[go: up one dir, main page]

YU51692A - Novi derivati perhidroizoindola i njihovo dobijanje - Google Patents

Novi derivati perhidroizoindola i njihovo dobijanje

Info

Publication number
YU51692A
YU51692A YU51692A YU51692A YU51692A YU 51692 A YU51692 A YU 51692A YU 51692 A YU51692 A YU 51692A YU 51692 A YU51692 A YU 51692A YU 51692 A YU51692 A YU 51692A
Authority
YU
Yugoslavia
Prior art keywords
denotes
halogen atom
obtaining
symbol
preparation
Prior art date
Application number
YU51692A
Other languages
English (en)
Inventor
S. Grisoni
S. Hanessian
C. Moutonnier
Y.F. Peyronel
M. Tabart
A. Truchon
Original Assignee
Rhone-Poulenc Rorer S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone-Poulenc Rorer S.A. filed Critical Rhone-Poulenc Rorer S.A.
Publication of YU51692A publication Critical patent/YU51692A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Novi derivati perhidroizoindola opšte formule (I) u kojoj su radikali R1 identični i označavaju atome vodonika ili zajedno formirajuvezu, simboli R2 su identični i označavaju radikale fenil koji su u datom slučaju supstituisani atomom halogena ili radikalom metil u položaju 2 ili 3, simbol R3 označava atom halogena ili radikal hidroksi i simbol R4 označava atom vodonika ili istovremeno sa R3 označava atom halogena, u obliku svojih izomera i njihovih smeša, i u datom slučaju u obliku svojih soli, kada ove postoje, i njihovo dobijanje. Novi derivati prema pronalasku su intermedijeri za dobijanje an-tagonista supstance P.
YU51692A 1991-05-17 1992-05-15 Novi derivati perhidroizoindola i njihovo dobijanje YU51692A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9106036A FR2676443B1 (fr) 1991-05-17 1991-05-17 Nouveaux derives de perhydroisoindole et leur preparation.

Publications (1)

Publication Number Publication Date
YU51692A true YU51692A (sh) 1994-06-10

Family

ID=9412908

Family Applications (1)

Application Number Title Priority Date Filing Date
YU51692A YU51692A (sh) 1991-05-17 1992-05-15 Novi derivati perhidroizoindola i njihovo dobijanje

Country Status (23)

