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YU93503A - Inhalacione kapsule - Google Patents

Inhalacione kapsule

Info

Publication number
YU93503A
YU93503A YU93503A YUP93503A YU93503A YU 93503 A YU93503 A YU 93503A YU 93503 A YU93503 A YU 93503A YU P93503 A YUP93503 A YU P93503A YU 93503 A YU93503 A YU 93503A
Authority
YU
Yugoslavia
Prior art keywords
capsules
ingalation
moisture content
capsule material
tiotropium
Prior art date
Application number
YU93503A
Other languages
English (en)
Inventor
Karoline Bechtold-Peters
Dieter Hochrainer
Michael Trunk
Michael Walz
Original Assignee
Boehringer Ingelheim Pharma Gmbh. & Co.Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7687020&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU93503(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma Gmbh. & Co.Kg filed Critical Boehringer Ingelheim Pharma Gmbh. & Co.Kg
Publication of YU93503A publication Critical patent/YU93503A/sh
Publication of RS50353B publication Critical patent/RS50353B/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/003—Particle size control by passing the aerosol trough sieves or filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Pronalazak se odnosi na inhalacione kapsule (inhalete) načinjene od specifičnog materijala za kapsule, sa smanjenim sadržajem vlage, koje kao delotvornu supstancu sadrže tiotropijum, u obliku preparata u prahu, za koje je karakteristična povećana stabilnost.[The invention relates to inhalation capsules (Inhalettes) made from specific capsule material with reduced moisture content, containing the active agent tiotropium in the form of a powder preparation and characterised by an improved stability.
YUP-935/03A 2001-06-01 2002-05-27 Inhalacione kapsule RS50353B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10126924A DE10126924A1 (de) 2001-06-01 2001-06-01 Inhalationskapseln

Publications (2)

Publication Number Publication Date
YU93503A true YU93503A (sh) 2006-05-25
RS50353B RS50353B (sr) 2009-11-10

Family

ID=7687020

Country Status (37)

