ZA200403198B - Crystal structure of phosphodiesterase 5 and use thereof. - Google Patents
Crystal structure of phosphodiesterase 5 and use thereof.Info
- Publication number
- ZA200403198B ZA200403198B ZA200403198A ZA200403198A ZA200403198B ZA 200403198 B ZA200403198 B ZA 200403198B ZA 200403198 A ZA200403198 A ZA 200403198A ZA 200403198 A ZA200403198 A ZA 200403198A ZA 200403198 B ZA200403198 B ZA 200403198B
- Authority
- ZA
- South Africa
- Prior art keywords
- phosphodiesterase
- crystal structure
- crystal
- Prior art date
Links
- 102000011016 Type 5 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 title 1
- 108010037581 Type 5 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 title 1
- 239000013078 crystal Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/04—Phosphoric diester hydrolases (3.1.4)
- C12Y301/04035—3',5'-Cyclic-GMP phosphodiesterase (3.1.4.35)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Food Science & Technology (AREA)
- Veterinary Medicine (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0126417.5A GB0126417D0 (en) | 2001-11-02 | 2001-11-02 | Crystal structure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200403198B true ZA200403198B (en) | 2005-11-18 |
Family
ID=9925082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200403198A ZA200403198B (en) | 2001-11-02 | 2004-04-28 | Crystal structure of phosphodiesterase 5 and use thereof. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20070015205A1 (xx) |
| EP (1) | EP1468082A1 (xx) |
| KR (1) | KR20050039728A (xx) |
| CN (1) | CN1585821A (xx) |
| BR (1) | BR0213717A (xx) |
| CA (1) | CA2478059A1 (xx) |
| GB (1) | GB0126417D0 (xx) |
| IL (1) | IL163926A0 (xx) |
| PL (1) | PL370513A1 (xx) |
| RU (1) | RU2301259C2 (xx) |
| WO (1) | WO2003038080A1 (xx) |
| YU (1) | YU36104A (xx) |
| ZA (1) | ZA200403198B (xx) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05011769A (es) * | 2003-05-01 | 2006-01-26 | Pfizer | Estructura cristalina. |
| CA2565308A1 (en) * | 2003-05-06 | 2004-11-25 | New Century Pharmaceuticals | Albumin binding sites for evaluating drug interactions and methods of evaluating or designing drugs based on their albumin binding properties |
| WO2005041895A2 (en) * | 2003-11-03 | 2005-05-12 | New Century Pharmaceuticals, Inc. | Albumin binding sites for evaluating drug interactions and methods of evaluating or designing drugs based on their albumin binding properties |
| ATE470681T1 (de) * | 2006-07-12 | 2010-06-15 | Novartis Ag | Aktinisch vernetzbare copolymere zur herstellung von kontaktlinsen |
| AR064286A1 (es) * | 2006-12-13 | 2009-03-25 | Quiceno Gomez Alexandra Lorena | Produccion de dispositivos oftalmicos basados en la polimerizacion por crecimiento escalonado fotoinducida |
| CN103865914B (zh) * | 2012-12-14 | 2016-05-25 | 上海美迪西生物医药股份有限公司 | Pde2催化结构域/pde2特异性抑制剂复合物的晶体及其生长方法 |
| KR102141542B1 (ko) | 2013-12-31 | 2020-09-14 | 엘지디스플레이 주식회사 | 표시장치 |
| FR3039297B1 (fr) * | 2015-07-20 | 2018-05-18 | Roam Data, Inc | Lecteur de carte compact |
| KR102576402B1 (ko) | 2016-05-31 | 2023-09-11 | 엘지디스플레이 주식회사 | 액정표시장치 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1038963B1 (en) * | 1993-05-27 | 2009-08-05 | Board Of Regents Of The University Of Washington | Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods |
| RU2174123C2 (ru) * | 1996-10-28 | 2001-09-27 | Новартис Аг | Производные 8-арил-1,7-нафтиридина и фармацевтическая композиция, обладающая противовоспалительной активностью |
| GB9923968D0 (en) * | 1999-10-11 | 1999-12-15 | Pfizer Ltd | Therapeutic agents |
| MXPA02006240A (es) * | 1999-12-24 | 2003-01-28 | Bayer Ag | Nuevas imidazo[1,3,5,) triazinonas y su uso. |
-
2001
- 2001-11-02 GB GBGB0126417.5A patent/GB0126417D0/en not_active Ceased
-
2002
- 2002-10-24 BR BR0213717-8A patent/BR0213717A/pt not_active IP Right Cessation
- 2002-10-24 KR KR1020047006733A patent/KR20050039728A/ko not_active Ceased
- 2002-10-24 CA CA002478059A patent/CA2478059A1/en not_active Abandoned
- 2002-10-24 CN CNA028266528A patent/CN1585821A/zh active Pending
- 2002-10-24 US US10/415,839 patent/US20070015205A1/en not_active Abandoned
- 2002-10-24 PL PL02370513A patent/PL370513A1/xx unknown
- 2002-10-24 YU YU36104A patent/YU36104A/sh unknown
- 2002-10-24 WO PCT/IB2002/004426 patent/WO2003038080A1/en not_active Ceased
- 2002-10-24 IL IL16392602A patent/IL163926A0/xx unknown
- 2002-10-24 RU RU2004113450/13A patent/RU2301259C2/ru not_active IP Right Cessation
- 2002-10-24 EP EP02775155A patent/EP1468082A1/en not_active Withdrawn
-
2003
- 2003-05-01 US US10/427,222 patent/US20040082052A1/en not_active Abandoned
-
2004
- 2004-04-28 ZA ZA200403198A patent/ZA200403198B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR0213717A (pt) | 2004-08-31 |
| CA2478059A1 (en) | 2003-05-08 |
| GB0126417D0 (en) | 2002-01-02 |
| CN1585821A (zh) | 2005-02-23 |
| US20070015205A1 (en) | 2007-01-18 |
| RU2004113450A (ru) | 2005-04-20 |
| RU2301259C2 (ru) | 2007-06-20 |
| PL370513A1 (en) | 2005-05-30 |
| WO2003038080A1 (en) | 2003-05-08 |
| KR20050039728A (ko) | 2005-04-29 |
| IL163926A0 (en) | 2005-12-18 |
| EP1468082A1 (en) | 2004-10-20 |
| US20040082052A1 (en) | 2004-04-29 |
| YU36104A (sh) | 2006-08-17 |
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