08	2022-07-15	Inserm(法国国家健康医学研究院)	对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (fr)	2020-01-22	2021-07-29	Onxeo	Nouvelle molécule dbait et son utilisation

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NL132137C (fr) *	1963-04-24
US4826853A (en)	1986-10-31	1989-05-02	Schering Corporation	6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
JP2852659B2 (ja) *	1988-03-03	1999-02-03	富山化学工業株式会社	ピペラジン誘導体およびその塩
IL98572A (en)	1990-06-22	1995-07-31	Schering Corp	Bis-benzo or benzopyrido cyclohepta piperidene, piperidylidene and piperazine compositions an methods of use
US6365588B1 (en) *	1993-10-15	2002-04-02	Schering Corporation	Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
ES2159047T3 (es) *	1995-10-16	2001-09-16	Kyowa Hakko Kogyo Kk	Compuestos triciclicos.
KR20000036102A (ko)	1996-09-13	2000-06-26	둘락 노먼 씨.	파르네실-단백질 트랜스퍼라제 억제제로서 유용한 치환된 벤조사이클로헵타피리딘
TR199900561T2 (xx)	1996-09-13	1999-06-21	Schering Corporation	G-protein i�levinin engellenmesi i�in ve �o�almaya y�nelik hastal�klar�n iyile�tirilmesi i�in yararl� trisiklik bile�ikler.
ES2286275T3 (es) *	2001-09-19	2007-12-01	Pharmacia Corporation	Compuestos de pirazolo sustituidos para el tratamiento de la inflamacion.
WO2003084931A1 (fr)	2002-04-02	2003-10-16	Merck & Co., Inc.	Antagonistes 5h-benzo[4,5]cyclohepta[1,2-b]pyridines de nmda/nr2b
GB0211649D0 (en) *	2002-05-21	2002-07-03	Novartis Ag	Organic compounds
ES2211315B1 (es)	2002-11-12	2005-10-16	Almirall Prodesfarma, S.A.	Nuevos compuestos triciclicos.
JP2006151809A (ja)	2002-12-26	2006-06-15	Ube Ind Ltd	ベンゾシクロヘプタピリジン化合物
CN101031551A (zh) *	2004-07-06	2007-09-05	安吉永生物制药公司	针对癌症治疗的肝细胞生长因子/c－met活性的喹唑啉调节剂
RU2408584C2 (ru)	2005-06-23	2011-01-10	Мерк Шарп Энд Домэ Корп.	Ингибиторы тирозинкиназы
TW200738638A (en)	2005-06-23	2007-10-16	Merck & Co Inc	Tyrosine kinase inhibitors

