TW226991B - - Google Patents

Info

Publication number: TW226991B
Authority: TW; Taiwan
Prior art keywords: halogen atom; symbol; preparation; new; radicals
Prior art date: 1991-05-17

Application number

TW081103793A

Other languages

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-17

Filing date

1992-05-15

Publication date

1994-07-21

1992-05-15 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1994-07-21 Application granted granted Critical

1994-07-21 Publication of TW226991B publication Critical patent/TW226991B/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

TW081103793A 1991-05-17 1992-05-15 TW226991B (zh)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9106036A FR2676443B1 (fr)	1991-05-17	1991-05-17	Nouveaux derives de perhydroisoindole et leur preparation.

Publications (1)

Publication Number	Publication Date
TW226991B true TW226991B (zh)	1994-07-21

Family

ID=9412908

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW081103793A TW226991B (zh)	1991-05-17	1992-05-15

Country Status (23)

Country	Link
US (1)	US5508433A (zh)
EP (2)	EP0514274A1 (zh)
JP (1)	JPH06507628A (zh)
AT (1)	ATE116295T1 (zh)
AU (1)	AU1884092A (zh)
CA (1)	CA2109297A1 (zh)
CZ (1)	CZ244893A3 (zh)
DE (1)	DE69201058T2 (zh)
DK (1)	DK0586471T3 (zh)
ES (1)	ES2066620T3 (zh)
FI (1)	FI935072L (zh)
FR (1)	FR2676443B1 (zh)
HU (1)	HUT68913A (zh)
IE (1)	IE921579A1 (zh)
IL (1)	IL101867A0 (zh)
MX (1)	MX9202288A (zh)
NO (1)	NO933976D0 (zh)
NZ (1)	NZ242773A (zh)
SK (1)	SK126893A3 (zh)
TW (1)	TW226991B (zh)
WO (1)	WO1992020654A1 (zh)
YU (1)	YU51692A (zh)
ZA (1)	ZA923541B (zh)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2676442B1 (fr) *	1991-05-17	1993-08-06	Rhone Poulenc Rorer Sa	Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2689889B1 (fr) *	1992-04-10	1994-06-10	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, et leur preparation.
US5508424A (en) *	1993-03-26	1996-04-16	Ortho Pharmaceutical Corporation	4-arylisoindole analgesics
FR2703679B1 (fr) *	1993-04-05	1995-06-23	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2710913B1 (fr) *	1993-10-07	1995-11-24	Rhone Poulenc Rorer Sa	Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2709752B1 (fr) *	1993-07-30	1995-10-06	Rhone Poulenc Rorer Sa	Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
TW365603B (en) *	1993-07-30	1999-08-01	Rhone Poulenc Rorer Sa	Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
FR2728165A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2728169A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2728166A1 (fr)	1994-12-19	1996-06-21	Oreal	Composition topique contenant un antagoniste de substance p
FR2741262B1 (fr)	1995-11-20	1999-03-05	Oreal	Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
MXPA02004330A (es)	1999-11-03	2004-07-30	Albany Molecular Res Inc	Tetrahidroisoquinolinas aril-y heteroaril-sustituidas y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina..
US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
CN100430401C (zh)	2000-07-11	2008-11-05	Amr科技公司	新的4-苯基取代的四氢异喹啉类化合物及其治疗用途
US6709651B2 (en)	2001-07-03	2004-03-23	B.M.R.A. Corporation B.V.	Treatment of substance P-related disorders
CN103880827B (zh)	2004-07-15	2017-01-04	阿尔巴尼分子研究公司	芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和血清素的重摄取的应用
EP1888050B1 (en)	2005-05-17	2012-03-21	Merck Sharp & Dohme Ltd.	cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid for the treatment of cancer
UA95454C2 (uk)	2005-07-15	2011-08-10	Амр Текнолоджи, Інк.	Арил- і гетероарилзаміщені тетрагідробензазепіни і їх застосування для блокування зворотного захоплення норепінефрину, допаміну і серотоніну
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
RS51780B (sr)	2007-01-10	2011-12-31	Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.R.L.	Indazoli supstituisani amidom kao inhibitori poli(adp-riboza)polimeraze (parp)
