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ZA200700101B - Prodrugs of HIV protease inhibitors - Google Patents

Prodrugs of HIV protease inhibitors

Info

Publication number
ZA200700101B
ZA200700101B ZA200700101A ZA200700101A ZA200700101B ZA 200700101 B ZA200700101 B ZA 200700101B ZA 200700101 A ZA200700101 A ZA 200700101A ZA 200700101 A ZA200700101 A ZA 200700101A ZA 200700101 B ZA200700101 B ZA 200700101B
Authority
ZA
South Africa
Prior art keywords
prodrugs
protease inhibitors
hiv protease
hiv
inhibitors
Prior art date
Application number
ZA200700101A
Other languages
English (en)
Inventor
David A Degoey
David J Grampovnik
Dale J Kempf
William J Flosi
Larry L Klein
Xiu C Wang
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of ZA200700101B publication Critical patent/ZA200700101B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200700101A 2004-07-06 2007-01-03 Prodrugs of HIV protease inhibitors ZA200700101B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58571004P 2004-07-06 2004-07-06

Publications (1)

Publication Number Publication Date
ZA200700101B true ZA200700101B (en) 2009-10-28

Family

ID=35063063

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200700101A ZA200700101B (en) 2004-07-06 2007-01-03 Prodrugs of HIV protease inhibitors

Country Status (15)

Country Link
US (2) US7718633B2 (xx)
EP (2) EP2336138A3 (xx)
JP (2) JP5142714B2 (xx)
KR (1) KR101229431B1 (xx)
CN (1) CN101023090B (xx)
AU (1) AU2005270124B2 (xx)
BR (1) BRPI0512970A (xx)
CA (1) CA2571726C (xx)
ES (1) ES2402552T3 (xx)
IL (1) IL180433A (xx)
MX (1) MXPA06015108A (xx)
NZ (2) NZ590128A (xx)
TW (1) TWI365876B (xx)
WO (1) WO2006014282A2 (xx)
ZA (1) ZA200700101B (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ590128A (en) * 2004-07-06 2012-08-31 Abbott Lab Prodrugs of HIV protease inhibitors
CN101490023B (zh) 2006-07-07 2013-05-29 吉里德科学公司 治疗剂的药代动力学特性调节剂
AP2986A (en) * 2007-02-23 2014-09-30 Gilead Sciences Inc Modulators of pharmacokinetic properties of therapeutics
DE602008000255D1 (de) 2007-06-12 2009-12-17 Concert Pharmaceuticals Inc Azapeptid-Derivate als HIV-Protease-Inhibitoren
FI20070574A0 (fi) * 2007-07-30 2007-07-30 Kuopion Yliopisto Vesiliukoinen propofolin etylideenifosfaatti-aihiolääke
KR101677126B1 (ko) 2008-05-20 2016-11-22 노이로제스엑스, 인코포레이티드 탄산염 프로드러그 및 그것의 사용 방법
CN105254662A (zh) 2008-05-20 2016-01-20 阿索尔达治疗公司 水溶性对乙酰氨基酚类似物
MY158809A (en) * 2010-09-22 2016-11-15 Craun Res Sdn Bhd Pharmaceutical compositions for calanolides, their derivatives and analogues, and process for producing the same
EP2624869A4 (en) * 2010-10-08 2015-11-04 Univ Virginia Commonwealth PRODRUGS USING A CONTAINER CONTROLLED ABSORPTION MECHANISM
WO2012075117A2 (en) * 2010-12-01 2012-06-07 Ablitech, Inc. Small molecule-polymer conjugates and methods of making same
JP6567049B2 (ja) 2014-10-21 2019-08-28 アッヴィ・インコーポレイテッド カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2019515908A (ja) * 2016-04-20 2019-06-13 アッヴィ・インコーポレイテッド カルビドパ及びｌ−ドパプロドラッグ並びに使用方法
JOP20180009A1 (ar) 2017-02-06 2019-01-30 Gilead Sciences Inc مركبات مثبط فيروس hiv
TWI766172B (zh) 2018-07-30 2022-06-01 美商基利科學股份有限公司 抗hiv化合物
SG11202104499RA (en) 2018-11-15 2021-05-28 Abbvie Inc Pharmaceutical formulations for subcutaneous administration

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696270A (en) * 1989-05-23 1997-12-09 Abbott Laboratories Intermediate for making retroviral protease inhibiting compounds
EP0487270A3 (en) 1990-11-19 1992-11-25 Merck & Co. Inc. Hiv protease inhibitors having polyether substituents
NO310238B1 (no) * 1992-12-24 2001-06-11 Bristol Myers Squibb Co Kjemiske forbindelser og farmasöytisk preparat samt anvendelse av slike preparater
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
JPH09503497A (ja) * 1993-09-10 1997-04-08 ナルヘックス リミテッド 極性置換炭化水素
US5914332A (en) * 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
ZA9710071B (en) * 1996-11-21 1998-05-25 Abbott Lab Pharmaceutical composition.
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
US20030100088A1 (en) * 2001-07-13 2003-05-29 Sigler Gerald F. Protease inhibitor conjugates and antibodies useful in immunoassay
US7205413B2 (en) * 2002-05-03 2007-04-17 Transform Pharmaceuticals, Inc. Solvates and polymorphs of ritonavir and methods of making and using the same
NZ590128A (en) 2004-07-06 2012-08-31 Abbott Lab Prodrugs of HIV protease inhibitors

Also Published As

Publication number Publication date
CA2571726A1 (en) 2006-02-09
WO2006014282A3 (en) 2006-05-11
AU2005270124A1 (en) 2006-02-09
ES2402552T3 (es) 2013-05-06
IL180433A (en) 2013-07-31
AU2005270124B2 (en) 2011-09-08
US7718633B2 (en) 2010-05-18
JP2008505898A (ja) 2008-02-28
EP1773850A2 (en) 2007-04-18
US8426388B2 (en) 2013-04-23
NZ590128A (en) 2012-08-31
CA2571726C (en) 2013-05-21
EP2336138A2 (en) 2011-06-22
CN101023090A (zh) 2007-08-22
EP1773850B1 (en) 2013-01-30
EP2336138A3 (en) 2011-11-16
KR101229431B1 (ko) 2013-02-04
IL180433A0 (en) 2007-06-03
CN101023090B (zh) 2013-03-27
MXPA06015108A (es) 2007-03-26
KR20070029244A (ko) 2007-03-13
US20100286032A1 (en) 2010-11-11
TWI365876B (en) 2012-06-11
TW200613289A (en) 2006-05-01
WO2006014282A2 (en) 2006-02-09
BRPI0512970A (pt) 2008-04-22
JP2013040178A (ja) 2013-02-28
US20070270383A1 (en) 2007-11-22
NZ552276A (en) 2011-03-31
JP5142714B2 (ja) 2013-02-13
HK1104558A1 (en) 2008-01-18

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