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WO2025225923A1 - Dispositif de pulvérisation de composition et système de pulvérisation le comprenant - Google Patents

Dispositif de pulvérisation de composition et système de pulvérisation le comprenant

Info

Publication number
WO2025225923A1
WO2025225923A1 PCT/KR2025/004436 KR2025004436W WO2025225923A1 WO 2025225923 A1 WO2025225923 A1 WO 2025225923A1 KR 2025004436 W KR2025004436 W KR 2025004436W WO 2025225923 A1 WO2025225923 A1 WO 2025225923A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
coolant
guide structure
injection device
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/KR2025/004436
Other languages
English (en)
Korean (ko)
Inventor
김대현
김건호
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Recensmedical Inc
Original Assignee
Recensmedical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recensmedical Inc filed Critical Recensmedical Inc
Priority to KR1020250052802A priority Critical patent/KR20250156642A/ko
Priority to PCT/KR2025/005483 priority patent/WO2025226030A1/fr
Publication of WO2025225923A1 publication Critical patent/WO2025225923A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body

Definitions

  • the present disclosure relates to a composition injection device and a spraying system including the same. Specifically, the present disclosure relates to a composition injection device and a spraying system including the same, which freezes a composition introduced into the composition injection device by a coolant passing through the composition injection device while being injected therein, and allows the frozen composition to penetrate the skin.
  • Boosting Container is a composition spraying device that sprays a composition onto the skin together with a coolant to evenly apply the composition to the skin surface.
  • the applicant went further, believing that if the amount of the composition that penetrates into the inner layers of the skin, such as the epidermis or dermis, could be increased, the skin improvement effect would be further enhanced. Accordingly, the applicant sought to develop a device that effectively penetrates the composition into the skin to further enhance its skin improvement effect compared to existing products.
  • the present disclosure provides a composition injection device and an injection system including the same.
  • the present invention aims to provide a composition spraying device and a spraying system including the same, which freezes a composition using a coolant so that the composition can better penetrate into the skin and sprays the frozen composition onto the skin.
  • a composition spraying device for spraying a composition frozen by a coolant comprises: an enclosure providing an inner space where the composition meets the coolant; a composition inflow hole which is an inlet through which the composition flows into the inner space; a coolant inflow hole which allows the coolant to be sprayed into the inner space; And a guide structure for moving the composition introduced from the composition inflow hole to the injected coolant, wherein the guide structure has an end that meets the injected coolant, and at least a portion of the guide structure including the end is disposed within the internal space of the enclosure, wherein an imaginary center line of the guide structure is disposed to intersect an imaginary center axis of the coolant inflow hole; wherein the guide structure has a first surface through which the composition moves and a second surface facing the inner surface of the composition injection device on the opposite side to the first surface, wherein the enclosure has an external air inflow hole through which the guide structure can meet external air to prevent the guide structure from freezing while the coolant is injected.
  • the above external air inlet hole may be
  • a composition spraying device for spraying a composition frozen by a coolant comprises: a composition inflow hole which is an inlet for introducing the composition into the composition spraying device; a coolant inflow hole which allows the coolant to be sprayed into the composition spraying device; And a guide structure for moving the composition introduced from the composition inlet hole to the end so that it can meet the coolant, including an end through which the composition meets the coolant to be injected; and the guide structure further includes a first side meeting at a first point of the end and a second side meeting at a second point of the end which is opposite to the first point, and an angle between an imaginary first line extending along the first side and an imaginary second line extending along the second side is less than 180 degrees, and the angle between the imaginary first line and the imaginary second line, which is less than 180 degrees, can cause the composition moved to the end to meet the coolant at the end and be injected, thereby freezing the injected composition to a size sufficiently small for skin penetration.
  • a composition spraying device for spraying a frozen composition due to a coolant comprises: a composition inflow hole which is an inlet for introducing the composition into the composition spraying device; a coolant inflow hole which allows the coolant to be sprayed into the composition spraying device; And a guide structure for moving the composition introduced from the composition inlet hole to the end so that it can meet the coolant, including an end through which the composition meets the coolant to be injected; and the guide structure further includes a first side and a second side that meet at a first point of the end, and an angle between the first side and the second side is less than 180 degrees, and the angle between the first side and the second side, which is less than 180 degrees, allows the composition that has moved to the end to meet the coolant at the end and be injected, so that the injected composition can be frozen to a size sufficiently small for skin penetration.
  • a composition spraying device for spraying a composition frozen by a coolant comprises: a composition inflow hole which is an inlet for introducing the composition into the composition spraying device; a coolant inflow hole which allows the coolant to be sprayed into the composition spraying device; a guide structure having a first surface and a second surface opposite to the first surface, wherein the guide structure includes a movement path of the composition extending from the composition inflow hole to an end of the guide structure, the movement path being formed on the first surface, and the composition moving to the end of the guide structure encounters the coolant; And a tunnel forming member that is physically in contact with the first surface of the guide structure to form a tunnel in a part of the movement path; and among the movement paths, a remaining part in which the tunnel is not formed may have a length of a predetermined value or less that allows the composition passing through the tunnel to move along the movement path to the end of the guide structure due to negative pressure formed while the coolant is sprayed.
  • a composition spraying device for spraying a composition frozen by a coolant comprises: a composition inflow hole which is an inlet for introducing the composition into the composition spraying device; a coolant inflow hole which allows the coolant to be sprayed into the composition spraying device; and a guide structure including a plate along which the composition introduced from the composition inflow hole moves, wherein the guide structure includes an end at which the composition moving along one surface of the plate meets the sprayed coolant; wherein the plate is folded to form a groove, and the formed groove can be a movement path for allowing the composition to move from the composition inflow hole to the end of the guide structure without being dispersed.
  • a composition spraying device for spraying a composition frozen by a coolant comprises: a composition inflow hole which is an inlet for introducing the composition into the composition spraying device; a coolant inflow hole which allows the coolant to be sprayed into the composition spraying device; And a guide structure including a first plate and a second plate, wherein the guide structure includes an end where the composition moving along one side of the guide structure meets the sprayed coolant; and the guide structure is formed by joining the first plate and the second plate, wherein the first plate and the second plate are joined such that an angle between the first plate and the second plate is less than 180 degrees so that a groove is formed between the first plate and the second plate, and the formed groove can be a movement path that allows the composition to move from the composition inlet hole to the end of the guide structure without being dispersed.
  • a composition can be frozen using a composition spraying device, and particles of the frozen composition can be more effectively penetrated into the skin. Specifically, particles of the frozen composition can be effectively penetrated into the epidermis or dermis of the skin.
  • a composition spraying device can be used to uniformly produce frozen composition particles of a size, thereby evenly permeating a uniform amount of the composition into the skin, thereby uniformly exhibiting a skin improvement effect.
  • the composition can be more effectively penetrated into the skin, and the composition effective for skin beauty/treatment can be more effectively absorbed into the skin, thereby exhibiting an excellent skin improvement effect.
  • FIG. 1 is a drawing for explaining a design principle for increasing a freezing ratio in a composition spraying device according to the present disclosure.
  • Figures 2 and 3 are drawings for explaining a composition spraying device according to the present disclosure.
  • FIGS. 4 to 11 are drawings for explaining the design principle of the composition injection device to solve one problem of the composition injection device according to the present disclosure.
  • FIGS. 12 to 15 are drawings for explaining the design principle of the composition spraying device for more effectively freezing the composition according to the present disclosure.
  • FIGS. 16 to 26 are drawings for explaining the design principle of the composition injection device for maintaining a constant amount of composition per hour transferred to the coolant stream according to the present disclosure.
  • Figures 27 to 38 are drawings for explaining implementation examples of a composition injection device.
  • FIGS. 39 to 44 are drawings for explaining a coolant injection device used with a composition injection device according to the present disclosure.
  • FIGS. 45 and 46 are drawings for comparing and explaining the skin penetration ability of a composition between a composition spraying device according to the present disclosure and a conventional composition spraying device.
  • Figures 47 and 48 are drawings for explaining problems and effects according to the coolant stream and the position of the guide structure within the coolant stream.
  • a film, region, component, etc. when it is said that a film, region, component, etc. are connected, it includes not only cases where the films, regions, and components are directly connected, but also cases where other films, regions, and components are interposed between the films, regions, and components and are indirectly connected.
  • a film, region, component, etc. are electrically connected, it includes not only cases where the film, region, component, etc. are directly electrically connected, but also cases where another film, region, component, etc. is interposed and indirectly electrically connected.
  • a membrane, region, component, etc. are fluidly connected can be interpreted to mean that the membrane, region, component, etc. each form at least a portion of a flow path through which a fluid flows.
  • a component A when a component A is fluidly connected to a component B, it means that a fluid can flow from component A to component B or vice versa.
  • components A and B when components A and B are combined and a flow path formed by component A and a flow path formed by component B are directly connected, components A and B can be considered to be fluidly connected.
  • components A and B when components A and B are connected through a component C, such as a conduit, such that a fluid can reach component B from component A through a flow path formed by component C, or when a fluid can reach component A from component B through a flow path formed by component C, components A and B can be considered to be fluidly connected.
  • component C can be interpreted as fluidly connecting components A and B.
  • components A and B can be considered to be fluidly connected even when components A and B are fluidly connected through a plurality of components.
  • a composition spraying device for spraying a composition frozen by a coolant comprises: an enclosure providing an inner space in which the composition is sprayed by the coolant; a guide structure for moving the composition to the coolant to be sprayed, wherein the guide structure has an end that meets the coolant to be sprayed, and at least a portion of the guide structure including the end is disposed within the inner space of the enclosure, wherein an imaginary center line of the guide structure is disposed to intersect an imaginary center axis of the coolant inflow hole; a composition inflow hole which is an inlet for providing the composition to the guide structure; And a coolant inflow hole that allows the coolant to be sprayed into the internal space; wherein the guide structure has a first surface through which the composition moves and a second surface facing the inner surface of the composition spraying device on which the coolant inflow hole is formed on the opposite side to the first surface, and the enclosure includes an external air inflow hole that allows the guide structure to meet the external air to prevent the composition from freezing on the guide structure
  • the enclosure may be arranged so that while the coolant is being sprayed, the outside air flows between the inner surface where the coolant inlet hole is formed and the second surface, and meets at least a portion of the second surface.
  • the outside air inlet hole may be arranged in the enclosure such that the outside air moves out of the inner space without meeting the first surface while meeting at least a portion of the second surface.
  • outside air inlet hole and the coolant inlet hole may be arranged so that the outside air meets at least a portion of the second surface and is mixed with the stream of the sprayed coolant and moves out of the internal space.
  • outside air inlet hole may be arranged in the enclosure such that the outside air meets a portion of the second surface between the composition inlet hole and the end, but the portion of the second surface where the outside air meets does not meet the coolant.
  • the enclosure may further include an additional External Air Inflow hole that allows external air to flow into the first surface and meet the first surface while the coolant is being sprayed.
  • the enclosure may be included in a housing for protecting the composition spraying device.
  • the housing further includes a support part that allows the target area where the frozen composition is sprayed and the coolant inlet hole to maintain a predetermined distance, wherein the target area is a part of the skin, and the predetermined distance can allow the composition to be frozen at a predetermined freezing rate or higher to meet the target area.
  • the support member may form an inner passage through which the frozen composition can be sprayed together with the coolant and penetrate the target area.
  • the end of the guide structure may be positioned closer to the coolant inlet hole than the end of the support part that contacts the target area.
  • composition injection device may include a plurality of the guide structures, and the outside air inlet hole may be arranged in the enclosure so that while the coolant is injected, the outside air is introduced between the inner surface and the second surfaces of the plurality of guide structures, and meets at least a portion of each of the second surfaces of the plurality of guide structures.
  • a composition spraying device for spraying a composition frozen by a coolant comprises: a composition inflow hole which is an inlet for introducing the composition into the composition spraying device; a coolant inflow hole which allows the coolant to be sprayed into the composition spraying device; And a guide structure for moving the composition introduced from the composition inlet hole to the end so that it can meet the coolant, including an end through which the composition meets the coolant to be injected; and the guide structure further includes a first side meeting at a first point of the end and a second side meeting at a second point of the end which is opposite to the first point, and an angle between an imaginary first line extending along the first side and an imaginary second line extending along the second side is less than 180 degrees, and the angle between the imaginary first line and the imaginary second line, which is less than 180 degrees, can cause the composition moved to the end to meet the coolant at the end and be injected, thereby freezing the injected composition to a size sufficiently small for skin penetration.
  • a composition spraying device for spraying a frozen composition due to a coolant comprises: a composition inflow hole which is an inlet for introducing the composition into the composition spraying device; a coolant inflow hole which allows the coolant to be sprayed into the composition spraying device; And a guide structure for moving the composition introduced from the composition inlet hole to the end so that it can meet the coolant, including an end through which the composition meets the coolant to be injected; and the guide structure further includes a first side and a second side that meet at a first point of the end, and an angle between the first side and the second side is less than 180 degrees, and the angle between the first side and the second side, which is less than 180 degrees, allows the composition that has moved to the end to meet the coolant at the end and be injected, so that the injected composition can be frozen to a size sufficiently small for skin penetration.
  • a composition spraying device for spraying a composition frozen by a coolant comprises: a composition inflow hole which is an inlet for introducing the composition into the composition spraying device; a coolant inflow hole which allows the coolant to be sprayed into the composition spraying device; a guide structure having a first surface and a second surface opposite to the first surface, wherein the guide structure includes a movement path of the composition extending from the composition inflow hole to an end of the guide structure, the movement path being formed on the first surface, and the composition moving to the end of the guide structure encounters the coolant; And a tunnel forming member that is physically in contact with the first surface of the guide structure to form a tunnel in a part of the movement path; and among the movement paths, a remaining part in which the tunnel is not formed may have a length of a predetermined value or less that allows the composition passing through the tunnel to move along the movement path to the end of the guide structure due to negative pressure formed while the coolant is sprayed.
  • a composition spraying device for spraying a composition frozen by a coolant comprises: a composition inflow hole which is an inlet for introducing the composition into the composition spraying device; a coolant inflow hole which allows the coolant to be sprayed into the composition spraying device; and a guide structure including a plate along which the composition introduced from the composition inflow hole moves, wherein the guide structure includes an end at which the composition moving along one surface of the plate meets the sprayed coolant; wherein the plate is folded to form a groove, and the formed groove can be a movement path for allowing the composition to move from the composition inflow hole to the end of the guide structure without being dispersed.
