ZA200510330B - Novel method of synthesising perindopril and the pharmaceutically-acceptable salts thereof - Google Patents
Novel method of synthesising perindopril and the pharmaceutically-acceptable salts thereofInfo
- Publication number
- ZA200510330B ZA200510330B ZA200510330A ZA200510330A ZA200510330B ZA 200510330 B ZA200510330 B ZA 200510330B ZA 200510330 A ZA200510330 A ZA 200510330A ZA 200510330 A ZA200510330 A ZA 200510330A ZA 200510330 B ZA200510330 B ZA 200510330B
- Authority
- ZA
- South Africa
- Prior art keywords
- perindopril
- synthesising
- pharmaceutically
- acceptable salts
- novel method
- Prior art date
Links
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title 1
- 229960002582 perindopril Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03291601A EP1367061B1 (fr) | 2003-06-30 | 2003-06-30 | Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200510330B true ZA200510330B (en) | 2007-05-30 |
Family
ID=29414888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200510330A ZA200510330B (en) | 2003-06-30 | 2004-06-28 | Novel method of synthesising perindopril and the pharmaceutically-acceptable salts thereof |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7179833B2 (xx) |
| EP (1) | EP1367061B1 (xx) |
| JP (1) | JP4347341B2 (xx) |
| CN (1) | CN1802384B (xx) |
| AR (1) | AR044944A1 (xx) |
| AT (1) | ATE315043T1 (xx) |
| AU (1) | AU2004253721B2 (xx) |
| DE (1) | DE60303101T2 (xx) |
| DK (1) | DK1367061T3 (xx) |
| EA (1) | EA008836B1 (xx) |
| ES (1) | ES2256689T3 (xx) |
| MY (1) | MY139159A (xx) |
| NZ (1) | NZ544003A (xx) |
| PL (1) | PL211161B1 (xx) |
| SI (1) | SI1367061T1 (xx) |
| WO (1) | WO2005003153A1 (xx) |
| ZA (1) | ZA200510330B (xx) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1362864E (pt) * | 2003-06-30 | 2007-07-23 | Servier Lab | Novo processo de síntese do perindopril e dos seus sais aceitáveis do ponto de vista farmacêutico |
| SI1380591T1 (sl) * | 2003-08-29 | 2006-02-28 | Servier Lab | Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli |
| SI21800A (sl) * | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
| US7615571B2 (en) * | 2004-05-31 | 2009-11-10 | Ipca Laboratories Ltd. | Process for manufacture of pure (2S, 3aS, 7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl) butyl]amino]-1-oxopropyl] octahydro-1H-indole-2-carboxylic acid and its tert. butyl amine salt |
| KR20070095870A (ko) * | 2004-10-20 | 2007-10-01 | 에디컨인코포레이티드 | 흡수성 지혈제 |
| US9358318B2 (en) * | 2004-10-20 | 2016-06-07 | Ethicon, Inc. | Method of making a reinforced absorbable multilayered hemostatic wound dressing |
| EP1679072B9 (en) | 2005-01-06 | 2009-09-02 | IPCA Laboratories Limited | Process for for synthesis of (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indole-2- carboxylic acid derivatives and use in the synthesis of perindopril |
| US7291745B2 (en) | 2005-03-21 | 2007-11-06 | Glenmark Pharmaceuticals Limited | Process for the preparation of perindopril |
| JP2008019214A (ja) * | 2006-07-13 | 2008-01-31 | Shiono Chemical Co Ltd | ペリンドプリルまたはその誘導体の製造方法 |
| RU2433998C1 (ru) * | 2010-03-16 | 2011-11-20 | Закрытое акционерное общество "Активный Компонент" | Способ получения периндоприла и его фармацевтически приемлемых солей |
| WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
| PH12018502155B1 (en) | 2016-04-20 | 2024-03-27 | Servier Lab | Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2503155A2 (fr) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| SI9500140A (en) * | 1995-04-24 | 1996-10-31 | Genesis Para La Investigacion | Novel n-sulfoxy anhydrides, process for the preparation thereof and its use for the preparation of bioactive substances having ace inhibitory action |
| PT1321471E (pt) * | 2003-03-12 | 2005-07-29 | Servier Lab | Novo processo de sintese do perindopril e dos seus sais aceitaveis sob o ponto de vista farmaceutico |
| US20050171165A1 (en) * | 2003-11-12 | 2005-08-04 | Bhirud Shekhar B. | Process for the preparation of perindopril |
-
2003
- 2003-06-30 EP EP03291601A patent/EP1367061B1/fr not_active Expired - Lifetime
- 2003-06-30 DK DK03291601T patent/DK1367061T3/da active
- 2003-06-30 ES ES03291601T patent/ES2256689T3/es not_active Expired - Lifetime
- 2003-06-30 SI SI200330154T patent/SI1367061T1/sl unknown
- 2003-06-30 DE DE60303101T patent/DE60303101T2/de not_active Expired - Lifetime
- 2003-06-30 AT AT03291601T patent/ATE315043T1/de active
-
2004
- 2004-06-28 PL PL380408A patent/PL211161B1/pl unknown
- 2004-06-28 AU AU2004253721A patent/AU2004253721B2/en not_active Ceased
- 2004-06-28 NZ NZ544003A patent/NZ544003A/en not_active IP Right Cessation
- 2004-06-28 EA EA200501925A patent/EA008836B1/ru not_active IP Right Cessation
- 2004-06-28 US US10/562,490 patent/US7179833B2/en not_active Expired - Fee Related
- 2004-06-28 MY MYPI20042540A patent/MY139159A/en unknown
- 2004-06-28 WO PCT/FR2004/001637 patent/WO2005003153A1/fr not_active Ceased
- 2004-06-28 CN CN2004800160147A patent/CN1802384B/zh not_active Expired - Fee Related
- 2004-06-28 JP JP2006515295A patent/JP4347341B2/ja not_active Expired - Fee Related
- 2004-06-28 ZA ZA200510330A patent/ZA200510330B/xx unknown
- 2004-06-29 AR ARP040102277A patent/AR044944A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1367061A1 (fr) | 2003-12-03 |
| ATE315043T1 (de) | 2006-02-15 |
| WO2005003153A1 (fr) | 2005-01-13 |
| EA008836B1 (ru) | 2007-08-31 |
| ES2256689T3 (es) | 2006-07-16 |
| DK1367061T3 (da) | 2006-05-15 |
| AU2004253721A1 (en) | 2005-01-13 |
| NZ544003A (en) | 2009-03-31 |
| CN1802384B (zh) | 2010-06-16 |
| PL380408A1 (pl) | 2007-01-22 |
| JP4347341B2 (ja) | 2009-10-21 |
| DE60303101T2 (de) | 2006-09-28 |
| DE60303101D1 (de) | 2006-03-30 |
| AU2004253721B2 (en) | 2007-12-20 |
| MY139159A (en) | 2009-08-28 |
| PL211161B1 (pl) | 2012-04-30 |
| JP2007537974A (ja) | 2007-12-27 |
| EP1367061B1 (fr) | 2006-01-04 |
| US20060178421A1 (en) | 2006-08-10 |
| SI1367061T1 (sl) | 2006-04-30 |
| CN1802384A (zh) | 2006-07-12 |
| US7179833B2 (en) | 2007-02-20 |
| EA200501925A1 (ru) | 2006-06-30 |
| HK1089188A1 (en) | 2006-11-24 |
| AR044944A1 (es) | 2005-10-12 |
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