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YU22598A - Derivati 5'-dezoksi-citidina - Google Patents

Derivati 5'-dezoksi-citidina

Info

Publication number
YU22598A
YU22598A YU22598A YU22598A YU22598A YU 22598 A YU22598 A YU 22598A YU 22598 A YU22598 A YU 22598A YU 22598 A YU22598 A YU 22598A YU 22598 A YU22598 A YU 22598A
Authority
YU
Yugoslavia
Prior art keywords
group
hydrogen
atom
desoxy
saturated
Prior art date
Application number
YU22598A
Other languages
English (en)
Inventor
Kazuo Nattori
Ishikawa Tohru
Ishitsuka Hideo
Kohchi Yasunori
Oikawa Nobuhiro
Shimma Nobuo
Suda Hitomi
Original Assignee
F.Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag. filed Critical F.Hoffmann-La Roche Ag.
Publication of YU22598A publication Critical patent/YU22598A/sh
Publication of RS50010B publication Critical patent/RS50010B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Novi derivati 5'-dezoksi-citidina predstavljeni opstom formulom (I): u kojoj je R1 atom vodonika ili grupa, koja se lako hidrolizuje pod fizioloskim uslovima; R2 je atom vodonika, ili -CO-OR4 grupa /u kojoj je R4 zasicen ili nezasicena, parav ili razgranata ugljovodonicna grupa, koja se sastoji od jednog do 15 atoma ugljenika, ili grupa formule -(CH2)n-Y (u kojoj je Y cikloheksil ili fenil; n je ceo broj od 0 do 4; R3 je atom vodonika, brom, jod, cijano, alkilna grupa C1-4/koja moze biti supstituisana halogenim atomom(ima)/, vinil ili etinil grupa /koja moze biti supstituisana halogenim atomom(ima), C1-4 alkilom, cikloalkilom, aralkilom, ili aromatskim prstenom, koji moze imati jedan ili vise atoma vezanih za sebe, ili aralkil grupom, koja moze biti supstituisana za upotrebu u medicinskoj praksi, posebno uterapiji tumora.
YUP-225/98A 1997-06-02 1998-05-25 Derivati 5'-dezoksi-citidina RS50010B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97108791 1997-06-02

Publications (2)

Publication Number Publication Date
YU22598A true YU22598A (sh) 2001-12-26
RS50010B RS50010B (sr) 2008-09-29

Family

ID=8226859

Country Status (33)

