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ZA200403198B - Crystal structure of phosphodiesterase 5 and use thereof. - Google Patents

Crystal structure of phosphodiesterase 5 and use thereof.

Info

Publication number
ZA200403198B
ZA200403198B ZA200403198A ZA200403198A ZA200403198B ZA 200403198 B ZA200403198 B ZA 200403198B ZA 200403198 A ZA200403198 A ZA 200403198A ZA 200403198 A ZA200403198 A ZA 200403198A ZA 200403198 B ZA200403198 B ZA 200403198B
Authority
ZA
South Africa
Prior art keywords
phosphodiesterase
crystal structure
crystal
Prior art date
Application number
ZA200403198A
Other languages
English (en)
Inventor
David Graham Brown
Andrew Lee Hopkins
Sarah Helen Kamp
Heather Joan Ringrose
Wendy Elaine Taylor
Colin Roger Groom
Timothy Mark Jenkins
Margaret Mary O'gara
Colin Mark Robinson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA200403198B publication Critical patent/ZA200403198B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/04Phosphoric diester hydrolases (3.1.4)
    • C12Y301/040353',5'-Cyclic-GMP phosphodiesterase (3.1.4.35)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2299/00Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
ZA200403198A 2001-11-02 2004-04-28 Crystal structure of phosphodiesterase 5 and use thereof. ZA200403198B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0126417.5A GB0126417D0 (en) 2001-11-02 2001-11-02 Crystal structure

Publications (1)

Publication Number Publication Date
ZA200403198B true ZA200403198B (en) 2005-11-18

Family

ID=9925082

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200403198A ZA200403198B (en) 2001-11-02 2004-04-28 Crystal structure of phosphodiesterase 5 and use thereof.

Country Status (13)

Country Link
US (2) US20070015205A1 (xx)
EP (1) EP1468082A1 (xx)
KR (1) KR20050039728A (xx)
CN (1) CN1585821A (xx)
BR (1) BR0213717A (xx)
CA (1) CA2478059A1 (xx)
GB (1) GB0126417D0 (xx)
IL (1) IL163926A0 (xx)
PL (1) PL370513A1 (xx)
RU (1) RU2301259C2 (xx)
WO (1) WO2003038080A1 (xx)
YU (1) YU36104A (xx)
ZA (1) ZA200403198B (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05011769A (es) * 2003-05-01 2006-01-26 Pfizer Estructura cristalina.
CA2565308A1 (en) * 2003-05-06 2004-11-25 New Century Pharmaceuticals Albumin binding sites for evaluating drug interactions and methods of evaluating or designing drugs based on their albumin binding properties
WO2005041895A2 (en) * 2003-11-03 2005-05-12 New Century Pharmaceuticals, Inc. Albumin binding sites for evaluating drug interactions and methods of evaluating or designing drugs based on their albumin binding properties
ATE470681T1 (de) * 2006-07-12 2010-06-15 Novartis Ag Aktinisch vernetzbare copolymere zur herstellung von kontaktlinsen
AR064286A1 (es) * 2006-12-13 2009-03-25 Quiceno Gomez Alexandra Lorena Produccion de dispositivos oftalmicos basados en la polimerizacion por crecimiento escalonado fotoinducida
CN103865914B (zh) * 2012-12-14 2016-05-25 上海美迪西生物医药股份有限公司 Pde2催化结构域/pde2特异性抑制剂复合物的晶体及其生长方法
KR102141542B1 (ko) 2013-12-31 2020-09-14 엘지디스플레이 주식회사 표시장치
FR3039297B1 (fr) * 2015-07-20 2018-05-18 Roam Data, Inc Lecteur de carte compact
KR102576402B1 (ko) 2016-05-31 2023-09-11 엘지디스플레이 주식회사 액정표시장치

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1038963B1 (en) * 1993-05-27 2009-08-05 Board Of Regents Of The University Of Washington Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods
RU2174123C2 (ru) * 1996-10-28 2001-09-27 Новартис Аг Производные 8-арил-1,7-нафтиридина и фармацевтическая композиция, обладающая противовоспалительной активностью
GB9923968D0 (en) * 1999-10-11 1999-12-15 Pfizer Ltd Therapeutic agents
MXPA02006240A (es) * 1999-12-24 2003-01-28 Bayer Ag Nuevas imidazo[1,3,5,) triazinonas y su uso.

Also Published As

Publication number Publication date
BR0213717A (pt) 2004-08-31
CA2478059A1 (en) 2003-05-08
GB0126417D0 (en) 2002-01-02
CN1585821A (zh) 2005-02-23
US20070015205A1 (en) 2007-01-18
RU2004113450A (ru) 2005-04-20
RU2301259C2 (ru) 2007-06-20
PL370513A1 (en) 2005-05-30
WO2003038080A1 (en) 2003-05-08
KR20050039728A (ko) 2005-04-29
IL163926A0 (en) 2005-12-18
EP1468082A1 (en) 2004-10-20
US20040082052A1 (en) 2004-04-29
YU36104A (sh) 2006-08-17

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