ZA200803803B - Recombinant expression of multiprotein complexes using polygenes - Google Patents
Recombinant expression of multiprotein complexes using polygenesInfo
- Publication number
- ZA200803803B ZA200803803B ZA200803803A ZA200803803A ZA200803803B ZA 200803803 B ZA200803803 B ZA 200803803B ZA 200803803 A ZA200803803 A ZA 200803803A ZA 200803803 A ZA200803803 A ZA 200803803A ZA 200803803 B ZA200803803 B ZA 200803803B
- Authority
- ZA
- South Africa
- Prior art keywords
- polygene
- present
- multiprotein complexes
- vector
- relates
- Prior art date
Links
- 108010085220 Multiprotein Complexes Proteins 0.000 title abstract 3
- 102000007474 Multiprotein Complexes Human genes 0.000 title abstract 3
- 238000003259 recombinant expression Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 6
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 108010076039 Polyproteins Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 229940000406 drug candidate Drugs 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 238000011835 investigation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/866—Baculoviral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14041—Use of virus, viral particle or viral elements as a vector
- C12N2710/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vectore
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05024271A EP1783228A1 (en) | 2005-11-08 | 2005-11-08 | Recombinant expression of multiprotein complexes using polygenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200803803B true ZA200803803B (en) | 2009-03-25 |
Family
ID=35811626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200803803A ZA200803803B (en) | 2005-11-08 | 2008-05-05 | Recombinant expression of multiprotein complexes using polygenes |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9512443B2 (xx) |
| EP (2) | EP1783228A1 (xx) |
| JP (1) | JP5075833B2 (xx) |
| KR (1) | KR101307880B1 (xx) |
| CN (1) | CN101356275A (xx) |
| AT (1) | ATE426029T1 (xx) |
| AU (1) | AU2006312659B2 (xx) |
| CA (1) | CA2626891C (xx) |
| DE (1) | DE602006005835D1 (xx) |
| ES (1) | ES2324495T3 (xx) |
| IL (1) | IL240971A0 (xx) |
| NZ (1) | NZ568270A (xx) |
| WO (1) | WO2007054250A1 (xx) |
| ZA (1) | ZA200803803B (xx) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0820631D0 (en) * | 2008-11-11 | 2008-12-17 | London School Hygiene & Tropical Medicine | Vectors |
| JP5036741B2 (ja) * | 2009-02-18 | 2012-09-26 | 中原大學 | 翻訳段階で自己切断活性を有するポリヌクレオチド配列を同定するための方法およびシステム |
| SG10201603033QA (en) | 2009-05-01 | 2016-05-30 | Pfizer | Recombinant virus-like particles encoded by multi-gene vector |
| CN101591716B (zh) * | 2009-06-12 | 2011-12-14 | 宁波检验检疫科学技术研究院 | 香蕉苞片花叶病毒实时荧光rt-pcr检测试剂及制备方法和应用 |
| IN2012DN03281A (xx) * | 2009-10-30 | 2015-10-23 | Abbott Lab | |
| US8945876B2 (en) | 2011-11-23 | 2015-02-03 | University Of Hawaii | Auto-processing domains for polypeptide expression |
| WO2014141170A1 (en) | 2013-03-14 | 2014-09-18 | Friedrich Miescher Institute For Biomedical Research | Method for the generation of polycystronic vectors |
| CN103740758B (zh) * | 2013-12-18 | 2015-03-18 | 广东华南联合疫苗开发院有限公司 | 一种重组杆状病毒载体及病毒样颗粒及制备方法和用途 |
| EP3139953A1 (en) | 2014-05-08 | 2017-03-15 | Pfizer Inc. | Means and methods for treating cmv |
| BR112018014639A2 (pt) * | 2016-01-27 | 2018-12-11 | Total Raffinage Chimie | expressão de múltiplos genes em microalgas |
| US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| CN118949021A (zh) | 2016-03-14 | 2024-11-15 | 雷德生物科技股份公司 | 用于治疗hsv的手段和方法 |
| IL266628B2 (en) * | 2016-11-17 | 2024-06-01 | Bluebird Bio Inc | TGFBeta signal converter |
| JP7240749B2 (ja) * | 2017-09-29 | 2023-03-16 | ベスファジェン・インコーポレイテッド | 心不全の予防または治療のための医薬組成物 |
| GB201721069D0 (en) * | 2017-12-15 | 2018-01-31 | Glaxosmithkline Biologicals Sa | Hepatitis B Immunisation regimen and compositions |
| US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| US11639954B2 (en) | 2019-05-29 | 2023-05-02 | Rosemount Aerospace Inc. | Differential leakage current measurement for heater health monitoring |
| US11472562B2 (en) | 2019-06-14 | 2022-10-18 | Rosemount Aerospace Inc. | Health monitoring of an electrical heater of an air data probe |
