ZA200703888B - Anti-glypican 3 antibody having modified sugar chain - Google Patents

Anti-glypican 3 antibody having modified sugar chain

Info

Publication number: ZA200703888B
Authority: ZA; South Africa
Prior art keywords: glypican; antibody; sugar chain; modified sugar; modified
Prior art date: 2004-10-26

Application number

ZA200703888A

Other languages

English (en)

Inventor

Nakano Kiyotaka

Sugimoto Masamichi

Tanaka Megumi

Sugo Izumi

Ishiguro Takahiro

Iijima Shigeyuki

Original Assignee

Chugai Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-26

Filing date

2007-05-14

Publication date

2009-11-25

2007-05-14 Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd

2009-11-25 Publication of ZA200703888B publication Critical patent/ZA200703888B/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Wood Science & Technology (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Cell Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Zoology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Mycology (AREA)
Epidemiology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

ZA200703888A 2004-10-26 2007-05-14 Anti-glypican 3 antibody having modified sugar chain ZA200703888B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2004311356		2004-10-26

Publications (1)

Publication Number	Publication Date
ZA200703888B true ZA200703888B (en)	2009-11-25

Family

ID=36227980

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200703888A ZA200703888B (en)	2004-10-26	2007-05-14	Anti-glypican 3 antibody having modified sugar chain

Country Status (19)

