ZA200908751B - ACE2 polypeptide - Google Patents

ACE2 polypeptide

Info

Publication number: ZA200908751B
Authority: ZA; South Africa
Prior art keywords: ace2 polypeptide; ace2; polypeptide
Prior art date: 2007-06-12

Application number

ZA200908751A

Other languages

English (en)

Inventor

Manfred Schuster

Hans Loibner

Evelyne Janzek-Hawlat

Bernhard Peball

Stefan Stranner

Bettina Wagner

Robert Weik

Original Assignee

Apeiron Biologics Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-06-12

Filing date

2009-01-01

Publication date

2010-07-28

2008-04-08 Priority claimed from EP08450052A external-priority patent/EP2108695A1/de

2009-01-01 Application filed by Apeiron Biologics Ag filed Critical Apeiron Biologics Ag

2010-07-28 Publication of ZA200908751B publication Critical patent/ZA200908751B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/485—Exopeptidases (3.4.11-3.4.19)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/17—Metallocarboxypeptidases (3.4.17)
- C12Y304/17023—Angiotensin-converting enzyme 2 (3.4.17.23)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Cardiology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Cell Biology (AREA)
Toxicology (AREA)
Biophysics (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

ZA200908751A 2007-06-12 2009-01-01 ACE2 polypeptide ZA200908751B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AT0091307A AT505262A1 (de)	2007-06-12	2007-06-12	Rekombinantes ace2 polypeptid
EP08450052A EP2108695A1 (de)	2008-04-08	2008-04-08	Ace2 Polypeptid

Publications (1)

Publication Number	Publication Date
ZA200908751B true ZA200908751B (en)	2010-07-28

Family

ID=39720296

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200908751A ZA200908751B (en)	2007-06-12	2009-01-01	ACE2 polypeptide

Country Status (35)

Country	Link
US (3)	US8586319B2 (xx)
EP (3)	EP3375872A1 (xx)
JP (1)	JP5731193B2 (xx)
KR (2)	KR101682240B1 (xx)
CN (2)	CN104450654A (xx)
AT (1)	AT505262A1 (xx)
AU (1)	AU2008261591B2 (xx)
BR (1)	BRPI0813942B8 (xx)
CA (1)	CA2692854C (xx)
CO (1)	CO6270265A2 (xx)
CR (1)	CR11213A (xx)
CY (2)	CY1116873T1 (xx)
DK (2)	DK2543724T3 (xx)
DO (1)	DOP2009000282A (xx)
EA (1)	EA027399B1 (xx)
EG (1)	EG27095A (xx)
ES (2)	ES2670938T3 (xx)
HK (1)	HK1255493A1 (xx)
HR (2)	HRP20151120T1 (xx)
HU (2)	HUE028012T2 (xx)
IL (1)	IL202653B (xx)
LT (1)	LT2543724T (xx)
MA (1)	MA31472B1 (xx)
MX (1)	MX2009013472A (xx)
MY (1)	MY180672A (xx)
NO (1)	NO2543724T3 (xx)
NZ (1)	NZ581704A (xx)
PL (2)	PL2543724T3 (xx)
PT (2)	PT2155871E (xx)
RS (2)	RS57292B1 (xx)
SI (2)	SI2543724T1 (xx)
TR (1)	TR201808117T4 (xx)
UA (1)	UA106869C2 (xx)
WO (1)	WO2008151347A1 (xx)
ZA (1)	ZA200908751B (xx)

