ZA200600651B - Conjugates of hydroxyalkyl starch and G-CSF - Google Patents

Conjugates of hydroxyalkyl starch and G-CSF

Info

Publication number: ZA200600651B
Authority: ZA; South Africa
Prior art keywords: csf; conjugates; hydroxyalkyl starch; hydroxyalkyl; starch
Prior art date: 2002-09-11

Application number

ZA200600651A

Other languages

English (en)

Inventor

Eichner Wolfram

Knoller Helmut

Lutterback Katharina

Zander Norbert

Frank Ronald

Sommermeyer Klaus

Harald S Conradt

Grabenhorst Eckart

Original Assignee

Fresenius Kabi De Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-11

Filing date

2004-08-06

Publication date

2007-04-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31995520&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200600651(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-09-11 Priority claimed from EP02020425A external-priority patent/EP1400533A1/fr

2004-08-06 Application filed by Fresenius Kabi De Gmbh filed Critical Fresenius Kabi De Gmbh

2007-04-25 Publication of ZA200600651B publication Critical patent/ZA200600651B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/08—Ethers
- C08B31/10—Alkyl or cycloalkyl ethers
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/08—Ethers
- C08B31/12—Ethers having alkyl or cycloalkyl radicals substituted by heteroatoms, e.g. hydroxyalkyl or carboxyalkyl starch
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/10—Peptides being immobilised on, or in, an organic carrier the carrier being a carbohydrate
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/003—Crosslinking of starch
- C08B31/006—Crosslinking of derivatives of starch
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/08—Ethers
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/18—Oxidised starch
- C08B31/185—Derivatives of oxidised starch, e.g. crosslinked oxidised starch
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Materials Engineering (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Polymers & Plastics (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Hematology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

ZA200600651A 2002-09-11 2004-08-06 Conjugates of hydroxyalkyl starch and G-CSF ZA200600651B (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US40978102P	2002-09-11	2002-09-11
EP02020425A EP1400533A1 (fr)	2002-09-11	2002-09-11	Polypeptides hasylés, érythropoiétine hasylée en particulier
PCT/EP2003/008829 WO2004024776A1 (fr)	2002-09-11	2003-08-08	Procede de production de derives d'amidon hydroxyalkyle

Publications (1)

Publication Number	Publication Date
ZA200600651B true ZA200600651B (en)	2007-04-25

Family

ID=31995520

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200600651A ZA200600651B (en)	2002-09-11	2004-08-06	Conjugates of hydroxyalkyl starch and G-CSF

Country Status (24)

Country	Link
US (5)	US8618266B2 (fr)
EP (8)	EP2272865A3 (fr)
JP (4)	JP2006516534A (fr)
KR (3)	KR101045401B1 (fr)
CN (2)	CN1681844A (fr)
AR (3)	AR041097A1 (fr)
AT (3)	ATE449112T1 (fr)
AU (6)	AU2003255406B2 (fr)
BR (3)	BR0314106A (fr)
CA (2)	CA2495242A1 (fr)
CY (1)	CY1109813T1 (fr)
DE (7)	DE60330098D1 (fr)
DK (3)	DK1398327T3 (fr)
ES (4)	ES2399006T3 (fr)
IL (5)	IL166506A0 (fr)
MX (4)	MXPA05002591A (fr)
NO (2)	NO20051419L (fr)
PL (3)	PL375037A1 (fr)
PT (3)	PT1398327E (fr)
RU (3)	RU2328505C2 (fr)
SI (2)	SI1398328T1 (fr)
TW (1)	TW200418875A (fr)
WO (3)	WO2004024777A1 (fr)
ZA (1)	ZA200600651B (fr)

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Also Published As

Publication number	Publication date
AR045234A1 (es)	2005-10-19
DE60304640T2 (de)	2007-05-16
CN100348618C (zh)	2007-11-14
AU2003260393B2 (en)	2009-10-01
DE60330098D1 (de)	2009-12-31
PT1398328E (pt)	2010-02-19
EP2316850A3 (fr)	2011-11-09
US8618266B2 (en)	2013-12-31
DK1398328T3 (da)	2010-03-08
ES2213505T1 (es)	2004-09-01
EP2154160A1 (fr)	2010-02-17
DE03020424T1 (de)	2004-07-15
JP2006516534A (ja)	2006-07-06
PL216545B1 (pl)	2014-04-30
BR0314227A (pt)	2005-10-25
US20050238723A1 (en)	2005-10-27
KR20050072417A (ko)	2005-07-11
CA2496317C (fr)	2014-02-18
PL374490A1 (en)	2005-10-31
MXPA05002593A (es)	2005-05-27
DK1398322T3 (da)	2006-08-21
ES2213506T1 (es)	2004-09-01
ATE406387T1 (de)	2008-09-15
SI1398327T1 (sl)	2009-02-28
KR20050061466A (ko)	2005-06-22
US20100317609A1 (en)	2010-12-16
JP5275293B2 (ja)	2013-08-28
DE03020423T1 (de)	2004-07-15
AU2011200219B2 (en)	2012-05-17
AU2011200158B2 (en)	2012-08-02
EP1398327A1 (fr)	2004-03-17
CY1109813T1 (el)	2014-09-10
EP1398322B1 (fr)	2006-04-19
EP1398327B1 (fr)	2008-08-27
PL374969A1 (en)	2005-11-14
IL166931A (en)	2012-06-28
IL166930A (en)	2012-08-30
HK1063477A1 (en)	2004-12-31
US20060019877A1 (en)	2006-01-26
AU2003253399B2 (en)	2010-10-14
ATE323723T1 (de)	2006-05-15
MXPA05002591A (es)	2005-09-20
MX2010006175A (es)	2010-07-05
US20050234230A1 (en)	2005-10-20
US7815893B2 (en)	2010-10-19
TW200418875A (en)	2004-10-01
NO20051419L (no)	2005-05-30
IL166506A0 (en)	2006-01-15
CN1681846A (zh)	2005-10-12
EP2316850A2 (fr)	2011-05-04
DE20321836U1 (de)	2011-04-07
IL200150A0 (en)	2011-07-31
AR041097A1 (es)	2005-05-04
KR20050075336A (ko)	2005-07-20
RU2329274C2 (ru)	2008-07-20
ES2213506T3 (es)	2009-02-16
ES2213505T3 (es)	2006-11-16
WO2004024777A1 (fr)	2004-03-25
AU2003253399A1 (en)	2004-04-30
AU2011200158A1 (en)	2011-02-03
KR101174510B1 (ko)	2012-08-16
EP1398328B1 (fr)	2009-11-18
JP2011089125A (ja)	2011-05-06
PL375037A1 (en)	2005-11-14
EP2143736A1 (fr)	2010-01-13
PT1398327E (pt)	2008-10-31
AU2011200219A1 (en)	2011-02-10
RU2328505C2 (ru)	2008-07-10
EP1398328A1 (fr)	2004-03-17
US20110054152A1 (en)	2011-03-03
EP1398322A1 (fr)	2004-03-17
BR0314107A (pt)	2005-07-19
AU2003255406B2 (en)	2009-09-10
US20120046240A9 (en)	2012-02-23
RU2005110423A (ru)	2006-01-20
JP2010248528A (ja)	2010-11-04
MXPA05002594A (es)	2005-05-27
AU2003260393A1 (en)	2004-04-30
HK1136226A1 (en)	2010-06-25
BR0314106A (pt)	2005-07-19
EP2272865A2 (fr)	2011-01-12
ATE449112T1 (de)	2009-12-15
HK1063478A1 (en)	2004-12-31
DK1398327T3 (da)	2008-11-10
RU2005110415A (ru)	2006-08-27
KR101045422B1 (ko)	2011-06-30
ES2399006T3 (es)	2013-03-25
ES2213507T3 (es)	2010-04-15
DE60323192D1 (de)	2008-10-09
EP2272865A3 (fr)	2014-06-18
JP5455821B2 (ja)	2014-03-26
RU2005110412A (ru)	2006-01-20
SI1398328T1 (sl)	2010-02-26
JP2010265464A (ja)	2010-11-25
CA2496317A1 (fr)	2004-03-25
WO2004024777A8 (fr)	2005-03-24
AU2009238372A1 (en)	2009-12-17
AR045235A1 (es)	2005-10-19
PL217085B1 (pl)	2014-06-30
WO2004024776A1 (fr)	2004-03-25
ES2213507T1 (es)	2004-09-01
WO2004024761A1 (fr)	2004-03-25
NO20051427L (no)	2005-05-31
EP2017287A3 (fr)	2009-11-04
IL166506A (en)	2010-02-17
CA2495242A1 (fr)	2004-03-25
PT1398322E (pt)	2006-08-31
EP2017287A2 (fr)	2009-01-21
EP2143736B1 (fr)	2012-11-07
DE03020425T1 (de)	2004-07-15
DE60304640D1 (de)	2006-05-24
AU2009238372B2 (en)	2012-08-23
RU2326891C2 (ru)	2008-06-20
US8475765B2 (en)	2013-07-02
CN1681844A (zh)	2005-10-12
HK1063475A1 (en)	2004-12-31
AU2003255406A1 (en)	2004-04-30
KR101045401B1 (ko)	2011-06-30

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ZA200501725B (en)	2006-05-31	Hydroxyalkyl starch derivatives
PL377791A1 (pl)	2006-02-20	Pochodne 3-aminopiperydyny i sposoby ich wytwarzania
AU2003233069A8 (en)	2003-10-20	Gel and powder making
HRP20040711A2 (en)	2004-12-31	Controlled synthesis of ziprasidone and compositions thereof
EP1539692A4 (fr)	2005-08-24	Derives de furanone et leurs procedes de production
IL163868A0 (en)	2005-12-18	Hermiasterlin derivatives and uses thereof
AU2003296369A8 (en)	2004-06-30	Imminoamines and preparation thereof
GB0205699D0 (en)	2002-04-24	Amplifier and turner
IL173187A0 (en)	2006-06-11	Conjugates of hydroxyalkyl starch and g-csf
EP1539191A4 (fr)	2007-03-21	Compositions contenant des glyco-alcaloides et leurs diverses utilisations
AU2003297612A8 (en)	2004-06-23	2-substituted-3-propenamide derivatives and methods of using the same
GB2384705B (en)	2006-09-27	Cosmetic and related compositions
AU2003212515A8 (en)	2003-09-16	Indole-amide derivatives and their use as glycogen phosphorylase inhibitors
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HUP0401162A3 (en)	2007-05-02	Substituted c-furan-2-yl-methylamine and c-thiophen-2-yl-methylamine derivatives
AU2003302173A8 (en)	2004-07-14	Spirotetrathiocarbamates and spirooxothiocarbamates
SI1660134T1 (sl)	2011-04-29	Konjugati hidroksialkil ĺ kroba in g-csf
PL369327A1 (en)	2005-04-18	Synthesis of 2-aralkoxy adenosines and 2-alkoxyadenosines
AU2003264474A8 (en)	2004-04-08	Novel uracil derivatives and medicinal use thereof
EP1392460A4 (fr)	2009-11-04	Hydrofluorures d'aminosilanols et leur utilisation