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YU74201A - Nova sinteza prstena piperazina - Google Patents

Nova sinteza prstena piperazina

Info

Publication number
YU74201A
YU74201A YU74201A YUP74201A YU74201A YU 74201 A YU74201 A YU 74201A YU 74201 A YU74201 A YU 74201A YU P74201 A YUP74201 A YU P74201A YU 74201 A YU74201 A YU 74201A
Authority
YU
Yugoslavia
Prior art keywords
piperazine ring
arylalkoxy
aryloxy
alkoxy
aryl
Prior art date
Application number
YU74201A
Other languages
English (en)
Inventor
Ben-Zion Dolitzky
Original Assignee
Teva Pharmaceutical Industries Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd. filed Critical Teva Pharmaceutical Industries Ltd.
Publication of YU74201A publication Critical patent/YU74201A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Opisan je novi postupak za pripremanje jedinjenja formule (I) naznačenog time što R1 označava supstituisani ili nesupstituisani alkil, alkoksi, aril, ariloksi ili arilalkoksi, R2 označava supstituisani ili nesupstituisani alkil, alkoksi, aril, ariloksi, arilalkoksi, tozil, formil, acetil ili amin, a R3 označava supstituisani ili nesupstituisani alkil, alkoksi, aril, ariloksi ili arilalkoksi. Ova jedinjenja su korisna u sintezi antidepresiva mirtazapina i drugih tetracikličnih jedinjenja.
YU74201A 1999-04-19 2000-04-07 Nova sinteza prstena piperazina YU74201A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13004899P 1999-04-19 1999-04-19

Publications (1)

Publication Number Publication Date
YU74201A true YU74201A (sh) 2004-05-12

Family

ID=22442818

Family Applications (1)

Application Number Title Priority Date Filing Date
YU74201A YU74201A (sh) 1999-04-19 2000-04-07 Nova sinteza prstena piperazina

Country Status (19)

Country Link
US (2) US6339156B1 (sh)
EP (1) EP1178972A4 (sh)
JP (1) JP2002542234A (sh)
KR (1) KR20020015313A (sh)
CN (1) CN1355793A (sh)
AU (1) AU777105B2 (sh)
CA (1) CA2370389A1 (sh)
CZ (1) CZ20013698A3 (sh)
HK (1) HK1042696A1 (sh)
HR (1) HRP20010759A2 (sh)
HU (1) HUP0200808A3 (sh)
IL (1) IL146024A0 (sh)
PL (1) PL351395A1 (sh)
RU (1) RU2001128228A (sh)
SK (1) SK14802001A3 (sh)
TR (1) TR200103035T2 (sh)
WO (1) WO2000063185A1 (sh)
YU (1) YU74201A (sh)
ZA (1) ZA200108480B (sh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL146024A0 (en) * 1999-04-19 2002-07-25 Teva Pharma Novel synthesis of piperazine ring
AU6476300A (en) 1999-09-30 2001-05-10 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a piperazine derivative
WO2001042239A1 (en) * 1999-12-13 2001-06-14 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a pyridinemethanol compound
HUP0401921A3 (en) * 2001-09-14 2008-03-28 Medichem Sa Intermediate compounds for the preparation of mirtazapine and the production methods thereof
US7041826B2 (en) * 2003-06-02 2006-05-09 Aurobindo Pharma Ltd. Process for preparing 1-methyl-3-phenylpiperazine using a novel intermediate
EP1930325A4 (en) * 2005-09-26 2010-02-24 Sumitomo Chemical Co METHOD FOR PRODUCING AN OPTICALLY ACTIVE PIPERAZINE COMPOUND
CN101440067B (zh) * 2007-11-21 2010-08-25 上海津力化工有限公司 一种药物中间体1-甲基-3-苯基哌嗪的制备方法
CN102649779A (zh) * 2012-04-20 2012-08-29 山东鲁药制药有限公司 一种药物中间体1-甲基-3-苯基哌嗪的合成方法
PL3261645T3 (pl) 2015-02-27 2021-12-06 Dechra Limited Pobudzanie apetytu, zarządzanie utratą masy ciała, i leczenie anoreksji u psów i kotów

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2891063A (en) * 1959-06-16 Piperazine derivatives and process of
US2830056A (en) * 1958-04-08 Chj oh
US2507408A (en) * 1948-03-05 1950-05-09 Rhone Poulenc Sa 1-alkylsulfonyl-4-alkyl piperazines
GB1181322A (en) * 1967-06-29 1970-02-11 Chugai Pharmaceutical Co Ltd Piperazine Derivatives and processes for preparing the same
NL179906C (nl) 1974-02-09 1986-12-01 Akzo Nv Werkwijze voor het bereiden van 1,2,3,4,10,14b-hexahydrodibenzo(c,f)pyrazino (1,2-a)azepine derivaten.
US4217452A (en) * 1974-02-09 1980-08-12 Akzona Incorporated Synthesis for the preparation of tetracyclic compounds
NL189199C (nl) 1975-04-05 1993-02-01 Akzo Nv Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
FR2585702B1 (fr) * 1985-07-31 1989-03-03 Lafon Labor Derives de phenyl-piperazine, procede de preparation et utilisation en therapeutique
US4918190A (en) * 1986-08-06 1990-04-17 Ube Industries, Ltd. Crystalline complex compounds of propargyl alcohols and tertiary diamines, and process of separation and purification of propargyl alcohols using the same
US4935515A (en) 1988-02-23 1990-06-19 American Home Products Corporation 2,3,4,5-tetrahydro-1H-[1,2,5]triazocino(1,2-a)[1,2,4]benzotriazin-7(8H)-ones, thiones and derivatives
IL146024A0 (en) * 1999-04-19 2002-07-25 Teva Pharma Novel synthesis of piperazine ring

Also Published As

Publication number Publication date
JP2002542234A (ja) 2002-12-10
CA2370389A1 (en) 2000-10-26
IL146024A0 (en) 2002-07-25
EP1178972A1 (en) 2002-02-13
EP1178972A4 (en) 2002-06-12
TR200103035T2 (tr) 2002-01-21
HK1042696A1 (zh) 2002-08-23
HRP20010759A2 (en) 2003-02-28
CZ20013698A3 (cs) 2002-05-15
ZA200108480B (en) 2003-01-29
WO2000063185A1 (en) 2000-10-26
US20020035256A1 (en) 2002-03-21
US6339156B1 (en) 2002-01-15
RU2001128228A (ru) 2003-07-20
KR20020015313A (ko) 2002-02-27
AU777105B2 (en) 2004-09-30
AU4219000A (en) 2000-11-02
PL351395A1 (en) 2003-04-07
US6852855B2 (en) 2005-02-08
HUP0200808A3 (en) 2002-12-28
CN1355793A (zh) 2002-06-26
SK14802001A3 (sk) 2002-07-02
HUP0200808A2 (hu) 2002-11-28

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