WO2025205042A1 - Usage method for topical agent composition and topical agent composition - Google Patents

Abstract

Provided are a usage method for a topical agent composition and a topical agent composition that make it possible for an oil-soluble component of the topical agent composition to achieve effective penetration. According to the present invention, a usage method for a topical agent composition involves applying a topical agent composition that includes water and solubilized micelles that encapsulate an oil-soluble component in a surfactant to a body surface, applying energy to the body surface to which the topical agent composition has been applied from above the topical agent composition using a beauty apparatus, and allowing the solubilized micelles to penetrate in from the body surface.

Description

Method of using topical composition and topical composition

The present disclosure relates to a method for using a topical composition and the topical composition.

In recent years, topical compositions such as beauty serums are often used in conjunction with beauty devices such as facial massagers.

For example, Patent Document 1 proposes a skin treatment device that includes an electric circuit that generates a specific output waveform to the skin via electrodes.
Such a skin treatment device can effectively increase the penetration effect of active ingredients into the user's skin.

International Publication No. 2023/095688

However, when it comes to topical compositions used in conjunction with beauty devices, methods for effectively penetrating the oil-soluble ingredients in the topical compositions have not yet been fully explored.

The present disclosure therefore aims to provide a method for using an external preparation composition and an external preparation composition that allows the oil-soluble components in the composition to penetrate effectively.

The present disclosure includes the following aspects.
[1] A topical composition containing water and a solubilized micelle in which an oil-soluble component is encapsulated in a surfactant is applied to a body surface,
A method of using the topical composition (excluding medical procedures) comprises applying energy to the body surface to which the topical composition has been applied using a beauty device, thereby causing the solubilized micelles to penetrate from the body surface to its interior.
[2] A composition comprising water and a solubilizing micelle in which a surfactant encapsulates an oil-soluble component,
An external preparation composition to be used in combination with a beauty device.

The present disclosure provides a method for using an external preparation composition and an external preparation composition that allows the oil-soluble components in the external preparation composition to penetrate effectively.

FIG. 1 is a schematic diagram illustrating the structure of a solubilizing micelle. FIG. 2 is a schematic diagram illustrating, as an example, the mechanism by which an external preparation composition containing solubilized micelles is applied to the skin and energy is applied using a skin cosmetic device, causing the solubilized micelles to penetrate from the surface of the skin to its interior. FIG. 3 is a schematic diagram illustrating, as an example, the mechanism by which an external preparation composition containing negatively charged solubilized micelles is applied to the skin and energy is applied using a skin cosmetic device, causing the negatively charged solubilized micelles to penetrate from the surface of the skin to its interior. FIG. 4 is a schematic diagram illustrating, as an example, the mechanism by which an external preparation composition containing solubilized micelles with water-soluble components attached thereto is applied to the skin, and energy is applied using a skin cosmetic device, causing the solubilized micelles with water-soluble components attached thereto to penetrate from the surface of the skin into its interior. FIG. 5 is a graph comparing the changes in the improvement rate of the stratum corneum moisture content between Examples 1 and 2 and Comparative Example 1.

One embodiment of the present disclosure will be described in detail below, but the scope of the present disclosure is not limited to the embodiment described herein, and various modifications may be made without departing from the spirit of the present disclosure. Each aspect disclosed in this specification can be combined with any other feature disclosed in this specification. Note that in this disclosure, a combination of preferred aspects is a more preferred aspect. Furthermore, when multiple upper and lower limit values are listed for a specific parameter, any of these upper and lower limit values can be combined to form a suitable numerical range. Furthermore, the lower and/or upper limit values of a numerical range described in this disclosure are numerical values within that numerical range and may be replaced with numerical values shown in the examples. The expression "X to Y" indicating a numerical range means "greater than or equal to X and less than or equal to Y." If a specific description given for one embodiment also applies to other embodiments, that description may be omitted in other embodiments.

[Method of using the topical composition]
The method of using the topical composition of the present disclosure (excluding medical procedures) involves applying the topical composition, which contains water and solubilized micelles formed by surfactants encapsulating oil-soluble components, to a body surface, and then applying energy from above the topical composition using a beauty device to the body surface to which the topical composition has been applied, thereby allowing the solubilized micelles to penetrate from the body surface into the interior.

The method of using the topical composition disclosed herein is believed to enable the oil-soluble components in the topical composition to penetrate effectively, due to the above-described configuration.

It is not clear why the method of using the topical composition disclosed herein achieves the above-mentioned effects, but one possible reason is as follows.

In general, oil-soluble and water-soluble components contained in topical preparation compositions are not sufficiently absorbed even when applied directly to the body surface. Specifically, for example, (1) the surface of the skin has a stratum corneum, which has a high defensive function, making it difficult for useful components to penetrate into the stratum corneum, and (2) hair has a cuticle, making it difficult for the above components to penetrate into the hair, even if it is damaged.
It is generally known that oil-soluble components penetrate relatively easily from the body surface to the interior thereof compared with water-soluble components. However, in the case of an oil-in-water topical composition, it is difficult to uniformly disperse the oil-soluble components in the topical composition in the first place, and when the topical composition is applied to the body surface, the oil-soluble components remain on the body surface, preventing sufficient penetration from the body surface to the interior thereof.

As a result of extensive research, the inventors discovered that by encapsulating oil-soluble ingredients in a surfactant in an aqueous solution to form solubilized micelles, it is possible to uniformly disperse the oil-soluble ingredients in a topical composition in fine particle sizes (for example, an average particle size of approximately 10 nm to 200 nm). They also discovered that by applying such a topical composition to a body surface and applying energy from above the topical composition to the body surface to which the topical composition has been applied using a beauty device (hereinafter sometimes simply referred to as "using a beauty device in combination"), it is possible to effectively penetrate the oil-soluble ingredients from the body surface into its interior.

