YU48294B - Novi 1-(arilalkilaminoalkil)imidazoli i postupci za njihovo dobijanje - Google Patents
Novi 1-(arilalkilaminoalkil)imidazoli i postupci za njihovo dobijanjeInfo
- Publication number
- YU48294B YU48294B YU110592A YU110592A YU48294B YU 48294 B YU48294 B YU 48294B YU 110592 A YU110592 A YU 110592A YU 110592 A YU110592 A YU 110592A YU 48294 B YU48294 B YU 48294B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- group
- alkyl group
- halogen
- optionally substituted
- alkoxy
- Prior art date
Links
- 150000002460 imidazoles Chemical class 0.000 title abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 13
- 229910052736 halogen Inorganic materials 0.000 abstract 10
- 150000002367 halogens Chemical class 0.000 abstract 10
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 9
- 239000001257 hydrogen Substances 0.000 abstract 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000005242 carbamoyl alkyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Lubricants (AREA)
Abstract
NOVI 1-(ARILALKILAMINOALKIL)IMIDAZOLI I POSTUPCI ZA NJIHOVO DOBIJANJE - Novi 1-(arilalkilaminoalkil)imidazoli formule (I): i njihove farmaceutski prihvatljive soli, gde R1, R2 i R3 nezavisno predstavljaju vodonik; halogen; C1-6alkil grupu; C1-6alkoksi grupu; fenoksi grupu po potrebi supstituisanu sa C1-4 alkil grupom, C1-4 alkoksi grupom ili halogenom; fenil grupu po potrebi supstituisanu sa C1-4 alkil grupom, C1-4 alkoksi grupom ili halogenom; C2-6 alkoksikarbonil grupu; amino grupu formule -NR13R14 u kojoj su R13 i R14 nezavisno vodonik ili C1-4 alkil grupa, ili R13 i R14 zajedno sa azotovim atomom za koji su vezani grade pirolidinski, morfolinski ili piperidinski prsten; halogenovanu C1-4 alkil grupu; benziloksi grupu po potrebi supstituisanu sa C1-4 alkil grupom, C1-4 alkoksi grupom ili halogenom; hidroksi; C1-4 hidroksialkil grupu; (C2-6 alkoksikarbonil)-vinil grupu; grupu formule-S(O)nR7 u kojoj je R7C1-4 alkil grupa a n je O, 1 ili 2; C2-4 karbamoilalkil grupu; C2-6 alkoksikarbonil-C1-2alkil grupu; karbamoil grupu formule -CONR11R12 u kojoj R11 i R12 nezavisno predstavljaju vodonik ili C1-6 alkil grupu; ili R1 i R2 zajedno sa fenil prstenom za koji su vezani predstavljaju naftil grupu; R4 i R5 su nezavisno vodonik; C1-4 alkil grupa; fenil grupa po potrebi supstituisana sa C1-4 alkil grupom, C1-4 alkoksi grupom ili halogenom; ili R4 i R5 zajedno sa ugljenikovim atomom za koji su vezani grade C3-6 cikloalkil grupu; R6 je vodonik; C1-4alkil grupa; ili w-hidroksi-C1-4alkil grupa; A je C2-9 alkilenska grupa pravog ili racvastog niza; R8 predstavlja vodonik; C1-6 alkil grupu; halogen; C1-4 alkoksi grupu; C1-4 hidroksialkil grupu; fenil grupu po potrebi supstituisanu sa C1-4 alkil grupom, C1-4 alkoksi grupom ili halogenom; ili benzil grupu po potrebi supstituisanu sa C1-4 alkil grupom, C1-4 alkoksi grupom ili halogenom; R9 i R10 su nezavisno vodonik; C1-6 alkil grupa; halogen; C1-4 alkoksi grupa; C1-4 hidroksialkil grupa; fenil grupa po potrebi supstituisana sa C1-4 alkil grupom, C1-4 alkoksi grupom ili halogenom; C2-6 alkoksikarbonil