2007
- 2007-07-02 TW TW096124020A patent/TW200813021A/zh unknown
- 2007-07-03 AR ARP070102972A patent/AR061804A1/es not_active Application Discontinuation
- 2007-07-05 PE PE2007000877A patent/PE20080275A1/es not_active Application Discontinuation
- 2007-07-06 WO PCT/US2007/015675 patent/WO2008008310A2/fr not_active Ceased
- 2007-07-06 BR BRPI0713941-1A patent/BRPI0713941A2/pt not_active Application Discontinuation
- 2007-07-06 US US12/309,149 patent/US8222269B2/en active Active
- 2007-07-06 ES ES07810282.9T patent/ES2497493T3/es active Active
- 2007-07-06 JP JP2008536664A patent/JP4203121B1/ja not_active Expired - Fee Related
- 2007-07-06 RU RU2009104303/04A patent/RU2009104303A/ru not_active Application Discontinuation
- 2007-07-06 EP EP07810282.9A patent/EP2049494B1/fr active Active
- 2007-07-06 MX MX2009000410A patent/MX2009000410A/es not_active Application Discontinuation
- 2007-07-06 KR KR1020097000538A patent/KR20090026187A/ko not_active Ceased
- 2007-07-06 CN CN2007800335075A patent/CN101535268B/zh not_active Expired - Fee Related
- 2007-07-06 CA CA2656578A patent/CA2656578C/fr active Active
- 2007-07-06 AU AU2007273081A patent/AU2007273081B2/en not_active Ceased
- 2007-07-09 US US11/827,109 patent/US8101603B2/en active Active
2008
- 2008-04-21 JP JP2008109902A patent/JP5245045B2/ja not_active Expired - Fee Related
2009
- 2009-01-01 IL IL196337A patent/IL196337A0/en unknown
- 2009-01-05 ZA ZA200900019A patent/ZA200900019B/xx unknown
- 2009-01-06 CO CO09000744A patent/CO6190518A2/es not_active Application Discontinuation
- 2009-01-07 HN HN2009000018A patent/HN2009000018A/es unknown
- 2009-01-09 GT GT200900004A patent/GT200900004A/es unknown
- 2009-01-09 EC EC2009009051A patent/ECSP099051A/es unknown
- 2009-01-14 CR CR10560A patent/CR10560A/es not_active Application Discontinuation
- 2009-02-09 MA MA31620A patent/MA30631B1/fr unknown
- 2009-02-09 NO NO20090608A patent/NO20090608L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2656578C (fr)	2012-09-04
MX2009000410A (es)	2009-01-27
US8222269B2 (en)	2012-07-17
ES2497493T3 (es)	2014-09-23
KR20090026187A (ko)	2009-03-11
CA2656578A1 (fr)	2008-01-17
IL196337A0 (en)	2009-09-22
GT200900004A (es)	2010-04-13
PE20080275A1 (es)	2008-04-03
JP5245045B2 (ja)	2013-07-24
US8101603B2 (en)	2012-01-24
AU2007273081B2 (en)	2011-04-07
WO2008008310A2 (fr)	2008-01-17
ECSP099051A (es)	2009-02-27
RU2009104303A (ru)	2010-08-20
US20090012076A1 (en)	2009-01-08
CN101535268B (zh)	2012-11-14
US20090203684A1 (en)	2009-08-13
HN2009000018A (es)	2011-01-24
AR061804A1 (es)	2008-09-24
CN101535268A (zh)	2009-09-16
JP4203121B1 (ja)	2008-12-24
AU2007273081A1 (en)	2008-01-17
WO2008008310A3 (fr)	2008-05-15
NO20090608L (no)	2009-04-14
JP2009512698A (ja)	2009-03-26
EP2049494A2 (fr)	2009-04-22
TW200813021A (en)	2008-03-16
CR10560A (es)	2009-02-26
JP2009173622A (ja)	2009-08-06
EP2049494B1 (fr)	2014-06-25
BRPI0713941A2 (pt)	2012-12-04
CO6190518A2 (es)	2010-08-19
MA30631B1 (fr)	2009-08-03

Publication	Publication Date	Title
IL284889A (en)	2021-08-31	Imidazotriazines and imidazopyrimidines as kinase inhibitors
ZA200900019B (en)	2009-11-25	Tyrosine kinase inhibitors
EP2040546A4 (fr)	2009-12-23	Inhibiteurs de tyrosine kinase
IL197381A0 (en)	2009-12-24	Kinase inhibitor
IL190078A0 (en)	2008-08-07	Kinase inhibitors
ZA200900109B (en)	2010-03-31	Pyrrolotriazine kinase inhibitors
IL193482A0 (en)	2009-05-04	Hydantoin based kinase inhibitors
IL186845A0 (en)	2008-02-09	Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
IL206416A0 (en)	2010-12-30	Benzofuropyrimidinones as protein kinase inhibitors
EP2247185A4 (fr)	2012-01-25	Inhibiteurs de la tyrosine kinase
PL1943243T3 (pl)	2011-05-31	Inhibitory kinazy
EP2036893A4 (fr)	2011-04-13	INHIBITEUR DE KINASE Abl
SI1896422T1 (sl)	2011-11-30	Tirosin kinazni inhibitorji
ZA200908943B (en)	2010-08-25	Pyrazolopyrimidinone kinase inhibitor
IL197981A0 (en)	2009-12-24	Kinase inhibitors
ZA200810573B (en)	2009-09-30	Substituted 3-cyanopyridines as protein kinase inhibitors
GB0603522D0 (en)	2006-04-05	Kinase inhibition
ZA200709732B (en)	2008-11-26	Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
ZA200806993B (en)	2009-09-30	Hydantoin based kinase inhibitors
GB0621719D0 (en)	2006-12-13	Ikk- serine-threonine protein kinase inhibitors
IL189985A0 (en)	2008-08-07	Kinase inhibitors
ZA200803287B (en)	2009-10-28	Kinase inhibitors
GB0715470D0 (en)	2007-09-19	IKK- serine-threonine protein kinase inhibitors
GB0606238D0 (en)	2006-05-10	Kinase inhibition
HK1120508A (en)	2009-04-03	Kinase inhibitors