  • a composition spraying device for spraying a composition frozen by a coolant comprises: a composition inflow hole which is an inlet for introducing the composition into the composition spraying device; a coolant inflow hole which allows the coolant to be sprayed into the composition spraying device; And a guide structure including a first plate and a second plate, wherein the guide structure includes an end where the composition moving along one side of the guide structure meets the sprayed coolant; and the guide structure is formed by joining the first plate and the second plate, wherein the first plate and the second plate are joined such that an angle between the first plate and the second plate is less than 180 degrees so that a groove is formed between the first plate and the second plate, and the formed groove can be a movement path that allows the composition to move from the composition inlet hole to the end of the guide structure without being dispersed.
  • composition is a substance that is delivered transdermally, and may refer to a substance that contains an active ingredient that can provide a cosmetic effect and/or a medical effect to the skin when delivered transdermally.
  • the composition may contain Vitamin C, Niacinamide, Soluble Licorice Extract, Arbutin, Hyaluronic Acid, Potassium Hyaluronate, Hydrolyzed Hyaluronic Acid, Hydrolyzed Sodium Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Sodium Acetylated Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate.
  • Hyaluronate Retinol, Retinyl palmitate, Adenosine, Peptide, Coenzyme Q10, Adult stem cell, Antioxidant, Lidocaine, Botulinum toxin, Exosome, PDRN (Polydeoxyribonucleotide), PDLLA (Poly-d,l-lactic acid), Proparacaine, Tetracaine, Human growth hormone, Growth factor, Cell therapy products, or a combination thereof.
  • composition may further include base ingredients such as purified water, glycerin, butylene glycol, propanediol, and silicone oil; ingredients that create formulations such as emulsifiers, surfactants, and viscosity modifiers; and preservative ingredients such as parabens, phenoxyethanol, benzoic acid, triclosan, benzyl alcohol, methylisothiazolinone, and 1,2-hexanediol.
  • base ingredients such as purified water, glycerin, butylene glycol, propanediol, and silicone oil
  • ingredients that create formulations such as emulsifiers, surfactants, and viscosity modifiers
  • preservative ingredients such as parabens, phenoxyethanol, benzoic acid, triclosan, benzyl alcohol, methylisothiazolinone, and 1,2-hexanediol.
  • ingredients that can be included in the composition are not limited to the ingredients listed above, and any composition that includes an effective ingredient that can improve the skin when penetrated into the skin as described above can be a composition according to the present disclosure.
  • a coolant may refer to a substance capable of transferring cooling energy to a composition so that the composition can be frozen.
  • the coolant may provide a force that causes the composition to be sprayed to a target area.
  • CO2 carbon dioxide
  • LN liquid nitrogen
  • O2O oxygen
  • N2O nitrous oxide
  • NO nitrogen monoxide
  • HFC hydrofluorocarbon
  • CH4 methane
  • the target area refers to a portion of the skin where the user wishes to improve the skin condition for the purpose of skin beauty and/or skin treatment.
  • the composition may be sprayed onto the target area to improve the skin condition of the target area.
  • a coolant that freezes the composition may be sprayed onto the target area together with the composition.
  • Frozen particles refer to particles of a composition that have been frozen by a coolant.
  • frozen particles refer to particles of a composition that have been frozen, and refer to a phase change of the composition from a liquid phase to a solid phase.
  • Spraying of Composition means that the composition is expeld outside the composition spraying device by the force provided to the composition by the coolant as described above.
  • Spraying of Composition of Coolant means that the coolant is rapidly sprayed from the coolant spraying portion (e.g., nozzle) by the pressure applied to the coolant as the internal passage of the coolant spraying portion becomes narrower as the coolant passes through the coolant spraying portion.
  • a solid-phase composition i.e., frozen particles
  • a liquid-phase composition penetrates the skin better than a liquid-phase composition, as shown in Experimental Example #1 described below. It is presumed that the reason that a solid-phase composition penetrates the skin better than a liquid-phase composition is that, when the composition is sprayed onto the skin and hits the skin surface, the impact per unit time that the solid-phase composition exerts on the skin surface is greater than the impact per unit time that the liquid-phase composition exerts on the skin surface.
  • high freezing may mean that when the composition is broken into multiple particles due to the coolant, the freezing ratio, which is the ratio of frozen and non-frozen particles among the broken particles, increases.
  • the freezing ratio which is the ratio of frozen and non-frozen particles among the broken particles.
  • high freezing ratio means that the number of frozen particles among the broken particles of the composition is large.
  • composition spraying device capable of increasing the freezing ratio in order to more effectively penetrate the composition into the skin as described above will be described.
  • Figure 1 is a drawing for explaining the design principle of a composition injection device (3000) for increasing the freezing ratio.
  • the lower the temperature of the coolant that freezes the split particles of the composition the more thermal energy of the split particles is released, thereby increasing the freezing ratio.
  • the longer the time that the split particles are exposed to the coolant the longer the time that the thermal energy is released from the split particles, thereby increasing the freezing ratio.
  • the coolant rapidly expands adiabatically when discharged from the coolant injector (e.g., nozzle). Consequently, the coolant has its lowest temperature immediately after discharge from the coolant injector. Thereafter, as it is injected, it gradually comes into contact with the outside air and its temperature increases. Therefore, to increase the freezing rate, it is desirable to ensure that the composition is injected together with the coolant as close as possible to the coolant injector.
  • the coolant injector e.g., nozzle
  • the position at which the composition is injected is between the target area and the coolant injection portion, but the closer the position is to the coolant injection portion, the longer the distance the injected composition travels to the target area, so that more time the composition is exposed to the coolant can be secured, and as a result, the freezing ratio can be higher.
  • the composition injection device (3000) may include a guide structure (Guide Structure, 3200) for moving the composition introduced into the composition injection device (3000) as described above to the coolant near the coolant injection portion.
  • the guide structure (3200) may include a first end (3210) and a second end (3220), and the second end (3220) is fluidly connected to the composition inlet hole to enable the composition to be delivered to the guide structure (3200), and the first end (3210) allows the composition to meet the coolant.
  • the first end (3210) may be positioned within a coolant stream (Coolant Steam) formed when the coolant is injected.
  • a coolant stream Coolant Steam
  • the composition may move from the second end (3220) to the first end (3210) and may be detached from the guide structure (3200) by collision with the coolant at the first end (3210) or by the surrounding air flow caused by the coolant being sprayed.
  • the detached composition may be frozen as heat energy is released by the coolant.
  • Figure 1 (a) shows the positional relationship between the coolant injection unit (1200) and the guide structure (3200) when viewed from the side of the coolant injection unit (1200), and Figure 1 (b) shows the positional relationship between the coolant injection unit (1200) and the guide structure (3200) when viewed from the D direction of Figure 1 (a).
  • the first end (3210) of the guide structure (3200) may be spaced apart from the orifice of the coolant injection unit (1200) in the direction of the central axis by d, and may be spaced apart from the central axis of the coolant injection unit (1200) by G in a direction perpendicular to the central axis.
  • the distance between the guide structure (3200) and the coolant injection unit (1200) may be appropriately selected in consideration of the diameter of the orifice.
  • d may be determined as a distance that is 50 times or less of the orifice diameter.
  • d may be 7.5 mm or less.
  • d may be 5 mm or less.
  • G may be 5 to 10 times the orifice diameter.
  • d may be 0.75 to 1.5 mm.
  • G may be 0.8 to 1.2 mm.
  • d may be set to d as long as the temperature of the coolant is low enough to sufficiently increase the freezing ratio of the composition and the distance from the target area (i.e., cooling time) can be sufficiently secured.
  • G can be set to a position where the composition can enter a coolant stream having a sufficiently cold temperature to sufficiently increase the freezing ratio of the composition.
  • FIGS. 2 and 3 are drawings for explaining the configuration of a composition injection device (3000) for moving a composition to a position close to a coolant injection unit (1200) in a composition injection device (3000) in which a guide structure (3200) and a coolant injection unit (1200) can be arranged as described in FIG. 1.
  • the composition injection device (3000) may include a coolant inlet hole (3100), a guide structure (3200), a composition inlet hole (3300), a composition storage unit (3400), and an actuator (3500).
  • the coolant inlet hole (3100) allows the coolant to be injected into the composition injection device (3000).
  • the coolant inlet hole (3100) may be an inlet that is fluidly connected to a passage in which the coolant injection unit (1200) is arranged, and allows the coolant injected from the coolant injection unit (1200) to flow into the composition injection device (3000).
  • the coolant injection unit (1200) may pass through the passage and allow the orifice of the coolant injection unit (1200) to be positioned inside the composition injection device (3000), thereby allowing the coolant to be injected inside the composition injection device (3000).
  • the coolant injection device (2000) and the composition injection device (3000) may be implemented as one body, and in this case, the coolant inlet hole (3100) may be implemented as being physically integrated with the coolant injection unit (1200). In other words, the coolant inlet hole (3100) and the coolant injection unit (1200) can be manufactured as a single structure.
  • the composition storage (3400) provides a space for storing the composition.
  • the composition storage (3400) can be detached from the composition injection device (3000) to receive the composition, and can be reattached to the composition injection device (3000).
  • the composition storage (3400) may be implemented as an integral part of the composition injection device (3000), but may have an inlet for injecting the composition into the composition storage (3400).
  • the composition inlet hole (3300) may be fluidly connected to the composition reservoir (3400).
  • the composition inlet hole (3300) may be fluidly connected to the composition reservoir (3400) through a composition movement channel (3001).
  • the composition inlet hole (3300) may be an inlet that provides the composition moved from the composition reservoir (3400) through the composition movement channel (3001) to a guide structure (3200) described below.
  • the composition movement channel (3001) allows the composition stored in the composition reservoir (3400) to be introduced into the guide structure (3200) through the composition inlet hole (3300).
  • the composition movement channel (3001) has two ends, one end of which may be fluidly connected to the composition inlet hole (3300), and the other end of which may be fluidly connected to the composition reservoir (3400).
  • the composition movement channel (30010) may be implemented in various forms.
  • the composition movement channel (3001) may be a pipe or tube connecting the composition reservoir (3400) and the guide structure (3200).
  • the composition movement channel (3001) may be a groove formed on one surface of a connector connecting the composition reservoir (3400) and the guide structure (3200).
  • the guide structure (3200) provides a movement path for moving the composition introduced from the composition introduction hole (3300) as described above to the coolant injected inside the composition injection device (3300), and the first end (3210) of the guide structure (3200) can meet the coolant.
  • the guide structure (3200) can be manufactured using a metal having thermal conductivity.
  • the guide structure (3200) can be stainless steel (SUS), but is not limited thereto, and any material (for example, a metal material) having a certain level of thermal conductivity or higher can be used as the material of the guide structure (3200) according to the present disclosure. Since the guide structure (3200) has been described above, a redundant description will be omitted.
  • the actuator (3500) provides a force that allows the composition stored in the composition reservoir (3400) to pass through the composition inlet hole (3300) and move to the guide structure (3200).
  • the actuator (3500) may be a device that provides a pushing force (e.g., pressure) that moves the composition stored in the composition reservoir (3400). More specifically, the actuator (3500) may push a plunger included in the composition reservoir (3400), and the plunger pushed by the actuator (3500) may push the composition again to move the composition to the guide structure (3200).
  • a linear actuator may be used as the actuator (3500) according to the present disclosure.
  • the linear actuator may be driven by an electric motor.
  • the actuator (3500) should not be construed as being limited to a linear actuator, and any device capable of providing a force capable of moving the composition from the composition reservoir (3400) to the guide structure (3200) may be used as the actuator (3500) according to the present disclosure.
  • the actuator (3500) providing a force to move the composition or the actuator (3500) providing a pushing force (or pressure) to the composition may mean that the actuator (3500) transmits the pushing force (or pressure) to the composition through a pressure transmitting medium such as a plunger, an elastic tube, and a diaphragm included in the composition reservoir (3400).
  • a pump may be used instead of the actuator (3500) according to the present disclosure.
  • the pump instead of the plunger contained within the composition reservoir (3400), the pump may be fluidly connected to the composition reservoir, and the pump may apply hydraulic pressure to the composition reservoir (3400) to provide a pushing force to the composition stored in the composition reservoir (3400).
  • the pump may be, for example, a piston pump, a precision gear pump, or a peristaltic pump.
  • the strength of the pushing force provided to the composition by the actuator (3500), the continuous application time of the pushing force, the application cycle of the pushing force, etc. can be adjusted according to the control of a controller (not shown).
  • the actuator (3500) can control the speed of the moving composition and/or the flow rate of the composition by adjusting the strength of the pushing force, the application time, the application cycle, etc.
  • the controller (not shown) that controls the actuator (3500) may be a controller included in the coolant injection device (2000) or may be a controller separately mounted on the composition injection device (3000).
  • the first end (3210) of the guide structure (3200) is arranged close to the coolant injection unit (1200) so as to meet the coolant having a very low temperature.
  • the temperature of the first end (3210) is unintentionally lowered, and as the lowered temperature of the first end (3210) is conducted to the entire guide structure (3200), the temperature of the entire guide structure (3200) is lowered.
  • the composition moving along the movement path provided by the guide structure (3200) freezes at the guide structure (3200) before reaching the first end (3210) of the guide structure (3200) and being separated from the guide structure (3200). If the composition is frozen without being released from the guide structure (3200), not only is the composition not sprayed to the target area, but the movement of subsequent compositions is also hindered, making it impossible for the composition to be used for skin beauty and treatment.
  • the composition should move to the first end (3210) of the guide structure (3200) and not freeze until it is released from the guide structure (3200), and the composition should freeze after it is released from the guide structure (3200) and be sprayed onto the target area.
  • composition injection device (3000) that prevents the composition from freezing until it leaves the guide structure (3200).
  • structure of the composition injection device (3000) that prevents the composition from freezing until it leaves the guide structure (3200) while ensuring a sufficient freezing ratio after it leaves.
  • Solution 1 A structure that prevents the composition from freezing before leaving the guide structure (3200) by using outside air to prevent the guide structure (3200) from freezing.