Country	Link
US (2)	US7867734B2 (xx)
EP (1)	EP1816140A4 (xx)
JP (1)	JP4794457B2 (xx)
KR (1)	KR101296931B1 (xx)
CN (1)	CN101068836B (xx)
AU (1)	AU2005297772B2 (xx)
BR (1)	BRPI0518279A2 (xx)
CA (1)	CA2585196C (xx)
CR (1)	CR9151A (xx)
IL (1)	IL182662A (xx)
MA (1)	MA29025B1 (xx)
MX (1)	MX2007004593A (xx)
NO (1)	NO20072366L (xx)
NZ (1)	NZ554940A (xx)
RU (1)	RU2451030C2 (xx)
TW (1)	TWI468514B (xx)
UA (1)	UA93488C2 (xx)
WO (1)	WO2006046751A1 (xx)
ZA (1)	ZA200703888B (xx)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002338020A1 (en) *	2002-09-04	2004-03-29	Chugai Seiyaku Kabushiki Kaisha	Antibody against blood-solubilized n-terminal peptide in gpc3
US7863042B2 (en) *	2003-06-18	2011-01-04	Chugai Seiyaku Kabushiki Kaisha	Fucose transporter
ES2353967T3 (es)	2004-07-09	2011-03-08	Chugai Seiyaku Kabushiki Kaisha	Anticuerpo anti-glipicano 3 .
US7871613B2 (en)	2004-08-24	2011-01-18	Chugai Seiyaku Kabushiki Kaisha	Adjuvant therapy with the use of anti-glypican 3 antibody
WO2006046751A1 (ja) *	2004-10-26	2006-05-04	Chugai Seiyaku Kabushiki Kaisha	糖鎖改変抗グリピカン３抗体
US20070087005A1 (en)	2005-10-14	2007-04-19	Lazar Gregory A	Anti-glypican-3 antibody
KR101527342B1 (ko)	2007-07-17	2015-06-09	메다렉스, 엘.엘.시.	글리피칸-3에 대한 단클론 항체
US9096651B2 (en)	2007-09-26	2015-08-04	Chugai Seiyaku Kabushiki Kaisha	Method of modifying isoelectric point of antibody via amino acid substitution in CDR
WO2009041062A1 (ja) *	2007-09-28	2009-04-02	Chugai Seiyaku Kabushiki Kaisha	血漿中動態が改善されたグリピカン３抗体
CL2009000647A1 (es) *	2008-04-04	2010-06-04	Chugai Pharmaceutical Co Ltd	Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto.
US8589541B2 (en)	2009-01-28	2013-11-19	Headwater Partners I Llc	Device-assisted services for protecting network capacity
US8839387B2 (en)	2009-01-28	2014-09-16	Headwater Partners I Llc	Roaming services network and overlay networks
US12452377B2 (en)	2009-01-28	2025-10-21	Headwater Research Llc	Service design center for device assisted services
US11985155B2 (en)	2009-01-28	2024-05-14	Headwater Research Llc	Communications device with secure data path processing agents
US12166596B2 (en)	2009-01-28	2024-12-10	Disney Enterprises, Inc.	Device-assisted services for protecting network capacity
US12389218B2 (en)	2009-01-28	2025-08-12	Headwater Research Llc	Service selection set publishing to device agent with on-device service selection
DK2686020T3 (en)	2011-03-17	2017-05-01	Univ Birmingham	REDIRECTED IMMUNTERY
EP4119947A1 (en)	2012-12-21	2023-01-18	Chugai Seiyaku Kabushiki Kaisha	Gpc3-targeting drug which is administered to patient responsive to gpc3-targeting drug therapy
TWI693073B (zh)	2012-12-21	2020-05-11	日商中外製藥股份有限公司	對ｇｐｃ３標的治療劑療法為有效之患者投與的ｇｐｃ３標的治療劑
AU2015206272B2 (en) *	2014-01-16	2020-12-03	Calysta, Inc.	Microorganisms for the enhanced production of amino acids and related methods
CN106459959A (zh)	2014-05-08	2017-02-22	中外制药株式会社	对gpc3靶向治疗剂疗法有效的患者施用的gpc3靶向治疗剂
MA40764A (fr)	2014-09-26	2017-08-01	Chugai Pharmaceutical Co Ltd	Agent thérapeutique induisant une cytotoxicité
JP7096667B2 (ja)	2015-07-01	2022-07-06	中外製薬株式会社	Ｇｐｃ３標的治療剤が有効である患者に投与されるｇｐｃ３標的治療剤
AU2016304060B2 (en) *	2015-08-03	2022-09-29	Crage Medical Co., Limited	Antibody against glypican-3 and application thereof
KR101796688B1 (ko) *	2015-10-29	2017-12-01	재단법인 목암생명과학연구소	신규 항-글리피칸 3 항체 및 이를 포함하는 약학적 조성물
RU2018128784A (ru)	2016-01-27	2020-02-27	МЕДИММЬЮН, ЭлЭлСи	Способы получения антител с заданным профилем гликозилирования
US11767362B1 (en)	2016-03-15	2023-09-26	Chugai Seiyaku Kabushiki Kaisha	Methods of treating cancers using PD-1 axis binding antagonists and anti-GPC3 antibodies
US20190262397A1 (en)	2016-07-26	2019-08-29	Tessa Therapeutics Pte. Ltd.	Chimeric antigen receptor
US11793180B2 (en)	2016-08-22	2023-10-24	Chugai Seiyaku Kabushiki Kaisha	Gene-modified mouse expressing human GPC3 polypeptide
CN106591371A (zh) *	2016-11-25	2017-04-26	哈尔滨百伊生生物科技有限公司	Cd16a/gpc3双抗慢病毒表达载体及其构建方法和应用
JP7382922B2 (ja)	2017-09-20	2023-11-17	中外製薬株式会社	Ｐｄ－１系結合アンタゴニストおよびｇｐｃ３標的化剤を使用する併用療法のための投与レジメン
US20210388109A1 (en)	2018-10-01	2021-12-16	Adicet Bio, Inc.	Compositions and methods regarding engineered and non-engineered gamma delta t-cells for treatment of solid tumors
US11702482B2 (en)	2018-12-17	2023-07-18	Revitope Limited	Twin immune cell engager
EP3976104A4 (en)	2019-05-24	2023-10-04	Elixiron Immunotherapeutics (Hong Kong) Limited	ANTI-CSF1R ANTIBODIES, IL10 FUSION PROTEINS AND THEIR USES
WO2020246563A1 (ja)	2019-06-05	2020-12-10	中外製薬株式会社	抗体切断部位結合分子
KR20220155588A (ko) *	2020-03-18	2022-11-23	주식회사 유틸렉스	Gpc3 car-t 세포 조성물 및 이의 제조 및 사용 방법
US20240301085A1 (en) *	2021-02-10	2024-09-12	Simcere Zaiming Pharmaceutical Co., Ltd.	Humanized gpc3 antibody and application thereof

