ZA200402849B - Himbacine analogues as thrombin receptor antagonists. - Google Patents

Himbacine analogues as thrombin receptor antagonists.

Info

Publication number: ZA200402849B
Authority: ZA; South Africa
Prior art keywords: himbacine; analogues; receptor antagonists; thrombin receptor; thrombin
Prior art date: 2001-10-18

Application number

ZA200402849A

Other languages

English (en)

Inventor

Samuel Chackalamannil

Martin C Clasby

Mariappan V Chelliah

Yan Xia

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-18

Filing date

2004-04-15

Publication date

2005-01-14

2004-04-15 Application filed by Schering Corp filed Critical Schering Corp

2005-01-14 Publication of ZA200402849B publication Critical patent/ZA200402849B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

ZA200402849A 2001-10-18 2004-04-15 Himbacine analogues as thrombin receptor antagonists. ZA200402849B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US33035901P	2001-10-18	2001-10-18

Publications (1)

Publication Number	Publication Date
ZA200402849B true ZA200402849B (en)	2005-01-14

Family

ID=23289411

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200402849A ZA200402849B (en)	2001-10-18	2004-04-15	Himbacine analogues as thrombin receptor antagonists.

Country Status (23)

Country	Link
US (2)	US7037920B2 (xx)
EP (1)	EP1436298B1 (xx)
JP (2)	JP4307260B2 (xx)
KR (1)	KR100960170B1 (xx)
CN (1)	CN100369917C (xx)
AR (1)	AR036832A1 (xx)
AT (1)	ATE525378T1 (xx)
AU (1)	AU2002335031C1 (xx)
BR (1)	BR0213967A (xx)
CA (1)	CA2463628A1 (xx)
CO (1)	CO5570668A2 (xx)
EC (1)	ECSP045064A (xx)
HU (1)	HUP0500443A3 (xx)
IL (1)	IL160918A0 (xx)
MX (1)	MXPA04003610A (xx)
MY (1)	MY139335A (xx)
NO (1)	NO329349B1 (xx)
NZ (1)	NZ531869A (xx)
PE (1)	PE20030808A1 (xx)
PL (1)	PL371948A1 (xx)
RU (1)	RU2319704C9 (xx)
WO (1)	WO2003033501A1 (xx)
ZA (1)	ZA200402849B (xx)