WO2009002495A1 (en)	2007-06-27	2008-12-31	Merck & Co., Inc.	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es)	2008-06-04	2010-07-28	Bristol Myers Squibb Co	Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
EP2413932A4 (en)	2009-04-01	2012-09-19	Merck Sharp & Dohme	HAMMER OF ACT ACTIVITY
EP2429295B1 (en)	2009-05-12	2013-12-25	Albany Molecular Research, Inc.	Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
US8815894B2 (en)	2009-05-12	2014-08-26	Bristol-Myers Squibb Company	Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
KR101830447B1 (ko)	2009-05-12	2018-02-20	알바니 몰레큘라 리써치, 인크.	7-(［1,2,4］트리아졸로［1,5-α］피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린 및 이의 용도
UA109417C2 (uk)	2009-10-14	2015-08-25	Мерк Шарп Енд Доме Корп.	ЗАМІЩЕНІ ПІПЕРИДИНИ, ЯКІ ПІДВИЩУЮТЬ АКТИВНІСТЬ p53, І ЇХ ЗАСТОСУВАННЯ
CN103068980B (zh)	2010-08-02	2017-04-05	瑟纳治疗公司	使用短干扰核酸（siNA）的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1（CTNNB1）基因表达的抑制
LT2606134T (lt)	2010-08-17	2019-07-25	Sirna Therapeutics, Inc.	Hepatito b viruso (hbv) geno raiškos slopinimas, tarpininkaujant rnr interferencijai naudojant mažą interferuojančią nukleorūgštį (sina)
US8883801B2 (en)	2010-08-23	2014-11-11	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
US8946216B2 (en)	2010-09-01	2015-02-03	Merck Sharp & Dohme Corp.	Indazole derivatives useful as ERK inhibitors
EP2615916B1 (en)	2010-09-16	2017-01-04	Merck Sharp & Dohme Corp.	Fused pyrazole derivatives as novel erk inhibitors
EP2632472B1 (en)	2010-10-29	2017-12-13	Sirna Therapeutics, Inc.	Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina)
US9351965B2 (en)	2010-12-21	2016-05-31	Merck Sharp & Dohme Corp.	Indazole derivatives useful as ERK inhibitors
WO2012143879A1 (en)	2011-04-21	2012-10-26	Piramal Healthcare Limited	A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
US9023865B2 (en)	2011-10-27	2015-05-05	Merck Sharp & Dohme Corp.	Compounds that are ERK inhibitors
EP3453762B1 (en)	2012-05-02	2021-04-21	Sirna Therapeutics, Inc.	Short interfering nucleic acid (sina) compositions
EP2900241B1 (en)	2012-09-28	2018-08-08	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
SI2925888T1 (en)	2012-11-28	2018-02-28	Merck Sharp & Dohme Corp.	Compounds and methods for the treatment of cancer
TW201429969A (zh)	2012-12-20	2014-08-01	Merck Sharp & Dohme	作爲ｈｄｍ２抑制劑之經取代咪唑吡啶
EP2951180B1 (en)	2013-01-30	2018-05-02	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as hdm2 inhibitors
EP3041938A1 (en)	2013-09-03	2016-07-13	Moderna Therapeutics, Inc.	Circular polynucleotides
EP3525785B1 (en)	2016-10-12	2025-08-27	Merck Sharp & Dohme LLC	Kdm5 inhibitors
EP3706742B1 (en)	2017-11-08	2023-03-15	Merck Sharp & Dohme LLC	Prmt5 inhibitors
WO2019094312A1 (en)	2017-11-08	2019-05-16	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
EP3833668B1 (en)	2018-08-07	2025-03-19	Merck Sharp & Dohme LLC	Prmt5 inhibitors
US12173026B2 (en)	2018-08-07	2024-12-24	Merck Sharp & Dohme Llc	PRMT5 inhibitors
WO2020033284A1 (en)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Prmt5 inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4042707A (en) *	1976-02-19	1977-08-16	E. I. Du Pont De Nemours And Company	3α-Arylhydroisoindoles
AU502760B2 (en) *	1977-02-28	1979-08-09	Science Union Et Cie, Societe Francaise De Recherche Medicale	Azabicycloalkanes and their preparation
EP0058567B1 (en) *	1981-02-17	1984-07-25	Warner-Lambert Company	Substituted acyl derivatives of octahydro-1h-isoindole-1-carboxylic acids and esters
US4439229A (en) *	1981-06-29	1984-03-27	Rohm And Haas Company	Substituted phthalimides herbicides
JPH0278659A (ja) *	1988-09-12	1990-03-19	Shionogi & Co Ltd	アザビシクロアルカン類化合物
FR2654725B1 (fr) *	1989-11-23	1992-02-14	Rhone Poulenc Sante	Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.

