ZA200301079B - 7-oxo pyridopyrimidines as inhibitors of a cellular proliferation. - Google Patents

7-oxo pyridopyrimidines as inhibitors of a cellular proliferation. Download PDF

Info

Publication number: ZA200301079B
Authority: ZA; South Africa
Prior art keywords: compound; alkyl; cycloalkyl; hydrogen; compound according
Prior art date: 2000-08-31

Application number

ZA200301079A

Other languages

English (en)

Inventor

Jian Jeffrey Chen

David Michael Goldstein

James Patrick Dunn

Julie Anne Lim

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-31

Filing date

2003-02-07

Publication date

2004-05-07

2003-02-07 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-05-07 Publication of ZA200301079B publication Critical patent/ZA200301079B/en

Links

239000003112 inhibitor Substances 0.000 title description 4
230000004663 cell proliferation Effects 0.000 title description 3
UWABAWGNHPXGBQ-UHFFFAOYSA-N 6h-pyrido[3,2-d]pyrimidin-7-one Chemical class C1=NC=NC2=CC(=O)CN=C21 UWABAWGNHPXGBQ-UHFFFAOYSA-N 0.000 title description 2
-1 cyanomethyl Chemical group 0.000 claims description 168
150000001875 compounds Chemical class 0.000 claims description 157
150000003839 salts Chemical class 0.000 claims description 98
125000000217 alkyl group Chemical group 0.000 claims description 74
239000001257 hydrogen Substances 0.000 claims description 64
229910052739 hydrogen Inorganic materials 0.000 claims description 64
125000000753 cycloalkyl group Chemical group 0.000 claims description 52
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 39
150000002431 hydrogen Chemical class 0.000 claims description 35
239000000203 mixture Substances 0.000 claims description 35
125000000623 heterocyclic group Chemical group 0.000 claims description 31
238000000034 method Methods 0.000 claims description 29
238000011282 treatment Methods 0.000 claims description 27
125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 24
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 24
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 23
125000004663 dialkyl amino group Chemical group 0.000 claims description 23
102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 claims description 23
125000003118 aryl group Chemical group 0.000 claims description 22
125000003545 alkoxy group Chemical group 0.000 claims description 20
125000004404 heteroalkyl group Chemical group 0.000 claims description 20
125000001188 haloalkyl group Chemical group 0.000 claims description 18
238000002360 preparation method Methods 0.000 claims description 16
238000004519 manufacturing process Methods 0.000 claims description 15
230000001404 mediated effect Effects 0.000 claims description 15
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 15
150000001412 amines Chemical class 0.000 claims description 14
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 14
239000000651 prodrug Substances 0.000 claims description 11
229940002612 prodrug Drugs 0.000 claims description 11
125000002252 acyl group Chemical group 0.000 claims description 10
125000004442 acylamino group Chemical group 0.000 claims description 10
125000003710 aryl alkyl group Chemical group 0.000 claims description 10
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 10
239000003814 drug Substances 0.000 claims description 9
239000000126 substance Substances 0.000 claims description 9
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims description 7
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 6
125000004966 cyanoalkyl group Chemical group 0.000 claims description 6
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125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 6
208000024827 Alzheimer disease Diseases 0.000 claims description 5
125000004688 alkyl sulfonyl alkyl group Chemical group 0.000 claims description 5
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125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 5
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208000011231 Crohn disease Diseases 0.000 claims description 4
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201000000028 adult respiratory distress syndrome Diseases 0.000 claims description 4
206010003246 arthritis Diseases 0.000 claims description 4
125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 4
125000001475 halogen functional group Chemical group 0.000 claims description 4
208000002551 irritable bowel syndrome Diseases 0.000 claims description 4
230000008569 process Effects 0.000 claims description 4
125000004487 4-tetrahydropyranyl group Chemical group [H]C1([H])OC([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 3
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims description 2
125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims description 2
125000004777 2-fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 claims description 2
125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims description 2
239000013543 active substance Substances 0.000 claims description 2
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208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 3
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239000012458 free base Substances 0.000 description 10
125000005843 halogen group Chemical group 0.000 description 10
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
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CXMXRPHRNRROMY-UHFFFAOYSA-L sebacate(2-) Chemical compound [O-]C(=O)CCCCCCCCC([O-])=O CXMXRPHRNRROMY-UHFFFAOYSA-L 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1
239000012265 solid product Substances 0.000 description 1
201000005671 spondyloarthropathy Diseases 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
230000035882 stress Effects 0.000 description 1
TYFQFVWCELRYAO-UHFFFAOYSA-L suberate(2-) Chemical compound [O-]C(=O)CCCCCCC([O-])=O TYFQFVWCELRYAO-UHFFFAOYSA-L 0.000 description 1
239000000758 substrate Substances 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
201000000596 systemic lupus erythematosus Diseases 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000003396 thiol group Chemical group [H]S* 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
230000009772 tissue formation Effects 0.000 description 1
ZBZJXHCVGLJWFG-UHFFFAOYSA-N trichloromethyl(.) Chemical compound Cl[C](Cl)Cl ZBZJXHCVGLJWFG-UHFFFAOYSA-N 0.000 description 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
229960000281 trometamol Drugs 0.000 description 1
230000006433 tumor necrosis factor production Effects 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
230000009385 viral infection Effects 0.000 description 1
230000003612 virological effect Effects 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Communicable Diseases (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Oncology (AREA)
Virology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Hospice & Palliative Care (AREA)
Tropical Medicine & Parasitology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
AIDS & HIV (AREA)
Pulmonology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ZA200301079A 2000-08-31 2003-02-07 7-oxo pyridopyrimidines as inhibitors of a cellular proliferation. ZA200301079B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US22958400P	2000-08-31	2000-08-31