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US6346510B1 (en)	1995-10-23	2002-02-12	The Children's Medical Center Corporation	Therapeutic antiangiogenic endostatin compositions
US7488742B2 (en) *	2000-06-15	2009-02-10	Schering Corporation	Thrombin receptor antagonists
US7235567B2 (en) *	2000-06-15	2007-06-26	Schering Corporation	Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
ATE378330T1 (de)	2002-04-16	2007-11-15	Schering Corp	Trizyklische thrombin rezeptor antagonisten
US20070243632A1 (en) *	2003-07-08	2007-10-18	Coller Barry S	Methods for measuring platelet reactivity of patients that have received drug eluting stents
EP1641492B1 (en)	2003-07-08	2011-12-14	Accumetrics, Inc.	Controlled platelet activation to monitor therapy of adp antagonists
DE602005009355D1 (de) *	2004-05-28	2008-10-09	Schering Corp	Gehinderte himbacinanaloga als thrombinrezeptorantagonisten
CA2576971A1 (en) *	2004-08-20	2006-03-02	Entremed, Inc.	Compositions and methods comprising proteinase activated receptor antagonists
CA2582353A1 (en) *	2004-10-06	2006-04-20	University Of Rochester	Treatment of pulmonary hypertension using an agent that inhibits a tissue factor pathway
US7488752B2 (en) *	2004-10-08	2009-02-10	Schering Corporation	Thrombin receptor antagonists
US7772276B2 (en) *	2005-01-14	2010-08-10	Schering Corporation	Exo-selective synthesis of himbacine analogs
EP1848705B1 (en) *	2005-01-14	2010-02-24	Schering Corporation	Exo- and diastereo- selective syntheses of himbacine analogs
PT1853592E (pt) *	2005-01-14	2011-05-10	Schering Corp	S?ntese de an?logos da himbacina
AU2006230292A1 (en) *	2005-03-31	2006-10-05	Schering Corporation	Spirocyclic thrombin receptor antagonists
US7595169B2 (en) *	2005-04-27	2009-09-29	Accumetrics, Inc.	Method for determining percent platelet aggregation
US20070219154A1 (en) *	2005-12-20	2007-09-20	Suxing Liu	Methods for preventing and/or treating a cell proliferative disorder
EP1966203B1 (en) *	2005-12-22	2013-11-13	Merck Sharp & Dohme Corp.	Oxazoloisoquinoline derivatives as thrombin receptor antagonists
AU2006331583A1 (en) *	2005-12-22	2007-07-05	Schering Corporation	Thrombin receptor antagonists as prophylaxis to complications from cardiopulmonary surgery
MX2008012574A (es) *	2006-03-29	2008-10-10	Schering Corp	Derivados de himbacina monociclitos y biciclicos utiles como antagonistas del receptor de trombina.
CA2650404A1 (en) *	2006-04-13	2007-10-25	Schering Corporation	Fused ring thrombin receptor antagonists
EP2032560B1 (en)	2006-06-29	2013-05-01	Merck Sharp & Dohme Corp.	Substituted bicyclic and tricyclic thrombin receptor antagonists
AR061727A1 (es)	2006-06-30	2008-09-17	Schering Corp	Sintesis de dietil [[ 5- ( 3-fluorofenil) -piridin -2il] metil] fosfonato
TWI367112B (en)	2006-06-30	2012-07-01	Schering Corp	Immediate-release tablet formulations of a thrombin receptor antagonist
TWI343262B (en) *	2006-09-26	2011-06-11	Schering Corp	Rapidly disintegrating lyophilized oral formulations of a thrombin receptor antagonist
AU2007320029A1 (en) *	2006-10-04	2008-05-22	Schering Corporation	Thrombin receptor antagonists based on the modified tricyclic unit of himbacine
WO2008042422A2 (en) *	2006-10-04	2008-04-10	Schering Corporation	Bicyclic and tricyclic derivatives as thrombin receptor antagonists
MX2009006873A (es) *	2006-12-22	2009-07-03	Schering Corp	Promotores de desintegracion en formulaciones de granulacion humeda de dosis solida.
BRPI0809095A2 (pt) *	2007-03-23	2014-09-09	Schering Corp	Redução de eventos adversos após intervenção percutânea através de uso de um antagonista de receptor de trombina
ES2387700T3 (es) *	2007-05-03	2012-09-28	Accumetrics, Inc.	Métodos para medir la inhibición de la agregación de plaquetas mediante antagonistas del receptor de trombina
WO2009097970A1 (de)	2008-02-05	2009-08-13	Sanofi-Aventis	Triazolopyridazine als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel
WO2009143039A2 (en)	2008-05-19	2009-11-26	Schering Corporation	Heterocyclic compounds as factor ixa inhibitors
MX2011012861A (es)	2009-06-04	2012-01-25	Schering Corp	Metabolito activo de un antagonista de receptor de trombina.
WO2010144339A2 (en)	2009-06-08	2010-12-16	Schering Corporation	A thrombin receptor antagonist and clopidogrel fixed dose tablet
WO2011017296A1 (en)	2009-08-04	2011-02-10	Schering Corporation	4, 5, 6-trisubstituted pyrimidine derivatives as factor ixa inhibitors
EP2822557B1 (en)	2012-03-06	2017-08-23	Merck Sharp & Dohme Corp.	Preparation and use of bicyclic himbacine derivatives as par-receptor antagonists
US9808473B2 (en)	2013-08-22	2017-11-07	Merck Sharp & Dohme Corp.	Preparation and use of 3-pyridyl substituted-6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists
WO2015026693A1 (en)	2013-08-22	2015-02-26	Merck Sharp & Dohme Corp.	7a-amide substituted-6,6-difluoro bicyclic himbacine derivatives
EP3035930A4 (en)	2013-08-22	2017-03-08	Merck Sharp & Dohme Corp.	7a-heterocycle substituted- 6, 6-difluoro bicyclic himbacine derivatives
US9969724B2 (en)	2014-04-16	2018-05-15	Merck Sharp & Dohme Corp.	Factor IXa inhibitors
CN104610330A (zh) *	2015-02-25	2015-05-13	成都安斯利生物医药有限公司	一种制备(e)-3-丙烯酸乙酯频呐硼酸酯的方法
CN116133660B (zh)	2020-07-22	2025-05-02	詹森药业有限公司	可用作因子XIa抑制剂的化合物
US11919881B2 (en)	2021-03-18	2024-03-05	Janssen Pharmaceutica Nv	Substituted pyridine N-oxide derivatives useful as a factor XIa inhibitors
US11814364B2 (en)	2021-03-18	2023-11-14	Janssen Pharmaceutica Nv	Pyridine N-oxide derivatives useful as factor XIa inhibitors
US11845748B2 (en)	2021-03-18	2023-12-19	Janssen Pharmaceutica Nv	Bicyclic pyridine N-oxide derivatives useful as a factor XIa inhibitors
US11897880B2 (en)	2021-04-30	2024-02-13	Janssen Pharmaceutica Nv	7,8-dihydrobenzo[e]pyrido[3,4-c]azocine-2,5(3H,6H)-dione derivatives useful as a factor XIa inhibitors
US11958856B2 (en)	2021-07-22	2024-04-16	Janssen Pharmaceutica Nv	Substituted 1,2,3,8,9,9a-hexahydro-5H-pyrrolo[1,2-a]azepin-5-ones as factor XIa inhibitors
US12286429B2 (en)	2021-07-22	2025-04-29	Janssen Pharmaceutica Nv	5-oxo-1,2,3,5,8,8a-hexahydroindolizine-3-carboxamide derivatives useful as a factor XIa inhibitors