grupa; nitro; amino grupa formule NR30R31, gde su R30 i R31 nezavisno vodonik ili C1-4 alkil grupa; C1-6 alkanoiloksi-C1-4alkil grupa; ili aminometil grupa; pod uslovima da, kada A predstavlja (CH2)2 i R2, R3, R4, R5, R6, R7, R8, R9 i R10 predstavljaju atome vodonika, onda R1 ne moze da bude vodonik niti 4-hloro; i kada je A (CH2)5 i R1, R2, R3, R4, R5, R6, R9 i R10 predstavljaju atome vodonika, onda R8 ne moze da bude metil. - Prijava sadrzi jos 1 nezavisan i 12 zavisnih zahteva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919127304A GB9127304D0 (en) | 1991-12-23 | 1991-12-23 | Therapeutic agents |
| CN93107988A CN1037511C (zh) | 1991-12-23 | 1993-06-22 | 1－(芳烷基－氨烷基)咪唑化合物的制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU110592A YU110592A (sh) | 1996-01-08 |
| YU48294B true YU48294B (sh) | 1998-05-15 |
Family
ID=36822309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU110592A YU48294B (sh) | 1991-12-23 | 1992-12-23 | Novi 1-(arilalkilaminoalkil)imidazoli i postupci za njihovo dobijanje |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5547972A (sh) |
| EP (1) | EP0618907B1 (sh) |
| JP (1) | JP2633087B2 (sh) |
| CN (1) | CN1037511C (sh) |
| AT (1) | ATE179416T1 (sh) |
| AU (1) | AU656839B2 (sh) |
| BG (1) | BG98812A (sh) |
| CA (1) | CA2126177A1 (sh) |
| CZ (1) | CZ153394A3 (sh) |
| DE (1) | DE69229057T2 (sh) |
| ES (1) | ES2131574T3 (sh) |
| FI (1) | FI943020A7 (sh) |
| GB (1) | GB9127304D0 (sh) |
| HR (1) | HRP921457A2 (sh) |
| HU (2) | HUT67372A (sh) |
| IL (1) | IL104168A (sh) |
| IN (1) | IN174436B (sh) |
| MX (1) | MX9207491A (sh) |
| NO (1) | NO304373B1 (sh) |
| NZ (1) | NZ246336A (sh) |
| PH (1) | PH30660A (sh) |
| PL (1) | PL172497B1 (sh) |
| RO (1) | RO113985B1 (sh) |
| RU (1) | RU2118957C1 (sh) |
| SI (1) | SI9200411A (sh) |
| SK (1) | SK75294A3 (sh) |
| WO (1) | WO1993013075A1 (sh) |
| YU (1) | YU48294B (sh) |
| ZA (1) | ZA929914B (sh) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5741800A (en) * | 1993-06-22 | 1998-04-21 | Knoll Aktiengesellachaft | Azolyl-cyclic amine derivates with immunomodulatory activity |
| GB9312893D0 (en) * | 1993-06-22 | 1993-08-04 | Boots Co Plc | Therapeutic agents |
| WO1995022327A1 (en) * | 1994-02-22 | 1995-08-24 | Knoll Ag | Use of 1-(arylalkylaminoalkyl) imidazoles for treating neurological damage |
| US5700825A (en) * | 1995-03-31 | 1997-12-23 | Florida State University | Radiosensitizing diamines and their pharmaceutical preparations |
| US6060604A (en) * | 1995-03-31 | 2000-05-09 | Florida State University | Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups |
| US5710171A (en) * | 1995-05-24 | 1998-01-20 | Merck & Co., Inc. | Bisphenyl inhibitors of farnesyl-protein transferase |
| US6063930A (en) * | 1996-04-03 | 2000-05-16 | Merck & Co., Inc. | Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors |
| US6080870A (en) * | 1996-04-03 | 2000-06-27 | Merck & Co., Inc. | Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors |
| US6358060B2 (en) | 1998-09-03 | 2002-03-19 | Jsr Llc | Two-stage transmucosal medicine delivery system for symptom relief |
