BR0113628A - 7-oxo-piridopirimidinas como inibidores de uma proliferação celular - Google Patents
7-oxo-piridopirimidinas como inibidores de uma proliferação celularInfo
- Publication number
- BR0113628A BR0113628A BR0113628-3A BR0113628A BR0113628A BR 0113628 A BR0113628 A BR 0113628A BR 0113628 A BR0113628 A BR 0113628A BR 0113628 A BR0113628 A BR 0113628A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- cycloalkyl
- hydrogen
- heterocyclyl
- aryl
- Prior art date
Links
- 230000004663 cell proliferation Effects 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- UWABAWGNHPXGBQ-UHFFFAOYSA-N 6h-pyrido[3,2-d]pyrimidin-7-one Chemical class C1=NC=NC2=CC(=O)CN=C21 UWABAWGNHPXGBQ-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
- 125000004367 cycloalkylaryl group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- -1 monoalkylamino Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22958400P | 2000-08-31 | 2000-08-31 | |
| PCT/EP2001/009689 WO2002018380A1 (en) | 2000-08-31 | 2001-08-22 | 7-oxo pyridopyrimidines as inhibitors of a cellular proliferation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0113628A true BR0113628A (pt) | 2003-07-01 |
Family
ID=22861859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0113628-3A BR0113628A (pt) | 2000-08-31 | 2001-08-22 | 7-oxo-piridopirimidinas como inibidores de uma proliferação celular |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1315726A1 (es) |
| JP (1) | JP4141830B2 (es) |
| KR (1) | KR100571339B1 (es) |
| CN (1) | CN1275964C (es) |
| AR (1) | AR033681A1 (es) |
| AU (2) | AU9378401A (es) |
| BR (1) | BR0113628A (es) |
| CA (1) | CA2420286A1 (es) |
| GT (1) | GT200100191A (es) |
| MX (1) | MXPA03001821A (es) |
| PA (1) | PA8527301A1 (es) |
| PE (1) | PE20020406A1 (es) |
| UY (1) | UY26918A1 (es) |
| WO (1) | WO2002018380A1 (es) |
| ZA (1) | ZA200301079B (es) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6518276B2 (en) | 2000-08-31 | 2003-02-11 | Syntex (U.S.A.) Llc | 7-oxo-pyridopyrimidines (II) |
| CA2420122A1 (en) * | 2000-08-31 | 2002-03-07 | F. Hoffmann-La Roche Ag | 7-oxo pyridopyrimidines |
| PL374544A1 (en) * | 2002-04-03 | 2005-10-31 | F.Hoffmann-La Roche Ag | Imidazo fused compounds |
| PL373339A1 (en) * | 2002-04-19 | 2005-08-22 | Smithkline Beecham Corporation | Novel compounds |
| US7084270B2 (en) | 2002-08-14 | 2006-08-01 | Hoffman-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| UY27939A1 (es) | 2002-08-21 | 2004-03-31 | Glaxo Group Ltd | Compuestos |
| US7129351B2 (en) | 2002-11-04 | 2006-10-31 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| DE60327097D1 (de) * | 2002-11-18 | 2009-05-20 | Hoffmann La Roche | Diazinopyrimidine und ihre verwendung als proteinkinaseinhibitoren |
| US7098332B2 (en) | 2002-12-20 | 2006-08-29 | Hoffmann-La Roche Inc. | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones |
| KR100864393B1 (ko) | 2003-04-10 | 2008-10-20 | 에프. 호프만-라 로슈 아게 | 피리미도 화합물 |
| ATE451115T1 (de) * | 2003-07-07 | 2009-12-15 | Van Andel Res Inst | Hemmung der tumor-angiogenese durch eine kombination von thrombospondin-1 und hemmern des vaskulären endothel-wachstumsfaktors |
| SI1685131T1 (sl) * | 2003-11-13 | 2007-06-30 | Hoffmann La Roche | Hidroksialkil-substituirani pirido-7-pirimidin-7-oni |
| WO2005105097A2 (en) * | 2004-04-28 | 2005-11-10 | Gpc Biotech Ag | Pyridopyrimidines for treating inflammatory and other diseases |
| US20070054916A1 (en) * | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| WO2006056863A1 (en) * | 2004-11-23 | 2006-06-01 | Ranbaxy Laboratories Limited | Pyrido’2, 3-d!pyrimidines as anti-inflammatory agents |
| EP1846403A1 (en) * | 2005-02-02 | 2007-10-24 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as anti-inflammatory agents |
| US20090221600A1 (en) * | 2005-09-28 | 2009-09-03 | Ashwani Kumar Verma | Pyrido-pyridimidine derivatives useful as antiinflammatory agents |
| DE602007001952D1 (de) | 2006-01-31 | 2009-09-24 | Hoffmann La Roche | 7h-pyridoä3,4-düpyrimidin-8-one, ihre herstellung und ihre verwendung als proteinkinaseinhibitoren |
| KR100661523B1 (ko) * | 2006-06-09 | 2006-12-26 | 주식회사 청용산기 | 포장박스 제조장치에 장착되는 개선된 비틀림 교정 장치 |