Country Link
US (1) US5508433A (sh)
EP (2) EP0514274A1 (sh)
JP (1) JPH06507628A (sh)
AT (1) ATE116295T1 (sh)
AU (1) AU1884092A (sh)
CA (1) CA2109297A1 (sh)
CZ (1) CZ244893A3 (sh)
DE (1) DE69201058T2 (sh)
DK (1) DK0586471T3 (sh)
ES (1) ES2066620T3 (sh)
FI (1) FI935072L (sh)
FR (1) FR2676443B1 (sh)
HU (1) HUT68913A (sh)
IE (1) IE921579A1 (sh)
IL (1) IL101867A0 (sh)
MX (1) MX9202288A (sh)
NO (1) NO933976D0 (sh)
NZ (1) NZ242773A (sh)
SK (1) SK126893A3 (sh)
TW (1) TW226991B (sh)
WO (1) WO1992020654A1 (sh)
YU (1) YU51692A (sh)
ZA (1) ZA923541B (sh)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676442B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2689889B1 (fr) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, et leur preparation.
US5508424A (en) * 1993-03-26 1996-04-16 Ortho Pharmaceutical Corporation 4-arylisoindole analgesics
FR2703679B1 (fr) * 1993-04-05 1995-06-23 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2710913B1 (fr) * 1993-10-07 1995-11-24 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2709752B1 (fr) * 1993-07-30 1995-10-06 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
TW365603B (en) * 1993-07-30 1999-08-01 Rhone Poulenc Rorer Sa Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
FR2728165A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2728169A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2728166A1 (fr) 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
MXPA02004330A (es) 1999-11-03 2004-07-30 Albany Molecular Res Inc Tetrahidroisoquinolinas aril-y heteroaril-sustituidas y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina..
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
CN100430401C (zh) 2000-07-11 2008-11-05 Amr科技公司 新的4-苯基取代的四氢异喹啉类化合物及其治疗用途
US6709651B2 (en) 2001-07-03 2004-03-23 B.M.R.A. Corporation B.V. Treatment of substance P-related disorders
CN103880827B (zh) 2004-07-15 2017-01-04 阿尔巴尼分子研究公司 芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和血清素的重摄取的应用
EP1888050B1 (en) 2005-05-17 2012-03-21 Merck Sharp & Dohme Ltd. cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid for the treatment of cancer
UA95454C2 (uk) 2005-07-15 2011-08-10 Амр Текнолоджи, Інк. Арил- і гетероарилзаміщені тетрагідробензазепіни і їх застосування для блокування зворотного захоплення норепінефрину, допаміну і серотоніну
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
RS51780B (sr) 2007-01-10 2011-12-31 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.R.L. Indazoli supstituisani amidom kao inhibitori poli(adp-riboza)polimeraze (parp)
WO2009002495A1 (en) 2007-06-27 2008-12-31 Merck & Co., Inc. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es) 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
EP2413932A4 (en) 2009-04-01 2012-09-19 Merck Sharp & Dohme HAMMER OF ACT ACTIVITY
EP2429295B1 (en) 2009-05-12 2013-12-25 Albany Molecular Research, Inc. Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
US8815894B2 (en) 2009-05-12 2014-08-26 Bristol-Myers Squibb Company Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
KR101830447B1 (ko) 2009-05-12 2018-02-20 알바니 몰레큘라 리써치, 인크. 7-(［1,2,4］트리아졸로［1,5-α］피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린 및 이의 용도
UA109417C2 (uk) 2009-10-14 2015-08-25 Мерк Шарп Енд Доме Корп. ЗАМІЩЕНІ ПІПЕРИДИНИ, ЯКІ ПІДВИЩУЮТЬ АКТИВНІСТЬ p53, І ЇХ ЗАСТОСУВАННЯ
CN103068980B (zh) 2010-08-02 2017-04-05 瑟纳治疗公司 使用短干扰核酸（siNA）的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1（CTNNB1）基因表达的抑制
LT2606134T (lt) 2010-08-17 2019-07-25 Sirna Therapeutics, Inc. Hepatito b viruso (hbv) geno raiškos slopinimas, tarpininkaujant rnr interferencijai naudojant mažą interferuojančią nukleorūgštį (sina)
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
US8946216B2 (en) 2010-09-01 2015-02-03 Merck Sharp & Dohme Corp. Indazole derivatives useful as ERK inhibitors
EP2615916B1 (en) 2010-09-16 2017-01-04 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel erk inhibitors
EP2632472B1 (en) 2010-10-29 2017-12-13 Sirna Therapeutics, Inc. Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina)
US9351965B2 (en) 2010-12-21 2016-05-31 Merck Sharp & Dohme Corp. Indazole derivatives useful as ERK inhibitors
WO2012143879A1 (en) 2011-04-21 2012-10-26 Piramal Healthcare Limited A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
US9023865B2 (en) 2011-10-27 2015-05-05 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
EP3453762B1 (en) 2012-05-02 2021-04-21 Sirna Therapeutics, Inc. Short interfering nucleic acid (sina) compositions
EP2900241B1 (en) 2012-09-28 2018-08-08 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
SI2925888T1 (en) 2012-11-28 2018-02-28 Merck Sharp & Dohme Corp. Compounds and methods for the treatment of cancer
TW201429969A (zh) 2012-12-20 2014-08-01 Merck Sharp & Dohme 作爲ｈｄｍ２抑制劑之經取代咪唑吡啶
EP2951180B1 (en) 2013-01-30 2018-05-02 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
EP3041938A1 (en) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Circular polynucleotides
EP3525785B1 (en) 2016-10-12 2025-08-27 Merck Sharp & Dohme LLC Kdm5 inhibitors
EP3706742B1 (en) 2017-11-08 2023-03-15 Merck Sharp & Dohme LLC Prmt5 inhibitors
WO2019094312A1 (en) 2017-11-08 2019-05-16 Merck Sharp & Dohme Corp. Prmt5 inhibitors
EP3833668B1 (en) 2018-08-07 2025-03-19 Merck Sharp & Dohme LLC Prmt5 inhibitors
US12173026B2 (en) 2018-08-07 2024-12-24 Merck Sharp & Dohme Llc PRMT5 inhibitors
WO2020033284A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042707A (en) * 1976-02-19 1977-08-16 E. I. Du Pont De Nemours And Company 3α-Arylhydroisoindoles
AU502760B2 (en) * 1977-02-28 1979-08-09 Science Union Et Cie, Societe Francaise De Recherche Medicale Azabicycloalkanes and their preparation
EP0058567B1 (en) * 1981-02-17 1984-07-25 Warner-Lambert Company Substituted acyl derivatives of octahydro-1h-isoindole-1-carboxylic acids and esters
US4439229A (en) * 1981-06-29 1984-03-27 Rohm And Haas Company Substituted phthalimides herbicides
JPH0278659A (ja) * 1988-09-12 1990-03-19 Shionogi & Co Ltd アザビシクロアルカン類化合物
FR2654725B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
FI935072A0 (fi) 1993-11-16
WO1992020654A1 (fr) 1992-11-26
NO933976L (no) 1993-11-03
HU9303250D0 (en) 1994-03-28
FI935072A7 (fi) 1993-11-16
FR2676443A1 (fr) 1992-11-20
EP0514274A1 (fr) 1992-11-19
ATE116295T1 (de) 1995-01-15
JPH06507628A (ja) 1994-09-01
EP0586471A1 (fr) 1994-03-16
US5508433A (en) 1996-04-16
EP0586471B1 (fr) 1994-12-28
DE69201058D1 (de) 1995-02-09
MX9202288A (es) 1992-11-01
ES2066620T3 (es) 1995-03-01
IE921579A1 (en) 1992-11-18
DK0586471T3 (da) 1995-06-06
DE69201058T2 (de) 1995-05-11
HUT68913A (en) 1995-08-28
ZA923541B (en) 1993-01-27
TW226991B (sh) 1994-07-21
FI935072L (fi) 1993-11-16
CA2109297A1 (fr) 1992-11-18
AU1884092A (en) 1992-12-30
NO933976D0 (no) 1993-11-03
FR2676443B1 (fr) 1993-08-06
CZ244893A3 (en) 1994-04-13
SK126893A3 (en) 1994-11-09
IL101867A0 (en) 1992-12-30
NZ242773A (en) 1994-06-27