  • the temperature of the guide structure (3200) must not drop to such an extent that the composition freezes on the guide structure (3200) even while the coolant is being sprayed.
  • the above-described outside air circulation structure was a structure that was possible because the guide structure of "Korean Patent Publication No. 10-2024-0070463" had a shape that extended parallel to the direction in which the coolant was sprayed. That is, because the guide structure had a structure that extended from a close portion of the nozzle to a distance away from the nozzle along the virtual central axis of the nozzle, it was possible to create an outside air circulation structure by having outside air pass through both sides of the guide structure.
  • the guide structure (3200) of the composition spraying device (3000) according to the present application has a different structure from the guide structure in "Korean Patent Publication No. 10-2024-0070463", so it was impossible to design the guide structure (3200) so that outside air would pass through both sides.
  • the guide structure (3200) of the present application is arranged not parallel to the coolant injection unit (1200) (e.g., nozzle). That is, in the present application, the imaginary center line of the guide structure (3200) intersects the imaginary central axis of the coolant injection unit (1200), and the guide structure (3200) has a structure extending along the imaginary center line.
  • This is a structure for increasing the freezing rate of the detached composition by allowing the composition provided from the guide structure (3200) to meet the coolant that is as close as possible to the coolant injection unit (1200).
  • the composition detached by hitting the coolant can be sprayed in the form of particles. Accordingly, in the following description, the composition detached from the guide structure (3200) can be understood as composition particles.
  • composition injection device (3000) of the present application in order to prevent the temperature of the guide structure (3200) from dropping too low and the composition from freezing on the guide structure (3200), a design is required that allows the outside air to effectively meet the guide structure (3200) while the coolant is injected, taking into account the arrangement relationship between the guide structure (3200) and the coolant injection unit (1200).
  • the guide structure (3200) is divided into an outer surface that collides with the injected coolant and an outer surface that does not directly collide with the injected coolant when the coolant is injected, as the guide structure (3200) is arranged not parallel to the coolant injection unit (1200).
  • the outer surface that does not directly collide with the injected coolant is referred to as the first outer surface of the guide structure (3200)
  • the surface that directly collides with the injected coolant is referred to as the second outer surface of the guide structure (3200).
  • the second outer surface is a surface opposite to the first outer surface
  • the second outer surface is a surface that faces the inner surface of the composition injection device (3000) in which the coolant inlet hole (3100) is formed.
  • an air path is configured so that the outside air sucked into the coolant by the coolant injection smoothly flows toward the surface where the coolant is injected and collides with the injected coolant, even if the outside air does not flow toward the surface where the coolant is not directly injected, the temperature of the guide structure (3200) does not drop too much, and accordingly, the composition does not freeze on the guide structure (3200) and can escape the guide structure (3200).
  • composition injection device 3000
  • a guide structure 3200
  • directly collides with the injected coolant as described above we will look at the structure of a composition injection device (3000) that allows the surface of a guide structure (3200) that directly collides with the injected coolant as described above to come into contact with the outside air.
  • FIG. 4 will examine a composition injection device (3000) that allows the outer surface of the guide structure (3200) to meet the outside air.
  • the composition injection device (3000) may include a coolant inlet hole (3100), a guide structure (3200), a composition inlet hole (3300), a composition storage (3400), and an actuator (3500). Since the above components have already been described in detail while describing FIGS. 2 and 3, a duplicate description will be omitted. Meanwhile, referring to FIG. 4, the composition injection device (3000) according to the present disclosure may further include an enclosure (3900). Referring to FIG.
  • the enclosure (3900) provides an internal space in which the composition, which has moved from the composition inlet hole (3300) to the first end (3210) of the guide structure (3200) along the movement path provided by the guide structure (3200), meets the coolant sprayed from the coolant spray unit (1200).
  • the enclosure (3900) may be disposed to surround at least a portion of the guide structure (3200) and the coolant inlet hole (3100) and/or the coolant spray unit (1200).
  • the enclosure (3900) may form at least a portion of the outer wall of the composition spray device (3000), and may be a housing or a portion of the housing of the composition spray device (3000).
  • the enclosure (3900) may include an external air inflow hole (3910) that allows the guide structure (3200) to meet the outside air in order to prevent the guide structure (3200) from freezing while the coolant is sprayed.
  • the coolant injection unit (1200) injects the coolant
  • the air in the area where the coolant is injected is pushed out by the injected coolant, thereby generating a negative pressure that lowers the pressure around the injected coolant.
  • the faster the coolant injection speed the lower the pressure around the coolant, and accordingly, the pressure around the orifice of the coolant injection unit (1200) becomes the lowest. Therefore, as the difference between the pressure outside the composition injection device (3000) and the pressure around the orifice of the coolant injection unit (1200) becomes the largest, outside air is introduced from outside the composition injection device (3000) to the orifice of the coolant injection unit (1200).
  • the outside air inflow hole (3910) may be arranged in the enclosure (3900) so that the outside air that enters the internal space of the enclosure (3900) through the outside air inflow hole (3910) due to the difference in pressure between the negative pressure generated by the injection of the coolant by the coolant injection unit (1200) and the external pressure of the composition injection device (3000) while the coolant is injected may be introduced between the inner surface of the composition injection device (3000) where the coolant inflow hole (3300) is formed and the second outer surface of the guide structure (3200), and may meet at least a part of the second outer surface.
  • the outside air may encounter a region of the second outer surface other than the first end (3210) of the guide structure (3200). In other words, the outside air may encounter a portion of the second outer surface of the guide structure (3200) that does not encounter the coolant.
  • the outside air may be mixed with the coolant stream due to the pressure difference between the outside air and the coolant stream and may escape to the outside of the composition injection device (3000) along the coolant stream. In this process, the outside air may escape to the outside of the composition injection device (3000) by being mixed with the coolant stream without encountering the first outer surface of the guide structure (3200).
  • the outside air inlet hole (3910) may be arranged so that the outside air meets at least a portion of the second outer surface of the guide structure (3200), mixes with the coolant stream, and escapes out of the inner space of the enclosure (3900).
  • (a) of FIG. 6 is a view of the composition injection device (3000) from the direction of looking straight at the orifice of the coolant injection unit (1200)
  • (b) of FIG. 6 is a view of the composition injection device (3000) from the direction of D'.
  • the external air inlet hole (3910) when looking from the outside to the inside of the composition injection device (3000) along the direction of an imaginary line (VL) that vertically penetrates the imaginary center point of the external air inlet hole (3910), the external air inlet hole (3910) may be arranged so that the space (SB) between the area included in the second outer surface of the guide structure (3200) among the first end (3210) of the guide structure (3200) and the coolant injection unit (1200) (or the coolant inlet hole (3100)) is visible.
  • the temperature of the guide structure (3200) does not drop below a certain level due to the outside air, and accordingly, the composition can be separated from the guide structure (3200) without freezing on the guide structure (3200).
  • the outside air inlet hole (3910) as described above is arranged so that the outside air meets the second surface of the guide structure (3200), the composition can be prevented from freezing on the guide structure (3200), but if the outside air inlet hole (3901) is arranged so that it meets only the first surface, the composition may not be prevented from freezing on the guide structure (3200).
  • the heat capacity of the guide structure (3200) can be configured to be large so that the composition can be separated from the guide structure (3200) without freezing on the guide structure (3200).
  • the guide structure (3200) with a mass of 0.1 g or more of metal to have a large heat capacity, the composition can be prevented from freezing on the guide structure (3200).
  • heat may be applied to the guide structure (3200) to prevent the temperature of the guide structure (3200) from dropping, thereby preventing the composition from freezing on the guide structure (3200).
  • the guide structure (3200) is connected to a heat sink, the cooling energy transferred from the coolant to the guide structure (3200) is transferred to the heat sink, thereby preventing the temperature of the guide structure (3200) from dropping, and preventing the composition from freezing on the guide structure (3200).
  • the temperature of the guide structure (3200) can be prevented from decreasing, thereby preventing the composition from freezing on the guide structure (3200).
  • Solution 2 A structure that reduces freezing of the composition before it leaves the guide structure (3200) by allowing the surface on which the composition does not move to directly collide with the coolant.
  • the guide structure (3200) may be implemented as a pipe or a plate. However, if the guide structure (3200) is configured as a plate, at least a portion of the movement path of the composition provided by the guide structure (3200) is open, so that it can directly collide with the coolant. However, if the movement path of the composition is arranged on a surface that directly collides with the coolant, the composition moving along the movement path directly collides with the coolant, and as a result, the composition releases thermal energy more quickly, so that it cannot escape from the guide structure (3200) and can be frozen.
  • the guide structure (3200) when the guide structure (3200) is implemented as a plate as shown in FIG. 7, it is preferable to arrange the third outer surface on which the composition moves in the guide structure (3200) so as not to directly collide with the sprayed coolant, and the fourth outer surface on which the composition does not move (here, the fourth outer surface is the opposite surface of the third outer surface) so as to face the inner surface of the composition spraying device (3000) in which the coolant inlet hole (3100) is formed, so that the fourth outer surface comes into contact with the coolant.
  • the fourth outer surface on which the composition does not move here, the fourth outer surface is the opposite surface of the third outer surface
  • Solution 3 Place the first end (3210) of the guide structure (3200) in the substream of the coolant stream, but place it as close as possible to the boundary between the main stream and the substream.
  • the coolant stream refers to the flow of coolant formed when the coolant is emitted from a coolant injection part (1200) such as a nozzle.
  • the width and height of the coolant stream are determined by the diameter of the orifice of the coolant injection part (1200) and the pressure applied to the coolant from the coolant injection part (1200).
  • the coolant stream can be divided into a main stream (MS) and a substream (SS).
  • the main stream (MS) has a higher coolant density than the substream (SS). That the coolant density of the main stream (MS) is higher than that of the substream (SS) can be clearly seen through FIG. 9.
  • FIG. 9 is a photograph of the coolant stream taken with an ultra-high-speed camera. As can be seen, due to its high density, the main stream (MS) has a clear shape that can be seen with the naked eye, while the substream (SS) appears somewhat faint.
  • the coolant moves away from the orifice of the coolant injection unit (1200) toward the central axis of the coolant injection unit (1200) at a fast speed, and moves in a straight line from the coolant injection unit (1200) to the target area.
  • This mainstream (MS) can be formed when high-pressure coolant is ejected at atmospheric pressure.
  • the coolant can have a speed higher than the speed of sound. Accordingly, it can be understood that in the mainstream (MS), substances other than the coolant (e.g., air) have little effect on the flow of the coolant.
  • the substream (SS) is a region where the velocity gradient and temperature gradient begin abruptly as the surrounding air surrounding the mainstream (MS) is sucked toward the mainstream (MS) due to the rapid movement of the coolant within the mainstream (MS).
  • the substream (SS) includes the surrounding air sucked in by the mainstream (MS) and the injected coolant, and can be said to be a boundary layer that has a colder temperature than the surrounding air outside the substream (SS) but a higher temperature than the mainstream (MS).
  • the sucked-in ambient air contained within the substream (SS) has a speed lower than the speed of sound. Accordingly, the sucked-in ambient air collides with the coolant and slows down the coolant, and thus the coolant speed in the substream (SS) is slower than that in the mainstream (MS).
  • the amount or ratio of the ambient air contained in the substream (SS) decreases as it gets closer to the mainstream (MS), and accordingly, since the coolant in the substream (SS) closer to the mainstream (MS) is not hindered by the ambient air, the speed of the air in the substream (SS) increases as it gets closer to the mainstream (MS).
  • the density of the coolant within the substream (SS) is lower than that of the coolant within the main stream (MS).
  • the temperature of the coolant in the mainstream (MS) is much lower than that of the substream (SS).
  • the mainstream (MS) contains coolant that has a high velocity due to the high-pressure coolant expansion and a cold temperature
  • the substream (SS) contains more ambient air that has been sucked toward the mainstream (MS) by the negative pressure generated by the high velocity of the mainstream (MS) along with the coolant.
  • the amount or ratio of ambient air contained in the substream (SS) increases as it moves away from the center of the mainstream (MS), so the velocity of the substream (SS) decreases as it moves away from the center of the mainstream (MS).
  • the substream (SS) has a velocity gradient that decreases as it moves away from the center of the mainstream (MS).
  • the substream (SS) since the substream (SS) is cooled by the cold temperature of the mainstream (MS) as it approaches the mainstream (MS), the substream (SS) has a temperature gradient that decreases as it moves away from the mainstream (MS).
  • the guide structure (3200) obstructs the straight flow of the mainstream (MS), so that the coolant within the mainstream (MS) does not collide with the frozen particles in a straight direction, thereby obstructing the frozen particles from accelerating in a straight direction. Therefore, even if the composition is released from the guide structure (3200), problems such as reaching a location other than the target area due to irregular flow or the speed at which the composition reaches the target area becomes significantly irregular may occur, making it difficult to spray a uniform composition.
  • the composition may not be efficiently released from the guide structure (3200) or the released composition may not be sufficiently frozen.
  • the applicant placed the first end (2310) of the guide structure (3200) at several points in the main stream (MS) and the sub stream (SS), and found a position where the composition does not freeze on the guide structure (3200), but has a high freezing ratio enough to allow the composition to sufficiently penetrate into the skin.
  • the substream (SS) has a high speed as the coolant is located closer to the mainstream (MS) within the substream (SS) due to the negative pressure generated by the high speed of the mainstream (MS), so that the first end (3210) of the guide structure (3200) is disposed in the substream (SS), but the composition can collide with the high speed coolant as it is located closer to the mainstream (MS), so that it can easily escape from the guide structure (3200).
  • the substream (SS) contains surrounding air that is sucked toward the mainstream (MS) due to the negative pressure generated by the high speed of the mainstream (MS), the composition that is easily escaped can be introduced into the mainstream (MS) and frozen by the flow of surrounding air that is sucked toward the mainstream (MS).
  • direct cooling applied from the coolant to the guide structure (3200) can be minimized, so that the composition can be prevented from freezing on the guide structure (3200).
  • the first end (3210) of the guide structure (3200) should be positioned at a position where an amount of the composition capable of having a freezing ratio greater than a predetermined freezing ratio can flow into the main stream (MS).
  • the predetermined freezing ratio refers to a freezing ratio that can bring about a significant skin improvement effect when the frozen particles penetrate into the skin, taking into consideration the type of the composition, the active ingredient constituting the composition, and the amount of the active ingredient.