1 shows a schematic diagram illustrating the structure of a solubilizing micelle 10. Here, an oil-soluble component 4 is encapsulated by a surfactant 2 to form a solubilizing micelle 10.
It has been found that by using such an external preparation composition in combination with a cosmetic device M, the oil-soluble component 4 effectively penetrates into the interior of the body from the surface S. Although the detailed mechanism behind this is not entirely clear, the present inventors speculate as follows.

2 is a schematic diagram illustrating, as an example, the mechanism by which a topical composition containing solubilized micelles 10 is applied to the skin and energy is applied using a skin cosmetic device M, causing the solubilized micelles 10 to penetrate from the surface S of the skin to its interior. The following description will be made with reference to FIG. 2.
First, in STEP 1, the topical composition is applied to the skin, causing solubilized micelles 10 to be present on the skin surface S. Next, in STEP 2, a skin beauty device M, such as a facial massager, is applied to the skin to which the topical composition has been applied, and energy E is output from the beauty device M to widen the gaps in the stratum corneum and increase the fluidity of the lipid bilayer, known as the "brick and mortar structure" of the stratum corneum L, thereby allowing the solubilized micelles 10, which have been controlled to an appropriate size, to penetrate into the skin through the gaps in the stratum corneum. Furthermore, in STEP 3, the oil-soluble component 4 that has penetrated into the skin as the solubilized micelles 10 is thought to penetrate into the mortar structure in the stratum corneum L and contribute to the reconstruction (reinforcement) of the lipid bilayer. As a result, the barrier function of the stratum corneum L is enhanced, and absorbed moisture and the like are trapped, improving the skin's moisture retention. Furthermore, when oil-soluble component 4 is a component having specific useful properties (for example, cosmetic components such as moisturizing agents, whitening agents, and anti-wrinkle agents, or medical components such as analgesics, anti-inflammatory agents, anti-phlogistic agents, anti-cancer agents, antibacterial agents, and antiviral agents), it is believed that these useful properties will be more effectively exhibited by oil-soluble component 4 penetrating into the skin and being absorbed.

In this specification, the following terms are defined as follows:
"Solubilized micelles" refer to micelles (particulate complexes) in which a surfactant encapsulates an oil-soluble component, and refer to micelles so tiny in a topical preparation composition that they are indistinguishable from the naked eye (see Figure 1). Because water and oil typically have different refractive indices, relatively large micelles allow the water-oil interface to be discerned with the naked eye, and the aqueous solution appears cloudy and emulsion-like. However, in the case of very small micelles, the water-oil interface cannot be discerned with the naked eye, and a solution consisting of solubilized micelles and water appears transparent or translucent. In other words, as used herein, "solubilization" refers to a state in which micelles appear dissolved in water, the solvent for the topical preparation composition. Note that the topical preparation composition itself may not necessarily be transparent or translucent, as it may appear colored by components other than the solubilized micelles.
"Topical preparations" refer to preparations that are applied to the body surface (outside the body). Examples include serums, creams, emulsions, gels, lotions, and sheet masks impregnated with these. Topical preparations may be medicines, quasi-drugs, cosmetics, etc., and the purpose of use is not limited.
"Body surface" refers to the surface of an animal's body (preferably a human body). Specific examples include animal skin (including nails), mucous membranes, and hair. In particular, the topical preparation composition of the present disclosure is suitable for use on skin or hair, and more suitable for use on skin.
"From the body surface to its interior" refers to the region from the body surface to its interior. For example, if the body surface is skin, it refers to the region from the surface of the epidermis to the periphery of the subcutaneous tissue; if the body surface is mucous membrane, it refers to the region from the surface of the mucous membrane to the periphery of the muscle layer; and if the body surface is hair, it refers to the region from the surface of the cuticle to its interior.
"Oil-soluble ingredients" refer to ingredients that are compatible with oil and are hydrophobic substances. "Water-soluble ingredients" refer to ingredients that are compatible with water and are hydrophilic substances. While neither of these is limited to cosmetic ingredients, cosmetic ingredients that are useful for skin or hair are preferred.

<External preparation composition>
The topical composition used in the method of using the topical composition of the present disclosure contains water and a solubilized micelle in which a surfactant encapsulates an oil-soluble component.
In such topical preparation compositions, the surfactant encapsulates the oil-soluble component to form solubilizing micelles, thereby controlling the oil-soluble component to a fine particle size (e.g., an average particle size of about 10 nm to 200 nm), thereby allowing the oil-soluble component to be uniformly dispersed in the topical preparation composition. Furthermore, by applying such a topical preparation composition to a body surface and applying energy from above the topical preparation composition using a beauty device to the body surface to which the topical preparation composition has been applied, the oil-soluble component can be effectively penetrated from the body surface into the interior of the body.

The components of the topical composition will be described in detail below.
(water)
Water serves as a solvent in the topical composition.
Water is also a component that provides moisture by penetrating from the surface of the body to its interior.

The water content in the topical composition may be adjusted appropriately in relation to the other ingredients, for example as the remainder, and is, for example, 36% by mass or more and 96% by mass or less, preferably 60% by mass or more and 92% by mass or less.

(Solubilizing micelles)
The solubilizing micelle 10 is a particulate complex in which a surfactant 2 encapsulates an oil-soluble component 4 (see FIG. 1).
The formation of solubilized micelles in the topical preparation composition allows the oil-soluble component to be uniformly dispersed in the aqueous solution. Furthermore, it is believed that by applying such a topical preparation composition to the body surface and then applying energy from a beauty device, the solubilized micelles can penetrate from the body surface into the interior through gaps in the body surface (for example, gaps in the keratin of the skin or gaps in the hair cuticle). This is believed to enable the oil-soluble component to effectively penetrate from the body surface into the interior.

