DK1819816T3 - Fremgangsmåder til fremstilling og udskillelse af modificerede peptider - Google Patents
Fremgangsmåder til fremstilling og udskillelse af modificerede peptiderInfo
- Publication number
- DK1819816T3 DK1819816T3 DK05817110T DK05817110T DK1819816T3 DK 1819816 T3 DK1819816 T3 DK 1819816T3 DK 05817110 T DK05817110 T DK 05817110T DK 05817110 T DK05817110 T DK 05817110T DK 1819816 T3 DK1819816 T3 DK 1819816T3
- Authority
- DK
- Denmark
- Prior art keywords
- lantibiotic
- host cell
- polypeptide
- dehydratase
- secretion
- Prior art date
Links
- 230000003248 secreting effect Effects 0.000 title abstract 2
- 108091005601 modified peptides Proteins 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 9
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 8
- 229920001184 polypeptide Polymers 0.000 abstract 6
- 108010062877 Bacteriocins Proteins 0.000 abstract 5
- 102000004867 Hydro-Lyases Human genes 0.000 abstract 3
- 108090001042 Hydro-Lyases Proteins 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 230000028327 secretion Effects 0.000 abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04078318 | 2004-12-07 | ||
| PCT/NL2005/000842 WO2006062398A2 (en) | 2004-12-07 | 2005-12-07 | Methods for the production and secretion of modified peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1819816T3 true DK1819816T3 (da) | 2009-01-26 |
Family
ID=34928712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05817110T DK1819816T3 (da) | 2004-12-07 | 2005-12-07 | Fremgangsmåder til fremstilling og udskillelse af modificerede peptider |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8835616B2 (da) |
| EP (1) | EP1819816B1 (da) |
| CN (1) | CN101115838B (da) |
| AT (1) | ATE408016T1 (da) |
| CA (1) | CA2594151C (da) |
| DE (1) | DE602005009738D1 (da) |
| DK (1) | DK1819816T3 (da) |
| WO (1) | WO2006062398A2 (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9434770B2 (en) * | 2004-10-07 | 2016-09-06 | Tapas K Das Gupta | Modified cupredoxin derived peptides |
| CA2594151C (en) | 2004-12-07 | 2013-02-19 | Applied Nanosystems B.V. | Methods for the production and secretion of modified peptides |
| KR20090059148A (ko) | 2006-09-11 | 2009-06-10 | 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 | 쿠프레독신 유래된 펩티드의 변형 및 이의 이용 방법 |
| US7960336B2 (en) | 2007-08-03 | 2011-06-14 | Pharmain Corporation | Composition for long-acting peptide analogs |
| US8563527B2 (en) | 2007-08-20 | 2013-10-22 | Pharmain Corporation | Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same |
| KR20110122139A (ko) * | 2009-02-04 | 2011-11-09 | 노박타 바이오시스템스 리미티드 | 액타가르딘 유도체 |
| EP2267003A1 (en) | 2009-06-24 | 2010-12-29 | Applied NanoSystems B.V. | Biologically produced cyclic affinity tags |
| EP2405008A1 (en) | 2010-07-06 | 2012-01-11 | LanthioPep B.V. | Bacterial surface display of thioether-bridge-containing peptides |
| CN107058285A (zh) * | 2010-08-13 | 2017-08-18 | 米蒂生物系统有限公司 | 修饰肽的展示 |
| WO2016102434A1 (en) | 2014-12-22 | 2016-06-30 | Morphosys Ag | Novel methods for displaying cyclic peptides on bacteriophage particles |
| AU2016232361B2 (en) * | 2015-03-13 | 2020-06-25 | Lanthiopep B.V. | Cyclic galanin-analogs and uses thereof |