  • the first end (3210) of the guide structure (3200) can be positioned at a position where the freezing ratio can be 80% or more.
  • the first end (3210) of the guide structure (3200) may be positioned at a position where the freezing ratio may be 70% or more.
  • the first end (3210) of the guide structure (3200) may be positioned at a position where the freezing ratio may be 60% or more.
  • the first end (3210) of the guide structure (3200) may be positioned at a position where the freezing ratio may be 50% or more.
  • the first end (3210) of the guide structure (3200) may be positioned at a position where the freezing ratio may be 40% or more.
  • the first end (3210) of the guide structure (3200) may be positioned at a position where the freezing ratio may be 30% or more.
  • the first end (3210) of the guide structure (3200) may be positioned at a position where the freezing ratio may be 20% or more.
  • the first end (3210) of the guide structure (3200) may be positioned at a position where the freezing ratio may be 10% or more.
  • the first end (3210) of the guide structure (3200) may be positioned at a position where the freezing ratio may be 10% or more.
  • the guide structure (3200) may be disposed at a height spaced apart by d from the coolant injection unit (1200) in the direction of the central axis (CA) of the coolant injection unit (1200) and spaced apart by G from the central axis (CA).
  • d and G may be determined by the shapes of the main stream (MS) and the substream (SM) described above.
  • the main stream (MS) may disappear from the distance d' from the orifice of the coolant injection unit (1200) in the direction of the central axis (CA) due to the inflow of ambient air.
  • d must be smaller than d', which determines the section in which the main stream (MS) exists. That is, it should be positioned closer to the coolant injection unit (1200) than d', which determines the section where the main stream (MS) exists, but should be spaced apart from the orifice of the coolant injection unit (1200).
  • the diameter of the main stream (MS) may change depending on the distance from the orifice in the direction of the central axis, and G should be larger than the diameter of the main stream (MS) and smaller than the diameter of the sub stream (SS).
  • the composition injection device (3000) used in solution 3 may include a coolant inlet hole (3100), a guide structure (3200), a composition inlet hole (3300), a composition storage (3400), and an actuator (3500), as described in FIGS. 2 and 3, and each component has been described in detail above, so a duplicate description will be omitted.
  • composition injection device (3000) may include the outside air inlet hole and enclosure of solution 1, and may be arranged so that the first end (3210) of the guide structure (3200) is disposed in the substream (SS) as described in solution 3, but is disposed close to the mainstream (MS) so as to have a freezing ratio higher than a predetermined freezing ratio.
  • the composition injection device (3000) may include the outside air inlet hole and enclosure of solution 1, and may be arranged so that the fourth surface of the guide structure (3200) where the composition does not move directly collides with the coolant, facing the inner surface where the coolant inlet hole (3100) is formed.
  • the composition injection device (3000) may be positioned so that the fourth surface of the guide structure (3200) where the composition does not move directly collides with the coolant, while facing the inner surface where the coolant inlet hole (3100) is formed, and the first end (3210) of the guide structure (3200) may be positioned in the substream (SS) as described in solution 3, but may be positioned close to the main stream (MS) so as to have a freezing ratio higher than a predetermined freezing ratio.
  • the composition injection device (3000) may include the external air inlet hole and enclosure of solution 1, and may be arranged so that the first end (3210) of the guide structure (3200) is positioned in the substream (SS) as described in solution 3, but is positioned close to the main stream (MS) so as to have a sufficient freezing ratio, and the fourth surface of the guide structure (3200) where the composition does not move may be positioned so as to face the inner surface where the coolant inlet hole (3100) is formed so as to collide directly with the coolant.
  • the cooling energy required for the composition to freeze is proportional to (1) the specific heat of the composition, (2) the mass of the composition, and (3) the temperature difference between the current temperature of the composition and the freezing point of the composition, and the solidification heat energy required for the composition to freeze into a solid phase is proportional to (1) the latent heat coefficient of the composition and (2) the mass of the composition. Therefore, when the composition is atomized by the coolant stream and released into the guide structure (3200), and the size of the composition decreases, the mass of the composition decreases. In addition, since the cooling energy and solidification heat energy required for the composition to freeze decrease as the mass of the composition decreases, the smaller the size of the composition, the faster the composition freezes.
  • the freezing rate can be increased as the size of the droplet of the composition released from the guide structure (3200) decreases.
  • the composition lump detached from the guide structure (3200) by the coolant stream may continue to be fragmented by the coolant stream until it freezes after detachment, thereby becoming smaller in size.
  • the size of the composition lump may vary depending on the viscosity of the composition and the velocity of the coolant stream (i.e., the pressure of the coolant reservoir).
  • the size of the frozen particles needs to be made small enough to have a sufficient freezing ratio and not cause discomfort to the subject.
  • the negative pressure formed while the coolant is being sprayed is constant, if the meeting area is small, the adhesive force between the composition and the guide structure (3200) becomes small, so that the force required for the composition to detach from the guide structure (3200) becomes small. Therefore, the composition can be detached from the guide structure (3200) before the size of the composition that is formed at the first end (3210) increases, so that the size of the composition can be reduced.
  • FIGS. 12 to 15 show various examples of the first end (3210).
  • Fig. 12 shows that the guide structure (3200) is a pipe.
  • the first end (3210) of the guide structure (3200) of Fig. 12 (a) is cylindrical
  • Figs. 12 (b) and (c) show that the first end (3210) of the guide structure (3200) is pointed.
  • the first end (3210) of the guide structure (3200) of Fig. 13 (a) has a flat shape
  • Figs. 13 (b) and (c) show that the first end (3210) of the guide structure (3200) is pointed.
  • the width (W) of the guide structure (3200) is the same and the height of the area where the guide structure (3200) and the composition meet is the same as z
  • the area where the guide structure (3200) and the composition meet is smaller in Figs. 13 (b) and (c) than in Fig. 13 (a).
  • the sharper the first end (3210) the smaller the area where the guide structure (3200) and the composition that has moved to the first end (3210) meet, and accordingly, the size of the detached composition can be reduced.
  • FIG. 14 shows that the first end (3210) of the guide structure (3200) is completely pointed, and (a) of FIG. 14 shows that the guide structure (3200) is a tube, and (b) of FIG. 14 shows that the guide structure (3200) is a plate.
  • the first end (3210) of the guide structure (3200) includes a first side and a second side that meet at a first point, which is a trailing edge of the first end (3210).
  • the trailing edge corresponds to a point where the composition is formed in the guide structure (3200) and refers to a side included in the first end (3210) of the guide structure (3200).
  • the angle (a) between the first side and the second side is less than 180 degrees.
  • the angle between the first side and the second side is frozen to a size sufficiently small to penetrate the skin when the composition that has moved to the first end (3210) is sprayed after leaving the guide structure (3200).
  • the angle may be 90 degrees or more and less than 120 degrees, but is not limited thereto, and the angle may be smaller than 90 degrees.
  • FIG. 15 shows that the first end (3210) of the guide structure (3200) is sharp, but the rear edge is somewhat blunt due to a line connecting two points.
  • FIG. 15 (a) shows that the guide structure (3200) is a tube
  • FIG. 15 (b) shows that the guide structure (3200) is a plate.
  • the first end (3210) of the guide structure (3200) has a first point and a second point, which are both ends of the trailing edge of the first end (3210), and may include a first side that meets the first point and a second side that meets the second point. In this case, the first point and the second point are opposite points.
  • the composition injection device (3000) including the above-described guide structure (3200) may include a coolant inlet hole (3100), a guide structure (3200), a composition inlet hole (3300), a composition storage (3400), and an actuator (3500), as described in FIGS. 2 and 3 , and each component has been described in detail above, so a duplicate description thereof will be omitted.
  • the device may further include an enclosure (3900) and an external air inlet hole (3910) as described in FIG. 4 .
  • the guide structure (3200) described in [Structure of guide structure (3200) for increasing freezing ratio] can be used as the guide structure (3200) in [Structure of composition injection device for increasing freezing ratio] and [Problems and solutions that occur when the first end (3210) of the guide structure (3200) is arranged close to the coolant injection unit (1200)].
  • the guide structure (3200) may be a tube or a plate.
  • the composition can be uniformly moved to the first end (3210) of the guide structure (3200).
  • the composition injection device (3000) is a small device, and the guide structure (3200) included therein is very small in size. Therefore, if the guide structure (3200) is made of a tube, the possibility of an assembly tolerance occurring increases. That is, when connecting the composition inlet hole (3300) and the guide structure (3200), the guide structure (3200) may not be positioned as desired, and thus, the composition may not properly enter the movement path provided by the guide structure (3200).
  • the applicant has conceived a method of making the guide structure (3200) into a plate. If the guide structure (3200) is made into a plate, it is easy to assemble, making it easy to arrange the guide structure (3200) as desired.
  • FIG. 16 is a drawing for explaining a problem when the guide structure (3200) is a plate and has a flat surface.
  • the guide structure (3200) is made of a plate, if the distance between the first end (3210) and the second end (3220) of the guide structure (3200) becomes longer than a certain amount, it was found that the composition did not move well to the first end (3210) of the guide structure (3200) but spread out on the guide structure (3200). Accordingly, the amount of the composition per unit time moving to the first end (3210) was not constant, and accordingly, there was a problem in that the size of the frozen particles that escaped to the first end (3210) of the guide structure (3200) and were frozen was also not constant. If the size of the frozen particles is not constant, it is difficult to evenly penetrate the desired amount of the composition into the target area for skin improvement, and thus, it is difficult to improve the effect of the composition.
  • the applicant changed the structure of the guide structure (3200) in various ways to make the size of the frozen particles uniform, and experimented to see if the size of the frozen particles was created uniformly, and was able to observe that the size of the frozen particles was created uniformly in several changed structures.
  • Solution 4-1 Structure forming a groove on the first surface of the guide structure (3200)
  • Figure 17 shows that when the guide structure (3200) is a plate, a groove (OG) is formed on the first surface along which the composition moves.
  • the groove formed above forces the movement path along which the composition moves, and thus, the amount of the composition moving toward the first end (3210) can be uniformly controlled.
  • the width of the groove should be determined according to the size of the frozen particles to be generated, the magnitude of the pushing force provided by the actuator (3500), the period of providing the pushing force, etc.
  • the width of the groove may be set to be smaller as the size of the frozen particles to be generated becomes smaller.
  • the width of the groove may be set to a width that allows the amount of composition to be moved per unit time to be determined based on the size of the frozen particles to be generated, and the determined amount of composition to fill the groove.
  • the composition injection device (3000) including the above-described guide structure (3200) may include a coolant inlet hole (3100), a guide structure (3200), a composition inlet hole (3300), a composition reservoir (3400), and an actuator (3500), as described in FIGS. 2 and 3, and each component has been described in detail above, so a duplicate description thereof will be omitted.
  • the device may further include an enclosure (3900) and an outside air inlet hole (3910) as described in FIG. 4.
  • the guide structure (3200) described in [Solution 4-1] can be used as the guide structure (3200) in [Structure of a composition injection device for increasing a freezing ratio] and [Problems and solutions that occur when the first end (3210) of the guide structure (3200) is arranged close to the coolant injection unit (1200)].
  • Solution 4-2 Folded structure of the guide structure (3200)
  • Fig. 18 shows that the guide structure (3200) has a folded structure.
  • the groove formed by the folded structure of the guide structure (3200) forces a movement path of the composition, so that the composition moves uniformly from the composition inlet hole (3300) to the first end (3210) of the guide structure (3200) without being dispersed. Accordingly, the amount of the composition per unit time moving to the first end (3210) of the guide structure (3200) can be controlled to be uniform.
  • a guide structure (3200) having a folded structure can be manufactured in the following manner.
  • a guide structure (3200) having a folded structure can be manufactured by folding a flat plate so that the groove is formed.
  • the flat plate can be bent.
  • 3230 and 3240 in FIG. 18 may each be a portion of a flat plate distinguished by the groove.
  • a guide structure (3200) having a folded structure can be manufactured by joining a first plate and a second plate so that a groove is formed between the first plate and the second plate.
  • the angle a between the first plate and the second plate may be less than 180 degrees.
  • 3210 in FIG. 18 may be a first plate and 3220 may be a second plate.
  • the composition injection device (3000) including the above-described guide structure (3200) may include a coolant inlet hole (3100), a guide structure (3200), a composition inlet hole (3300), a composition reservoir (3400), and an actuator (3500), as described in FIGS. 2 and 3, and each component has been described in detail above, so a duplicate description thereof will be omitted.
  • the device may further include an enclosure (3900) and an outside air inlet hole (3910) as described in FIG. 4.
  • the guide structure (3200) described in [Solution 4-2] can be used as the guide structure (3200) in [Structure of a composition injection device for increasing a freezing ratio] and [Problems and solutions that occur when the first end (3210) of the guide structure (3200) is arranged close to the coolant injection unit (1200)].
  • Fig. 19 shows the amount of the composition supplied from the guide structure (3200) according to the above-described solution 4-1 or solution 4-2 and the size of the sprayed frozen particles.
  • a groove is formed on the first surface of the guide structure (3200) along which the composition moves, or when the guide structure (3200) is made into a structure that folds to form the groove, the composition moves evenly without being dispersed to the first end (3210) of the guide structure (3200). Accordingly, the size of the frozen particles in which the composition is frozen after being separated from the guide structure (3200) can be generated evenly.
  • the composition when a composition moves on a flat plate, the composition is freely spread and dispersed. Since the movement width of the dispersed composition is not constant, the amount of the composition reaching the first end (3210) of the guide structure (3200) per unit time is not uniform. On the other hand, if a groove is formed on the first surface of the guide structure (3200) along which the composition moves, or if the guide structure (3200) is made into a structure that folds to form the groove, as shown in FIG. 19, the composition is not dispersed, but moves uniformly along a constant path to the first end (3210) of the guide structure (3200), thereby solving the above-described problem.
  • the guide structure (3200) having a groove or folded structure as described above can have a first end (3210) made pointed as described above in order to reduce the size of the detached composition.
  • Fig. 20 shows that the guide structure (3200) has a pointed first end (3210) and a groove formed on the first surface along which the composition moves.
  • Fig. 21 shows that the guide structure (3200) has a pointed first end (3210) and a folded structure.