The average particle size of the solubilizing micelles is, for example, approximately 10 to 200 nm, preferably 10 to 100 nm. Within this range, the penetration effect is enhanced when applied to the body surface.

[Surfactant]
The surfactant is a component that encapsulates the oil-soluble component to form a solubilizing micelle.
The surfactant is not particularly limited as long as it can encapsulate an oil-soluble component and form a solubilizing micelle, and a wide range of surfactants known as external agents for skin, hair, etc. can be used.
Specifically, the surfactant may be any of an ionic surfactant such as an anionic surfactant or a cationic surfactant, or a nonionic surfactant, or a combination thereof. Furthermore, the surfactant preferably contains an ionic surfactant, and may further contain a nonionic surfactant.

The content of the surfactant in the topical preparation composition may be at a level that allows the formation of solubilized micelles, and is, for example, 15% by mass or less, 0.0001% by mass or more and 15% by mass or less, preferably 0.01% by mass or more and 15% by mass or less, and more preferably 0.1% by mass or more and 10% by mass or less, based on 100% by mass of the topical preparation composition.
When the surfactant comprises an ionic surfactant, the content of the ionic surfactant in the topical preparation composition is, for example, from 0.01 to 10% by mass, preferably from 0.05 to 10% by mass, and more preferably from 0.1 to 5% by mass, based on 100% by mass of the topical preparation composition. In this case, the content of the nonionic surfactant in the topical preparation composition may be, for example, from 0 to 15% by mass, based on 100% by mass of the topical preparation composition.

Examples of anionic surfactants include dioleth-8-phosphate, dilauroyl glutamic acid lysine salt, stearoyl methyl taurine salt, acyl amino acid salts including acyl glutamic acid, cetyl phosphate and its salts, etc. When the anionic surfactant is a salt, specific examples include potassium salt, sodium salt, magnesium salt, arginine salt, lysine salt, and histidine salt.

Examples of cationic surfactants include fatty acid amidopropyldimethylamine, fatty acid dimethylaminopropylamide and its salts, single-chain or double-chain quaternary ammonium salts, benzalkonium chloride, and cocoyl arginine ethyl ester PCA salt.

Examples of nonionic surfactants include POE (40) hydrogenated castor oil, POE (60) hydrogenated castor oil, PCA isostearate PEG-40 hydrogenated castor oil, and fatty acid polyglyceryl.

Among these, it is preferable that the surfactant is at least an ionic surfactant, in which case the solubilized micelles formed will carry a positive or negative charge depending on the ionic nature of the surfactant. In other words, it is preferable that the solubilized micelles carry a positive or negative charge. Positively or negatively charged solubilized micelles are more likely to penetrate from the surface of the body to its interior than uncharged solubilized micelles. The reason for this effect is not clear, but the inventors speculate as follows.

It has long been known that the surface of the body is positively or negatively charged. Therefore, by making the solubilizing micelles themselves positively or negatively charged, it is thought that an interaction occurs between the body surface and the solubilizing micelles, making it easier for them to penetrate from the surface of the body into the interior.

Furthermore, when used in conjunction with a beauty device that emits energy with the same charge as the solubilized micelles, electrostatic repulsion is thought to make it easier for the solubilized micelles to penetrate from the surface of the body to its interior.

3 is a schematic diagram illustrating, as an example, a mechanism in which a topical composition containing negatively charged solubilized micelles 10′ is applied to the skin, and negative electrical energy E′ is applied using a skin cosmetic device M, causing the negatively charged solubilized micelles 10′ to penetrate into the skin from the surface S. The following description will be made with reference to FIG.
First, in STEP 1, the topical composition is applied to the skin, causing negatively charged solubilized micelles 10' to be present on the skin surface S. Next, in STEP 2, a skin beauty device M, such as a facial massager, is applied to the skin to which the topical composition has been applied, and the negative electrical energy E' emitted from the beauty device M generates electrostatic repulsion between the negatively charged solubilized micelles 10' and the solubilized micelles 10', forcing the solubilized micelles 10', which have been controlled to an appropriate size, into the skin through gaps in the stratum corneum. Furthermore, in STEP 3, the oil-soluble component 4 that has penetrated into the skin as the solubilized micelles 10' is thought to penetrate into the mortar structure in the stratum corneum L and contribute to the reconstruction (reinforcement) of the lipid bilayer. As a result, the barrier function of the stratum corneum L is enhanced, and absorbed moisture and the like are trapped, resulting in improved moisturizing effects. In addition, if the oil-soluble component 4 is a component with specific useful properties, it is thought that these useful properties will be more effectively exerted by the oil-soluble component penetrating into the skin and being absorbed.

This method of pushing charged ingredients using electrostatic repulsion (charge repulsion) has been known for some time, such as electrorepulsion. However, because the ingredients to be pushed into the skin were not applied in the form of solubilized micelles, a significant penetration effect could only be achieved with high-voltage beauty devices like those used in medical institutions, and sufficient penetration effect could not be achieved with low-voltage beauty devices for home use.
However, according to the method of using the topical composition disclosed herein, the composition is applied to the body surface in the form of fine solubilized micelles, and it is therefore believed that the penetration effect of the ingredients being pushed in can be enhanced even when using a low-voltage home beauty device.