| DE19850301A1 (de) | 1998-10-30 | 2000-05-04 | Basf Ag | Verfahren zur Racematspaltung von 2-Hydroxypropionsäuren |
| EP1741709A1 (en) * | 2005-06-28 | 2007-01-10 | Sanofi-Aventis Deutschland GmbH | Heteroaryl-substituted amides comprising a saturated linker group, and their use as pharmaceuticals |
| US8642016B2 (en) | 2006-07-21 | 2014-02-04 | Jsrnti, Llc | Medicinal delivery system, and related methods |
| RU2339625C2 (ru) * | 2006-11-02 | 2008-11-27 | Российский химико-технологический университет (РХТУ им. Д.И. Менделеева) | ЗАМЕЩЕННЫЕ N-[ω-АЗОЛ-1-ИЛ)АЛКИЛ]БЕНЗОЛСУЛЬФАМИДЫ В КАЧЕСТВЕ СРЕДСТВ С АНТИАГРЕГАЦИОННОЙ АКТИВНОСТЬЮ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ |
| WO2016126957A1 (en) * | 2015-02-04 | 2016-08-11 | The Board Of Trustees Of The University Of Alabama | Gas treating solutions containing imidazole-amine compounds |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU557755A3 (ru) * | 1968-08-19 | 1977-05-05 | Янссен Фармасьютика Н.В. (Фирма) | Способ получени производных имидазола |
| GB1341375A (en) * | 1969-11-19 | 1973-12-19 | Smith Kline French Lab | Aminoalkylimidazoles and process for their production |
| DE2107487A1 (de) * | 1970-02-26 | 1971-09-09 | CIBA Geigy AG, Basel (Schweiz) | Neue Amine und Verfahren zu ihrer Herstellung |
| DE2041771C3 (de) * | 1970-08-22 | 1979-07-26 | Bayer Ag, 5090 Leverkusen | derivate |
| IE47132B1 (en) * | 1977-08-19 | 1983-12-28 | Roche Products Ltd | Novel nitroimidazoles and pharmaceutical preparations containing these as well as their manufacture |
| DE2862340D1 (en) * | 1978-02-01 | 1983-11-24 | Wellcome Found | Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof |
| JPS55313A (en) * | 1978-06-13 | 1980-01-05 | Kissei Pharmaceut Co Ltd | Imidazole derivative |
| DE2833140A1 (de) * | 1978-07-28 | 1980-02-07 | Boehringer Sohn Ingelheim | Neue n-substituierte heterocyclen |
| US4404387A (en) * | 1980-09-17 | 1983-09-13 | The Upjohn Company | Aminoalkyl-substituted imidazoles |
| US4338453A (en) * | 1980-09-17 | 1982-07-06 | The Upjohn Company | Aminoalkyl-1,2,4-triazoles |
| JPS5769089A (en) * | 1980-10-17 | 1982-04-27 | Fuji Photo Film Co Ltd | Desensitizer composition |
| DK162882A (da) * | 1981-04-13 | 1982-10-14 | Searle & Co | Imidazolderivater eller syreadditionssalte deraf,deres fremstilling og anvendelse |
| GB2110663B (en) * | 1981-12-04 | 1985-08-07 | Farmos Group Ltd | Imidazole derivatives |
| EP0105575B1 (en) * | 1982-07-12 | 1987-03-04 | G.D. Searle & Co. | 1-(1h-imidazolyl), 1-n-morpholinyl and pyridyl compounds, their preparation and pharmaceutical compositions containing them |
| DE3238006A1 (de) * | 1982-10-13 | 1984-04-19 | Bayer Ag, 5090 Leverkusen | Azolyl-methylamine, ihre herstellung und verwendung in mikrobiziden mitteln |
| EP0117462A3 (en) * | 1983-02-28 | 1986-08-20 | American Cyanamid Company | N-(2-4-(1h-imidazol-1-yl)alkyl)arylamides |
| US4581370A (en) * | 1983-07-12 | 1986-04-08 | Schering A.G. | Antiarrhythmic imidazoliums |
| US5105017A (en) * | 1983-07-18 | 1992-04-14 | Eli Lilly And Company | Leukotriene antagonist intermediates |