| EP1914234A1 (en) | 2006-10-16 | 2008-04-23 | GPC Biotech Inc. | Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors |
| CN101535308A (zh) | 2006-11-09 | 2009-09-16 | 霍夫曼-拉罗奇有限公司 | 作为激酶抑制剂的取代的6-苯基-吡啶并[2，3-d]嘧啶-7-酮衍生物及其使用方法 |
| WO2008078249A1 (en) * | 2006-12-21 | 2008-07-03 | Ranbaxy Laboratories Limited | Anti-inflammatory agents |
| EP2112150B1 (en) | 2008-04-22 | 2013-10-16 | Forma Therapeutics, Inc. | Improved raf inhibitors |
| KR101106162B1 (ko) * | 2010-04-20 | 2012-01-20 | 주식회사 청용산기 | 포장박스 제조장치용 스티칭 장치에 있어서의 하역가이드 지지유닛 |
| ES2694223T3 (es) * | 2012-03-22 | 2018-12-19 | Oscotec, Inc. | Compuestos de piridopirimidina y su uso como inhibidores de FLT3 |
| CN111793068A (zh) | 2013-03-15 | 2020-10-20 | 西建卡尔有限责任公司 | 杂芳基化合物和其用途 |
| KR102350704B1 (ko) | 2013-03-15 | 2022-01-13 | 셀젠 카르 엘엘씨 | 헤테로아릴 화합물 및 이의 용도 |
| TWI647220B (zh) | 2013-03-15 | 2019-01-11 | 美商西建卡爾有限責任公司 | 雜芳基化合物及其用途 |
| KR20170054408A (ko) | 2014-09-12 | 2017-05-17 | 바이오랩 세너스 팔마씨우티카 엘티디에이. | 신규한 피리도피리미딘 유도체 화합물 |
| EP3692144A1 (en) | 2017-10-05 | 2020-08-12 | Fulcrum Therapeutics, Inc. | Use of p38 inhibitors to reduce expression of dux4 |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| TWI831829B (zh) | 2018-09-12 | 2024-02-11 | 美商建南德克公司 | 苯氧基-吡啶基-嘧啶化合物及使用方法 |
| US12077534B2 (en) | 2018-12-27 | 2024-09-03 | Les Laboratoires Servier | Aza-heterobicyclic inhibitors of MAT2A and methods of use for treating cancer |
| EP3941919B1 (en) | 2019-01-03 | 2025-12-24 | Genentech, Inc. | Pyrido-pyrimidinone and pteridinone compounds as inhibitors of endoribonuclease inositol requiring enzyme i (ire i alpha) for the treatment of cancer diseases. |
| MA56050A (fr) * | 2019-05-31 | 2022-04-06 | Servier Lab | Inhibiteurs hétérobicycliques de mat2a et procédés d'utilisation pour le traitement du cancer |
| WO2022052924A1 (zh) * | 2020-09-11 | 2022-03-17 | 上海凌达生物医药有限公司 | 一类含氮稠环类化合物的制备方法和用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2146782T3 (es) * | 1994-11-14 | 2000-08-16 | Warner Lambert Co | 6-aril-pirido(2,3-d)pirimidinas y naftiridinas para la inhibicion de la proliferacion celular inducida por la proteina tirosina quinasa. |
| IL117923A (en) * | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| CN1138778C (zh) * | 1998-05-26 | 2004-02-18 | 沃尼尔·朗伯公司 | 用作细胞增殖抑制剂的二环嘧啶及二环3,4-二氢嘧啶化合物及用途 |
-
2001
- 2001-08-22 JP JP2002523895A patent/JP4141830B2/ja not_active Expired - Fee Related
- 2001-08-22 MX MXPA03001821A patent/MXPA03001821A/es active IP Right Grant
- 2001-08-22 KR KR1020037002936A patent/KR100571339B1/ko not_active Expired - Fee Related
- 2001-08-22 CA CA002420286A patent/CA2420286A1/en not_active Abandoned
- 2001-08-22 AU AU9378401A patent/AU9378401A/xx active Pending
- 2001-08-22 AU AU2001293784A patent/AU2001293784B2/en not_active Ceased
- 2001-08-22 WO PCT/EP2001/009689 patent/WO2002018380A1/en not_active Ceased
- 2001-08-22 EP EP01974206A patent/EP1315726A1/en not_active Withdrawn
- 2001-08-22 BR BR0113628-3A patent/BR0113628A/pt not_active Application Discontinuation
- 2001-08-22 CN CNB018150306A patent/CN1275964C/zh not_active Expired - Fee Related
- 2001-08-28 PE PE2001000860A patent/PE20020406A1/es not_active Application Discontinuation
- 2001-08-28 PA PA20018527301A patent/PA8527301A1/es unknown
- 2001-08-30 UY UY26918A patent/UY26918A1/es not_active Application Discontinuation
- 2001-08-30 AR ARP010104132A patent/AR033681A1/es unknown
- 2001-09-18 GT GT200100191A patent/GT200100191A/es unknown
-
2003
- 2003-02-07 ZA ZA200301079A patent/ZA200301079B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1451005A (zh) | 2003-10-22 |
| AU9378401A (en) | 2002-03-13 |
| KR20030022422A (ko) | 2003-03-15 |
| JP4141830B2 (ja) | 2008-08-27 |
| GT200100191A (es) | 2002-05-16 |
| CN1275964C (zh) | 2006-09-20 |
| JP2004507541A (ja) | 2004-03-11 |
| EP1315726A1 (en) | 2003-06-04 |
| AR033681A1 (es) | 2004-01-07 |
| PA8527301A1 (es) | 2002-07-30 |
| WO2002018380A1 (en) | 2002-03-07 |
| MXPA03001821A (es) | 2003-06-04 |
| PE20020406A1 (es) | 2002-05-17 |
| AU2001293784B2 (en) | 2007-08-30 |
| UY26918A1 (es) | 2002-02-28 |
| KR100571339B1 (ko) | 2006-04-17 |
| ZA200301079B (en) | 2004-05-07 |
| CA2420286A1 (en) | 2002-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |