YU43010B - Process for obtaining new derivatives of 3-(1-piperidinylalkyl)-4h-pyrido /1,2a-/ pyrimidine-4-ones - Google Patents

Process for obtaining new derivatives of 3-(1-piperidinylalkyl)-4h-pyrido /1,2a-/ pyrimidine-4-ones

Info

Publication number: YU43010B
Authority: YU; Yugoslavia
Prior art keywords: piperidinylalkyl; pyrido; pyrimidine; ones; obtaining new
Prior art date: 1980-03-28

Application number

YU810/81A

Other languages

English (en)

Other versions

YU81081A (en

Inventor

L E Kennis

J C Mertens

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-03-28

Filing date

1981-03-27

Publication date

1989-02-28

1981-03-27 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1983-12-31 Publication of YU81081A publication Critical patent/YU81081A/xx

1989-02-28 Publication of YU43010B publication Critical patent/YU43010B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

YU810/81A 1980-03-28 1981-03-27 Process for obtaining new derivatives of 3-(1-piperidinylalkyl)-4h-pyrido /1,2a-/ pyrimidine-4-ones YU43010B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US13484580A	1980-03-28	1980-03-28
US06/191,632 US4342870A (en)	1980-03-28	1980-09-29	Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives

Publications (2)

Publication Number	Publication Date
YU81081A YU81081A (en)	1983-12-31
YU43010B true YU43010B (en)	1989-02-28

Family

ID=26832744

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
YU810/81A YU43010B (en)	1980-03-28	1981-03-27	Process for obtaining new derivatives of 3-(1-piperidinylalkyl)-4h-pyrido /1,2a-/ pyrimidine-4-ones

Country Status (22)

Country	Link
US (1)	US4342870A (fr)
EP (1)	EP0037265B1 (fr)
AU (1)	AU537700B2 (fr)
BG (1)	BG36199A3 (fr)
CA (1)	CA1163994A (fr)
CS (1)	CS256366B2 (fr)
DE (1)	DE3168433D1 (fr)
DK (1)	DK159390C (fr)
ES (1)	ES500814A0 (fr)
FI (1)	FI71737C (fr)
GR (1)	GR72488B (fr)
HU (1)	HU187329B (fr)
IE (1)	IE51319B1 (fr)
IL (1)	IL62494A (fr)
MA (1)	MA19107A1 (fr)
NO (1)	NO156752C (fr)
NZ (1)	NZ196522A (fr)
PH (1)	PH16530A (fr)
PT (1)	PT72740B (fr)
RO (1)	RO82508A (fr)
SU (1)	SU1068037A3 (fr)
YU (1)	YU43010B (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4443451A (en) *	1981-07-15	1984-04-17	Janssen Pharmaceutica N.V.	Bicyclic pyrimidin-5-one derivatives
US4548938A (en) *	1981-07-15	1985-10-22	Janssen Pharmaceutica N.V.	5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds
US4355037A (en) *	1981-11-12	1982-10-19	Hoechst-Roussel Pharmaceuticals	3-(4-Piperidyl)-1,2-benzisoxales
US4485107A (en) *	1982-11-01	1984-11-27	Janssen Pharmaceutica N.V.	[[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4581171A (en) *	1983-07-27	1986-04-08	Janssen Pharmaceutica, N.V.	[[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
US4888426A (en) *	1983-11-30	1989-12-19	Janssen Pharmaceutica N.V.	1-(5-methyl-furan-2-ylmethyl)-N-(4-piperidinyl)imidazo [4,5-6]pyridine-2-amine
US4695569A (en) *	1983-11-30	1987-09-22	Janssen Pharmaceutica N.V.	Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines
PH23995A (en) *	1984-01-09	1990-02-09	Janssen Pharmaceutica Nv	4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4548939A (en) *	1984-10-01	1985-10-22	Janssen Pharmaceutica N. V.	1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
US4804663A (en) *	1985-03-27	1989-02-14	Janssen Pharmaceutica N.V.	3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
ES2094718T3 (es) *	1986-09-22	1997-02-01	Janssen Pharmaceutica Nv	Antagonistas de la serotonine para el tratamiento de heridas.
IL90879A0 (en) *	1988-09-02	1990-02-09	Janssen Pharmaceutica Nv	3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
CA2000786C (fr) *	1988-11-07	1999-01-26	Cornelus G. M. Janssen	3-piperidinyl-1,2-benzisoxazoles
HU207310B (en) *	1988-12-02	1993-03-29	Pfizer	Process for producing aryl-piperidine derivatives
WO1990011093A1 (fr) *	1989-03-23	1990-10-04	Mallinckrodt, Inc.	Compose de piperidine marque a l'iode ou au brome radioactif, son procede de preparation et composition comprenant ledit compose
DE4138756A1 (de) *	1991-11-26	1993-05-27	Troponwerke Gmbh & Co Kg	Kombination mit neuroprotektiver wirkung
US5266571A (en) *	1992-01-09	1993-11-30	Amer Moh Samir	Treatment of hemorrhoids with 5-HT2 antagonists
EP0626968B1 (fr) *	1992-02-13	2001-09-26	Merrell Pharmaceuticals Inc.	Derives piperidinyles thiacycliques
CA2137673C (fr) *	1992-07-13	2005-09-06	Jan Vandenberk	Nouveaux derives 4-[3-benzofuranyl]piperidinyliques et 4-[3-benzothienyl]piperidinyliques
AU694147B2 (en)	1993-11-19	1998-07-16	Alkermes, Inc.	Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
ES2085234B1 (es) *	1994-02-24	1997-01-16	Vita Invest Sa	Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
TW421649B (en) *	1995-01-31	2001-02-11	Janssen Pharmaceutica Nv	4-(1H-indol-1yl)-1-piperidinyl derivatives
US5753664A (en) *	1995-03-16	1998-05-19	Takeda Chemical Industries, Ltd.	Heterocyclic compounds, their production and use
CN100390146C (zh) *	2002-11-13	2008-05-28	斯索恩有限公司	制备利培酮的方法和用于该方法的中间体
EP1615924A1 (fr) *	2003-04-22	2006-01-18	Synthon B.V.	Sels hydrosolubles de risperidone
ES2842289T3 (es)	2008-02-29	2021-07-13	Vm Therapeutics Llc	Compuestos para tratar el síndrome del dolor y otros trastornos
EP2812004B1 (fr)	2012-02-10	2018-06-27	PTC Therapeutics, Inc.	Composés destinés au traitement de l'amyotrophie spinale
BR112014021531B1 (pt)	2012-03-01	2022-10-04	Ptc Therapeutics, Inc.	Composto, composição farmacêutica e usos dos mesmos
CN104470909B (zh)	2012-03-23	2018-04-24	Ptc医疗公司	用于治疗脊髓性肌萎缩的化合物
US9724348B2 (en)	2013-03-15	2017-08-08	Vm Therapeutics Llc	Crystalline forms
US10195202B2 (en)	2013-12-19	2019-02-05	Ptc Therapeutics, Inc.	Methods for modulating the amount of RNA transcripts
EP3310169B1 (fr)	2015-05-30	2023-05-17	PTC Therapeutics, Inc.	Procédés de modulation de l'épissage de l'arn
CN108697709A (zh)	2015-12-10	2018-10-23	Ptc医疗公司	用于治疗亨廷顿病的方法
AU2017363369A1 (en)	2016-11-28	2019-05-30	Ptc Therapeutics, Inc	Methods for modulating RNA splicing
AU2018282154B2 (en)	2017-06-05	2022-04-07	Ptc Therapeutics, Inc.	Compounds for treating huntington's disease
US11608501B2 (en)	2017-06-14	2023-03-21	Ptc Therapeutics, Inc.	Methods for modifying RNA splicing
CN111182898B (zh)	2017-06-28	2024-04-16	Ptc医疗公司	用于治疗亨廷顿氏病的方法
WO2019005993A1 (fr)	2017-06-28	2019-01-03	Ptc Therapeutics, Inc.	Méthodes de traitement de la maladie de huntington
BR112020019373A2 (pt)	2018-03-27	2020-12-29	Ptc Therapeutics, Inc.	Compostos para o tratamento da doença de hutington
EP3814360B8 (fr)	2018-06-27	2024-11-06	PTC Therapeutics, Inc.	Composés hétéroaryl pour traiter la maladie de huntington
WO2020005877A1 (fr)	2018-06-27	2020-01-02	Ptc Therapeutics, Inc.	Composés hétéroaryles pour le traitement de la maladie de huntington
IL279688B2 (en)	2018-06-27	2025-01-01	Ptc Therapeutics Inc	Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3412094A (en) *	1967-06-21	1968-11-19	Searle & Co	5-alkyl-2-amino-4-azido-6-phenylpyrimidines and congeners
US3960863A (en) *	1974-06-25	1976-06-01	Sankyo Company Limited	Pyrido[1,2-a]pyrimidinone derivatives
JPS5146497A (en) *	1974-10-19	1976-04-20	Masato Aiura	Hobuban
JPS525795A (en) *	1975-06-28	1977-01-17	Sankyo Co Ltd	Preparation of tetrahydro pyridopyrimidinone derivatives
HU173438B (hu) *	1975-11-27	1979-05-28	Chinoin Gyogyszer Es Vegyeszet	Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom

1980
- 1980-09-29 US US06/191,632 patent/US4342870A/en not_active Expired - Lifetime
1981
- 1981-03-03 GR GR64291A patent/GR72488B/el unknown
- 1981-03-04 CA CA000372258A patent/CA1163994A/fr not_active Expired
- 1981-03-17 AU AU68429/81A patent/AU537700B2/en not_active Ceased
- 1981-03-17 NZ NZ196522A patent/NZ196522A/en unknown
- 1981-03-21 MA MA19313A patent/MA19107A1/fr unknown
- 1981-03-24 CS CS812134A patent/CS256366B2/cs unknown
- 1981-03-24 SU SU813261927A patent/SU1068037A3/ru active
- 1981-03-26 IL IL62494A patent/IL62494A/xx unknown
- 1981-03-26 DK DK138281A patent/DK159390C/da not_active IP Right Cessation
- 1981-03-26 PT PT72740A patent/PT72740B/pt not_active IP Right Cessation
- 1981-03-26 PH PH25429A patent/PH16530A/en unknown
- 1981-03-27 EP EP81301335A patent/EP0037265B1/fr not_active Expired
- 1981-03-27 FI FI810956A patent/FI71737C/fi not_active IP Right Cessation
- 1981-03-27 ES ES500814A patent/ES500814A0/es active Granted
- 1981-03-27 YU YU810/81A patent/YU43010B/xx unknown
- 1981-03-27 BG BG051433A patent/BG36199A3/xx unknown
- 1981-03-27 IE IE706/81A patent/IE51319B1/en not_active IP Right Cessation
- 1981-03-27 NO NO811058A patent/NO156752C/no unknown
- 1981-03-27 HU HU81783A patent/HU187329B/hu not_active IP Right Cessation
- 1981-03-27 DE DE8181301335T patent/DE3168433D1/de not_active Expired
- 1981-03-28 RO RO81103848A patent/RO82508A/fr unknown

Also Published As

Publication number	Publication date
DK159390B (da)	1990-10-08
FI71737C (fi)	1987-02-09
AU6842981A (en)	1981-10-01
ES8300763A1 (es)	1982-11-01
RO82508A (fr)	1983-09-26
IL62494A (en)	1984-08-31
EP0037265B1 (fr)	1985-01-23
CA1163994A (fr)	1984-03-20
SU1068037A3 (ru)	1984-01-15
PH16530A (en)	1983-11-10
CS256366B2 (en)	1988-04-15
MA19107A1 (fr)	1981-10-01
IL62494A0 (en)	1981-05-20
BG36199A3 (en)	1984-09-14
PT72740A (en)	1981-04-01
NO811058L (no)	1981-09-29
DK138281A (da)	1981-09-29
AU537700B2 (en)	1984-07-05
HU187329B (en)	1985-12-28
DE3168433D1 (de)	1985-03-07
US4342870A (en)	1982-08-03
GR72488B (fr)	1983-11-14
YU81081A (en)	1983-12-31
ES500814A0 (es)	1982-11-01
FI810956L (fi)	1981-09-29
NZ196522A (en)	1985-10-11
NO156752B (no)	1987-08-10
EP0037265A1 (fr)	1981-10-07
DK159390C (da)	1991-03-04
FI71737B (fi)	1986-10-31
IE51319B1 (en)	1986-12-10
NO156752C (no)	1987-11-18
RO82508B (ro)	1983-08-30
PT72740B (en)	1982-11-16
IE810706L (en)	1981-09-28