  • Fig. 20 is a combined form of Fig. 17 and Fig. 14(b)
  • Fig. 21 is a combined form of Fig. 18 and Fig. 14(b).
  • Fig. 17 and Fig. 15(b) can also be combined
  • Fig. 18 and Fig. 15(b) can also be combined.
  • FIG. 22 shows various implementations of a guide structure (3200) having a pointed first end (3210) and a folded structure, as in FIG. 21.
  • FIG. 22 (a) shows a first embodiment of the guide structure (3200). As shown in FIG. 22 (a), the guide structure (3200) has a folded structure, so that a groove (3250) through which a composition can move is formed. In addition, a hole for coupling with a composition inlet hole (3000) may be present in the middle of the groove.
  • FIG. 22 (b) shows a structure in which FIG. 22 (a) has two parts.
  • the two guide structures (3200) can be arranged so that the first ends (3210) of the two guide structures (3200) face each other based on the imaginary central axis of the coolant inlet hole (3100), and in this case, the size of the detached composition can be sufficiently reduced while doubling the amount of composition supplied per unit time.
  • FIG. 22 (c) shows four guide structures (3200) having the same structure as FIG. 22 (a) joined so as to be in contact. That is, the dotted line portion of FIG. 22 (c) is one guide structure (3200), and the four guide structures (3200) can be joined clockwise or counterclockwise to form a crown-shaped collective guide structure.
  • the amount of the composition supplied per unit time can be increased by four times.
  • a composition spraying device (3000) including an appropriate number of guide structures (3200) can be used depending on the amount, viscosity, type, efficacy of the composition used, the purpose of use of the composition spraying device (3000), the target of use, etc.
  • the number of guide structures (3200) used in the composition injection device (3000) may be 2, 3, 4, 5, 6, 7, or 8 or more.
  • a composition injection device (3000) including a guide structure (3200) having a first end (3210) that is pointed and has a folded structure may include a coolant inlet hole (3100), a guide structure (3200), a composition inlet hole (3300), a composition storage (3400), and an actuator (3500) as described in FIGS. 2 and 3, and each component has been described in detail above, so a duplicate description will be omitted.
  • an enclosure (3900) and an outside air inlet hole (3910) as described in FIG. 4 may be further included.
  • the guide structure (3200) can be used as the guide structure (3200) in [Structure of a composition injection device for increasing a freezing ratio] and [Problems and solutions that occur when the first end (3210) of the guide structure (3200) is positioned close to the coolant injection unit (1200)].
  • the size of the detached composition can be made small while the amount of the composition moving toward the first end (3210) of the guide structure (3200) can be made uniform. That is, the composition moves toward the first end (3210) of the guide structure (3200) without being dispersed, and the size of the composition detached from the first end (3210) by the force applied by the coolant after moving to the first end (3210) can also be small. Accordingly, the size of the sprayed frozen particles can be made uniform while having a sufficient freezing ratio.
  • the composition must move to the first end (3210) of the guide structure (3200) by the pushing force applied by the actuator (3500).
  • the guide structure (3200) is a flat plate
  • the composition encounters an open space when introduced into the guide structure (3200).
  • the composition is in a state where it can move anywhere, and it is very difficult to control the moving direction of the composition consistently only with the pushing force applied by the actuator (3500). Therefore, the composition spreads in the open space, and this spreading phenomenon ultimately causes a problem of flowing in an unintended direction.
  • a guide structure (3200) for preventing the composition from spreading in an open space may be in physical contact with a tunnel forming member (3600).
  • the tunnel forming member (3600) may be in physical contact with a first surface of the guide structure (3200) along which the composition moves, and may form a tunnel in a portion of the movement path of the composition on the first surface.
  • the tunnel forming member (3600) may be in physical contact with the first surface so that a tunnel is formed from a hole in the guide structure (3200) to which the composition inlet hole (3300) is coupled to a point that is a distance of I.
  • the composition since the composition passes through the tunnel along a movement path of I from the composition inlet hole (3300), it may be moved to the end of the tunnel without spreading even by a pushing force provided by the actuator (3500).
  • the composition passing through the tunnel can move along the movement path to the first end (3210) of the guide structure (3200) by the negative pressure formed while the coolant is sprayed after passing through the tunnel.
  • the composition moves by the pushing force provided by the actuator (3500), and in the movement path of x, the composition can move by the pushing force provided by the actuator (3500) and the negative pressure formed while the coolant is sprayed. Therefore, X should be set to a length that can provide sufficient negative pressure to the composition.
  • sufficient negative pressure may mean a negative pressure that, when applied to the composition immediately after passing through the tunnel, overcomes the frictional force acting by the attractive force between the composition and the guide structure (3200), thereby forming a pulling force that allows the composition to move to the first end (3210) of the guide structure (3200).
  • the length of X must be such that a negative pressure greater than the frictional force due to the attractive force between the composition and the guide structure (3200) can be applied to the composition.
  • X should have a length equal to or less than a predetermined value that allows sufficient negative pressure to be applied to the composition immediately after passing through the tunnel so that the composition can move to the first end (3210) of the guide structure (3200) by the pulling force.
  • X may be 3 mm or less, and preferably 2.7 mm or less.
  • X may vary depending on the size of the negative pressure formed while the coolant is injected. For example, when the diameter of the orifice of the coolant injection portion (1200) is small or the pressure of the coolant storage portion is large, and the injection speed of the coolant becomes fast, the size of the negative pressure may increase, and in this case, the length of x may become long. That is, x may vary depending on the injection speed of the coolant according to the diameter of the orifice and the injection pressure of the coolant, and the size of the negative pressure generated thereby.
  • FIG. 26 is a drawing showing the configuration of a composition injection device (3000) that prevents the above-described composition from spreading in an open space.
  • the composition injection device (3000) may include a coolant inlet hole (3100), a guide structure (3200), a composition inlet hole (3300), a composition reservoir (3400), and an actuator (3500), as described with reference to FIGS. 2 and 3 , and each component has been described in detail above, so a duplicate description thereof will be omitted.
  • the above-described guide structure (3200) may be any one of the guide structures (3200) disclosed in [Structure of a composition injection device for increasing a freezing ratio], [Structure of a guide structure (3200) for increasing a freezing ratio], and [Problem of uneven size of frozen particles when the guide structure (3200) is a plate].
  • the tunnel forming member (3600) can physically contact any one of the guide structures (3200) disclosed in [Structure of a composition injection device for increasing a freezing ratio], [Structure of a guide structure (3200) for increasing a freezing ratio], and [Problem of non-uniform size of frozen particles when the guide structure (3200) is a plate].
  • the composition injection device (3000) according to the present disclosure may further include a tunnel forming member (3600).
  • This tunnel forming member (3600) may physically contact the first surface on which the composition moves in the guide structure (3200) as described above.
  • the tunnel forming member (3600) may be implemented as a separate component, but may also be implemented as a part of the housing or enclosure (3900).
  • the tunnel forming member (3600) may be implemented integrally with the housing or enclosure (3900). This will be described in detail later.
  • the composition injection device (3000) may include a coolant inlet hole (3100), a guide structure (3200), a composition inlet hole (3300), a composition storage (3400), and an actuator (3500), as described in FIGS. 2 and 3, and each component has been described in detail above, so a duplicate description will be omitted.
  • the composition injection device (3000) may further include a housing (3800).
  • the housing (3800) is for protecting components of the composition injection device (3000) and may form an outer wall of the composition injection device (3000).
  • the housing (3800) may include at least one of an enclosure (3900), an external air inlet hole (3910), and a tunnel forming member (3600), as described above.
  • the enclosure (3900), the external air inlet hole (3910), and the tunnel forming member (3600) may be implemented separately rather than as components of the housing (3800).
  • the housing (3800) may also include a supporting part.
  • the support member is configured to maintain a constant distance between the coolant injection unit (1200) and the target area, and may be positioned on the side of the discharge hole of the housing (3800) through which the coolant and composition are discharged out of the housing (3800).
  • the support member may have a length that allows the composition that has escaped the guide structure (3200) to be frozen for a sufficient freezing time so as to increase the freezing rate. In other words, the support member can secure a freezing time that allows the composition to be sufficiently frozen. Accordingly, the support member may have a length greater than the recommended length required to achieve the expected freezing rate.
  • a plunger for pushing the composition into the guide structure (3200) may be included inside the composition reservoir (3400).
  • the plunger may include a grip portion that allows a user to remove or insert the plunger into the composition reservoir (3400). That is, the grip portion may be connected to the plunger. The user may remove the plunger from the composition reservoir (3400) using the grip portion and then refill the composition reservoir (3400) with the composition.
  • the plunger may be reinserted into the composition reservoir (3400) using the grip portion. At this time, the plunger must be inserted to a certain position within the composition reservoir (3400) so that a certain amount of the composition can be contained in the composition reservoir (3400).
  • the composition reservoir (3400) and the plunger may have a structure in which the grip portion is automatically detached from the plunger when the plunger is inserted to the predetermined position.
  • one end of the composition reservoir (3400) is covered with a lid, and the lid serves to protect the composition from leaking out.
  • the lid When the composition reservoir (3400) filled with the composition is inserted into the composition reservoir connection portion of the housing (3800), the lid is pierced or removed, and the inner wall of the composition reservoir connection portion of the housing (3800) and the outer wall of the composition reservoir (3400) are pressurized, so that one end of the composition reservoir (3400) can be sealed. Accordingly, the composition can be prevented from leaking to a place other than the movement channel for introducing it to the guide structure (3200).
  • the actuator (3500) may be a device that pushes the plunger of the composition reservoir (3400), and may provide a pushing force to the composition by pushing the plunger. At this time, the actuator (3500) may estimate the amount of the composition remaining in the current composition reservoir (3400) by calculating the distance that the plunger moves per unit time and the force applied by the actuator (3500) during the distance.
  • the composition injection device (3000) may further include a sensor that measures the amount of the composition remaining in the composition reservoir (3400), and the controller (not shown) described above may detect the amount of the remaining composition based on the value measured by the sensor. If, on the other hand, the coolant injection device (1000) described below is below a certain amount of the remaining composition, it may provide an alarm to the user.
  • FIG. 28 is a drawing for explaining an example of an implementation of a composition injection device (3000) according to the present disclosure.
  • the composition injection device (3000) may include a guide structure (3200), a coolant injection connector (3002), a seal (3810), a housing (3800), a composition reservoir (3400), and an actuator (3500).
  • the guide structure (3200) may be any one of the guide structures (3200) disclosed in [Structure of composition spraying device for increasing freezing ratio], [Structure of guide structure (3200) for increasing freezing ratio], and [Problem of non-uniform size of frozen particles when guide structure (3200) is a plate] as described above.
  • composition storage (3400) and the actuator (3500) are the composition storage (3400) and the actuator (3500) already described above, and the actuator (3500) may also be an actuator.
  • the coolant injection connector (3002) is a device for connecting the coolant injection unit (1200) and the composition injection device (3000).
  • the coolant injection connector (3002) may include a coolant inlet hole (3100) and a coolant injection receiving space (NAS).
  • the coolant inlet hole (3100) may be formed in the coolant injection connector (3002), and the coolant injection receiving space (NAS) may be fluidly connected to the coolant inlet hole (3100).
  • the coolant inlet hole (3100) may be an inlet that allows the coolant injected from the coolant injection unit (1200) to flow into the composition injection device (3000).
  • the coolant injection unit (1200) may be allowed to pass through the coolant injection unit receiving space (NAS) so that the orifice of the coolant injection unit (1200) is positioned within the composition injection device (3000).
  • the coolant injection unit receiving space (NAS) is coupled to the coolant injection unit (1200) or allows the coolant injection unit (1200) to pass therethrough.
  • the coolant injection unit connector (3002) may also include a composition inlet hole (3300) which is an inlet that allows the composition to flow into the guide structure (3200).
  • a movement channel groove (3001) may be formed on the outer surface of the coolant injection unit connector (3002) to extend between the coolant storage unit (3400) and the composition inlet hole (3300) and form a movement channel through which the composition can move.
  • the movement channel groove (3001) can become a movement channel for the composition to move from the composition storage (3400) to the composition inlet hole (3300).
  • the coolant injection connector (3002) and the housing (3800) can be coupled by a coupling member (3005), and the fixing member (3004) of the coolant injection connector (3002) enables the coolant injection device (1000) and the composition injection device (3000) to be coupled. If the coolant injection device (1000) and the composition injection device (3000) are implemented as an integrated unit, the fixing member (3004) may be omitted.
  • the coolant injection connector (3002) may include at least one protruding member (3003).
  • the number of protruding members (3003) of the coolant injection connector (3002) may be formed as many as the number of guide structures (3200) used in the composition injection device (3000). For example, if two guide structures (3200) are used in the composition injection device (3000), the number of protruding members (3003) may also be two, and if four guide structures (3200) are used in the composition injection device (3000), the number of protruding members (3003) may be four.
  • the protruding members (3003) may support the metal member (3200). Accordingly, damage such as bending of the guide structure (3200) may be prevented.
  • FIG. 30 shows examples in which a guide structure (3200) is mounted on a coolant injection connector (3002).
  • the coolant injection unit (1200) is mounted on the coolant injection receiving space (NAS) of the coolant injection connector (3002), and the guide structure (3200) is mounted on the protruding member (3003) of the coolant injection connector (3002), so that the relative positional relationship between the coolant injection unit (1200) and the guide structure (3200) can be precisely adjusted.
  • NAS coolant injection receiving space
  • the guide structure (3200) is mounted on the protruding member (3003) of the coolant injection connector (3002), so that the relative positional relationship between the coolant injection unit (1200) and the guide structure (3200) can be precisely adjusted.
  • the first end (3210) of the guide structure (3200) can be precisely adjusted at a predetermined distance (G) in a direction perpendicular to the central axis (CA) of the coolant injection unit (1200) and at a predetermined distance (d) along the central axis (CA) of the coolant injection unit (1200).
  • the seal (3810) can surround at least a portion of the side surface of the coolant injection connector (3002). At this time, the composition can be prevented from leaking out from the composition movement channel formed on the side surface of the coolant injection connector (3002). In addition, the seal (3810) can close a gap between the housing (3800) and the composition injection connector (3002). Specifically, the seal (3810) is positioned between the housing (3800) and the composition injection connector (3002) to close a gap that may occur when the housing (3800) is mounted on the composition injection connector (3002), thereby preventing the composition from leaking out of the housing (3800).