Publications (1)

Publication Number	Publication Date
ZA200301079B true ZA200301079B (en)	2004-05-07

Family

ID=22861859

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200301079A ZA200301079B (en)	2000-08-31	2003-02-07	7-oxo pyridopyrimidines as inhibitors of a cellular proliferation.

Country Status (15)

Country	Link
EP (1)	EP1315726A1 (es)
JP (1)	JP4141830B2 (es)
KR (1)	KR100571339B1 (es)
CN (1)	CN1275964C (es)
AR (1)	AR033681A1 (es)
AU (2)	AU9378401A (es)
BR (1)	BR0113628A (es)
CA (1)	CA2420286A1 (es)
GT (1)	GT200100191A (es)
MX (1)	MXPA03001821A (es)
PA (1)	PA8527301A1 (es)
PE (1)	PE20020406A1 (es)
UY (1)	UY26918A1 (es)
WO (1)	WO2002018380A1 (es)
ZA (1)	ZA200301079B (es)

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BR0309053A (pt) *	2002-04-19	2005-02-22	Smithkline Beecham Corp	Compostos
US7084270B2 (en)	2002-08-14	2006-08-01	Hoffman-La Roche Inc.	Pyrimido compounds having antiproliferative activity
UY27939A1 (es)	2002-08-21	2004-03-31	Glaxo Group Ltd	Compuestos
US7129351B2 (en)	2002-11-04	2006-10-31	Hoffmann-La Roche Inc.	Pyrimido compounds having antiproliferative activity
WO2004046152A1 (en) *	2002-11-18	2004-06-03	F. Hoffmann La Roche Ag	Diazinopyrimidines
US7098332B2 (en)	2002-12-20	2006-08-29	Hoffmann-La Roche Inc.	5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
WO2004089955A1 (en)	2003-04-10	2004-10-21	F.Hoffmann-La Roche Ag	Pyrimido compounds
WO2005007193A2 (en) *	2003-07-07	2005-01-27	Vande Woude, George, F.	Inhibition of tumor angiogenesis by combination of thrombospondin-1 and inhibitors of vascular endothelial growth factor
DE602004005238T2 (de) *	2003-11-13	2007-11-08	F. Hoffmann-La Roche Ag	Hydroxyalkylsubstituierte pyrido-7-pyrimidin-7-one
WO2005105097A2 (en) *	2004-04-28	2005-11-10	Gpc Biotech Ag	Pyridopyrimidines for treating inflammatory and other diseases
US20070054916A1 (en) *	2004-10-01	2007-03-08	Amgen Inc.	Aryl nitrogen-containing bicyclic compounds and methods of use
US20090131430A1 (en) *	2004-11-23	2009-05-21	Palle Venkata P	Pyrido'2,3-dipyrimidines as anti-inflammatory agents
US20090036472A1 (en) *	2005-02-02	2009-02-05	Palle Venkata P	Azabicyclo derivatives as anti-inflammatory agents
EP1931667A1 (en) *	2005-09-28	2008-06-18	Ranbaxy Laboratories Limited	Pyrido-pyridimidine derivatives useful as antiinflammatory agents
ES2329419T3 (es)	2006-01-31	2009-11-25	F. Hoffmann-La Roche Ag	7h-pirido(3,4-d)pirimidin-8-onas, su preparacion y uso como inhibidores de proteinas cinasas.
KR100661523B1 (ko) *	2006-06-09	2006-12-26	주식회사 청용산기	포장박스 제조장치에 장착되는 개선된 비틀림 교정 장치
EP1914234A1 (en)	2006-10-16	2008-04-23	GPC Biotech Inc.	Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
CN101535308A (zh)	2006-11-09	2009-09-16	霍夫曼-拉罗奇有限公司	作为激酶抑制剂的取代的6-苯基-吡啶并[2，3-d]嘧啶-7-酮衍生物及其使用方法
WO2008078249A1 (en) *	2006-12-21	2008-07-03	Ranbaxy Laboratories Limited	Anti-inflammatory agents
EP2112150B1 (en)	2008-04-22	2013-10-16	Forma Therapeutics, Inc.	Improved raf inhibitors
KR101106162B1 (ko) *	2010-04-20	2012-01-20	주식회사 청용산기	포장박스 제조장치용 스티칭 장치에 있어서의 하역가이드 지지유닛
EP2828259B1 (en) *	2012-03-22	2018-08-08	Oscotec, Inc.	Substituted pyridopyrimidine compounds and their use as flt3 inhibitors
TWI647220B (zh)	2013-03-15	2019-01-11	美商西建卡爾有限責任公司	雜芳基化合物及其用途
AU2014228746B2 (en)	2013-03-15	2018-08-30	Celgene Car Llc	Heteroaryl compounds and uses thereof
ES2892423T3 (es)	2013-03-15	2022-02-04	Celgene Car Llc	Compuestos de heteroarilo y usos de los mismos
PT3191099T (pt)	2014-09-12	2018-12-18	Biolab Sanus Farmaceutica Ltda	Derivados de piridopirimidinas
PT3691620T (pt)	2017-10-05	2022-10-06	Fulcrum Therapeutics Inc	Os inibidores da quinase p38 reduzem a expressão de dux4 e genes a jusante para o tratamento de fshd
US10342786B2 (en)	2017-10-05	2019-07-09	Fulcrum Therapeutics, Inc.	P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
TWI831829B (zh)	2018-09-12	2024-02-11	美商建南德克公司	苯氧基-吡啶基-嘧啶化合物及使用方法
US12077534B2 (en)	2018-12-27	2024-09-03	Les Laboratoires Servier	Aza-heterobicyclic inhibitors of MAT2A and methods of use for treating cancer
WO2020142612A1 (en) *	2019-01-03	2020-07-09	Genentech, Inc.	Pyrido-pyrimidinone and pteridinone compounds as inhibitors of endoribonuclease inositol requiring enzyme i (ire i alpha) for the treatment of cancer diseases.
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WO2022052924A1 (zh) *	2020-09-11	2022-03-17	上海凌达生物医药有限公司	一类含氮稠环类化合物的制备方法和用途