Similar Documents

Publication Publication Date Title
YU51692A (sh) Novi derivati perhidroizoindola i njihovo dobijanje
YU223590A (sh) Novi derivati izoindolona i njihovo dobijanje
YU51092A (sh) Novi derivati tiopiranopirola i njihovo dobijanje
YU223490A (sh) Novi derivati izoindolana, njihovo dobijanje i farmaceutske smeše koje ih sadrže
YU61192A (sh) Imidazo(2,1-b)(3)benzazepinski derivati i preparati
MX9202287A (es) Nuevos derivados de perhidroisoindol, procedimiento para su preparacion y composicion farmaceutica que los contiene.
CO4700455A1 (es) Derivados tetraciclicos y proceso para su preparacion
YU45095A (sh) Derivati benzimidazola, postupci za njihovo prirpremanje i primena tih derivata u medicinskoj terapiji, naročito za lečenje ili sprečavanje virusnih infekcija
MX9301986A (es) Derivados de perhidroisoindol, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
YU46890B (sh) Postupak za dobijanje cikličnih sulfata
ATE245644T1 (de) 1,3-dihydro-2h-indol-2-on derivate und deren verwendung als liganden der arginin-vasopressin rezeptoren v1b oder v1b und v1a
ES2174298T3 (es) Derivados de aminotiazol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
YU120991A (sh) Postupak za dobivanje cikličnih sulfata
YU45993A (sh) Fenilbenzamidni fungicidi i postupci za njihovo pripremanje
YU47694B (sh) Novi derivati 1,8-benzonaftiridina, postupak za njihovo dobivanje i postupak za dobivanje farmaceutske smeše
ATE210642T1 (de) 2-substituierte vitamin-d3-derivate
BR0213359A (pt) Aralquiltetrahidropiridinas, sua preparação e composições farmacêuticas contendo as mesmas
YU31191A (sh) Novi derivati beta-fenilizoserina njegovo dobijanje i primena
AR009105A1 (es) Derivados de n-(benzotiazol-2-il) piperidina-1-etanamina, su preparacion y aplicacion en terapeutica
YU48443B (sh) Novi derivati fluorhinolin-3-karboksilne kiseline postupak za njihovo dobijanje i njihova primena kao intermedijera
FR2616433B1 (fr) Nouveaux derives piperazinyl alkyl piperazine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
MEP12408A (en) Acyloxypyrrolidine derivatives and use thereof as ligands of v1b or both v1b and v1a receptors
FR2555170B1 (fr) Nouveaux derives insatures, leur preparation et leur emploi
DE69222143D1 (de) Indanderivate
FI925618A0 (fi) Etanoladdukter av 6-sulfonylsubstituerade 3-hydroxikromaner och deras anvaendning som inhalationsmedel vid sjukdomar