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2002
- 2002-10-16 MX MXPA04003610A patent/MXPA04003610A/es active IP Right Grant
- 2002-10-16 BR BR0213967-7A patent/BR0213967A/pt not_active IP Right Cessation
- 2002-10-16 CA CA002463628A patent/CA2463628A1/en not_active Abandoned
- 2002-10-16 HU HU0500443A patent/HUP0500443A3/hu unknown
- 2002-10-16 KR KR1020047005435A patent/KR100960170B1/ko not_active Expired - Fee Related
- 2002-10-16 JP JP2003536240A patent/JP4307260B2/ja not_active Expired - Fee Related
- 2002-10-16 AR ARP020103876A patent/AR036832A1/es unknown
- 2002-10-16 PL PL02371948A patent/PL371948A1/xx not_active Application Discontinuation
- 2002-10-16 CN CNB028206665A patent/CN100369917C/zh not_active Expired - Fee Related
- 2002-10-16 RU RU2004115114/04A patent/RU2319704C9/ru not_active IP Right Cessation
- 2002-10-16 NZ NZ531869A patent/NZ531869A/en not_active IP Right Cessation
- 2002-10-16 EP EP02801732A patent/EP1436298B1/en not_active Expired - Lifetime
- 2002-10-16 AT AT02801732T patent/ATE525378T1/de not_active IP Right Cessation
- 2002-10-16 AU AU2002335031A patent/AU2002335031C1/en not_active Ceased
- 2002-10-16 IL IL16091802A patent/IL160918A0/xx not_active IP Right Cessation
- 2002-10-16 PE PE2002001022A patent/PE20030808A1/es not_active Application Discontinuation
- 2002-10-16 MY MYPI20023859A patent/MY139335A/en unknown
- 2002-10-16 US US10/271,715 patent/US7037920B2/en not_active Expired - Fee Related
- 2002-10-16 WO PCT/US2002/032936 patent/WO2003033501A1/en not_active Ceased
2004
- 2004-04-15 EC EC2004005064A patent/ECSP045064A/es unknown
- 2004-04-15 ZA ZA200402849A patent/ZA200402849B/xx unknown
- 2004-04-16 CO CO04034781A patent/CO5570668A2/es not_active Application Discontinuation
- 2004-05-14 NO NO20042021A patent/NO329349B1/no not_active IP Right Cessation
2005
- 2005-12-19 US US11/311,083 patent/US20060106050A1/en not_active Abandoned
2008
- 2008-09-17 JP JP2008238716A patent/JP2009029820A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
JP2005529841A (ja)	2005-10-06
KR20050036845A (ko)	2005-04-20
CA2463628A1 (en)	2003-04-24
ECSP045064A (es)	2004-05-28
RU2319704C9 (ru)	2008-08-20
KR100960170B1 (ko)	2010-05-26
US20060106050A1 (en)	2006-05-18
RU2004115114A (ru)	2005-10-27
RU2319704C2 (ru)	2008-03-20
BR0213967A (pt)	2005-08-30
NO20042021L (no)	2004-05-14
US7037920B2 (en)	2006-05-02
JP2009029820A (ja)	2009-02-12
US20030203927A1 (en)	2003-10-30
HUP0500443A2 (hu)	2005-08-29
JP4307260B2 (ja)	2009-08-05
NZ531869A (en)	2006-11-30
EP1436298B1 (en)	2011-09-21
AU2002335031C1 (en)	2006-11-16
EP1436298A1 (en)	2004-07-14
PE20030808A1 (es)	2003-09-22
IL160918A0 (en)	2004-08-31
HUP0500443A3 (en)	2009-12-28
PL371948A1 (en)	2005-07-11
AR036832A1 (es)	2004-10-06
ATE525378T1 (de)	2011-10-15
CO5570668A2 (es)	2005-10-31
CN1571789A (zh)	2005-01-26
CN100369917C (zh)	2008-02-20
NO329349B1 (no)	2010-10-04
MY139335A (en)	2009-09-30
AU2002335031B2 (en)	2005-06-30
MXPA04003610A (es)	2004-07-27
WO2003033501A1 (en)	2003-04-24