Country Link
US (2) US6114520A (sh)
JP (1) JP3081185B2 (sh)
KR (1) KR100312899B1 (sh)
CN (1) CN1197871C (sh)
AR (1) AR012878A1 (sh)
AT (1) ATE440854T1 (sh)
AU (1) AU746170B2 (sh)
BR (1) BR9801744A (sh)
CA (1) CA2237368C (sh)
CO (1) CO4940436A1 (sh)
CZ (1) CZ295706B6 (sh)
DE (2) DE69841086D1 (sh)
ES (2) ES2329428T3 (sh)
FR (1) FR2763953B1 (sh)
GB (1) GB2325931B (sh)
HR (1) HRP980290A2 (sh)
HU (1) HU227852B1 (sh)
ID (1) ID19801A (sh)
IL (1) IL124661A0 (sh)
IT (1) ITMI981196A1 (sh)
MA (1) MA26503A1 (sh)
MY (1) MY128985A (sh)
NO (1) NO316609B1 (sh)
NZ (1) NZ330360A (sh)
PE (1) PE79599A1 (sh)
PL (1) PL192832B1 (sh)
RS (1) RS50010B (sh)
RU (1) RU2238278C2 (sh)
SA (1) SA98190103B1 (sh)
SG (1) SG66466A1 (sh)
TR (1) TR199800988A2 (sh)
TW (1) TW584636B (sh)
ZA (1) ZA984478B (sh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030119724A1 (en) * 1995-11-22 2003-06-26 Ts`O Paul O.P. Ligands to enhance cellular uptake of biomolecules
DK1057831T3 (da) * 1999-05-26 2005-01-31 Hoffmann La Roche Fremgangsmåde til fremstilling af vinylpyrimidinderivater
US6906182B2 (en) 2000-12-01 2005-06-14 Cell Works Therapeutics, Inc. Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and method of use
CN101068549A (zh) * 2004-12-03 2007-11-07 阿迪赫里克斯技术公司 与5－fu和5－fu前药组合施用dpd抑制剂的方法
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
NZ574362A (en) * 2006-07-24 2010-10-29 Taiho Pharmaceutical Co Ltd 3'-ethynylcytidine derivative
WO2009042064A2 (en) 2007-09-21 2009-04-02 Nektar Therapeutics Al, Corporation Oligomer-nucleoside phosphate conjugates
KR101013312B1 (ko) * 2007-11-19 2011-02-09 한미홀딩스 주식회사 카페시타빈의 제조방법 및 이에 사용되는 β-아노머가강화된 트리알킬카보네이트 화합물의 제조방법
WO2009082846A1 (fr) * 2007-12-28 2009-07-09 Topharman Shanghai Co., Ltd. Dérivé hydroxyle de la capécitabine, ses procédés de préparation et ses utilisations pour préparer la capécitabine
CN101469008B (zh) * 2007-12-29 2013-08-07 上海特化医药科技有限公司 卡培他滨羟基衍生物、其制备方法和用于制备卡培他滨
WO2009082844A1 (fr) * 2007-12-28 2009-07-09 Topharman Shanghai Co., Ltd Dérivé hydroxyle de la capécitabine, ses procédés de préparation et ses utilisations pour préparer la capécitabine
WO2009094847A1 (fr) * 2007-12-28 2009-08-06 Topharman Shanghai Co., Ltd. Dérivé hydroxyle de capécitabine, procédés de préparation et d' utilisation de la capécitabine
US8637486B2 (en) * 2008-03-14 2014-01-28 Retrotope, Inc. Therapeutic substances that modulate genome methylation
WO2010063080A1 (en) 2008-12-05 2010-06-10 Commonwealth Scientific And Industrial Research Organisation Amphiphile prodrugs
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
BR112012008951A2 (pt) * 2009-10-14 2019-09-24 Adherex Tech Inc tratamento de neurotoxidez associada com combinações de 5-fu ou seus profármacos e inibidores de dpd
CN104926890B (zh) * 2015-06-04 2018-04-03 新乡学院 一种1,2‑o‑二乙酰基‑3,5‑o‑二苯甲酰基核糖的合成方法
EP3746134A1 (en) 2018-02-02 2020-12-09 Maverix Oncology, Inc. Small molecule drug conjugates of gemcitabine monophosphate
CN113321694A (zh) * 2021-06-22 2021-08-31 药康众拓(江苏)医药科技有限公司 N4-羟基胞苷衍生物及其制备方法和用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5726278B2 (sh) * 1973-03-13 1982-06-03
GB1561290A (en) * 1975-10-16 1980-02-20 Nyegaard & Co As Pyrimid - 2 - ones
US4071680A (en) * 1976-12-20 1978-01-31 Hoffmann-La Roche Inc. 5'-Deoxy-5-fluoropyrimidine nucleosides
CH633810A5 (en) * 1978-01-01 1982-12-31 Hoffmann La Roche Novel nucleosides and process for their preparation
US4328229A (en) * 1978-03-29 1982-05-04 Taiho Pharmaceutical Company Limited Anti-cancer composition for delivering 5-fluorouracil to cancer tissues
JPS5677226A (en) * 1979-11-27 1981-06-25 Taiho Yakuhin Kogyo Kk Antitumorigenic agent
EP0160079B1 (en) * 1983-10-26 1990-01-31 GREER, Sheldon B. Method and materials for sensitizing neoplastic tissue to radiation
US5736531A (en) * 1987-10-28 1998-04-07 Pro-Neuron, Inc. Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
CA1327358C (en) * 1987-11-17 1994-03-01 Morio Fujiu Fluoro cytidine derivatives
GB9020930D0 (en) * 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
JP2614164B2 (ja) * 1991-05-27 1997-05-28 大鵬薬品工業株式会社 抗腫瘍効果増強のための及び腫瘍治療のための組成物
DE4123520A1 (de) * 1991-07-16 1993-01-21 Inst Molekularbiologie Ak Mittel zur regeneration des blutbildes durch foerderung der leukozytenproliferation
TW254946B (sh) * 1992-12-18 1995-08-21 Hoffmann La Roche
AU671491B2 (en) * 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
AU6081294A (en) * 1993-05-14 1994-12-12 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
CA2170608C (en) * 1993-09-14 1999-03-30 James R. Mccarthy 5-(1-fluoro-vinyl)-1h-pyrimidine-2,4-dione derivatives useful as antineoplastic agents
US5476932A (en) * 1994-08-26 1995-12-19 Hoffmann-La Roche Inc. Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives
WO1996037214A2 (en) * 1995-05-26 1996-11-28 F. Hoffmann-La Roche Ag Compositions of interleukin and pyrimidine nucleosides