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2001
- 2001-08-22 CN CNB018150306A patent/CN1275964C/zh not_active Expired - Fee Related
- 2001-08-22 CA CA002420286A patent/CA2420286A1/en not_active Abandoned
- 2001-08-22 EP EP01974206A patent/EP1315726A1/en not_active Withdrawn
- 2001-08-22 AU AU9378401A patent/AU9378401A/xx active Pending
- 2001-08-22 WO PCT/EP2001/009689 patent/WO2002018380A1/en not_active Ceased
- 2001-08-22 KR KR1020037002936A patent/KR100571339B1/ko not_active Expired - Fee Related
- 2001-08-22 MX MXPA03001821A patent/MXPA03001821A/es active IP Right Grant
- 2001-08-22 AU AU2001293784A patent/AU2001293784B2/en not_active Ceased
- 2001-08-22 JP JP2002523895A patent/JP4141830B2/ja not_active Expired - Fee Related
- 2001-08-22 BR BR0113628-3A patent/BR0113628A/pt not_active Application Discontinuation
- 2001-08-28 PA PA20018527301A patent/PA8527301A1/es unknown
- 2001-08-28 PE PE2001000860A patent/PE20020406A1/es not_active Application Discontinuation
- 2001-08-30 AR ARP010104132A patent/AR033681A1/es unknown
- 2001-08-30 UY UY26918A patent/UY26918A1/es not_active Application Discontinuation
- 2001-09-18 GT GT200100191A patent/GT200100191A/es unknown
2003
- 2003-02-07 ZA ZA200301079A patent/ZA200301079B/en unknown

Also Published As

Publication number	Publication date
PE20020406A1 (es)	2002-05-17
JP4141830B2 (ja)	2008-08-27
AR033681A1 (es)	2004-01-07
AU9378401A (en)	2002-03-13
KR100571339B1 (ko)	2006-04-17
KR20030022422A (ko)	2003-03-15
MXPA03001821A (es)	2003-06-04
UY26918A1 (es)	2002-02-28
CN1451005A (zh)	2003-10-22
CA2420286A1 (en)	2002-03-07
CN1275964C (zh)	2006-09-20
PA8527301A1 (es)	2002-07-30
WO2002018380A1 (en)	2002-03-07
GT200100191A (es)	2002-05-16
BR0113628A (pt)	2003-07-01
JP2004507541A (ja)	2004-03-11
AU2001293784B2 (en)	2007-08-30
EP1315726A1 (en)	2003-06-04

Publication	Publication Date	Title
ZA200301079B (en)	2004-05-07	7-oxo pyridopyrimidines as inhibitors of a cellular proliferation.
EP1539755B1 (en)	2007-09-26	6-alkoxy-pyrido-pyrimidines as p-38 map kinase inhibitors
ZA200305938B (en)	2005-01-26	6-substituted pyrido-pyrimidines
US7750016B2 (en)	2010-07-06	Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones
AU2001293784A1 (en)	2002-06-06	7-OXO pyridopyrimidines as inhibitors of a cellular proliferation
EP1315727B1 (en)	2005-06-29	7-oxo pyridopyrimidines
AU2002212147A1 (en)	2002-06-06	7-OXO pyridopyrimidines
US6753427B2 (en)	2004-06-22	7-oxo-pyridopyrimidines (II)
US6506749B2 (en)	2003-01-14	7-oxo-pyridopyrimidines (I)
BG108085A (bg)	2004-12-30	6-заместени пиридо-пиримидини