Furthermore, electrostatic repulsion cannot be utilized when the component to be pushed in is non-polar. Therefore, when the oil-soluble component is non-polar, the above-mentioned method cannot be utilized even if the component is applied to the body surface in its original form, and the oil-soluble component cannot be effectively penetrated from the body surface into the interior.
However, according to the method of using the topical composition of the present disclosure, by selecting an ionic surfactant as the surfactant for encapsulating the oil-soluble component, it is possible to give the oil-soluble component a positive or negative charge in the form of a solubilized micelle, regardless of the polarity of the oil-soluble component, and therefore it is possible to utilize the electrostatic repulsion as described above, and more effectively penetrate the oil-soluble component from the surface of the body into its interior.

The charge of the solubilizing micelles can be selected depending on the type of surfactant. For example, when the surfactant is an anionic surfactant, negatively charged solubilizing micelles are obtained. When the surfactant is a cationic surfactant, positively charged solubilizing micelles are obtained.
Since electrorepulsion is a method of pushing in charged ingredients using electrostatic repulsion, the energy emitted from the beauty device must be the same as the charge on the solubilized micelles.
FIG. 3 illustrates the use of an external preparation composition containing negatively charged solubilized micelles. However, if, for example, an external preparation composition containing positively charged solubilized micelles is used instead, it is possible to generate electrostatic repulsion between the positively charged solubilized micelles and the energy emitted from the cosmetic device by converting it to positive electrical energy, thereby forcing the solubilized micelles, which have been controlled to an appropriate size, to penetrate into the skin through gaps in the stratum corneum.

[Oil-soluble component (oil-soluble component A)]
The oil-soluble component is a component that is encapsulated by a surfactant and forms solubilized micelles together with the surfactant (hereinafter, this component may be referred to as "oil-soluble component A"). In the topical preparation composition, this oil-soluble component A is primarily encapsulated in the surfactant and exists as solubilized micelles, but a portion of the component may be present alone or together with an oil-soluble component other than oil-soluble component A (hereinafter, this component may be referred to as "oil-soluble component B") without being encapsulated in the surfactant, as long as the effects of the present disclosure are not impaired.
The oil-soluble component A is not particularly limited as long as it can be encapsulated in a surfactant, and a wide range of known external preparations for skin, hair, etc. can be used.

The content of oil-soluble component A in the topical composition may be at a level sufficient to form solubilized micelles, and is, for example, 11% by mass or less, 0.0001% by mass to 11% by mass, preferably 0.0001% by mass to 2.7% by mass, more preferably 0.0001% by mass to 1.5% by mass, and even more preferably 0.0001% by mass to 0.9% by mass, based on 100% by mass of the topical composition.

Specific examples of the oil-soluble component A include oil-soluble components (A1) such as vegetable oils, animal oils, and mineral oils, regardless of their origin. These may also be used in combination.
Examples of vegetable oils include vegetable squalane, olive oil, palm oil, safflower oil, and sesame oil.
Examples of animal oils include animal squalane, whale oil, mink oil, lanolin and its derivatives, sterols and their derivatives, and the like.
Examples of mineral oils include hydrogenated polyisobutene, liquid paraffin (mineral oil), silicone oils and derivatives thereof, and ester oils derived from fatty acids such as cetyl ethylhexanoate (CEH), tri(capric/caproic) glyceryl, isopropyl myristate, and isopropyl palmitate. Among these, low-viscosity branched fatty acid liquid oils such as cetyl ethylhexanoate (CEH), tri(capric/caproic) glyceryl, isopropyl myristate, and isopropyl palmitate, and liquid ester oils of straight-chain or branched fatty acids are preferred.
The oil-soluble component A preferably contains an oil-soluble component (A1), and the oil-soluble component (A1) penetrates from the surface of the body to the interior thereof, thereby improving the moisturizing effect.
Among these, oil-soluble component A preferably contains one or more selected from the group consisting of cetyl ethylhexanoate (CEH), tri(capric/caproic) acid, squalane, isopropyl myristate, and isopropyl palmitate, and more preferably contains one or more selected from the group consisting of cetyl ethylhexanoate (CEH), tri(capric/caproic) acid, and squalane.

The oil-soluble component A may also be an oil-soluble component (A2) known to be useful as follows:
Examples of the oil-soluble component (A2) include vitamin E and its derivatives, vitamin A and its derivatives, oil-soluble derivatives of vitamin C, vitamin P, other oil-soluble vitamins, quinones such as bakuchiol, ubiquinone, and hydroquinone, ceramides and their derivatives including ceramide-like substances such as di(phytosteryl/octyldodecyl) lauroyl glutamate, and phospholipids.
The usefulness of these ingredients as beauty ingredients includes, for example, ceramide for moisturizing and improving skin texture (skin conditioning), retinol and bakuchiol for improving skin firmness, oil-soluble vitamin C derivatives (such as VCIP) and hydroquinone for preventing blemishes and collagen production, vitamin E (tocopherol) and ubiquinone for antioxidant properties, and vitamin P (glycosyl hesperidin) for preventing dullness.
The oil-soluble component A preferably contains an oil-soluble component (A2), and the oil-soluble component (A2) penetrates from the surface of the body into the interior thereof, thereby exerting the usefulness corresponding to the component.

When the oil-soluble component A contains the oil-soluble component (A2), the content of the oil-soluble component (A2) in the topical preparation composition is, relative to 100% by mass of the topical preparation composition, from 0.0001% by mass to 4% by mass, preferably from 0.0001% by mass to 3% by mass, and more preferably from 0.0001% by mass to 1.2% by mass.
If necessary, the topical preparation composition may further contain the oil-soluble component (A1) as a solvent for dispersing the oil-soluble component (A2). In this case, the content of the oil-soluble component (A1) in the topical preparation composition may be, for example, more than 0% by mass and not more than 7% by mass, based on 100% by mass of the topical preparation composition.