  • the housing (3800) can be coupled to the coolant injection connector (3002).
  • the housing (3800) can be coupled to the coolant injection connector (3002) after the guide structure (3200) is mounted on the coolant injection connector (3002).
  • the guide structure (3200) positioned between the coolant injection connector (3002) and the housing (3800) can be fixed.
  • the housing (3800) is mounted on the coolant injection connector (3002) to which the guide structure (3200) is mounted, the composition moving on the guide structure (3200) can be prevented from leaking to the outside.
  • the housing (3800) may include a front portion covering a portion of the guide structure (3200), a base covering a side of the coolant injection connector (3002), and a connecting member (3008) corresponding to a joining member (3005) formed on the coolant injection connector (3002).
  • Fig. 32 shows another embodiment of a composition injection device (3000).
  • the composition injection device (3000) may include a housing (3800), a coolant injection connector (3002), a guide structure (3200), and a composition reservoir (3400).
  • the composition injection device (3000) may further include an actuator (3500), a seal (3810), etc.
  • the coolant injection connector (3002), the guide structure (3200), the actuator (3500), the seal (3810), and the composition reservoir (3400) are the same as those described above and in Embodiment Example 1, and thus their descriptions will be omitted.
  • the coupling relationship and coupling method between each component are the same as those described in Embodiment Example 1, and thus their descriptions will be omitted.
  • the housing (3800) basically includes all the components of the housing (3800) described in Implementation Example 1. Therefore, the following description focuses on the additional components in Implementation Example 2 compared to Implementation Example 1.
  • Fig. 33 shows an enclosure (3900) that can constitute a component of a housing (3800).
  • the enclosure (3900) can include at least one external air inlet hole (3910) and at least one additional external air inlet hole (3920). Since the functions and uses of the enclosure (3900) and the external air inlet hole (3910) have been discussed in [Solution 1], a duplicate description will be omitted. Referring to Fig.
  • the external air inlet hole (3910) can be arranged so that, when looking at the inside of the enclosure (3900) from the outside of the enclosure (3900) along an imaginary line that vertically passes through the center point of the external air inlet hole (3910), the second outer surface and the coolant injection portion (1200) that directly collide with the coolant at the first end (3210) of the guide structure (3200) are visible.
  • outside air can be introduced between one inner surface of the coolant injection connector (3002) in which the coolant inlet hole (3100) is formed and the second outer surface of the guide structure (3200), and can meet at least a portion of the second outer surface of the guide structure (3200).
  • the outside air inlet holes can be arranged so that, while the coolant is being injected, the outside air can be introduced between one inner surface of the coolant injection connector (3002) and the second outer surfaces of the plurality of guide structures (3200), and can meet at least a portion of each of the second surfaces of the plurality of guide structures.
  • Fig. 35 shows that at least one additional outside air inlet hole (3920) is arranged.
  • the additional outside air inlet hole (3920) is not an essential component, adding an additional outside air inlet hole (3920) in addition to the outside air inlet hole (3910) can more effectively prevent the composition from freezing before it leaves the guide structure (3200) by lowering the temperature of the guide structure (3200).
  • the additional outside air inlet hole (3920) can be arranged in various positions.
  • the additional outside air inlet hole (3920) can be arranged so that outside air is introduced to the first outer surface of the guide structure (3200) that does not directly collide with the coolant while the coolant is being sprayed, so that the first outer surface and the introduced outside air can meet, as shown in (a) of Fig. 35.
  • the outside air introduced into the additional outside air inlet hole (3920) can mix with the stream of the sprayed coolant after meeting the first outer surface and can escape out of the inner space of the enclosure (3900).
  • the additional outside air inlet hole (3920) can be arranged so that the outside air introduced into both the first outer surface and the second outer surface of the guide structure (3200) can meet while the coolant is being sprayed.
  • the outside air that has met both the first outer surface and the second outer surface can also mix with the stream of the sprayed coolant and escape out of the inner space of the enclosure (3900).
  • a large number of outside air inlet holes (3910) and additional outside air inlet holes (3920) in the enclosure (3900) it is possible to effectively prevent the composition from freezing before it leaves the guide structure (3200).
  • Fig. 36 shows a view of a housing including an enclosure (3900).
  • the housing (3800) may include a housing body (3810) and an enclosure (3900).
  • the housing body (3810) is configured to surround a coolant injection connector (3002), thereby protecting the coolant injection connector (3002) from damage, and may be coupled with the coolant injection connector (3002) to form a movement channel (3001) that allows a composition to move from a composition reservoir (3400) to a composition inlet hole (3300) together with a movement channel groove formed on an outer surface of the coolant injection connector (3002).
  • FIG. 37 shows that the housing (3800) described in FIG. 36 further includes a supporting part (3820).
  • the supporting part (3820) is configured to maintain a constant distance between the coolant injection part (1200) and the target area as described above, and may have a length that allows the composition to be frozen for a sufficient freezing time to increase the freezing ratio.
  • the first end of the supporting part (3820) is coupled to the enclosure (3900), and the second end of the supporting part (3820) contacts the target area, thereby maintaining a constant distance between the coolant injection part (1200) and the target area.
  • the first end (3210) of the guide structure (3200) is positioned closer to the coolant inlet hole (3100) than the second end of the support (3820), so that a freezing time sufficient for the composition to be sufficiently frozen can be secured due to a constant distance maintained by the support (3820).
  • the support members (3820) there may be two or more support members (3820), and they may be arranged symmetrically around the imaginary central axis of the coolant spray member (1200) along the perimeter of the internal space of the enclosure (3900).
  • the arrangement of the support members (3820) as described above may form an inner passage through which the frozen particles can be sprayed together with the coolant and penetrate the target area, i.e., the skin.
  • Fig. 38 illustrates a tunnel forming member (3600) formed inside a housing (3800). That is, Fig. 38 shows that the housing (3800) and the tunnel forming member (3600) are implemented as one body. Referring to Fig. 38, the tunnel forming member (3600) is positioned inside the housing (3800) so as to be in physical contact with the first outer surface through which the composition moves in each of the guide structures (3200). Accordingly, after at least one guide structure (3200) is mounted on the coolant injection connector (3002), when the coolant injection connector (3002) and the housing (3800) are coupled, the tunnel forming member (3600) is in physical contact with the first outer surface, so that a tunnel through which the composition moves can be formed on a portion of the first outer surface of the guide structure (3200). For example, the tunnel forming member (3600) may be formed to protrude from the inner surface of the enclosure (3900) toward the housing body (3810).
  • the composition that has escaped the guide structure (3200) is frozen by the coolant and sprayed onto the target area (e.g., skin). Therefore, the composition spraying device (3000) must be used together with the coolant spraying device (1000). Meanwhile, since the coolant and the composition must be sprayed together, the control timing of the actuator (3500) and the control timing of the valve that allows the spraying of the coolant in the coolant spraying device (1000) must be synchronized.
  • the control timing of the actuator (3500) and the valve must be determined by considering the time it takes for the composition to move to the first end (3210) of the guide structure (3200) and the time it takes for the coolant to meet the first end (3210) of the guide structure (3200) after the valve opens.
  • the coolant injection device (1000) and the actuator (3500) may be provided with a terminal that can be connected electrically to synchronize the operation timing of the actuator (3500) and the operation timing of the valve.
  • a portion of the coolant sprayed from the coolant spray unit (1200) may be in a liquid and/or solid phase, and another portion may be in a gaseous phase.
  • the coolant in the liquid and/or solid phase may be mainly distributed in the mainstream (MS).
  • the coolant in the liquid and/or solid phase has a higher heat capacity or a colder temperature than the coolant in the gaseous phase, and accordingly, when the detached composition flows into the mainstream (MS) where the coolant in the liquid and/or solid phase is mainly distributed, the freezing ratio may be increased and the penetration power into the skin may be increased.
  • the coolant injection device (1000) and the composition injection device (3000) may be manufactured separately and then combined with each other, but the coolant injection device (1000) and the composition injection device (3000) may be manufactured as one unit by being integrated into one device.
  • the coolant injection device (1000) for injecting a coolant into a composition injection device (3000) will be described.
  • the coolant injected by the coolant injection device (1000) may be carbon dioxide (CO2), but is not limited thereto.
  • the coolant may be liquid nitrogen (LN), oxygen (O2), nitrous oxide (N2O), nitrogen monoxide (NO), a hydrofluorocarbon (HFC) series substance, methane (CH4), PFC, SF6, krypton, helium-3, ethyl chloride, dimethyl ether, chlorofluoromethane, chloromethane, propane, butane, coolant, coolant gas, air, or a combination thereof.
  • FIG. 40 illustrates a coolant injection device (1000) for injecting coolant into a composition injection device (3000) according to an embodiment of the present disclosure.
  • the coolant injection device (1000) may include a flow controller (1000), a coolant injection unit (1200), a controller (1300), and an I/O interface (1400).
  • the flow controller (1100) and the coolant injection unit (1200) are fluidly connected to a coolant storage (2000) via at least one conduit.
  • the flow controller (1100) and the coolant injection unit (1200) may be fluidly connected to each other via a first conduit
  • the flow controller (1100) and the coolant storage (2000) may be fluidly connected to each other via a second conduit.
  • the cartridge may be coupled to a coolant inlet module (not shown) of a coolant injection device (1000) for receiving the coolant from the cartridge, and the cartridge may be fluidly connected to the flow regulator (1100) through the second conduit.
  • a third conduit fluidly connected to the tank may be coupled to a coolant inlet module (not shown) of a coolant injection device (1000) for receiving the coolant from the tank, so that the tank and the flow controller (1100) may be fluidly connected through the second conduit and the third conduit.
  • the second conduit may be a conduit fluidly connecting the flow controller (1100) and the coolant inlet module.
  • the flow controller (1100) is a device that controls the flow of coolant and can allow the coolant to be transported to the coolant injection unit (1200).
  • the flow controller (1100) may be a valve. When the valve is open, the coolant can be transported from the valve toward the coolant injection unit (1200), and when the valve is closed, the coolant that does not pass through the valve cannot be transported toward the coolant injection unit (1200).
  • the amount of cooling energy per unit time provided to the target area can be controlled by using the flow controller (1100). For example, when the opening and closing cycle of the valve is controlled, the amount of coolant sprayed per unit time to the target area can be controlled.
  • the valve may be a solenoid valve, but is not limited thereto. That is, any valve that can control the flow rate of the coolant can be used as the flow controller (1100) according to the present disclosure.
  • the flow regulator (1100) may be referred to as a valve.
  • the coolant injection unit (1200) may include a structure for injecting coolant. Specifically, the coolant injection unit (1200) may extend from one end to the other to form a flow path for the coolant to flow, and may include a portion where the flow path is relatively narrow. The coolant passing through the coolant injection unit (1200) experiences increased pressure as it passes through the narrow portion, and as it is injected at atmospheric pressure, it expands due to the pressure drop, rapidly cools its temperature, and may be injected at high speed. In the present disclosure, the coolant injection unit (1200) may be referred to as a nozzle.
  • the coolant injection unit (1200) may be understood as a configuration including a flow path for injecting the coolant to the outside of the coolant injection device (1000).
  • the coolant injection unit (1200) may be detachably attached to the coolant injection device (1000).
  • the coolant injection unit (1200) may be coupled to or separated from the coolant injection device (1000) via an injection unit coupling unit (not shown).
  • the coolant injection unit (1200) may be physically connected to and integrally configured with the coolant injection device (1000).
  • An I/O interface may include an input unit and an output unit.
  • the input unit may be referred to as an input interface since it provides an interface, such as a switch, to receive a user's input.
  • the input unit may receive a user's input.
  • the user may control the temperature of the coolant storage (2000).
  • the user may input a temperature of the coolant storage (2000) that can create a desired penetration strength through the input unit, thereby allowing the coolant injection device (1000) to heat the coolant storage (2000).
  • the coolant storage (2000) may be a tank.
  • the penetration strength of the frozen particles can vary depending on the coolant velocity and temperature. For example, by lowering the coolant temperature to increase the freezing rate of the composition, the composition can freeze intact before fragmenting into sufficiently small particles, resulting in larger frozen particles. Since these larger frozen particles have a stronger penetration strength than smaller frozen particles at the same velocity, the penetration strength (i.e., the depth of penetration into the skin) of the frozen particles can be controlled by controlling the coolant temperature.
  • the speed of the coolant when the speed of the coolant increases, the amount of impact transmitted to the frozen particles when the coolant and the frozen particles collide increases, which increases the speed of the frozen particles, and accordingly, the penetration strength of the frozen particles increases, and the depth of penetration into the skin can become deeper.
  • the speed of the coolant injected can be controlled by the pressure of the coolant reservoir (2000) that changes according to the temperature of the coolant reservoir (2000), the speed of the coolant can be controlled by controlling the temperature of the coolant reservoir (2000).
  • the user can control the penetration intensity of the frozen particles by inputting the temperature of the coolant storage (2000) through the input unit according to the desired penetration depth of the frozen particles into the skin.
  • the output unit may be called an output interface since it provides an interface for outputting various information for using the coolant injection device (1000) to the user.
  • the output unit may include a display, and real-time temperature of the target area, etc. may be output through the display.
  • the output unit may display the number of times the coolant has been injected or the number of times the coolant is left to be injected.
  • the number of times the coolant has been injected or the number of times the coolant is left to be injected may refer to the number of times the coolant has been injected since the coolant reservoir (2000) was first connected to the coolant injection device (1000), or may refer to the number of times the coolant is currently left to be injected based on the time point at which the coolant was first injected since the coolant reservoir (2000) was first connected to the coolant injection device (1000).
  • the coolant reservoir (2000) may be a cartridge.
  • the output unit may display a predetermined number of times the coolant is injected when the coolant reservoir (2000) is connected to the coolant injection device (1000).
  • the predetermined number of coolant injections may be determined based on the type of composition to be injected together with the coolant and/or the condition of the skin to which the composition is to be injected or information about the subject person. If the output unit displays the predetermined number of coolant injections, the user can refer to the displayed number of coolant injections and spray the coolant according to the displayed number of coolant injections. In addition, the output unit may also display the injection time for each injection of the coolant.