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0242355A (ja)	1988-08-02	1990-02-13	Hitachi Constr Mach Co Ltd	超音波検査装置
US5530101A (en) *	1988-12-28	1996-06-25	Protein Design Labs, Inc.	Humanized immunoglobulins
JPH04336051A (ja)	1991-05-10	1992-11-24	Toshiba Corp	超音波診断装置
AU4116793A (en) *	1992-04-24	1993-11-29	Board Of Regents, The University Of Texas System	Recombinant production of immunoglobulin-like domains in prokaryotic cells
US5622701A (en) *	1994-06-14	1997-04-22	Protein Design Labs, Inc.	Cross-reacting monoclonal antibodies specific for E- and P-selectin
WO1998023289A1 (en)	1996-11-27	1998-06-04	The General Hospital Corporation	MODULATION OF IgG BINDING TO FcRn
KR20000070989A (ko) *	1997-02-12	2000-11-25	나가야마 오사무	임파구계 종양의 치료제
US7361336B1 (en) *	1997-09-18	2008-04-22	Ivan Bergstein	Methods of cancer therapy targeted against a cancer stem line
ES2293691T3 (es) *	1997-10-03	2008-03-16	Chugai Seiyaku Kabushiki Kaisha	Anticuerpo humano natural.
JPH11118775A (ja)	1997-10-09	1999-04-30	Canon Inc	超音波検査装置
US6528624B1 (en) *	1998-04-02	2003-03-04	Genentech, Inc.	Polypeptide variants
DK1071700T3 (da)	1998-04-20	2010-06-07	Glycart Biotechnology Ag	Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet
US6737056B1 (en) *	1999-01-15	2004-05-18	Genentech, Inc.	Polypeptide variants with altered effector function
EP2278003B2 (en)	1999-04-09	2020-08-05	Kyowa Kirin Co., Ltd.	Method for controlling the activity of immunologically functional molecule
JP3606132B2 (ja)	1999-10-14	2005-01-05	Ｊｆｅエンジニアリング株式会社	超音波探傷方法およびその装置
JP2002048867A (ja)	2000-08-07	2002-02-15	Mitsubishi Heavy Ind Ltd	音響探査装置
ATE364063T1 (de)	2000-09-12	2007-06-15	Union Carbide Chem Plastic	Polymerische mischungen enthaltend ethylenoxid- copolymere
ES2620359T3 (es)	2000-10-06	2017-06-28	Kyowa Hakko Kirin Co., Ltd.	Células que producen unas composiciones de anticuerpo
JP4336051B2 (ja)	2001-01-31	2009-09-30	株式会社エヌ・ティ・ティ・ドコモ	無線通信端末、発呼制限方法及びプログラム
US20030003097A1 (en)	2001-04-02	2003-01-02	Idec Pharmaceutical Corporation	Recombinant antibodies coexpressed with GnTIII
ES2399028T3 (es) *	2001-06-22	2013-03-25	Chugai Seiyaku Kabushiki Kaisha	Inhibidores de la proliferación celular que contienen anticuerpo anti-glipicano 3
NZ571596A (en) *	2001-08-03	2010-11-26	Glycart Biotechnology Ag	Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
KR100572236B1 (ko)	2001-11-14	2006-04-19	가부시끼가이샤 도시바	초음파 검사 장치, 초음파 트랜스듀서 및 초음파 화상화 장치
JP4087098B2 (ja)	2001-11-14	2008-05-14	株式会社東芝	超音波検査装置
JP3961359B2 (ja)	2002-07-18	2007-08-22	株式会社東芝	超音波画像化装置
EP3960855A1 (en) *	2001-12-28	2022-03-02	Chugai Seiyaku Kabushiki Kaisha	Method for stabilizing proteins
US7317091B2 (en) *	2002-03-01	2008-01-08	Xencor, Inc.	Optimized Fc variants
US20040110226A1 (en)	2002-03-01	2004-06-10	Xencor	Antibody optimization
US7662925B2 (en) *	2002-03-01	2010-02-16	Xencor, Inc.	Optimized Fc variants and methods for their generation
US8188231B2 (en) *	2002-09-27	2012-05-29	Xencor, Inc.	Optimized FC variants
US20040132101A1 (en)	2002-09-27	2004-07-08	Xencor	Optimized Fc variants and methods for their generation
WO2003085119A1 (en) *	2002-04-09	2003-10-16	Kyowa Hakko Kogyo Co., Ltd.	METHOD OF ENHANCING ACTIVITY OF ANTIBODY COMPOSITION OF BINDING TO FcϜ RECEPTOR IIIa
ES2324029T3 (es)	2002-05-23	2009-07-29	Sunnybrook And Women's College Health Sciences Centre	Diagnostico de carcinoma hepatocelular.
WO2004018667A1 (ja)	2002-08-26	2004-03-04	Kirin Beer Kabushiki Kaisha	ペプチド及びこれを含む医薬
AU2002330482A1 (en)	2002-09-04	2004-03-29	Perseus Proteomics Inc.	Method of diagnosing cancer by detecting gpc3
AU2002338020A1 (en)	2002-09-04	2004-03-29	Chugai Seiyaku Kabushiki Kaisha	Antibody against blood-solubilized n-terminal peptide in gpc3
AU2002328429A1 (en)	2002-09-04	2004-03-29	Chugai Seiyaku Kabushiki Kaisha	CONSTRUCTION OF ANTIBODY USING MRL/lpr MOUSE
US20090010920A1 (en) *	2003-03-03	2009-01-08	Xencor, Inc.	Fc Variants Having Decreased Affinity for FcyRIIb
WO2005023301A1 (ja)	2003-09-04	2005-03-17	Chugai Seiyaku Kabushiki Kaisha	胆管癌治療剤および検出薬
ITBO20040008U1 (it)	2004-02-03	2004-05-03	Tonazzi S R L	Macchina per il riempimento e la chiusura di tubetti
ES2353967T3 (es) *	2004-07-09	2011-03-08	Chugai Seiyaku Kabushiki Kaisha	Anticuerpo anti-glipicano 3 .
DK1778359T3 (da) *	2004-08-08	2011-02-07	Eli Khayat	Farmaceutiske sammensætninger til lindring af oxcessive sukkerniveauer hos patienter med diabetes
JP2008510007A (ja) *	2004-08-16	2008-04-03	メディミューン，インコーポレーテッド	抗体依存性細胞性細胞傷害活性が増強されたＥｐｈ受容体Ｆｃ変異体
US7871613B2 (en)	2004-08-24	2011-01-18	Chugai Seiyaku Kabushiki Kaisha	Adjuvant therapy with the use of anti-glypican 3 antibody
WO2006046751A1 (ja)	2004-10-26	2006-05-04	Chugai Seiyaku Kabushiki Kaisha	糖鎖改変抗グリピカン３抗体
EP2208783A1 (en) *	2004-12-22	2010-07-21	Chugai Seiyaku Kabushiki Kaisha	Method of producing an antibody using a cell in which the function of fucose transporter is inhibited
US20070087005A1 (en) *	2005-10-14	2007-04-19	Lazar Gregory A	Anti-glypican-3 antibody
US9096651B2 (en) *	2007-09-26	2015-08-04	Chugai Seiyaku Kabushiki Kaisha	Method of modifying isoelectric point of antibody via amino acid substitution in CDR
CN102027372A (zh) *	2008-03-17	2011-04-20	国立大学法人宫崎大学	使用抗磷脂酰肌醇蛋白聚糖3抗体的肝癌细胞的检测法
CL2009000647A1 (es) *	2008-04-04	2010-06-04	Chugai Pharmaceutical Co Ltd	Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto.