1991
- 1991-05-17 FR FR9106036A patent/FR2676443B1/fr not_active Expired - Lifetime
1992
- 1992-05-12 CZ CS932448A patent/CZ244893A3/cs unknown
- 1992-05-14 IL IL101867A patent/IL101867A0/xx unknown
- 1992-05-15 EP EP92401330A patent/EP0514274A1/fr active Pending
- 1992-05-15 NZ NZ242773A patent/NZ242773A/xx unknown
- 1992-05-15 DE DE69201058T patent/DE69201058T2/de not_active Expired - Fee Related
- 1992-05-15 MX MX9202288A patent/MX9202288A/es unknown
- 1992-05-15 FI FI935072A patent/FI935072L/fi not_active Application Discontinuation
- 1992-05-15 TW TW081103793A patent/TW226991B/zh active
- 1992-05-15 ES ES92911071T patent/ES2066620T3/es not_active Expired - Lifetime
- 1992-05-15 EP EP92911071A patent/EP0586471B1/fr not_active Expired - Lifetime
- 1992-05-15 HU HU9303250A patent/HUT68913A/hu unknown
- 1992-05-15 WO PCT/FR1992/000430 patent/WO1992020654A1/fr not_active Ceased
- 1992-05-15 SK SK1268-93A patent/SK126893A3/sk unknown
- 1992-05-15 US US08/146,142 patent/US5508433A/en not_active Expired - Fee Related
- 1992-05-15 AT AT92911071T patent/ATE116295T1/de not_active IP Right Cessation
- 1992-05-15 AU AU18840/92A patent/AU1884092A/en not_active Abandoned
- 1992-05-15 YU YU51692A patent/YU51692A/sh unknown
- 1992-05-15 JP JP4510463A patent/JPH06507628A/ja active Pending
- 1992-05-15 DK DK92911071.6T patent/DK0586471T3/da active
- 1992-05-15 ZA ZA923541A patent/ZA923541B/xx unknown
- 1992-05-15 CA CA002109297A patent/CA2109297A1/fr not_active Abandoned
- 1992-07-01 IE IE157992A patent/IE921579A1/en not_active Application Discontinuation
1993
- 1993-11-03 NO NO1993933976A patent/NO933976D0/no unknown

Also Published As

Publication number	Publication date
FI935072A0 (fi)	1993-11-16
WO1992020654A1 (fr)	1992-11-26
NO933976L (no)	1993-11-03
HU9303250D0 (en)	1994-03-28
FI935072A7 (fi)	1993-11-16
FR2676443A1 (fr)	1992-11-20
EP0514274A1 (fr)	1992-11-19
ATE116295T1 (de)	1995-01-15
JPH06507628A (ja)	1994-09-01
EP0586471A1 (fr)	1994-03-16
US5508433A (en)	1996-04-16
EP0586471B1 (fr)	1994-12-28
DE69201058D1 (de)	1995-02-09
MX9202288A (es)	1992-11-01
ES2066620T3 (es)	1995-03-01
IE921579A1 (en)	1992-11-18
DK0586471T3 (da)	1995-06-06
DE69201058T2 (de)	1995-05-11
YU51692A (sh)	1994-06-10
HUT68913A (en)	1995-08-28
ZA923541B (en)	1993-01-27
FI935072L (fi)	1993-11-16
CA2109297A1 (fr)	1992-11-18
AU1884092A (en)	1992-12-30
NO933976D0 (no)	1993-11-03
FR2676443B1 (fr)	1993-08-06
CZ244893A3 (en)	1994-04-13
SK126893A3 (en)	1994-11-09
IL101867A0 (en)	1992-12-30
NZ242773A (en)	1994-06-27

Publication	Publication Date	Title
TW226991B (zh)	1994-07-21
MX9202287A (es)	1993-02-01	Nuevos derivados de perhidroisoindol, procedimiento para su preparacion y composicion farmaceutica que los contiene.
IL96447A0 (en)	1991-08-16	Isoindolone derivatives and their preparation
FR2749304B1 (fr)	1998-06-26	Nouveaux derives du 3-(piperid-4-yl)1,2-benzisoxazole et du 3-(piperazin-4-yl)1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
DK0700914T3 (da)	2000-07-31	Campththecinderivater, deres fremstilling og antitumormidler
DE69104075D1 (de)	1994-10-27	Mesomorphe Verbindung, sie enthaltende flüssigkristalline Zusammensetzung, sie verwendende flüssigkristalline Vorrichtung und Anzeigeapparat.
PT79214B (en)	1986-08-22	Derivatives of 4-(3-alkynyloxy-2-hydroxy-propyl)-piperazin-1-yl-n-acetamide
GR3003963T3 (zh)	1993-03-16
ES2098517T3 (es)	1997-05-01	Derivados de 1,2,4-tiadiazino(3,4-b)benzotiazol, su preparacion y los medicamentos que los contienen.
DK0538100T3 (da)	2002-04-29	Fremgangsmåde til fremstilling af derivater af fluorquinolin-3-carboxylsyre
ES469577A1 (es)	1978-12-01	Un procedimiento para la preparacion de 5-alquil y 5-alque- nil-sulfonil-halogenpirimidinas.
RU93058289A (ru)	1996-12-27	Производные пергидроизоиндола, способы их получения