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YU68601A - Jedinjenja i njihova upotreba za pripremu leka za tretiranje astme, alergije i inflamatornih bolesti - Google Patents

Jedinjenja i njihova upotreba za pripremu leka za tretiranje astme, alergije i inflamatornih bolesti

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Publication number
YU68601A
YU68601A YU68601A YUP68601A YU68601A YU 68601 A YU68601 A YU 68601A YU 68601 A YU68601 A YU 68601A YU P68601 A YUP68601 A YU P68601A YU 68601 A YU68601 A YU 68601A
Authority
YU
Yugoslavia
Prior art keywords
compounds
treatment
substituted
asthma
allergy
Prior art date
Application number
YU68601A
Other languages
English (en)
Inventor
Ralph Scannell
Pierre Chatelain
Anna Toy-Palmer
Edmond Differding
James Ellis
Marie-Agnes Lassoie
Michelle Young
Xiong Cai
Sajjat Hussoin
Gurmit Grewal
Timothy Lewis
Original Assignee
Ucb S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb S.A. filed Critical Ucb S.A.
Publication of YU68601A publication Critical patent/YU68601A/sh

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
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  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
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Abstract

Predmetni pronalazak obezbedjuje jedinjenja 1,4 supstitulsane piperazine, 1,4 supstituisane piperidine i 1-supstituisane, 4-alkilidenil piperidine. Jedinjenja pronalaska su dvostruko delujući molekuli koji imaju karakteristike inhibicije leukotriena, kao i antihistaminergične karakteristike. Jedinjenja pronalaska su korisna za upotrebu u pripremi leka za tretiranje stanja u kojima je verovatno da će sadržati histamin i/ili leukotrien. Ti uslovi uključuju preferentno astmu, sezonski ili trajan alergijski rinitis, sinusitis, konjuktivitis, alergiju na hranu, trovanje skušom, psorijazu, urtikariju, pruritus, ekcem, reumatoidini artritis, zapaljenje creva, hroničnu opstruktivnu plućnu bolest trombotičnu bolest i otitis media.
YU68601A 1999-03-26 2000-03-23 Jedinjenja i njihova upotreba za pripremu leka za tretiranje astme, alergije i inflamatornih bolesti YU68601A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12652199P 1999-03-26 1999-03-26

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YU68601A true YU68601A (sh) 2004-07-15

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YU68601A YU68601A (sh) 1999-03-26 2000-03-23 Jedinjenja i njihova upotreba za pripremu leka za tretiranje astme, alergije i inflamatornih bolesti

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US (3) US6451801B1 (sh)
EP (1) EP1165533B1 (sh)
JP (2) JP2002540198A (sh)
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Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6894059B1 (en) * 1999-03-26 2005-05-17 Ucb S.A. Compounds and methods for treatment of asthma, allergy and inflammatory disorders
PE20001566A1 (es) * 1999-03-26 2001-02-05 Ucb Sa Piperazinas 1,4-sustituidas, piperidinas 1,4-sustituidas y 4-alquilidenilpiperidinas 1-sustituidas
US6686502B1 (en) * 1999-03-26 2004-02-03 Ucb S.A. Compounds and methods for treatment of asthma, allergy and inflammatory disorders
EP1324996A2 (de) 2000-01-17 2003-07-09 Bayer CropScience AG Substituierte arylketone
US6440994B1 (en) * 2000-03-29 2002-08-27 Richard J. Sanders, Jr. Method of treating acne
GB0009479D0 (en) * 2000-04-17 2000-06-07 Cipla Limited Antihistaminic compounds
WO2003079970A2 (en) 2002-03-27 2003-10-02 Sun Pharmaceutical Industries Limited 4-(diarylmethyl)-1-piperazinyl derivatives
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