Publication	Publication Date	Title
ZA200402849B (en)	2005-01-14	Himbacine analogues as thrombin receptor antagonists.
AU6690001A (en)	2001-12-24	Thrombin receptor antagonists
IL174538A0 (en)	2006-08-01	Thrombin receptor antagonists
IL165841A0 (en)	2006-01-15	Mchir antagonists
ZA200408342B (en)	2006-05-31	Tricyclic thrombin receptor antagonists
MXPA03001143A (es)	2003-06-24	Derivados de 4-fenil-piridina como antagonistas del receptor de neuroquinina-1.
EP1553075A4 (en)	2009-11-04	LPA Receptor Antagonists
AU2002341834A1 (en)	2003-04-07	Antagonists
AU2003261392A8 (en)	2004-02-23	M3muscarinic acetylcholine receptor antagonists
EP1351933A4 (en)	2005-09-07	ANTAGONISTS OF IL-8 RECEPTORS
GB0130261D0 (en)	2002-02-06	Lactams as tachykinin antagonists
EP1359915A4 (en)	2004-07-21	UROTENSIN-II RECEPTOR ANTAGONISTS
ZA200105737B (en)	2002-01-22	N-Triazolyl-methyl-piperazine derivates as neurokinin- receptor antagonists.
PL362838A1 (en)	2004-11-02	Somatostatin antagonists
GB0203412D0 (en)	2002-04-03	5-HT 2B receptor antagonists
IL156087A0 (en)	2003-12-23	Histamine receptor antagonists
PL370821A1 (en)	2005-05-30	N-ureido-piperidines as antagonists viii for ccr-3 receptor
HK1065797A (en)	2005-03-04	Himbacine analogues as thrombin receptor antagonists
GB0026327D0 (en)	2000-12-13	Thrombin receptor antagonists
IL158063A0 (en)	2004-03-28	Crf receptor antagonists
AU2002240149A1 (en)	2002-09-12	Aminomethyl-pyrroloquinazoline compounds as thrombin receptor antagonists
SI1294714T1 (sl)	2007-12-31	Antagonisti trobinskega receptorja
SI1406888T1 (sl)	2006-10-31	Substituirane gama-laktonske spojine kot NMDA antagonisti
HK1086837A (en)	2006-09-29	Thrombin receptor antagonists
AU2002248361A1 (en)	2002-07-30	Il-8 receptor antagonists