Country Link
EP (2) EP1508330A1 (sh)
JP (3) JP4447311B2 (sh)
KR (2) KR100921904B1 (sh)
CN (3) CN101697965A (sh)
AR (2) AR034346A1 (sh)
AT (1) ATE285752T1 (sh)
AU (2) AU2002344354B2 (sh)
BG (1) BG65655B1 (sh)
BR (1) BR0209366A (sh)
CA (1) CA2448425C (sh)
CH (1) CH1379220H1 (sh)
CO (1) CO5540379A2 (sh)
CZ (1) CZ300284B6 (sh)
DE (2) DE10126924A1 (sh)
EA (1) EA005188B1 (sh)
EC (2) ECSP034868A (sh)
EE (1) EE05416B1 (sh)
EG (1) EG24227A (sh)
ES (1) ES2236590B5 (sh)
HR (1) HRP20030993B1 (sh)
HU (3) HU230827B1 (sh)
IL (2) IL158917A0 (sh)
ME (1) ME00301B (sh)
MX (1) MXPA03010990A (sh)
MY (1) MY126253A (sh)
NO (1) NO332857B3 (sh)
NZ (1) NZ530356A (sh)
PE (1) PE20030071A1 (sh)
PL (2) PL205714B1 (sh)
PT (1) PT1379220E (sh)
RS (1) RS50353B (sh)
SI (1) SI1379220T1 (sh)
SK (2) SK287379B6 (sh)
TW (1) TWI327921B (sh)
UA (1) UA75659C2 (sh)
WO (1) WO2002098874A2 (sh)
ZA (1) ZA200308340B (sh)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0107304A (pt) 2000-10-12 2002-08-13 Boehringer Ingelheim Pharma Pó para inalação contendo tiotrópio
DE10126924A1 (de) * 2001-06-01 2002-12-05 Boehringer Ingelheim Pharma Inhalationskapseln
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
KR20050003416A (ko) * 2002-05-07 2005-01-10 넥타르 테라퓨틱스 건조분말 흡입기용 캡슐 및 이의 제조 및 사용 방법
DE10255387A1 (de) * 2002-11-28 2004-06-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Tiotropium-haltige Pulverformulierung für die Inhalation
US7763280B2 (en) 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
DE10258360A1 (de) * 2002-12-12 2004-06-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator mit Kapselkammer zum Aufnehmen einer mit Wirkstoff gefüllten Einwegkapsel
DE10352277A1 (de) * 2003-11-08 2005-06-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator
SE0303570L (sv) 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
SE0303269L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Medicinsk produkt
GB0503738D0 (en) 2005-02-23 2005-03-30 Optinose As Powder delivery devices
RU2369411C2 (ru) * 2005-04-21 2009-10-10 Бёрингер Ингельхайм Интернациональ Гмбх Порошковый ингалятор
US7694676B2 (en) 2005-04-22 2010-04-13 Boehringer Ingelheim Gmbh Dry powder inhaler
JP4825455B2 (ja) * 2005-05-02 2011-11-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 粉末吸入器
DE102006016904A1 (de) 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator
DE102006016901A1 (de) 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Mundstück für einen Inhalator
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
DE102007036411A1 (de) 2007-07-20 2009-02-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator
DE102007052871A1 (de) * 2007-11-02 2009-05-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kapsel zur Aufnahme von pharmazeutischen Wirkstoffformulierungen
US20100327476A1 (en) * 2008-02-08 2010-12-30 Boehringer Ingelheim International Gmbh Method and device for filling capsules
EP2172190A1 (en) * 2008-10-02 2010-04-07 Laboratorios Liconsa, S.A. Inhalable particles comprising tiotropium
ES2739352T3 (es) 2009-02-26 2020-01-30 Glaxo Group Ltd Formulaciones farmacéuticas que comprenden 4-{(1R)-2-[(6-{2-[(2,6-diclorobencil)oxi]etoxi}hexil)amino]-1-hidroxietil}-2-(hidroximetil)fenol
WO2010110760A1 (en) * 2009-03-27 2010-09-30 Mahmut Bilgic Compositions comprising water with deuterium for the prevention or treatment of allergic diseases and a process for the preparation thereof
GB0921075D0 (en) 2009-12-01 2010-01-13 Glaxo Group Ltd Novel combination of the therapeutic agents
EP2575786B1 (en) 2010-06-03 2017-11-15 Sima Patent ve Lisanslama Hizmetleri Ltd.Sti. Process for dry powder formulations
DE202011102694U1 (de) 2011-06-29 2011-12-19 Zisser Gmbh Inhalationsgerät für Heimanwender
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
WO2014007768A1 (en) 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Dry powder inhaler compositions comprising long acting muscorinic antagonists
DE202013000774U1 (de) 2013-01-21 2013-04-15 Rhinofilt GmbH Miniaturisiertes Inhalationsgerät zur Privatanwendung
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
CN108295042A (zh) * 2018-03-05 2018-07-20 上海祺宇生物科技有限公司 一种用于吸入药剂的植物空心胶囊及其胶囊剂
CN108451920A (zh) * 2018-03-14 2018-08-28 绍兴康可胶囊有限公司 一种吸雾式胶囊及其制备方法
CN114848605B (zh) * 2022-03-25 2023-08-11 上海方予健康医药科技有限公司 一种供吸入粉雾剂用的明胶胶囊

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DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US5626871A (en) * 1992-06-12 1997-05-06 Teijin Limited Preparation for intratracheobronchial administration
US6228394B1 (en) * 1997-10-14 2001-05-08 Boehringer Ingelheim Pharmaceuticals, Inc. Supercritical fluid extraction of mould lubricant from hard shell capsules
DE19835346A1 (de) * 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren
JP2000143502A (ja) * 1998-11-11 2000-05-23 Shionogi Qualicaps Kk 吸入製剤
DK1131059T3 (da) * 1998-11-13 2003-06-30 Jago Res Ag Tørpulver til inhalation
DE19921693A1 (de) * 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
EP1072258A1 (de) * 1999-07-28 2001-01-31 Greither, Peter Eine Kapsel für die Freisetzung von Bakterien, enthaltend ein Bakterienlyophilisat und ein Verfahren zu ihrer Herstellung
AU7685200A (en) * 1999-10-12 2001-04-23 Kaken Pharmaceutical Co., Ltd. Powdery inhalational preparations and process for producing the same
DE10126924A1 (de) * 2001-06-01 2002-12-05 Boehringer Ingelheim Pharma Inhalationskapseln