| US11930563B2 (en) | 2019-09-16 | 2024-03-12 | Rosemount Aerospace Inc. | Monitoring and extending heater life through power supply polarity switching |
| CN119770638A (zh) | 2019-09-30 | 2025-04-08 | 吉利德科学公司 | Hbv疫苗和治疗hbv的方法 |
| US11630140B2 (en) | 2020-04-22 | 2023-04-18 | Rosemount Aerospace Inc. | Prognostic health monitoring for heater |
| CN111607615B (zh) * | 2020-06-03 | 2022-03-01 | 金河佑本生物制品有限公司 | 一种猪流行性腹泻、猪传染性胃肠炎病毒病二联亚单位疫苗的制备方法 |
| TWI871709B (zh) | 2020-06-21 | 2025-02-01 | 美商輝瑞股份有限公司 | 人巨細胞病毒糖蛋白Ｂ（ｇＢ）多肽 |
| US20220033383A1 (en) | 2020-07-20 | 2022-02-03 | Enanta Pharmaceuticals, Inc. | Functionalized peptides as antiviral agents |
| US11384090B2 (en) | 2020-11-23 | 2022-07-12 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| MX2023005983A (es) | 2020-11-23 | 2023-08-15 | Enanta Pharm Inc | Nuevos agentes antivirales derivados de la espiropirrolidina. |
| US11352363B1 (en) | 2020-11-23 | 2022-06-07 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| CN116981680A (zh) * | 2021-01-14 | 2023-10-31 | 生物催化剂有限责任公司 | 用于肽生产的组合物和方法 |
| US11319325B1 (en) | 2021-05-11 | 2022-05-03 | Enanta Pharmaceuticals, Inc. | Macrocyclic spiropyrrolidine derived antiviral agents |
| US11325916B1 (en) | 2021-07-29 | 2022-05-10 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US11339170B1 (en) | 2021-07-23 | 2022-05-24 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| CN115340996A (zh) * | 2022-08-30 | 2022-11-15 | 态创生物科技(广州)有限公司 | 利用特异性酶切位点的多亚基蛋白共表达方法 |
| CN116042720B (zh) * | 2023-02-14 | 2025-09-02 | 中国科学院武汉病毒研究所 | 一种转运载体 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5162601A (en) * | 1989-11-22 | 1992-11-10 | The Upjohn Company | Plant potyvirus expression vector with a gene for protease |
| EP2311962B1 (en) * | 2002-03-29 | 2013-03-13 | XOMA Technology Ltd. | Multigenic vectors plasmids and methods for increasing expression of recombinant polypeptides |
| US20040235011A1 (en) | 2002-06-26 | 2004-11-25 | Cooper Richard K. | Production of multimeric proteins |
| WO2005085426A1 (ja) * | 2004-03-04 | 2005-09-15 | Tanabe Seiyaku Co., Ltd. | 無フィ−ダ−分化用培地及び霊長類動物胚性幹細胞からの無フィ−ダ−分化方法 |
| AU2004316874B2 (en) * | 2004-03-09 | 2011-01-06 | Eidgenoessische Technische Hochschule Zurich | New expression tools for multiprotein applications |
-
2005
- 2005-11-08 EP EP05024271A patent/EP1783228A1/en not_active Withdrawn
-
2006
- 2006-11-06 EP EP06818378A patent/EP1945773B1/en not_active Not-in-force
- 2006-11-06 AT AT06818378T patent/ATE426029T1/de not_active IP Right Cessation
- 2006-11-06 CN CNA2006800506873A patent/CN101356275A/zh active Pending
- 2006-11-06 AU AU2006312659A patent/AU2006312659B2/en not_active Ceased
- 2006-11-06 KR KR1020087013594A patent/KR101307880B1/ko not_active Expired - Fee Related
- 2006-11-06 DE DE602006005835T patent/DE602006005835D1/de active Active
- 2006-11-06 US US12/084,649 patent/US9512443B2/en not_active Expired - Fee Related
- 2006-11-06 JP JP2008539315A patent/JP5075833B2/ja not_active Expired - Fee Related
- 2006-11-06 NZ NZ568270A patent/NZ568270A/en not_active IP Right Cessation
- 2006-11-06 WO PCT/EP2006/010608 patent/WO2007054250A1/en not_active Ceased
- 2006-11-06 CA CA2626891A patent/CA2626891C/en not_active Expired - Fee Related
- 2006-11-06 ES ES06818378T patent/ES2324495T3/es active Active
-
2008
- 2008-05-05 ZA ZA200803803A patent/ZA200803803B/xx unknown
-
2015
- 2015-08-31 IL IL240971A patent/IL240971A0/en unknown
-
2016
- 2016-10-26 US US15/334,532 patent/US20170037090A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2324495T3 (es) | 2009-08-07 |
| WO2007054250A1 (en) | 2007-05-18 |
| NZ568270A (en) | 2011-07-29 |
| CA2626891C (en) | 2015-01-13 |
| EP1783228A1 (en) | 2007-05-09 |
| KR20080066990A (ko) | 2008-07-17 |
| AU2006312659A1 (en) | 2007-05-18 |
| JP5075833B2 (ja) | 2012-11-21 |
| EP1945773A1 (en) | 2008-07-23 |
| US20170037090A1 (en) | 2017-02-09 |
| AU2006312659B2 (en) | 2012-04-12 |
| CA2626891A1 (en) | 2007-05-18 |
| IL240971A0 (en) | 2015-10-29 |
| KR101307880B1 (ko) | 2013-09-16 |
| JP2009514541A (ja) | 2009-04-09 |
| US20090222936A1 (en) | 2009-09-03 |
| CN101356275A (zh) | 2009-01-28 |
| US9512443B2 (en) | 2016-12-06 |
| EP1945773B1 (en) | 2009-03-18 |
| DE602006005835D1 (de) | 2009-04-30 |
| ATE426029T1 (de) | 2009-04-15 |
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