  • the controller (1300) can be electrically connected to the flow controller (1100) and the I/O interface (1400). In addition, the controller (1300) can control components electrically connected to the controller (1300). For example, when the controller (1300) receives a coolant injection command signal from the I/O interface (1400), it can control the opening and closing of the flow controller (1100) to inject coolant.
  • the controller (1300) may store at least one of an opening/closing cycle, an opening/closing time, and the number of openings/closing per unit time according to a preset temperature, and may retrieve at least one of the opening/closing cycle, the opening/closing time, and the number of openings/closing per unit time of the flow controller (1100) based on the preset temperature. Then, the controller (1300) may control the opening/closing of the flow controller (1100) to spray the coolant according to at least one of the retrieved opening/closing cycle, the opening/closing time, and the number of openings/closing per unit time.
  • the preset temperature may be a temperature of the target area that prevents the skin, which is the target area, from being supercooled and prevents an ice layer that impedes the penetration of the frozen particles into the skin from being formed on the skin.
  • the preset temperature may be 0 degrees or higher, and accordingly, the controller (1300) may control the opening/closing cycle, the opening/closing time, and the number of openings/closing per unit time of the flow controller (1100) so that the temperature of the target area becomes 0 degrees or higher.
  • the controller (1300) according to the present disclosure may be electrically connected to the actuator (3500) of the composition injection device (3000) as described above. And, the controller (1300) may control the actuator (3500). For example, the controller (1300) may control the pushing force provided to the composition by controlling the pushing force of the actuator (3500) on the plunger included in the composition reservoir (3400).
  • the actuator (3500) described in the present disclosure is not necessarily controlled by the controller (1300) of the coolant injection device (1000), and the actuator (3500) may have a separate controller so that the actuator (3500) may be controlled separately.
  • the controller (1300) of the actuator (3500) and the coolant injection device (100) may need to be synchronized.
  • the coolant injection device (1000) may further include a temperature sensor (not shown).
  • the temperature sensor (not shown) may measure the temperature of a target area where the coolant is injected to obtain temperature information of the target area.
  • the temperature sensor (not shown) may provide the obtained temperature information to the controller (1300).
  • the number of temperature sensors (not shown) included in the coolant injection device (1000) may be one or more. For example, one temperature sensor may measure the temperature of the target area and provide the obtained temperature information to the controller (1300), or two or more temperature sensors may each measure the temperature of the target area and provide the obtained temperature information to the controller (1300).
  • a temperature sensor may measure the temperature of a conduit included in the coolant injection device (1000).
  • the coolant injection device (1000) may include at least one of a first temperature sensor for measuring the temperature of the first conduit and a second temperature sensor for measuring the temperature of the second conduit.
  • the first temperature sensor and the second temperature sensor may provide the measured temperature to the controller (1300).
  • the method by which the controller (1300) controls the opening and closing of the flow controller (1100) may vary. For example, while the coolant is being injected, the controller (1300) may obtain temperature information through the temperature sensor (not shown), and, based on the obtained temperature information, determine at least one of the opening and closing cycle, the opening and closing time, and the number of openings and closings per unit time of the flow controller (1100), thereby controlling the opening and closing of the flow controller (1100) to inject the coolant.
  • the controller (1300) may control at least one of the opening and closing cycle, the opening and closing time, and the number of openings and closings per unit time of the flow controller (1100), based on the temperature information obtained from the temperature sensor (not shown), so that the skin, which is the target area, is not supercooled and an ice layer that impedes the penetration of the frozen particles into the skin is not formed on the skin.
  • the coolant injection device (1000) according to FIG. 40 may further include a memory (not shown).
  • the memory (not shown) may store basic programs for operating the coolant injection device (1000) according to a user's command.
  • the memory (not shown) may map and store the set temperature and the temperature that can be measured through the temperature sensor and the opening/closing cycle, opening/closing time, and the number of openings/closing times per unit time of the flow controller (1100).
  • the controller (1300) determines the opening/closing cycle, opening/closing time, and the number of openings/closing times per unit time of the flow controller (1100) based on the measured temperature information, and controls the flow controller (1100) accordingly.
  • FIG. 41 illustrates another example of a coolant injection device (1000) that injects coolant into a composition injection device (3000) according to an embodiment of the present disclosure.
  • the coolant injection device (1000) may include a flow controller (1100), a temperature controller (1500), a coolant injection unit (1200), a controller (1300), a temperature sensor (1600), and an I/O interface (1400).
  • the flow controller (1100), the temperature controller (1500), and the coolant injection unit (1200) are fluidly connected to a coolant storage (2000) via at least one conduit.
  • the flow controller (1100) and the temperature controller (1500) may be fluidly connected via a first conduit
  • the temperature controller (1500) and the coolant injection unit (1200) may be fluidly connected via a second conduit.
  • the flow controller (1100) and the temperature controller (1500) may be fluidly connected through a first conduit, and the flow controller (1100) and the coolant injection unit (1200) may be fluidly connected through a second conduit.
  • the coolant storage unit (2000) may be fluidly connected to the flow controller (1100) or the temperature controller (1500) through a third conduit.
  • the cartridge when the coolant storage unit (2000) is a cartridge, the cartridge may be coupled to a coolant inlet module (not shown) of a coolant injection unit (1000) for receiving the coolant from the cartridge, and the cartridge may be fluidly connected to the flow controller (1100) or the temperature controller (1500) through the third conduit.
  • a fourth conduit fluidly connected to the tank may be coupled to a coolant inlet module (not shown) of a coolant injection device (1000) for receiving the coolant, so that the tank and the flow controller (1100) may be fluidly connected through the third conduit and the fourth conduit.
  • the third conduit may be a conduit that fluidly connects the flow controller (1100) or the temperature controller (1500) and the coolant inlet module.
  • the flow controller (1100), the coolant injection unit (1200), the temperature sensor (1600), and the I/O interface (1400) are the same as the flow controller (1100), the coolant injection unit (1200), and the I/O interface (1400) in the above-described “Composition 1 of the coolant injection device (1000),” and therefore, any duplicate description will be omitted.
  • the temperature controller (1500) is a device for controlling the temperature of a coolant passing through the temperature controller (1500).
  • the temperature controller (1500) may control the temperature of the coolant by heating the coolant under the control of the controller (1300).
  • the temperature controller (1500) may be referred to as a heater.
  • the temperature controller (1500) may control the temperature of the coolant by expanding or compressing the coolant under the control of the controller (1300).
  • the temperature controller (1500) may be referred to as a pressure regulator.
  • the temperature controller (1500) may include a fifth conduit that allows the coolant to pass through the temperature controller (1500).
  • the temperature controller (1500) can heat the coolant using a thermoelectric element disposed around the fifth conduit, or can control the temperature of the coolant by controlling the pressure of the coolant using an expander/compressor disposed at either end of the fifth conduit or between the fifth conduits.
  • the temperature sensor (1600) can measure the temperature of the target area where the coolant is sprayed to obtain temperature information of the target area.
  • the temperature sensor (1600) can measure the temperature of the third conduit positioned between the coolant storage (15000) and the flow controller (1100) or the temperature controller (1500) and the fifth conduit included in the temperature controller (1500).
  • a first temperature sensor for measuring the temperature of the third conduit and a second temperature sensor for measuring the temperature of the fifth conduit may be included in the coolant spray device (1000).
  • the controller (1300) may be electrically connected to a flow controller (1100), a temperature controller (1500), a temperature sensor (1600), and an I/O interface (1400). In addition, the controller (1300) may control components electrically connected to the controller (1300). For example, when the controller (1300) receives an injection command signal from the I/O interface (1400), the controller (1300) may control the opening and closing of the flow controller (1100) so that the coolant is injected.
  • the controller (1300) may control the temperature controller (1500) to control the temperature of the coolant.
  • the controller (1300) may supply power to the temperature controller (1500) so that thermal energy for heating the coolant may be generated in the temperature controller (1500).
  • the controller (1300) may control the temperature controller (1500) so that the coolant expands or compresses within the temperature controller (1500) to control the temperature of the coolant.
  • the controller (1300) can control the temperature controller (1500) to expand the coolant to lower the temperature of the coolant by the Joule-Thomson effect, or to compress the coolant to raise the temperature of the coolant.
  • the controller (1300) can control the temperature controller (1500) based on the temperature information received from the temperature sensor (1600) and the preset temperature. For example, when the controller (1300) receives the injection command signal from the I/O interface (1400), it can control the opening and closing of the flow controller (1100) to inject the coolant. Meanwhile, the controller (1300) can obtain temperature information by measuring the temperature of the target area where the coolant is to be injected through the temperature sensor (1600) while the coolant is being injected, and control the power so that the power determined based on the obtained temperature information and the preset temperature is applied to the temperature controller (1500). Alternatively, the temperature controller (1500) can be controlled so that the coolant is expanded or compressed based on the obtained temperature information and the preset temperature.
  • the controller (1300) may obtain temperature information by measuring the temperatures of the third conduit and the fifth conduit through the temperature sensor (1600) while the coolant is being sprayed, and control power so that power determined based on the obtained temperature information and the preset temperature is applied to the temperature controller (1500).
  • the temperature controller (1500) may be controlled so that the coolant expands or compresses based on the obtained temperature information and the preset temperature.
  • the coolant injection device (1000) may not include a temperature sensor (1600).
  • the controller (1300) may control the temperature controller (1500) according to the predetermined heating amount or power amount that allows the coolant to have a temperature that prevents the skin, which is the target area, from being supercooled and prevents the formation of an ice layer that prevents the penetration of frozen particles into the skin.
  • the controller (1300) may control the temperature controller (1500) according to the predetermined pressure of the coolant that allows the coolant to have a temperature that prevents the skin, which is the target area, from being supercooled and prevents the formation of an ice layer that prevents the penetration of frozen particles into the skin.
  • the coolant injection device (1000) according to FIG. 41 may further include a memory (not shown).
  • the memory (not shown) may store the amount of heating or power to be applied to the temperature controller (1500) according to the preset temperature, or the amount of heating or power to be applied to the temperature controller (1500) according to the temperature of the measured target area, or the amount of heating or power to be applied to the temperature controller (1500) according to the temperature of the measured third and fifth conduits.
  • the memory may store the pressure of the coolant to be applied to the temperature controller (1500) according to the preset temperature, or the pressure of the coolant to be applied to the temperature controller (1500) according to the temperature of the measured target area, or the pressure of the coolant to be applied to the temperature controller (1500) according to the temperature of the measured third and fifth conduits.
  • Fig. 42 shows that the coolant storage (2000) is a cartridge. If the coolant storage (2000) is a cartridge, as described above, it is connected to the coolant inlet module of the coolant injection device (1000), so that the coolant stored in the cartridge can be transferred to the coolant injection device (1000). Meanwhile, the cartridge is a highly portable container designed to safely and efficiently store and transport the coolant. When such a cartridge is coupled to the coolant injection device (1000), the coolant injection device (1000) can be used in a portable manner, thereby increasing the convenience of use.
  • the cartridge can store the coolant under a certain pressure, and the pressure can be determined between about 35 bar and 1000 bar at 0 to 40°C, for example, between about 35 bar and 100 bar.
  • the coolant storage unit (2000) is a cartridge
  • the coolant injection device (1000) injects coolant
  • the amount of coolant stored in the cartridge decreases, lowering the internal temperature of the cartridge and thus reducing the pressure inside the cartridge.
  • the pressure inside the cartridge decreases
  • the pressure of the coolant when the coolant is injected through the coolant injection unit (1200) also decreases.
  • the degree of adiabatic expansion of the injected coolant decreases, and as the temperature of the injected coolant increases, the density of the liquid and/or solid coolant (e.g., dry ice if the coolant is CO2) contained in the mainstream (MS) continuously decreases, and the velocity of the coolant also decreases.
  • the proportion of the composition sucked into the mainstream (MS) also decreases, and the freezing ratio of the composition may decrease. Therefore, as more coolant is injected, the freezing ratio gradually decreases, resulting in a problem of reduced penetration of the composition.
  • a method is required to maintain the density of the liquid and/or solid phase coolant in the mainstream (MS) so as to maintain the freezing ratio of the composition introduced into the mainstream (MS).
  • Figure 43 is a drawing illustrating a method for maintaining the density of a liquid and/or solid coolant within a mainstream (MS).
  • the operation of the coolant injection device (1000) is performed under the control of the controller (1300) of the coolant injection device (1000).
  • the coolant injection device (1000) injects coolant (S4301).
  • the coolant injection device (1000) measures the temperature of each of the third conduit and the fifth conduit included in the temperature controller (1500) located between the coolant inlet module and the flow controller (1100) or the temperature controller (1500) through at least one temperature sensor (1600) within the coolant injection device (1000) (S4303).
  • the temperature of the third conduit is measured because the third conduit is the temperature of the coolant that has just exited the cartridge, and since the pressure also decreases when the temperature inside the cartridge decreases, the pressure inside the cartridge can be inferred by measuring the temperature of the coolant.
  • the temperature of the fifth conduit is measured because the temperature of the third conduit and the temperature of the fifth conduit can be compared to determine how much the temperature of the coolant passing through the fifth conduit should be changed.
  • the coolant injection device (1000) can determine the amount of heating of the temperature controller (1500) or the amount of power to be applied to the temperature controller (1500) based on the temperature of the third conduit and the temperature of the fifth conduit.
  • the coolant injection device (1000) can determine the pressure of the coolant to be controlled by the temperature controller (1500) based on the temperature of the third conduit and the temperature of the fifth conduit (S4305).
  • the coolant injection device (1000) can determine the amount of heating, the amount of power, or the pressure of the coolant through calculation by inputting the temperature of the third conduit and the temperature of the fifth conduit into a preset function.
  • the coolant injection device (1000) may determine the heating amount, power amount, or coolant pressure by loading the heating amount, power amount, or coolant pressure that matches the temperature of the third conduit and the temperature of the fifth conduit from a look-up table that is stored in advance.
  • the determined heating amount, power amount, or coolant pressure is the heating amount, power amount, or coolant pressure that maintains the density of the liquid and/or solid coolant in the mainstream, such that the freezing rate of the composition introduced into the mainstream is maintained while the density of the liquid and/or solid coolant is maintained.