(Water-soluble component)
The topical composition further contains a water-soluble component, and the water-soluble component is preferably attached to the solubilizing micelle via a surfactant.
Here, the type of attachment is not particularly limited, and may be physical, chemical, electrostatic, or the like. Specific examples include ionic bonds, hydrogen bonds, bonds due to dipole-dipole interactions, van der Waals forces, and the like. Among these, an association state in which molecules or ions are bound by a relatively weak force such as electrostatic interactions is preferred.

Generally, water-soluble ingredients are more difficult to penetrate into the skin than oil-soluble ingredients. Therefore, various penetration methods have been investigated, but methods using beauty devices require high voltages and special equipment, and no simple method that can be used at home has been able to enhance penetration effects.
In contrast, according to the method of using the topical composition disclosed herein, it is believed that the water-soluble components contained in the aqueous phase adhere to the finely divided solubilized micelles, and penetrate into the interior of the body from the surface of the body, integrated with the solubilized micelles (Figure 4).
FIG. 4 is a schematic diagram illustrating, as an example, the mechanism by which an external preparation composition containing solubilized micelles 10 to which a water-soluble component 6 is attached is applied to the skin, and energy E is applied using a skin cosmetic device M, causing the solubilized micelles 10 to which the water-soluble component 6 is attached to penetrate from the surface S of the skin into its interior.

Solubilized micelles are a type of colloid particle, and the attachment of electrolytes to positively or negatively charged colloid particles is known as an electric double layer. Not only do counterions exist on the surface of charged colloid particles, but ionic water-soluble components also surround the colloid particles in a cloud-like state of electrolyte ions known as a diffuse electric double layer (Source: Fundamentals of Modern Interfacial Colloid Chemistry - Lectures and Measurement Manual, edited by the Chemical Society of Japan, Maruzen Co., Ltd.). It is also thought that non-ionic water-soluble components are given an electrical polarity when electrical energy emitted from beauty devices is applied, allowing them to attach to charged colloid particles as a diffuse electric double layer like the one described above.

The water-soluble component is not particularly limited and may be a low-molecular-weight component, a high-molecular-weight component, or an extract whose usefulness has been recognized but whose components are not specified. These may also be used in combination.
Examples of low molecular weight components include vitamin C, its salts and derivatives, panthenol, niacinamide, B vitamins, adenosine triphosphate, peptides such as Synake and Syntac, glycine betaine, pyrrolidone carboxylate, amino acids such as hydroxyproline, alanine, lysine and proline and their derivatives, dipeptides, tripeptides, oligopeptides, polyhydric alcohols such as glycerin, and low molecular weight sugars including disaccharides such as trehalose.

Water-soluble polymers have long been known to adhere to colloid particles as protective colloids (Source: Fundamentals of Modern Interfacial Colloid Chemistry - Lectures and Measurement Manual, edited by the Chemical Society of Japan, Maruzen Co., Ltd.). As mentioned above, solubilized micelles are a type of colloidal particle, so water-soluble polymers function as protective colloids.
Examples of such polymeric components include hyaluronic acid and its salts, such as sodium hyaluronate, collagen and its hydrolysates, hydrolyzed silk peptide, acrylic acid polymers and their derivatives, cellulose-based water-soluble polymers and their derivatives, such as hydroxyethyl cellulose, xanthan gum and cationized xanthan gum, tamarind gum, pectin, locust bean gum, carrageenan, alginic acid and its salts, such as sodium alginate, mannans, guar gum and cationized guar gum, gellan gum, and polysaccharide polymers and their derivatives, such as Tremella fuciformis polysaccharides. Such polymeric components are also suitable for imparting an appropriate viscosity to the topical composition. In particular, when the topical composition is directly applied to the body surface, adjusting the viscosity to an appropriate level (e.g., 50 mPa s or higher) can prevent the topical composition from dripping from the application surface and maintain good slipperiness of the cosmetic device on the body surface.
In addition, from the viewpoint of increasing the water retention capacity of the topical composition, it is preferable that the polymer component is one or more selected from the group consisting of hydroxyethyl cellulose, sodium hyaluronate, pectin, carrageenan, and xanthan gum, which have high water retention capacity.

When the topical composition further contains a water-soluble component, the content of the water-soluble component in the topical composition is, for example, 40% by mass or less, 0.0001% by mass or more and 40% by mass or less, preferably 0.0005% by mass or more and 40% by mass or less, and more preferably 0.01% by mass or more and 30% by mass or less, based on 100% by mass of the topical composition.

(Other ingredients)
The topical preparation composition may further contain, as necessary, components other than those described above, such as a water-compatible solvent, an oil-soluble component other than the oil-soluble component A (oil-soluble component B), thickeners, preservatives and preservative aids, antioxidants, chelating agents, pH adjusters, etc. as components that enhance the stability of the topical preparation composition, and colorants, fragrances, texture improvers, film-forming agents, powders, fragrances (including essential oils and flower water, etc.) as components that enhance the usefulness and usability, such as the feel, of the topical preparation composition, and other components that are widely used as topical preparations for skin, hair, etc.

(Method for producing topical composition)
The topical composition may be produced by any known method as long as it can form solubilized micelles.

For example, a suitable example of a method for producing an external preparation composition is shown below.
(1) The surfactant and the oil-soluble component are mixed and dissolved.
At this time, the mixture may be heated as necessary, and is preferably mixed at a temperature of 50°C or higher and 100°C or lower.
(2) To the mixture obtained in (1) above, water is added in small amounts and stirred until homogenous, to obtain an external preparation composition containing water and solubilized micelles in which the surfactant encapsulates the oil-soluble component.
In this case, when the mixture (1) is heated, it is preferable to preheat the water to be added to the same temperature, and after the addition of water, it is preferable to gradually cool the mixture to room temperature (20°C ± 5°C, the same applies hereinafter) while stirring.