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US10221228B2 (en)	2006-02-03	2019-03-05	Opko Biologics Ltd.	Long-acting polypeptides and methods of producing and administering same
US20140113860A1 (en)	2006-02-03	2014-04-24	Prolor Biotech Ltd.	Long-acting polypeptides and methods of producing and administering same
US9458444B2 (en)	2006-02-03	2016-10-04	Opko Biologics Ltd.	Long-acting coagulation factors and methods of producing same
US10351615B2 (en)	2006-02-03	2019-07-16	Opko Biologics Ltd.	Methods of treatment with long-acting growth hormone
US8048849B2 (en)	2006-02-03	2011-11-01	Modigene, Inc.	Long-acting polypeptides and methods of producing same
US9249407B2 (en)	2006-02-03	2016-02-02	Opko Biologics Ltd.	Long-acting coagulation factors and methods of producing same
US20150038413A1 (en)	2006-02-03	2015-02-05	Opko Biologics Ltd.	Long-acting polypeptides and methods of producing and administering same
US8946155B2 (en)	2006-02-03	2015-02-03	Opko Biologics Ltd.	Long-acting polypeptides and methods of producing and administering same
AT505262A1 (de) *	2007-06-12	2008-12-15	Apeiron Biolog Forschungs Und	Rekombinantes ace2 polypeptid
EP2077119A1 (de) *	2007-12-21	2009-07-08	Apeiron Biologics Forschungs- und Entwicklungsgesellschaft M.B.H.	Behandlung von Fibrosen und Lebererkrankungen
AT506632A1 (de) *	2008-04-09	2009-10-15	Apeiron Biolog Forschungs Und	Behandlung von tumorerkrankungen
US9663778B2 (en)	2009-07-09	2017-05-30	OPKO Biologies Ltd.	Long-acting coagulation factors and methods of producing same
US12203113B2 (en)	2009-07-09	2025-01-21	Opko Biologics Ltd.	Long-acting coagulation factors and methods of producing same
WO2013157002A1 (en)	2012-04-19	2013-10-24	Prolor Biotech Inc.	Long-acting oxyntomodulin variants and methods of producing same
RU2015106812A (ru)	2012-08-02	2016-09-27	Ф.Хоффманн-Ля Рош Аг	Способ получения мономерных и мультимерных молекул и их применение
EA033788B1 (ru)	2012-11-20	2019-11-26	Opko Biologics Ltd	Способ увеличения гидродинамического объема полипептида путем присоединения карбоксиконцевого пептида гонадотропина
KR20150110607A (ko) *	2013-01-14	2015-10-02	아페이론 바이오로직스 아게	변형된 ａｃｅ２ 폴리펩티드
US20150158926A1 (en)	2013-10-21	2015-06-11	Opko Biologics, Ltd.	Long-acting polypeptides and methods of producing and administering same
CN107438623B (zh)	2014-12-10	2023-07-14	Opko生物科学有限公司	长效的ctp修饰的生长激素多肽的制备方法
HUE055449T2 (hu)	2015-06-19	2021-11-29	Opko Biologics Ltd	Hosszú hatástartamú koagulációs faktorok és eljárások ezek elõállítására
TW202444744A (zh)	2016-07-11	2024-11-16	以色列商歐科生物製品有限公司	長效型凝血因子及其生產方法
US11518788B2 (en) *	2020-07-10	2022-12-06	Avirus, Inc.	Methods and compositions for treating and preventing viral infection
WO2021151043A2 (en) *	2020-01-23	2021-07-29	Jang Hyun Han	Methods and compositions for treating and preventing viral infection
WO2021190980A1 (en)	2020-03-22	2021-09-30	Quadrucept Bio Limited	Multimers for viral strain evolution
EP3884957A1 (en)	2020-03-26	2021-09-29	The University of British Columbia	Methods for treatment of virus and methods for screening of anti-virus reagent using organoids
US20230293647A1 (en) *	2020-04-09	2023-09-21	Autolus Limited	Polypeptide
WO2021217120A2 (en) *	2020-04-24	2021-10-28	Administrators Of The Tulane Educational Fund	Compositions and methods for preventing or reducing the effects of infections by coronaviruses that bind the extracellular domain of the ace2 receptor
CN113667016A (zh) *	2020-05-15	2021-11-19	普米斯生物技术(珠海)有限公司	一种构建冠状病毒抗体的平台
WO2021247675A1 (en)	2020-06-02	2021-12-09	Ngm Biopharmaceuticals, Inc.	Coronavirus-binding agents and uses thereof
DE102020207224A1 (de)	2020-06-09	2021-12-09	Christoph Karle	Protein oder Peptid, insbesondere zur Prophylaxe und/oder Behandlung einer durch Coronaviren, insbesondere SARS-CoV-2-Viren, hervorgerufenen Infektion oder Infektionskrankheit und/oder einer Folgekrankheit davon
EP4171603A4 (en) *	2020-06-25	2024-06-26	Gliknik Inc.	ACE2-FC FUSION PROTEINS AND METHODS OF USE
WO2022008642A1 (en)	2020-07-08	2022-01-13	Apeiron Biologics Ag	Treatment of sars-cov-2 infection with a combination of targets
KR20230066317A (ko) *	2020-07-10	2023-05-15	바이오몰레큘러 홀딩스 엘엘씨	사면체 항체
US20240035012A1 (en) *	2020-08-21	2024-02-01	Westlake University	Engineered ace2 oligomers and uses thereof
KR102725210B1 (ko) *	2020-10-05	2024-11-04	한양대학교 산학협력단	안정화된 Ace2 변이체, 이를 이용한 Ace2-Fc 융합단백질 및 COVID-19 예방 또는 치료용 약학 조성물
CN112280764A (zh) *	2020-11-18	2021-01-29	通用生物系统（安徽）有限公司	一种新冠重组ace2蛋白在哺乳动物细胞中的生产方法
EP4011387A1 (en)	2020-12-11	2022-06-15	IMBA-Institut für Molekulare Biotechnologie GmbH	Superior neutralization of sars-cov-2 by deglycosylated human angiotensin converting enzyme 2
US20220226489A1 (en)	2021-01-20	2022-07-21	Singh Biotechnology, Llc	Therapeutics directed against coronavirus
WO2022184659A1 (en)	2021-03-01	2022-09-09	Quadrucept Bio Limited	Antibody domains & multimers
WO2022207918A1 (en)	2021-04-02	2022-10-06	Apeiron Biologics Ag	COVID-19 Therapy
EP4387732A4 (en)	2021-08-19	2025-09-03	Phenom Pharmaceuticals Inc	COMPOSITIONS AND METHODS FOR THE TREATMENT OF SARS-CoV-2
KR102834587B1 (ko) *	2021-09-16	2025-07-17	인에이블앱 주식회사	안지오텐신전환효소 2 수용체 및 이의 용도
CN113897346A (zh) *	2021-09-16	2022-01-07	四川大学	能够提高与SARS-CoV-2 S蛋白亲和力的ACE2突变组合及应用
DE102023118690A1 (de)	2023-07-14	2025-01-16	Christoph Karle	Protein oder Peptid, insbesondere zur Prophylaxe und/oder Behandlung einer Infektion und/oder Infektionskrankheit und/oder einer Folgeerkrankung davon