  • the heating amount, power amount, or coolant pressure can prevent an ice layer that impedes the penetration of freezing particles into the skin from being formed on the surface of the target area.
  • the coolant injection device (100) can determine the amount of heating, the amount of power, or the pressure of the coolant so that the coolant has a temperature that can prevent an ice layer from forming on the surface of the target area, which prevents the freezing particles from penetrating the skin, while maintaining the density of the liquid and/or solid coolant in the mainstream based on the temperature of the third conduit and the temperature of the fifth conduit. Meanwhile, the temperature of the coolant must be at least below 0 degrees Celsius for the composition to freeze. In addition, since the basic body temperature of human skin is about 35 to 37 degrees Celsius, even if the temperature of the coolant is below 0 degrees Celsius, the temperature of the target surface may be above 0 degrees Celsius, preventing the formation of an ice layer.
  • the temperature of the coolant is determined to be a temperature that makes the temperature of the target surface above 0 degrees Celsius while the temperature of the coolant is below 0 degrees Celsius, and the amount of heating, the amount of power, or the pressure of the coolant corresponding to this can be determined.
  • the coolant injection device (1000) can heat or expand/compress the coolant passing through the fifth conduit according to the determined heating amount, power amount, or pressure of the coolant (S4307).
  • the coolant injection device (1000) can control the temperature controller (1500) to gradually reduce the amount of heating of the coolant so that the temperature of the coolant passing through the fifth conduit continues to decrease, or to gradually reduce the pressure of the coolant. That is, as the coolant is injected in the above-described S4305, the amount of heating, power, or pressure of the coolant determined by the coolant injection device (1000) can gradually decrease.
  • the temperature of the cartridge can be controlled within a certain range to maintain the density of the liquid and/or solid coolant included in the mainstream (MS).
  • a cartridge temperature controller capable of heating the outside of the cartridge to increase the temperature inside the cartridge
  • the temperature inside the cartridge can be maintained within a certain range through the cartridge temperature controller, thereby maintaining the density of the liquid and/or solid coolant included in the mainstream (MS).
  • FIG 44 illustrates that the coolant storage unit (2000) is a tank.
  • the tank may be a large storage vessel for storing a large amount of coolant.
  • the tank may be placed within a housing for protecting the tank. Additionally, the tank within the housing may be fluidly connected to the coolant injection device (1000) via a hose. That is, the coolant stored in the tank is delivered to the coolant injection device via the hose.
  • the tank may restrict the mobility of the coolant injection device (1000), it may store a large amount of coolant, thereby reducing the number of times the coolant storage unit (2000) must be filled and/or replaced, thereby increasing the continuity of use of the coolant injection device (1000).
  • a separate tank temperature controller can be placed within the housing, and the temperature of the tank can be increased or decreased through the tank temperature controller, thereby controlling the temperature of the tank within a certain range.
  • Increasing the temperature of the tank increases the temperature of the coolant stored in the tank, which can increase the pressure of the coolant. Therefore, even if the coolant injection device (1000) continuously injects the coolant and the pressure inside the tank decreases, the density of the liquid and/or solid coolant within the mainstream (MS) can be maintained by increasing the temperature of the tank and thus increasing the pressure inside the tank.
  • the coolant storage unit (2000) is a tank, unlike when it is a cartridge, there is an advantage in that the density of the liquid and/or solid coolant within the mainstream (MS) can be maintained even without using a method such as that shown in FIG. 42.
  • the penetration strength of the frozen particles can be increased by increasing the temperature of the tank. That is, when the pressure of the coolant is high, the difference with the atmospheric pressure becomes large, the adiabatic expansion effect occurs significantly, and accordingly, the temperature of the injected coolant becomes lower and the speed of the injected coolant becomes faster.
  • increasing the temperature of the tank can increase the freezing rate and the speed of the frozen particles, thereby increasing the penetration strength of the frozen particles into the skin. Therefore, the penetration strength of the frozen particles into the skin can be controlled by adjusting the temperature of the tank.
  • the coolant storage (2000) of the coolant injection device (1000) can be used alternately as a cartridge and a tank.
  • the hose of the tank is made detachable and the tank is connected to the coolant injection device (1000), and then the coolant injection device (1000) needs to be moved, or if the coolant stored in the tank is unexpectedly exhausted, the hose of the tank can be separated from the coolant injection device (1000) and the cartridge can be connected to the coolant injection device (1000) for use.
  • a sealing portion can be attached to the end of the hose of the tank to prevent the coolant from leaking out from the tank.
  • the above sealing member may be positioned at the end of the hose of the tank, and may be inserted into the hose of the tank by a force generated when connecting to the coolant injection device (1000), and then separated and returned to the end of the hose of the tank to seal.
  • the sealing member may be attached to the end of the hose of the tank using a magnet or screw thread, etc.
  • the coolant spraying device (1000) may be configured with a single spraying time during which the coolant continues to spray when sprayed once, and a spraying interruption time during which the spraying is interrupted until the next spray after the single spraying is completed.
  • the single spraying time and the spraying interruption time may be input by a user through the I/O interface (1400) of the coolant spraying device (1000).
  • the coolant injection device (1000) can repeatedly perform the steps of injecting coolant for a set injection time and then stopping the coolant injection for a set injection pause time.
  • the single injection time and the injection pause time may be the same, but may also be different.
  • the single injection time may be set longer than the injection pause time to allow more frozen particles to penetrate the target area.
  • the injection pause time may be set longer than the single injection time to minimize the risk of the target area becoming supercooled.
  • the single injection time and the injection stop time can be set as a constant injection cycle.
  • the constant injection cycle can be set in units of Hz.
  • the coolant injection device (1000) can repeatedly perform the process of injecting the coolant for 0.25 seconds and stopping the coolant injection for 0.25 seconds.
  • the injection time and the injection stop time may be the same, but are not limited thereto.
  • the injection time and the injection stop time may be set to be different.
  • [2] Provides an alarm to allow the coolant injection device (1000) to change the target area.
  • a target area change cycle may be set, and the target area may be changed accordingly.
  • the change cycle may be determined based on the type of composition, the purpose of the treatment/procedure, the individual skin type of the person to whom the composition is sprayed, etc.
  • the coolant spray device (1000) can provide an alarm to the user whenever the change cycle elapses so that the user can change the target area at each change cycle.
  • the change cycle may be the same as the above-described constant spray cycle.
  • the spray cycle is 2 Hz as in the above-described example, the target area may be changed too frequently, which may not allow sufficient penetration of the composition and may cause the user to be too busy to change the target area. Therefore, the change cycle may be set to an integer multiple of the above-described constant spray cycle.
  • an alarm may be provided when one spray time has elapsed so that the target area is changed during the spray stop time, but for the same reason as described above, an alarm may be provided when several times one spray time has elapsed so that the target area is changed.
  • the change cycle may be set independently, regardless of the spray time, spray stop time, and spray cycle.
  • Experimental Example #1 is an experiment to show that freezing the composition in a solid state and allowing it to penetrate the skin is more effective than allowing it to penetrate the skin in a liquid state.
  • Experimental Group 1 and Experimental Group 2 were prepared.
  • Experimental Group 1 was prepared by injecting the composition into the Ice Needling Module (a composition injection device according to the present disclosure) of Licensmedical, a composition injection device having a relatively high freezing ratio of the composition.
  • Experimental Group 2 was prepared by injecting the composition into the Boosting Container Type 1 (AS00000017) of Licensmedical, a composition injection device having a relatively low freezing ratio of the composition.
  • human-derived skin tissue for experimental group 1 and human-derived skin tissue for experimental group 2 were prepared, and their sizes were identical.
  • compositions used in experimental group 1 and experimental group 2 were both identical, and acetyl hexapeptide-8 conjugated with a fluorescent substance (FITC) to confirm the penetration effect was included in both the compositions used in experimental group 1 and experimental group 2.
  • FITC fluorescent substance
  • the coolant spraying device for spraying coolant to the composition spraying devices of experimental groups 1 and 2 used Target Cool from Licensmetical. Meanwhile, the material used as the coolant was liquefied carbon dioxide.
  • the Target Cool which is connected to a cartridge filled with a coolant, was connected to the Ice Needling module, and the coolant and composition were sprayed together on human-derived skin tissue.
  • a Boosting Container Type 1 was connected to the Target Cool.
  • the cartridge was replaced with a new cartridge filled with a coolant.
  • the coolant and composition were sprayed together targeting human-derived skin tissue different from the human-derived skin tissue used in Test Group 1.
  • Figures 45 and 46 show the experimental results of Experimental Example #1. Referring to Figures 45 and 46, it can be seen that the degree of penetration of the composition into the skin of Test Group 1 is significantly higher than that of Test Group 2. Referring to Figure 45, the fluorescence intensity was 2136.44 in Test Group 1, and the fluorescence intensity was 1399.54 in Test Group 2. Through this, it can be seen that the degree of penetration of the composition into the skin of Test Group 1 is significantly higher than that of Test Group 2. Meanwhile, when the freezing ratio of Test Group 1 was measured, the freezing ratio was 17% (about 12% to about 22% with a measurement error of 5%), and when the freezing ratio of Test Group 2 was measured, the freezing ratio was 5% (about 4% to about 6% with a measurement error of 5%).
  • Experimental Example #2 is an experiment to determine whether it is more effective to place the first end of the guide structure in the main stream or the substream of the coolant stream as described above.
  • Two needles were prepared for injecting the composition into the coolant stream. Both needles were identical, syringe-shaped, with a pointed tip and a central passageway through which the composition could be injected into the coolant stream.
  • the two needles were made of thermally conductive stainless steel (SUS).
  • Target Cool from License Medical was used as a coolant injection device.
  • the coolant was liquefied carbon dioxide.
  • the tip of the needle was positioned directly in front of the center of the nozzle of the coolant injection device, and the coolant was sprayed while injecting the composition.
  • the center of the nozzle of the coolant injection device is where the mainstream stream must be, so when the coolant is sprayed, the tip of the needle is positioned in the mainstream stream.
  • the cartridge of the coolant injection device was replaced, and another needle was prepared. Then, while injecting the coolant, the tip of the other needle, which was injecting the composition, was positioned within the substream, but the tip of the other needle was gradually moved closer to the boundary between the substream and the main stream. The composition was then observed being injected.
  • Figure 47 shows the experimental results when the tip of the needle was placed directly in front of the center of the nozzle of the coolant injection device (i.e., the mainstream).
  • the tip of the needle when the tip of the needle was placed in the mainstream, it could be seen that the tip of the needle froze immediately.
  • the tip of the needle froze before the composition even moved to the tip of the needle, confirming that the composition was not injected into the coolant stream.
  • the mainstream did not form a laminar flow, but rather a turbulent flow.
  • Figure 48 shows the experimental results when the tip of the needle was placed in the substream, but close to the boundary between the main stream and the substream. Referring to Figure 47, it can be seen that the needle did not freeze and the composition was evenly sprayed. Furthermore, although there was a slight change in the stream shape, the laminar flow characteristics of the main stream did not change enough to affect the spraying and freezing of the composition. Furthermore, it was confirmed that the composition was introduced into the main stream due to the pressure difference and frozen.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)

Abstract

La présente divulgation concerne un dispositif de pulvérisation de composition pour pulvériser une composition congelée par un fluide de refroidissement. En particulier, le dispositif de pulvérisation de composition peut comprendre : une enceinte fournissant un espace interne dans lequel une composition entre en contact avec un fluide de refroidissement ; un trou d'entrée de composition qui est une entrée à travers laquelle la composition s'écoule dans l'espace interne ; un trou d'entrée de fluide de refroidissement permettant au fluide de refroidissement d'être pulvérisé dans l'espace interne ; et une structure de guidage pour déplacer la composition, qui s'est écoulée depuis le trou d'entrée de composition, vers le fluide de refroidissement qui est pulvérisé.
PCT/KR2025/004436 2024-04-25 2025-04-03 Dispositif de pulvérisation de composition et système de pulvérisation le comprenant Pending WO2025225923A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020250052802A KR20250156642A (ko) 2024-04-25 2025-04-23 피부 침투가 가능한 크기를 가지는 동결된 조성물 입자를 피부에 충돌시키는 방법 및 이를 수행하는 시스템
PCT/KR2025/005483 WO2025226030A1 (fr) 2024-04-25 2025-04-23 Procédé de collision de particules de composition congelées présentant une taille capable de pénétrer dans la peau avec la peau et système pour sa mise en œuvre

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KR20240055535 2024-04-25
KR10-2024-0055535 2024-04-25

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3821845B2 (ja) * 1994-10-26 2006-09-13 フラウンホーフアー−ゲゼルシヤフト ツール フエルデルング デル アンゲバンテン フオルシユング エー フアウ 生物学的物質の凍結保存と低温処理方法
US20070092545A1 (en) * 2005-10-25 2007-04-26 Isidore Bale Aerosol coolant spray for killing and removing ticks
KR100906754B1 (ko) * 2001-06-15 2009-07-09 오츠카 세이야쿠 가부시키가이샤 경폐 투여용 건조 분말 흡입 디바이스
KR20230160792A (ko) * 2021-01-20 2023-11-24 알2 테크놀로지스, 인크. 냉각, 국소제 및/또는 마모를 이용하는 피부과 처리및 시스템
KR102638608B1 (ko) * 2022-11-11 2024-02-21 주식회사 리센스메디컬 냉각제 공급 장치에 이용되는 혼합 모듈

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3821845B2 (ja) * 1994-10-26 2006-09-13 フラウンホーフアー−ゲゼルシヤフト ツール フエルデルング デル アンゲバンテン フオルシユング エー フアウ 生物学的物質の凍結保存と低温処理方法
KR100906754B1 (ko) * 2001-06-15 2009-07-09 오츠카 세이야쿠 가부시키가이샤 경폐 투여용 건조 분말 흡입 디바이스
US20070092545A1 (en) * 2005-10-25 2007-04-26 Isidore Bale Aerosol coolant spray for killing and removing ticks
KR20230160792A (ko) * 2021-01-20 2023-11-24 알2 테크놀로지스, 인크. 냉각, 국소제 및/또는 마모를 이용하는 피부과 처리및 시스템
KR102638608B1 (ko) * 2022-11-11 2024-02-21 주식회사 리센스메디컬 냉각제 공급 장치에 이용되는 혼합 모듈

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