(3) When the topical composition further contains a water-soluble component, the water-soluble component may be added to the topical composition of (2) above.
In this case, it is preferable that the water-soluble component be dissolved in water in advance, and the aqueous solution be added to the topical composition (2) above, followed by thorough stirring.
Furthermore, when the topical composition (2) above is heated, the water-soluble components may also be heated to the same temperature and added, if necessary.

(4) When obtaining an external preparation composition containing further ingredients, the further ingredients may be added to the external preparation composition obtained in (2) or (3) above.
In this case, if the other components are water-soluble, it is preferable to dissolve them in water in advance, add the aqueous solution to the topical composition (2) or (3) above, and stir thoroughly.
Furthermore, if the other components are oil-soluble, they may be mixed in advance with the oil-soluble component prior to step (1), or may be added directly to the topical composition of (2) or (3) above.
In addition, when the topical composition (2) above is heated, other components may also be heated to a similar temperature and added, if necessary.

The above is a suitable example, and the method for producing an external preparation composition is not limited to the above procedure, and steps (1) to (4) above may be interchanged as necessary.

<Beauty equipment>
The cosmetic device plays a role in emitting energy to cause the solubilized micelles in the topical composition to penetrate from the surface of the body to its interior.
The cosmetic device is not particularly limited as long as it can apply energy to the body surface to which the topical composition has been applied, and a wide variety of known cosmetic devices can be used.
The purpose of using a cosmetic device is to generate energy to allow the solubilized micelles in the topical preparation composition to penetrate from the surface of the body to its interior, and the beneficial effects of the topical preparation composition are not limited to cosmetic effects. The beneficial effects of the method of using the topical preparation composition of the present disclosure are primarily effects derived from the oil-soluble components (and also effects derived from the water-soluble components contained as needed). However, if the cosmetic device is capable of exerting unique cosmetic effects in addition to its role of emitting the specified energy, it goes without saying that these effects are included in addition to the effects derived from the oil-soluble components.

Examples of beauty devices include facial massagers, steamers, epilators, hair dryers, hair irons, electrical devices primarily intended for health promotion through weight loss and muscle training, etc. Even if a device is classified as a medical device, it is included in the beauty device of the present disclosure if its intended use is primarily for beauty purposes.
However, regardless of the type of cosmetic device used, the method of using the topical composition of the present disclosure does not include medical procedures.

Energy emitted by the beauty device may be light energy, electrical energy, thermal energy, etc. These may be used in combination as needed.
The light energy includes all wavelengths from ultraviolet light to visible light and far infrared light, and specifically includes light emitted from an LED.

Examples of electrical energy include energy emitted from a DC power source or an AC power source, and energy including plasma.
Examples of electrical energy emitted from an AC power source include high-frequency RF (Radio Frequency) and low-frequency EMS. RF is called radio wave and has a thermal effect, and the electrode shape may be either monopolar or bipolar. Low-frequency EMS has the effect of mainly moving muscles.
The electrical waveform may be a sine wave, a square wave, a combination of these, such as MSMP (multi-spike moist pulse wave, referred to as "electroosmotic wave" in this disclosure), or a high-voltage permeation waveform called electroporation, which creates temporary micro-perforations in the stratum corneum. Other examples include electropermeation techniques such as electrorepulsion, which uses positive or negative charges to push positively or negatively charged components into the stratum corneum through electrostatic repulsion, osmosis, and mesoporation, which is a combination of electroporation and electrorepulsion.
Examples of electrical energy containing plasma generated by beauty devices include electrical energy containing weak plasma such as Nanoe (registered trademark) and Plasmacluster (registered trademark). Such electrical energy may be direct current or alternating current, and may consist of positive or negative voltage.

In conventional topical compositions, the oil-soluble ingredients are often not uniformly dispersed, or even if they are uniformly dispersed, they are emulsions with large oil droplets, and when applied to the body surface, the oil-soluble ingredients tend to remain. Furthermore, since oil-soluble ingredients generally have low electrical conductivity, even when a conventional topical composition is used in combination with a beauty device that emits electrical energy, the electrical conductivity to the body surface is low, and the effect of the beauty device is not fully achieved.
In contrast, in the case of the topical preparation composition of the present invention, the oil-soluble ingredients are in the form of micelles small enough to be solubilized, which facilitates penetration from the surface of the body into the interior thereof, and the presence of solubilized micelles on the surface of the body does not impair the electrical conductivity of the cosmetic device. Therefore, it is believed that the electrical stimulation of the cosmetic device to the body surface is not hindered, the effects of the cosmetic device can be maximized, and the solubilized micelles can more easily penetrate from the surface of the body into the interior thereof.
That is, the topical composition of the present invention is more effective when used in combination with a cosmetic device that emits electrical energy.

Examples of thermal energy include heating using various heat media such as heated air, steam, and metal plates, as well as heating using electromagnetic waves, ultrasound, infrared rays, etc. Specific examples include heat from steam emitted from a thermal steamer.
The energy emitted by the cosmetic device preferably includes thermal energy, which can further widen the gaps in the keratin of the skin or the cuticle of the hair, for example.