Also Published As

Publication number Publication date
JP2008050364A (ja) 2008-03-06
PL364108A1 (en) 2004-12-13
SK16202003A3 (sk) 2004-05-04
NO20035265L (no) 2003-11-27
PT1379220E (pt) 2005-03-31
CA2448425C (en) 2010-12-21
HU231082B1 (hu) 2020-06-29
HU230058B1 (hu) 2015-06-29
KR100921904B1 (ko) 2009-10-16
AU2008203057C8 (en) 2017-04-06
PL205714B1 (pl) 2010-05-31
JP4447311B2 (ja) 2010-04-07
ATE285752T1 (de) 2005-01-15
SK287346B6 (sk) 2010-07-07
EA005188B1 (ru) 2004-12-30
AU2008203057B2 (en) 2011-12-08
ES2236590T3 (es) 2005-07-16
EE200300595A (et) 2004-02-16
HUP0400666A3 (en) 2009-06-29
CN1512875A (zh) 2004-07-14
BR0209366A (pt) 2004-06-08
WO2002098874A2 (de) 2002-12-12
RS50353B (sr) 2009-11-10
AU2002344354B2 (en) 2008-08-07
BG108380A (bg) 2004-11-30
BG65655B1 (bg) 2009-05-29
UA75659C2 (en) 2006-05-15
PL203801B1 (pl) 2009-11-30
SI1379220T1 (sl) 2005-04-30
ES2236590B5 (es) 2018-03-05
IL158917A0 (en) 2004-05-12
HRP20030993B1 (en) 2011-10-31
EP1379220A2 (de) 2004-01-14
AU2008203057C1 (en) 2017-05-18
TWI327921B (en) 2010-08-01
AU2008203057A1 (en) 2008-07-31
EP1379220B1 (de) 2004-12-29
NO20035265D0 (no) 2003-11-27
IL158917A (en) 2008-11-03
JP2006143747A (ja) 2006-06-08
CA2448425A1 (en) 2002-12-12
KR20040007638A (ko) 2004-01-24
SK287379B6 (sk) 2010-08-09
KR20090010140A (ko) 2009-01-28
CN101697965A (zh) 2010-04-28
CN101829072A (zh) 2010-09-15
NO332857B1 (no) 2013-01-21
NO332857B3 (no) 2016-01-25
PL387118A1 (pl) 2004-12-13
MXPA03010990A (es) 2004-02-27
AR034346A1 (es) 2004-02-18
JP2005500279A (ja) 2005-01-06
EG24227A (en) 2008-11-10
MEP42508A (en) 2011-02-10
KR100952321B1 (ko) 2010-04-09
ZA200308340B (en) 2004-05-21
HUP0400666A2 (hu) 2005-03-29
CH1379220H1 (sh) 2018-10-31
ME00301B (me) 2011-05-10
EE05416B1 (et) 2011-06-15
HRP20030993A2 (en) 2005-08-31
PE20030071A1 (es) 2003-03-04
WO2002098874A3 (de) 2003-09-12
HU230827B1 (hu) 2018-07-30
JP4787034B2 (ja) 2011-10-05
DE10126924A1 (de) 2002-12-05
NZ530356A (en) 2005-05-27
CZ20033579A3 (en) 2004-05-12
ECSP11004868A (es) 2011-02-28
CZ300284B6 (cs) 2009-04-08
EA200301275A1 (ru) 2004-06-24
EP1508330A1 (de) 2005-02-23
ECSP034868A (es) 2004-03-23
AR084804A2 (es) 2013-06-26
MY126253A (en) 2006-09-29
CO5540379A2 (es) 2005-07-29
HUP1500188A2 (en) 2005-03-29
DE50201898D1 (de) 2005-02-03

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