ZA200607752B - [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone hydrochloride as an inhibitor of mast cell tryptase - Google Patents

[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone hydrochloride as an inhibitor of mast cell tryptase Download PDF

Info

Publication number: ZA200607752B
Authority: ZA; South Africa
Prior art keywords: compound; pharmaceutical composition; inflammatory; pharmaceutically acceptable; arthritis
Prior art date: 2004-03-26

Application number

ZA200607752A

Other languages

English (en)

Inventor

Gao Zhongli

Levell Julian

Adam W Sledeski

Davis Larry

Czekaj Mark

Haddad El-Bdaoui

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-26

Filing date

2006-09-15

Publication date

2008-05-28

2006-09-15 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2008-05-28 Publication of ZA200607752B publication Critical patent/ZA200607752B/en

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Classifications

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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Immunology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
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Oncology (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Virology (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Gastroenterology & Hepatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA200607752A 2004-03-26 2006-09-15 [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone hydrochloride as an inhibitor of mast cell tryptase ZA200607752B (en)

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Application Number	Priority Date	Filing Date	Title
US55692704P	2004-03-26	2004-03-26

Publications (1)

Publication Number	Publication Date
ZA200607752B true ZA200607752B (en)	2008-05-28

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Country Status (25)

Country	Link
US (1)	US20070142435A1 (es)
EP (1)	EP1737848A1 (es)
JP (1)	JP2007530580A (es)
KR (1)	KR20060130682A (es)
CN (1)	CN1956978A (es)
AR (1)	AR048336A1 (es)
AU (1)	AU2005230934A1 (es)
BR (1)	BRPI0509245A (es)
CA (1)	CA2560649A1 (es)
CR (1)	CR8603A (es)
DO (1)	DOP2005000039A (es)
EC (1)	ECSP066878A (es)
IL (1)	IL178031A0 (es)
MA (1)	MA28547B1 (es)
MX (1)	MXPA06010610A (es)
NO (1)	NO20064811L (es)
PA (1)	PA8627601A1 (es)
PE (1)	PE20060084A1 (es)
RU (1)	RU2330034C1 (es)
TN (1)	TNSN06278A1 (es)
TW (1)	TW200602035A (es)
UA (1)	UA83738C2 (es)
UY (1)	UY28821A1 (es)
WO (1)	WO2005097780A1 (es)
ZA (1)	ZA200607752B (es)

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Publication number	Priority date	Publication date	Assignee	Title
PE20071148A1 (es) *	2006-03-29	2007-12-10	Sanofi Aventis	Mejoras en la preparacion de intermedios que conducen a hidrocloruro de [4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-(4-bromo-3-metil-5-propoxi-tiofen-2-il)-metanona
AR065616A1 (es) *	2007-03-07	2009-06-17	Sanofi Aventis	Sintesis regioselectiva de ullmann de acido 4- bromo-3- metil-5- propoxi- tiofeno-2- carboxilico
WO2008115912A1 (en) *	2007-03-21	2008-09-25	Sanofi-Aventis	Regio-specific synthesis of 4-bromo-3-methyl-5-propoxy-thiophene-2-carboxylic acid
AR065858A1 (es) *	2007-03-29	2009-07-08	Sanofi Aventis	Metodo para preparar el inhibidor de triptasa [ 4-(5-aminoetil-2-fluoro-fenil)-piperidin-1-il]-(4-bromo-3-metil-5-propoxi-tiofen-2-il)-metanona.
WO2008121669A1 (en) *	2007-03-29	2008-10-09	Sanofi-Aventis	4-bromo-3-methyl-5-propoxythiophene-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester, its regio-specific synthesis and intermediate thereto
ES2469824T3 (es)	2007-11-21	2014-06-20	Janssen Pharmaceutica N.V.	Espiropiperidinas para su uso como inhibidores de la triptasa
WO2009094641A2 (en) *	2008-01-24	2009-07-30	Dor Biopharma, Inc.	Topically active steroids for use in interstitial pulmonary fibrosis
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- 2005-03-24 CN CNA2005800164250A patent/CN1956978A/zh active Pending
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Also Published As

Publication number	Publication date
AU2005230934A1 (en)	2005-10-20
CR8603A (es)	2007-06-08
TW200602035A (en)	2006-01-16
US20070142435A1 (en)	2007-06-21
CA2560649A1 (en)	2005-10-20
RU2006137717A (ru)	2008-05-10
IL178031A0 (en)	2006-12-31
JP2007530580A (ja)	2007-11-01
RU2330034C1 (ru)	2008-07-27
UA83738C2 (en)	2008-08-11
CN1956978A (zh)	2007-05-02
KR20060130682A (ko)	2006-12-19
BRPI0509245A (pt)	2007-09-11
PE20060084A1 (es)	2006-03-09
UY28821A1 (es)	2005-10-31
TNSN06278A1 (en)	2007-12-03
NO20064811L (no)	2006-10-23
PA8627601A1 (es)	2006-01-23
WO2005097780A1 (en)	2005-10-20
MA28547B1 (fr)	2007-04-03
MXPA06010610A (es)	2006-12-15
DOP2005000039A (es)	2005-10-31
EP1737848A1 (en)	2007-01-03
ECSP066878A (es)	2006-11-24
AR048336A1 (es)	2006-04-19

Publication	Publication Date	Title
EP2367812B1 (en)	2015-09-16	[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[7-fluoro-1-(2-methoxy-ethyl)-4trifluoromethoxy-1h-indol-3-yl]methanone as an inhibitor of mast cell tryptase
ZA200607752B (en)	2008-05-28	[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone hydrochloride as an inhibitor of mast cell tryptase
US20120142735A1 (en)	2012-06-07	Disubstituted [4-(5-aminomethyl-phenyl)-piperidin-1-yl]- 1h-indol-3-yl]-methanones
US20120245199A1 (en)	2012-09-27	[4 [4-(aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(1h-pyrrolo-pyridin-yl)-methanones and synthesis thereof
EP2516418B1 (en)	2014-05-14	Prodrugs of [4[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(1h-pyrrolo-pyridin-yl)-methanones and synthesis thereof
US20040192734A1 (en)	2004-09-30	4-(3-aminomethylphenyl)piperidin-1-yl]-[5-(2-fluorophenylethynyl)furan-2-yl]-methanone as an inhibitor of mast cell tryptase
HK1178517B (en)	2015-03-06	Prodrugs of [4[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(1h-pyrrolo-pyridin-yl)-methanones and synthesis thereof
HK1101076A (en)	2007-10-05	[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone hydrochloride as an inhibitor of mast cell tryptase