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US6194556B1 (en) *	1997-12-11	2001-02-27	Millennium Pharmaceuticals, Inc.	Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therfor
US6989363B1 (en) *	1997-12-11	2006-01-24	Millennium Pharmaceuticals, Inc.	Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor
DE60324925D1 (de)	2002-06-19	2009-01-08	Univ Health Network	Ace2-aktivierung zur behandlung von herz, lungen, und nierenkrankheit und bluthochdruck
WO2004023270A2 (en)	2002-09-09	2004-03-18	Millenium Pharmaceuticals, Inc.	Crystal structure of angiotensin-converting enzyme-related carboxypeptidase
EP1723962A1 (en) *	2005-05-19	2006-11-22	IMBA-Institut für Molekulare Biotechnologie GmbH	Use of inhibitors of the renin-angiotensin system for the treatment of lung injuries
AT504443B1 (de)	2006-10-19	2008-11-15	Apeiron Biolog Forschungs Und	Verfahren zur bestimmung der aktivität von ace2
AT505262A1 (de) *	2007-06-12	2008-12-15	Apeiron Biolog Forschungs Und	Rekombinantes ace2 polypeptid
EP2108695A1 (de)	2008-04-08	2009-10-14	Apeiron Biologics Forschungs- und Entwicklungsgesellschaft M.B.H.	Ace2 Polypeptid
AT506258A1 (de) *	2007-12-18	2009-07-15	Apeiron Biolog Forschungs Und	Behandlung inflammatorischer krankheiten
AT506632A1 (de) *	2008-04-09	2009-10-15	Apeiron Biolog Forschungs Und	Behandlung von tumorerkrankungen