Also Published As

Publication number Publication date
CO4940436A1 (es) 2000-07-24
HUP9801256A2 (hu) 1999-05-28
CZ167598A3 (cs) 1998-12-16
JP3081185B2 (ja) 2000-08-28
ES2142763B1 (es) 2001-04-01
TW584636B (en) 2004-04-21
ATE440854T1 (de) 2009-09-15
AR012878A1 (es) 2000-11-22
KR100312899B1 (ko) 2002-03-08
CN1197871C (zh) 2005-04-20
HU9801256D0 (en) 1998-07-28
US6114520A (en) 2000-09-05
PL192832B1 (pl) 2006-12-29
KR19990006547A (ko) 1999-01-25
FR2763953B1 (fr) 2005-01-07
HU227852B1 (en) 2012-05-02
DE69841086D1 (de) 2009-10-08
RS50010B (sr) 2008-09-29
US6211166B1 (en) 2001-04-03
ES2329428T3 (es) 2009-11-25
CN1201037A (zh) 1998-12-09
SG66466A1 (en) 1999-07-20
BR9801744A (pt) 2000-03-21
NO982473D0 (no) 1998-05-29
TR199800988A3 (tr) 1998-12-21
GB2325931B (en) 2001-07-25
SA98190103B1 (ar) 2006-04-18
ITMI981196A1 (it) 1999-11-29
CZ295706B6 (cs) 2005-10-12
PL326604A1 (en) 1998-12-07
CA2237368C (en) 2009-03-03
CA2237368A1 (en) 1998-12-02
DE19823484A1 (de) 1998-12-03
NO982473L (no) 1998-12-03
HUP9801256A3 (en) 2004-03-01
MA26503A1 (fr) 2004-12-20
AU6798598A (en) 1998-12-03
TR199800988A2 (xx) 1998-12-21
FR2763953A1 (fr) 1998-12-04
AU746170B2 (en) 2002-04-18
ES2142763A1 (es) 2000-04-16
JPH10330395A (ja) 1998-12-15
ZA984478B (en) 1998-12-02
NO316609B1 (no) 2004-03-08
HRP980290A2 (en) 1999-04-30
MY128985A (en) 2007-03-30
IL124661A0 (en) 1998-12-06
GB9811762D0 (en) 1998-07-29
RU2238278C2 (ru) 2004-10-20
ID19801A (id) 1998-08-06
PE79599A1 (es) 1999-08-25
GB2325931A (en) 1998-12-09
NZ330360A (en) 1999-03-29

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