2005
- 2005-10-26 WO PCT/JP2005/020057 patent/WO2006046751A1/ja not_active Ceased
- 2005-10-26 AU AU2005297772A patent/AU2005297772B2/en not_active Ceased
- 2005-10-26 JP JP2006542382A patent/JP4794457B2/ja not_active Expired - Fee Related
- 2005-10-26 KR KR1020077011403A patent/KR101296931B1/ko not_active Expired - Fee Related
- 2005-10-26 NZ NZ554940A patent/NZ554940A/en not_active IP Right Cessation
- 2005-10-26 CA CA2585196A patent/CA2585196C/en not_active Expired - Fee Related
- 2005-10-26 MX MX2007004593A patent/MX2007004593A/es active IP Right Grant
- 2005-10-26 CN CN2005800368760A patent/CN101068836B/zh not_active Expired - Fee Related
- 2005-10-26 EP EP05800031A patent/EP1816140A4/en not_active Ceased
- 2005-10-26 UA UAA200705812A patent/UA93488C2/uk unknown
- 2005-10-26 BR BRPI0518279-4A patent/BRPI0518279A2/pt not_active IP Right Cessation
- 2005-10-26 US US11/577,944 patent/US7867734B2/en not_active Expired - Fee Related
- 2005-10-26 RU RU2007119579/10A patent/RU2451030C2/ru not_active IP Right Cessation
- 2005-10-26 TW TW94137496A patent/TWI468514B/zh not_active IP Right Cessation
2007
- 2007-04-19 IL IL182662A patent/IL182662A/en not_active IP Right Cessation
- 2007-05-09 NO NO20072366A patent/NO20072366L/no not_active Application Discontinuation
- 2007-05-14 ZA ZA200703888A patent/ZA200703888B/xx unknown
- 2007-05-17 MA MA29912A patent/MA29025B1/fr unknown
- 2007-05-25 CR CR9151A patent/CR9151A/es not_active Application Discontinuation
2010
- 2010-08-09 US US12/852,950 patent/US20110033452A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1816140A4 (en)	2009-09-02
US7867734B2 (en)	2011-01-11
AU2005297772B2 (en)	2011-06-23
RU2451030C2 (ru)	2012-05-20
AU2005297772A1 (en)	2006-05-04
KR101296931B1 (ko)	2013-08-14
CN101068836B (zh)	2013-08-14
CA2585196C (en)	2015-01-06
MX2007004593A (es)	2007-06-22
UA93488C2 (uk)	2011-02-25
NO20072366L (no)	2007-06-21
US20110033452A1 (en)	2011-02-10
CA2585196A1 (en)	2006-05-04
TW200621980A (en)	2006-07-01
NZ554940A (en)	2010-04-30
HK1110335A1 (en)	2008-07-11
BRPI0518279A2 (pt)	2008-11-11
US20080124330A1 (en)	2008-05-29
JP4794457B2 (ja)	2011-10-19
CR9151A (es)	2008-03-18
MA29025B1 (fr)	2007-11-01
TWI468514B (zh)	2015-01-11
IL182662A (en)	2014-09-30
RU2007119579A (ru)	2008-12-10
CN101068836A (zh)	2007-11-07
WO2006046751A1 (ja)	2006-05-04
IL182662A0 (en)	2007-09-20
JPWO2006046751A1 (ja)	2008-05-22
EP1816140A1 (en)	2007-08-08
KR20070070222A (ko)	2007-07-03