| GB8412750D0 (en) * | 1984-05-18 | 1984-06-27 | Ici Plc | Heterocyclic compounds |
| US4728663A (en) * | 1986-01-13 | 1988-03-01 | American Cyanamid Company | N-[(1H-imidazol-1-yl)alkyl]benz[cd]-indol-2-amines and use in inhibiting thromboxane synthetase enzyme |
| JPH0774205B2 (ja) * | 1986-12-04 | 1995-08-09 | 三井石油化学工業株式会社 | 新規イミダゾ−ル誘導体 |
| US4851423A (en) * | 1986-12-10 | 1989-07-25 | Schering Corporation | Pharmaceutically active compounds |
| KR920701167A (ko) * | 1989-07-07 | 1992-08-11 | 에릭 에스. 딕커 | 약제학적 활성 화합물 |
| FR2656610B1 (fr) * | 1989-12-29 | 1992-05-07 | Sanofi Sa | Derives d'amino-2 phenyl-4 thiazole, leur procede de preparation et leur application therapeutique. |
| EP0485890A3 (en) * | 1990-11-16 | 1992-07-08 | Hoechst Aktiengesellschaft | Use of 2,3-disubstituate 1-azolyl-propane for inhibiting the pathogenic growth phase of dimorph yeast cell |
| FR2686084B1 (fr) * | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
-
1991
- 1991-12-23 GB GB919127304A patent/GB9127304D0/en active Pending
-
1992
- 1992-12-12 ES ES93901678T patent/ES2131574T3/es not_active Expired - Lifetime
- 1992-12-12 DE DE69229057T patent/DE69229057T2/de not_active Expired - Fee Related
- 1992-12-12 RO RO94-01070A patent/RO113985B1/ro unknown
- 1992-12-12 EP EP93901678A patent/EP0618907B1/en not_active Expired - Lifetime
- 1992-12-12 AU AU32563/93A patent/AU656839B2/en not_active Ceased
- 1992-12-12 SK SK752-94A patent/SK75294A3/sk unknown
- 1992-12-12 CZ CZ941533A patent/CZ153394A3/cs unknown
- 1992-12-12 JP JP5511395A patent/JP2633087B2/ja not_active Expired - Lifetime
- 1992-12-12 RU RU94030470A patent/RU2118957C1/ru active
- 1992-12-12 AT AT93901678T patent/ATE179416T1/de not_active IP Right Cessation
- 1992-12-12 PL PL92304248A patent/PL172497B1/pl unknown
- 1992-12-12 HU HU9401453A patent/HUT67372A/hu unknown
- 1992-12-12 CA CA002126177A patent/CA2126177A1/en not_active Abandoned
- 1992-12-12 NZ NZ246336A patent/NZ246336A/en unknown
- 1992-12-12 WO PCT/EP1992/002899 patent/WO1993013075A1/en not_active Ceased
- 1992-12-12 US US08/244,246 patent/US5547972A/en not_active Expired - Fee Related
- 1992-12-15 PH PH45428A patent/PH30660A/en unknown
- 1992-12-17 IN IN756MA1992 patent/IN174436B/en unknown
- 1992-12-18 IL IL10416892A patent/IL104168A/en not_active IP Right Cessation
- 1992-12-21 ZA ZA929914A patent/ZA929914B/xx unknown
- 1992-12-22 MX MX9207491A patent/MX9207491A/es not_active IP Right Cessation
- 1992-12-22 SI SI19929200411A patent/SI9200411A/sl unknown
- 1992-12-22 HR HR921457A patent/HRP921457A2/xx not_active Application Discontinuation
- 1992-12-23 YU YU110592A patent/YU48294B/sh unknown
-
1993
- 1993-06-22 CN CN93107988A patent/CN1037511C/zh not_active Expired - Fee Related
-
1994
- 1994-05-31 BG BG98812A patent/BG98812A/bg unknown
- 1994-06-22 NO NO942374A patent/NO304373B1/no unknown
- 1994-06-22 FI FI943020A patent/FI943020A7/fi unknown
-
1995
- 1995-06-29 HU HU95P/P00583P patent/HU211598A9/hu unknown
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