2007
- 2007-06-12 AT AT0091307A patent/AT505262A1/de not_active Application Discontinuation
2008
- 2008-06-12 KR KR1020097027569A patent/KR101682240B1/ko active Active
- 2008-06-12 WO PCT/AT2008/000211 patent/WO2008151347A1/de not_active Ceased
- 2008-06-12 NO NO12165189A patent/NO2543724T3/no unknown
- 2008-06-12 CN CN201410412672.3A patent/CN104450654A/zh active Pending
- 2008-06-12 MX MX2009013472A patent/MX2009013472A/es active IP Right Grant
- 2008-06-12 DK DK12165189.7T patent/DK2543724T3/en active
- 2008-06-12 RS RS20180677A patent/RS57292B1/sr unknown
- 2008-06-12 DK DK08756821.8T patent/DK2155871T3/en active
- 2008-06-12 JP JP2010511445A patent/JP5731193B2/ja active Active
- 2008-06-12 EA EA201000002A patent/EA027399B1/ru unknown
- 2008-06-12 KR KR1020167011786A patent/KR20160054045A/ko not_active Ceased
- 2008-06-12 CA CA2692854A patent/CA2692854C/en active Active
- 2008-06-12 RS RS20150709A patent/RS54340B1/sr unknown
- 2008-06-12 PT PT87568218T patent/PT2155871E/pt unknown
- 2008-06-12 SI SI200831961T patent/SI2543724T1/en unknown
- 2008-06-12 PL PL12165189T patent/PL2543724T3/pl unknown
- 2008-06-12 TR TR2018/08117T patent/TR201808117T4/tr unknown
- 2008-06-12 CN CN200880100650A patent/CN101796183A/zh active Pending
- 2008-06-12 NZ NZ581704A patent/NZ581704A/en unknown
- 2008-06-12 ES ES12165189.7T patent/ES2670938T3/es active Active
- 2008-06-12 SI SI200831514T patent/SI2155871T1/sl unknown
- 2008-06-12 LT LTEP12165189.7T patent/LT2543724T/lt unknown
- 2008-06-12 EP EP18161541.0A patent/EP3375872A1/de not_active Withdrawn
- 2008-06-12 AU AU2008261591A patent/AU2008261591B2/en active Active
- 2008-06-12 HR HRP20151120TT patent/HRP20151120T1/hr unknown
- 2008-06-12 PL PL08756821T patent/PL2155871T3/pl unknown
- 2008-06-12 BR BRPI0813942A patent/BRPI0813942B8/pt active IP Right Grant
- 2008-06-12 US US12/664,641 patent/US8586319B2/en active Active
- 2008-06-12 UA UAA200912888A patent/UA106869C2/uk unknown
- 2008-06-12 HU HUE08756821A patent/HUE028012T2/en unknown
- 2008-06-12 HU HUE12165189A patent/HUE037877T2/hu unknown
- 2008-06-12 PT PT121651897T patent/PT2543724T/pt unknown
- 2008-06-12 EP EP12165189.7A patent/EP2543724B1/de active Active
- 2008-06-12 EP EP08756821.8A patent/EP2155871B1/de active Active
- 2008-06-12 MY MYPI20095316A patent/MY180672A/en unknown
- 2008-06-12 ES ES08756821.8T patent/ES2550390T3/es active Active
2009
- 2009-01-01 ZA ZA200908751A patent/ZA200908751B/xx unknown
- 2009-12-10 IL IL202653A patent/IL202653B/en active IP Right Grant
- 2009-12-10 EG EG2009121812A patent/EG27095A/xx active
- 2009-12-11 DO DO2009000282A patent/DOP2009000282A/es unknown
- 2009-12-30 MA MA32464A patent/MA31472B1/fr unknown
2010
- 2010-01-08 CO CO10001879A patent/CO6270265A2/es not_active Application Discontinuation
- 2010-01-12 CR CR11213A patent/CR11213A/es unknown
- 2010-04-28 HK HK18114676.2A patent/HK1255493A1/zh unknown
2013
- 2013-09-13 US US14/026,887 patent/US20140099297A1/en not_active Abandoned
2015
- 2015-10-26 CY CY20151100955T patent/CY1116873T1/el unknown
2017
- 2017-12-06 US US15/833,243 patent/US10716833B2/en active Active
2018
- 2018-05-23 CY CY20181100549T patent/CY1120426T1/el unknown
- 2018-05-30 HR HRP20180856TT patent/HRP20180856T1/hr unknown