| EP3294867A1 (en) * | 2015-05-12 | 2018-03-21 | Novozymes A/S | Bacillus licheniformis host cell with deleted lantibiotic gene(s) |
| CN106755220A (zh) * | 2015-11-23 | 2017-05-31 | 武汉臻智生物科技有限公司 | 制备乳酸链球菌素的方法 |
| US20190144908A1 (en) * | 2016-06-10 | 2019-05-16 | White Dog Labs, Inc. | High cell density anaerobic fermentation for protein expression |
| CN113354718B (zh) * | 2021-06-21 | 2023-06-02 | 重庆市畜牧科学院 | 一种哌尼生素前体、表达盒及其制备方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5218101A (en) | 1988-07-05 | 1993-06-08 | The University Of Maryland | Leader sequence inducing a post-translational modification of polypeptides in bacteria, and gene therefor |
| CA2081704C (en) | 1991-10-31 | 2007-05-01 | Karl-Dieter Entian | Biosynthetic process for the preparation of lantibiotics |
| FR2739629B1 (fr) * | 1995-10-06 | 1997-12-26 | Systems Bio Ind | Utilisation d'un systeme de secretion sec-dependant pour secreter des proteines normalement secretees par un systeme de secretion sec-independant, bacteries les contenant et leur utilisation |
| WO1999003352A1 (en) * | 1997-07-18 | 1999-01-28 | University Of Maryland | Sublancin lantibiotic produced by bacillus subtilis 168 |
| US6249606B1 (en) * | 1998-02-19 | 2001-06-19 | Mindmaker, Inc. | Method and system for gesture category recognition and training using a feature vector |
| US20040030531A1 (en) * | 2002-03-28 | 2004-02-12 | Honeywell International Inc. | System and method for automated monitoring, recognizing, supporting, and responding to the behavior of an actor |
| US6861236B2 (en) * | 2002-05-24 | 2005-03-01 | Applied Nanosystems B.V. | Export and modification of (poly)peptides in the lantibiotic way |
| US8686939B2 (en) * | 2002-07-27 | 2014-04-01 | Sony Computer Entertainment Inc. | System, method, and apparatus for three-dimensional input control |
| US20090143141A1 (en) * | 2002-08-06 | 2009-06-04 | Igt | Intelligent Multiplayer Gaming System With Multi-Touch Display |
| KR100465241B1 (ko) * | 2003-03-17 | 2005-01-13 | 삼성전자주식회사 | 가상 필기 평면을 이용한 모션 인식 시스템 및 그 인식방법 |
| US7785825B2 (en) | 2004-01-12 | 2010-08-31 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for dehydration and cyclization of peptides, synthetic compounds, and lantibiotics |
| KR100580647B1 (ko) * | 2004-04-01 | 2006-05-16 | 삼성전자주식회사 | 입력모드 분류가능한 동작기반 입력장치 및 방법 |
| JP2007533911A (ja) * | 2004-04-20 | 2007-11-22 | サウスウエスト リサーチ インスティテュート | 圧力関係の値用の個々の推量器を備える仮想シリンダ圧力センサ |
| US7519223B2 (en) * | 2004-06-28 | 2009-04-14 | Microsoft Corporation | Recognizing gestures and using gestures for interacting with software applications |
| WO2006014810A2 (en) * | 2004-07-29 | 2006-02-09 | Kevin Ferguson | A human movement measurement system |
| US20060071904A1 (en) * | 2004-10-05 | 2006-04-06 | Samsung Electronics Co., Ltd. | Method of and apparatus for executing function using combination of user's key input and motion |
| CA2594151C (en) | 2004-12-07 | 2013-02-19 | Applied Nanosystems B.V. | Methods for the production and secretion of modified peptides |
| US20090066641A1 (en) * | 2005-03-10 | 2009-03-12 | Motus Corporation | Methods and Systems for Interpretation and Processing of Data Streams |