The method of using a cosmetic device to penetrate the solubilized micelles from the surface of the body to the interior thereof can be selected depending on the energy emitted by the cosmetic device.
For example, when electrorepulsion (a method of pushing by electrostatic repulsion) is used, it is preferable to select positive or negative electrical energy, and when electroporation (electroporation method) is used, it is preferable to select low-voltage or high-voltage electrical energy. Osmosis is also effective. While electroporation may be performed alone, it is more effective when combined with electrorepulsion, RF, or EMS. Other methods that are preferable include RF, EMS, and ultrasound as a method for widening gaps in, for example, the keratin of skin or the cuticle of hair by vibration, and far-infrared rays or heat from a thermal steamer as a method for widening these gaps by heating. It is preferable to use two or more of these methods in combination, provided that the respective effects are not impaired. In particular, it is more preferable to combine these methods with a method that exerts a thermal effect by heating, from the viewpoint of further improving the permeability of solubilized micelles without impairing the other effects.
Furthermore, when using a cosmetic device that utilizes electrorepulsion, it is preferable to use it in combination with an external preparation composition that contains positively or negatively charged solubilized micelles.

[External preparation composition]
The topical composition of the present disclosure contains water and solubilized micelles in which a surfactant encapsulates an oil-soluble component, and is used in combination with a cosmetic device.

By having the above-described configuration, the topical composition of the present disclosure allows the oil-soluble ingredients in the topical composition to penetrate effectively.

It is not clear why the method of using the topical composition disclosed herein achieves the above-mentioned effects, but one possible reason is as follows.

As described above, the topical composition of the present disclosure encapsulates oil-soluble ingredients in an aqueous solution using a surfactant to form solubilized micelles, allowing the oil-soluble ingredients in the topical composition to be uniformly dispersed in fine particles (e.g., an average particle size of approximately 10 nm to 200 nm). Because these solubilized micelles are so fine, they easily penetrate from the surface of the body to its interior, and penetration is thought to be even easier when energy is applied using a cosmetic device.

In addition, the solubilizing micelles preferably have a positive or negative charge.
It has been known for some time that the surface of the body is positively or negatively charged. Therefore, by positively or negatively charging the solubilized micelles themselves, an interaction occurs between the body surface and the solubilized micelles, which is thought to facilitate their penetration from the body surface into the interior. Furthermore, when the solubilized micelles are used in combination with a beauty device that emits energy with the same charge as the charge on the solubilized micelles, electrostatic repulsion is thought to further facilitate their penetration from the body surface into the interior.

The zeta potential of an external preparation composition containing charged solubilized micelles can be measured using a zeta potential measuring device (e.g., Anton Paar, product names LITESIZER 500, SurPASS 3) to confirm whether an electric double layer is formed at the solubilized micelle interface by counter ions to the surface charge, resulting in a potential difference (ion concentration gradient).
In this case, the zeta potential is ±100 mV to ±5 mV, preferably ±60 mV to ±8 mV, and more preferably ±50 mV to ±10 mV.

The components and manufacturing method of the topical composition are as described above.

A non-limiting list of exemplary embodiments and combinations of exemplary embodiments of the present disclosure are disclosed below.
[1] A topical composition containing water and a solubilized micelle in which an oil-soluble component is encapsulated in a surfactant is applied to a body surface,
A method for using the topical composition, comprising applying energy to the body surface to which the topical composition has been applied using a beauty device, thereby causing the solubilized micelles to penetrate from the body surface to its interior.
[2] A method for using the topical composition according to the above [1], wherein the solubilized micelles are positively or negatively charged.
[3] A method for using the topical preparation composition according to the above [1] or [2], wherein the topical preparation composition further comprises a water-soluble component, and the water-soluble component is attached to the solubilizing micelle via the surfactant.
[4] A composition comprising water and a solubilizing micelle in which a surfactant encapsulates an oil-soluble component,
An external preparation composition to be used in combination with a beauty device.
[5] The topical composition according to the above-mentioned [4], wherein the solubilizing micelle is positively or negatively charged.
[6] The topical composition according to the above [4] or [5], further comprising a water-soluble component, and the water-soluble component is attached to the solubilizing micelle via the surfactant.
[7] The topical preparation composition according to the above [4] or [5], wherein the content of the surfactant is 15% by mass or less in 100% by mass of the topical preparation composition.
[8] The topical preparation composition according to the above [4] or [5], wherein the content of the oil-soluble component is 11% by mass or less in 100% by mass of the topical preparation composition.
[9] The topical preparation composition according to the above [6], wherein the content of the water-soluble component is 40% by mass or less in 100% by mass of the topical preparation composition.

Although the embodiments of the present disclosure have been described above, the configurations and combinations thereof in each embodiment are merely examples, and the configurations can be added, omitted, substituted, and otherwise modified as appropriate within the scope of the gist of the present disclosure. The present disclosure is not limited by the embodiments.
Each feature disclosed herein may be combined with any other feature disclosed herein.

The following examples further illustrate the present disclosure, but the interpretation of the present disclosure is not limited to these examples.

[1-1] Preparation of topical compositions (Preparation Examples 1 and 2, and Comparative Preparation Example 1)
In Preparation Examples 1 and 2, and Comparative Preparation Example 1, the components were blended in the compositions shown in Table 1 to prepare topical compositions.
Specifically, it was prepared according to the following procedure.
<Preparation method>
(1) The surfactant and the oil-soluble component were mixed and heated to 80°C to dissolve them.
(2) Water heated to 80°C was added little by little to the mixture obtained in (1) above, and the mixture was stirred until homogenized.
(3) Next, a previously prepared aqueous solution of low molecular weight components dissolved in water was heated to 80°C and added in small amounts to the mixture obtained in (2) above, followed by thorough stirring.
(4) Next, the polymer component, which had been prepared in advance, was mixed and dissolved in water, and the aqueous solution to which the preservative aid had been added was heated to 80°C, and the aqueous solution was added little by little to the mixture obtained in (3) above, followed by stirring.
(5) The mixture obtained in (4) above was cooled to room temperature while stirring to obtain an external preparation composition.