Also Published As

Publication number	Publication date
TR201808117T4 (tr)	2018-07-23
SI2155871T1 (sl)	2015-11-30
HRP20180856T1 (hr)	2018-08-24
US8586319B2 (en)	2013-11-19
EP2155871A1 (de)	2010-02-24
CR11213A (es)	2010-04-20
RS57292B1 (sr)	2018-08-31
EP2543724A3 (de)	2013-02-20
CY1120426T1 (el)	2019-07-10
JP5731193B2 (ja)	2015-06-10
HUE037877T2 (hu)	2018-09-28
KR20160054045A (ko)	2016-05-13
MA31472B1 (fr)	2010-06-01
US20180289779A1 (en)	2018-10-11
WO2008151347A1 (de)	2008-12-18
EA027399B1 (ru)	2017-07-31
BRPI0813942A2 (pt)	2014-12-30
CN101796183A (zh)	2010-08-04
HK1136602A1 (en)	2010-07-02
BRPI0813942B8 (pt)	2021-05-25
CN104450654A (zh)	2015-03-25
LT2543724T (lt)	2018-06-25
PL2543724T3 (pl)	2018-08-31
UA106869C2 (uk)	2014-10-27
US10716833B2 (en)	2020-07-21
RS54340B1 (sr)	2016-02-29
PT2543724T (pt)	2018-06-11
JP2011519264A (ja)	2011-07-07
CA2692854C (en)	2017-07-04
CA2692854A1 (en)	2008-12-18
AT505262A1 (de)	2008-12-15
MY180672A (en)	2020-12-05
EP2155871B1 (de)	2015-08-12
NZ581704A (en)	2012-05-25
CY1116873T1 (el)	2017-04-05
DOP2009000282A (es)	2010-03-31
IL202653A0 (en)	2011-08-01
CO6270265A2 (es)	2011-04-20
ES2670938T3 (es)	2018-06-04
IL202653B (en)	2018-01-31
EP2543724B1 (de)	2018-03-21
BRPI0813942B1 (pt)	2019-08-20
MX2009013472A (es)	2010-06-25
ES2550390T3 (es)	2015-11-06
SI2543724T1 (en)	2018-07-31
DK2543724T3 (en)	2018-05-28
US20100310546A1 (en)	2010-12-09
DK2155871T3 (en)	2015-11-09
EP2543724A2 (de)	2013-01-09
HRP20151120T1 (xx)	2015-11-20
US20140099297A1 (en)	2014-04-10
HK1255493A1 (zh)	2019-08-16
AU2008261591A1 (en)	2008-12-18
PL2155871T3 (pl)	2015-12-31
KR20100040809A (ko)	2010-04-21
EA201000002A1 (ru)	2010-08-30
PT2155871E (pt)	2015-10-26
AU2008261591B2 (en)	2014-08-07
HUE028012T2 (en)	2016-11-28
EP3375872A1 (de)	2018-09-19
KR101682240B1 (ko)	2016-12-06
NO2543724T3 (xx)	2018-08-18
EG27095A (en)	2015-05-28

Publication	Publication Date	Title
EG27095A (en)	2015-05-28	ACE2 polypeptide
ZA200810738B (en)	2018-11-28	Polypeptide
DE602007008470D1 (en)	2010-09-23	Off
GB0721686D0 (en)	2007-12-12	Polypeptides
AP2010005314A0 (en)	2010-08-31	Nanodispersian
ZA201000283B (en)	2011-06-29	Reinigung pegylierter polypeptide
GB0723712D0 (en)	2008-01-16	Peptides
EP2123666A4 (en)	2011-01-05	PEPTIDE
GB0723387D0 (en)	2008-01-09	Improved dehumldifier
GB0809659D0 (en)	2008-07-02	Polypeptides
GB0703945D0 (en)	2007-04-11	Peptide
GB0712302D0 (en)	2007-08-01	Chrondroitinase polypeptides
GB0713585D0 (en)	2007-08-22	Equivalent
IL197675A0 (en)	2009-12-24	Peptides
GB0703927D0 (en)	2007-04-11	Fuel
KG1098C1 (en)	2008-11-29	Towel-drying construction
GB0705115D0 (en)	2007-04-25	Peptides
GB0705251D0 (en)	2007-04-25	Peptides
GB0707626D0 (en)	2007-05-30	Peptides
GB0721702D0 (en)	2007-12-12	Hydrogienic globaltechnology limited
GB0609691D0 (en)	2006-06-28	Corcost 5a
GB0706942D0 (en)	2007-05-16	Fuel store-2
GB0717492D0 (en)	2007-10-24	Turn case
GB0705748D0 (en)	2007-05-02	Finally finally
GB0713339D0 (en)	2007-08-22	Richochet III