| US7508384B2 (en) * | 2005-06-08 | 2009-03-24 | Daka Research Inc. | Writing system |
| JP5028751B2 (ja) * | 2005-06-09 | 2012-09-19 | ソニー株式会社 | 行動認識装置 |
| JP4151982B2 (ja) * | 2006-03-10 | 2008-09-17 | 任天堂株式会社 | 動き判別装置および動き判別プログラム |
| US7702608B1 (en) * | 2006-07-14 | 2010-04-20 | Ailive, Inc. | Generating motion recognizers for arbitrary motions for video games and tuning the motion recognizers to the end user |
| EP2089125A4 (en) * | 2006-11-10 | 2011-04-06 | Mtv Networks | ELECTRONIC GAME WITH IDENTIFICATION AND IMPLEMENTATION OF THE FOOT MOVEMENTS OF A USER |
| US20090265671A1 (en) * | 2008-04-21 | 2009-10-22 | Invensense | Mobile devices with motion gesture recognition |
| US7770136B2 (en) * | 2007-01-24 | 2010-08-03 | Microsoft Corporation | Gesture recognition interactive feedback |
| US20090017910A1 (en) * | 2007-06-22 | 2009-01-15 | Broadcom Corporation | Position and motion tracking of an object |
| US8696458B2 (en) * | 2008-02-15 | 2014-04-15 | Thales Visionix, Inc. | Motion tracking system and method using camera and non-camera sensors |
| US20090258703A1 (en) * | 2008-04-09 | 2009-10-15 | Aaron Philip Brunstetter | Motion Assessment Using a Game Controller |
| US20090291759A1 (en) * | 2008-05-22 | 2009-11-26 | International Business Machines Corporation | Simulation of writing on game consoles through the use of motion-sensing technology |
| US8319771B2 (en) * | 2008-09-30 | 2012-11-27 | Disney Enterprises, Inc. | Computer modelled environment |
| US8682606B2 (en) * | 2008-10-07 | 2014-03-25 | Qualcomm Incorporated | Generating virtual buttons using motion sensors |
| US20100117959A1 (en) * | 2008-11-10 | 2010-05-13 | Samsung Electronics Co., Ltd. | Motion sensor-based user motion recognition method and portable terminal using the same |
| US20100171696A1 (en) * | 2009-01-06 | 2010-07-08 | Chi Kong Wu | Motion actuation system and related motion database |
| KR20100091434A (ko) * | 2009-02-10 | 2010-08-19 | 삼성전자주식회사 | 디지털 영상 처리장치 및 그 제어방법 |
-
2005
- 2005-12-07 CA CA2594151A patent/CA2594151C/en not_active Expired - Fee Related
- 2005-12-07 WO PCT/NL2005/000842 patent/WO2006062398A2/en not_active Ceased
- 2005-12-07 DK DK05817110T patent/DK1819816T3/da active
- 2005-12-07 EP EP05817110A patent/EP1819816B1/en not_active Expired - Lifetime
- 2005-12-07 AT AT05817110T patent/ATE408016T1/de not_active IP Right Cessation
- 2005-12-07 US US11/792,516 patent/US8835616B2/en not_active Expired - Fee Related
- 2005-12-07 DE DE602005009738T patent/DE602005009738D1/de not_active Expired - Lifetime
- 2005-12-07 CN CN200580047868.6A patent/CN101115838B/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20090042246A1 (en) | 2009-02-12 |
| EP1819816B1 (en) | 2008-09-10 |
| CN101115838A (zh) | 2008-01-30 |
| US8835616B2 (en) | 2014-09-16 |
| ATE408016T1 (de) | 2008-09-15 |
| CN101115838B (zh) | 2015-08-12 |
| CA2594151C (en) | 2013-02-19 |
| CA2594151A1 (en) | 2006-06-15 |
| EP1819816A2 (en) | 2007-08-22 |
| WO2006062398A3 (en) | 2006-10-19 |
| WO2006062398A2 (en) | 2006-06-15 |
| DE602005009738D1 (de) | 2008-10-23 |
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