Publication	Publication Date	Title
ZA200703888B (en)	2009-11-25	Anti-glypican 3 antibody having modified sugar chain
GB0228210D0 (en)	2003-01-08	Single chain antibodies
PT1599504E (pt)	2015-03-02	Anticorpo modificado
IL227753A0 (en)	2013-09-30	A qualified antibody or antibody residue
IL181575A0 (en)	2007-07-04	Anti-ox40l antibodies
IL228033A0 (en)	2013-09-30	Antibodies
IL179672A0 (en)	2007-05-15	Anti-cd3 antibodies
IL175710A0 (en)	2006-09-05	Anti-mpl antibody
IL187316A0 (en)	2008-04-13	Anti-interleukin 2 antibodies
IL187106A (en)	2015-10-29	Sclerostin binds antibody
IL190472A0 (en)	2008-11-03	Anti-glypican-3 antibody
IL192266A0 (en)	2008-12-29	Anti-ilt7 antibody
IL185366A0 (en)	2008-02-09	Antibody
GB0420466D0 (en)	2004-10-20	Anti-glucan antibodies
GB2420392B (en)	2009-05-06	Silent chain
ZA200701952B (en)	2008-10-29	Anti-OX40L antibodies
GB0306618D0 (en)	2003-04-30	Antibody
GB2417997B (en)	2008-12-24	Link chain
EP1780221A4 (en)	2007-10-03	ANTI-SYNOVIOLIN ANTIBODY
GB0418415D0 (en)	2004-09-22	Antibody
GB0420771D0 (en)	2004-10-20	Antibody
GB0417434D0 (en)	2004-09-08	Adaptable necklace
GB0421192D0 (en)	2004-10-27	Torque-chain combination necklace
GB0402642D0 (en)	2004-03-10	Antibodies
GB0402641D0 (en)	2004-03-10	Antibodies