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ZA200703677B - 3-(2-hydroxyphenyl)pyrazoles and their use as HSP90 modulators - Google Patents

3-(2-hydroxyphenyl)pyrazoles and their use as HSP90 modulators

Info

Publication number
ZA200703677B
ZA200703677B ZA200703677A ZA200703677A ZA200703677B ZA 200703677 B ZA200703677 B ZA 200703677B ZA 200703677 A ZA200703677 A ZA 200703677A ZA 200703677 A ZA200703677 A ZA 200703677A ZA 200703677 B ZA200703677 B ZA 200703677B
Authority
ZA
South Africa
Prior art keywords
pyrazoles
hydroxyphenyl
hsp90 modulators
hsp90
modulators
Prior art date
Application number
ZA200703677A
Other languages
English (en)
Inventor
Eggenweiler Hans-Michael
Wolf Michael
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA200703677B publication Critical patent/ZA200703677B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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ZA200703677A 2004-10-08 2007-05-07 3-(2-hydroxyphenyl)pyrazoles and their use as HSP90 modulators ZA200703677B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004049078A DE102004049078A1 (de) 2004-10-08 2004-10-08 Phenylpyrazole

Publications (1)

Publication Number Publication Date
ZA200703677B true ZA200703677B (en) 2008-08-27

Family

ID=35427769

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200703677A ZA200703677B (en) 2004-10-08 2007-05-07 3-(2-hydroxyphenyl)pyrazoles and their use as HSP90 modulators

Country Status (17)

Country Link
US (1) US20080090880A1 (xx)
EP (1) EP1799649B1 (xx)
JP (1) JP2008515823A (xx)
KR (1) KR20070098782A (xx)
CN (1) CN101035766A (xx)
AR (1) AR051135A1 (xx)
AU (1) AU2005293937A1 (xx)
BR (1) BRPI0515582A (xx)
CA (1) CA2583292A1 (xx)
DE (1) DE102004049078A1 (xx)
DK (1) DK1799649T3 (xx)
ES (1) ES2494920T3 (xx)
MX (1) MX2007004041A (xx)
PT (1) PT1799649E (xx)
RU (1) RU2007116868A (xx)
WO (1) WO2006039977A1 (xx)
ZA (1) ZA200703677B (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2586612C (en) 2004-11-18 2016-10-11 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
SI1877379T1 (sl) 2005-04-13 2013-05-31 Astex Therapeutics Limited Derivati hidroksibenzinamida in njih uporaba kot inhibitorji HSP90
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
DE102006023336A1 (de) 2006-05-18 2007-11-22 Merck Patent Gmbh 1,5-Diphenyl-pyrazole II
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
US8779132B2 (en) 2006-10-12 2014-07-15 Astex Therapeutics Limited Pharmaceutical compounds
WO2008044029A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
EP2073804B1 (en) 2006-10-12 2017-09-13 Astex Therapeutics Limited Hydroxy-substituted benzoic acid amide compounds for use in the treatment of pain
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
WO2009139834A1 (en) * 2008-05-13 2009-11-19 Poniard Pharmaceuticals, Inc. Bioactive compounds for treatment of cancer and neurodegenerative diseases
US20110144056A1 (en) * 2008-06-11 2011-06-16 Lin Linus S Pyrazole derivatives useful as inhibitors of faah
US9205086B2 (en) 2010-04-19 2015-12-08 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a Hsp90 inhibitory compounds and a EGFR inhibitor
AU2012332421A1 (en) 2011-11-02 2014-06-05 Synta Pharmaceuticals Corp. Cancer therapy using a combination of Hsp90 inhibitors with topoisomerase I inhibitors
EP2776025A1 (en) 2011-11-02 2014-09-17 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with platinum-containing agents
CA2854188A1 (en) 2011-11-14 2013-05-23 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with braf inhibitors
WO2015089800A1 (en) * 2013-12-19 2015-06-25 Eli Lilly And Company Fluorophenyl pyrazol compounds
ES2968785T3 (es) * 2014-10-31 2024-05-14 Hoffmann La Roche Nuevos compuestos de piridiniloxi- y feniloxipirazolilo
WO2017155942A2 (en) 2016-03-07 2017-09-14 Northwestern University Substituted heterocycles as c-myc targeting agents
US11142504B2 (en) 2016-03-07 2021-10-12 Northwestern University Substituted heterocycles as c-MYC targeting agents
CN114174265A (zh) * 2018-08-31 2022-03-11 西北大学 作为c-MYC靶向剂的取代的杂环
WO2020257261A1 (en) 2019-06-17 2020-12-24 Northwestern University SUBSTITUTED HETEROCYCLES AS c-MYC TARGETING AGENTS
CN118125978B (zh) * 2024-01-31 2025-08-12 安徽中医药大学 一种myc抑制剂及其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968921A (en) 1997-10-24 1999-10-19 Orgegon Health Sciences University Compositions and methods for promoting nerve regeneration
AU3378599A (en) 1998-04-03 1999-10-25 University Of Pittsburgh Benzoquinoid ansamycins for the treatment of cardiac arrest and stroke
CA2367108A1 (en) 1999-03-12 2000-09-14 The United States Of America, Represented By The Secretary, Department O F Health And Human Services Method of inhibiting a chaperone protein
CA2429196A1 (en) 2000-03-24 2001-10-04 Duke University Characterization of grp94-ligand interactions and purification, screening, and therapeutic methods relating thereto
WO2002002123A1 (en) 2000-06-29 2002-01-10 Trustees Of Boston University Use of geldanamycin and related compounds for prophylaxis or treatment of fibrogenic disorders
WO2002007761A1 (en) 2000-07-20 2002-01-31 Merck & Co., Inc. Inhibiting hepatitis c virus processing and replication
CA2417495C (en) 2000-07-28 2013-04-30 Sloan-Kettering Institute For Cancer Research Methods for treating cell proliferative disorders and viral infections
JP4406205B2 (ja) 2000-11-02 2010-01-27 スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ Ｈｓｐ９０に結合するための小分子組成物
WO2003041643A2 (en) 2001-11-09 2003-05-22 Conforma Therapeutics Corporation Hsp90-inhibiting zearalanol compounds and methods of producing and using same
DE60222804T2 (de) 2001-12-21 2008-07-03 Vernalis (Cambridge) Ltd., Abington 3-(2,4)dihydroxyphenyl-4-phenylpyrazole und deren medizinische verwendung
GB0228417D0 (en) * 2002-12-05 2003-01-08 Cancer Rec Tech Ltd Pyrazole compounds
GB0229618D0 (en) 2002-12-19 2003-01-22 Cancer Rec Tech Ltd Pyrazole compounds
JP2005225787A (ja) * 2004-02-12 2005-08-25 Nippon Kayaku Co Ltd Ｈｓｐ９０阻害剤

Also Published As

Publication number Publication date
US20080090880A1 (en) 2008-04-17
ES2494920T3 (es) 2014-09-16
WO2006039977A1 (de) 2006-04-20
CA2583292A1 (en) 2006-04-20
DK1799649T3 (da) 2014-08-11
JP2008515823A (ja) 2008-05-15
AU2005293937A1 (en) 2006-04-20
DE102004049078A1 (de) 2006-04-13
RU2007116868A (ru) 2008-11-20
CN101035766A (zh) 2007-09-12
EP1799649B1 (de) 2014-06-25
MX2007004041A (es) 2007-05-24
KR20070098782A (ko) 2007-10-05
EP1799649A1 (de) 2007-06-27
AR051135A1 (es) 2006-12-20
PT1799649E (pt) 2014-10-01
BRPI0515582A (pt) 2008-07-29

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