Publication	Publication Date	Title
YU43010B (en)	1989-02-28	Process for obtaining new derivatives of 3-(1-piperidinylalkyl)-4h-pyrido /1,2a-/ pyrimidine-4-ones
RO83101B (ro)	1984-02-28	Procedeu de preparare a unor derivati de nicotinamida
HUT34741A (en)	1985-04-28	Process for preparing new derivatives of 1-ethyl-2,6-dimethyl-8-hydroxy-polyhydro-naphthalene
YU126281A (en)	1984-02-29	Process for obtaining new pyridoxine derivatives
PL232331A1 (en)	1983-09-26	Method of obtaining new derivatives of 6a,10 n-trans-9-beta-amino-1-hydroxyocta-hydrobenzene/o/ quinoline
YU42448B (en)	1988-08-31	Process for obtaining derivative of 5,6,7,7a-tetrahydro-4h-thieno-(3,2-c)pyridinone-2-
PL232330A1 (en)	1983-09-26	Method of obtaining new derivatives of oxazolidinodione-2,4
GR64892B (en)	1980-06-06	Method for the preparation of new derivatives of 1,3 diphenoxypropan-2-on
YU44524B (en)	1990-08-31	Process for obtaining derivatives of 3,4-dihydro-2h-benzopyrans
PL241179A1 (en)	1984-03-26	Process for preparing novel derivatives of 4a,9b-trans-hexahydro-1h-pyridoindole
PL235949A1 (en)	1983-01-03	Process for preparing derivatives of 2,3,4-trinor-1,5-inter-m-phenyleneprostacyclin
PT72565A (en)	1981-03-01	Process for the preparation of phenoxy-aminopropanol derivatives
AU9141182A (en)	1983-06-16	9-(3-(3,5-cis-dimethylpiperazino)propyl)carbazole for treatment of anxiety
YU81181A (en)	1983-12-31	Process for obtaining substituted derivatives
NZ197563A (en)	1983-11-30	3-(1,2,4-triazinylthiomethyl)-3-cephem-1-sulphoxide derivatives
HU182341B (en)	1983-12-28	Process for preparing new substituted phenoxy-amino-propanol derivatives
YU163779A (en)	1983-06-30	Process for obtaining imidazolyl-ethoxy derivatives of pyrrazolo (3,4-b)-pyridine-5-methanol
YU41953B (en)	1988-02-29	Process for obtaining new derivatives of 1-xo-1h-thizolo (3,2-a) pyrimidine-2-carboxamides
PH19848A (en)	1986-07-22	Process for the preparation of 5,6,7,7a-tetrahydro-4-thieno (3,2-c)-pyridin-2-one derivatives
PT73870B (en)	1983-01-25	Process for the preparation of 11-dodecen-1-yl derivatives
PT74114A (en)	1982-01-01	Process for the preparation of 1,2-dihydro-5-(pyridinyl)-nico- tinamide derivatives
YU41184B (en)	1986-12-31	Process for obtaining 2-amino-or 2-thio-substituted derivatives of 4,5 dipheryl - oxazole
DE3163891D1 (en)	1984-07-05	Process for the preparation of vinylphosphoric-acid derivatives
PL231451A1 (en)	1983-12-19	Process for preparing derivatives of methylquinoxaline 1,4-dioxide
PT75026B (en)	1984-05-25	Process for the preparation of 1,2,3,4,4a,9b-hexahydro-4a-piperazinylmethyl 4-dibenzofuranone or -dibenzofuranol derivatives