In Table 1, the following materials were used for each component.
Ionic surfactant 1: DOP-8 (manufactured by Nikko Chemicals Co., Ltd., sodium dioleth-8 phosphate)
Nonionic surfactant 1: NIKKOL HCO-40 (manufactured by Nikko Chemicals Co., Ltd., POE (40) hydrogenated castor oil)
Oil-soluble component 1: Eldew (registered trademark) PS-203 (manufactured by Ajinomoto Co., Inc., di(phytosteryl/octyldodecyl) lauroyl glutamate)
Water-soluble component (low molecular weight component 1): moisturizer (composition: mixture of proline, trehalose, and glycerin, blending ratio: 1:1:4 by mass, in the order listed on the left)
Water-soluble component (polymer component 1): Lapol Gum (registered trademark) CX (MP Gokyo Food & Chemical Co., Ltd., cationized xanthan gum (xanthan hydroxypropyltrimonium chloride))
・Antiseptic aid: Pentylene glycol (manufactured by Kokyu Alcohol Kogyo Co., Ltd.)
・Water (purified water)

[1-2] Use of topical composition (Examples 1 and 2 and Comparative Example 1)
In Examples 1 and 2 and Comparative Example 1, the topical preparation compositions prepared in [1-1] above were used and evaluated by the following methods. The topical preparation compositions used and the results are shown in Figure 5.

<1> Improvement rate of keratin moisture content when not using beauty equipment (R1)
(1) The inside of the panelist's forearm was washed with a detergent, rinsed with water to remove any remaining detergent, and excess water was wiped off with tissue.
(2) After 10 minutes had passed since the above (1), the moisture content of the stratum corneum (W0) of the skin before application of the topical composition was measured in a measurement area (approximately 5 cm square) on the inside of the panelist's forearm using a stratum corneum moisture meter (Courage+Khazaka, Corneometer).
(3) Next, 0.18 ml of the topical composition of Preparation Example 1 was dropped onto the measurement area on the inside of the panelist's forearm, and a beauty device with its power turned off (no output) was placed on the topical composition, and moved at a speed of 1 cm per second to spread the composition over the entire measurement area while massaging for 90 seconds. Thereafter, the topical composition remaining on the skin was wiped off with a tissue, and immediately thereafter, the moisture content (W1) of the stratum corneum of the skin after application of the topical composition was measured in the same manner as in (2) above.
Here, the beauty device used was an RF facial beauty device (equivalent to Photoplus Shiny M18YL, manufactured by Ya-man Co., Ltd.). However, in this test, the device was simply placed on the skin with the power off, so no energy was applied to the skin, and this does not constitute actual use of a beauty device.
(4) The improvement rate of stratum corneum moisture content (R1) was calculated using the following formula (I) from the moisture content of the stratum corneum of the skin before application of the topical preparation composition (W0) and the moisture content of the stratum corneum of the skin after application of the topical preparation composition (W1).
R1 (%) = [(W1-W0)/W0] x 100...(I)

Note that steps (1) to (4) above were performed on one panelist. Measurement of stratum corneum moisture content was performed at 10 random points within the measurement range. The upper and lower limits of the measurement were discarded, and the average value was calculated from the remaining 8 measurement points (N=8), and this was used as the stratum corneum moisture content for that measurement.

In the above (2) and (3), the moisture content of the stratum corneum was measured under the following conditions.
The measurement area on the inside of the panelist's forearm was set to avoid areas near the wrist and elbow joint, as measurements are prone to fluctuating near the wrist and elbow joint.

<2> Improvement rate of keratinocyte moisture content when used in conjunction with beauty devices (R2)
In (3) of <1> above, the cosmetic device was simply applied to the skin onto which the topical preparation composition had been dropped with the power turned off (no output) (the cosmetic device was not used). In this measurement, however, the power of the cosmetic device was turned on, and the cosmetic device was applied to the skin onto which the topical preparation composition had been dropped for 90 seconds while applying RF (high frequency, 1 MHz radio wave) energy (essentially, the cosmetic device was used). The moisture content of the stratum corneum of the skin before application of the topical preparation composition (W0') and after application of the topical preparation composition and use of the cosmetic device (W2) were measured in the same manner as in <1> above, and the improvement rate of stratum corneum moisture content (R2) was calculated using the following formula (II).
R2 (%) = [(W2-W0')/W0'] x 100...(II)
Here, the output mode of the beauty device was set to 3 (3 out of 1 to 3 levels).

<3> Difference in the rate of improvement in stratum corneum moisture content with or without a beauty device (X)
The difference (X = R2 - R1) between the improvement rate of keratinocyte moisture content when no beauty device was used (R1) determined in <1> above and the improvement rate of keratinocyte moisture content when a beauty device was used (R2) determined in <2> above was determined.

In this evaluation, the higher the improvement rate (%) in stratum corneum moisture content, the greater the moisturizing effect of the topical composition. The difference (X) in the improvement rate in stratum corneum moisture content between the use of a cosmetic device and the absence of such a device indicates the effect of the use of a cosmetic device on the moisturizing effect of the topical composition. In other words, if the difference (X) in the improvement rate in stratum corneum moisture content is positive, it means that the moisturizing effect of the topical composition is further enhanced by the use of the cosmetic device in combination, and that the topical composition is suitable for use in combination with a cosmetic device.

As shown in Figure 5, it was found that when topical compositions containing solubilized micelles (topical compositions of Preparation Examples 1 and 2) are used in conjunction with a beauty device, they can further enhance the moisturizing effect compared to when no beauty device is used (Examples 1 and 2). From this, it is inferred that the oil-soluble components in the solubilized micelles effectively penetrate deep into the skin.

On the other hand, when the topical composition not containing solubilizing micelles (topical composition of Comparative Preparation Example 1) was used in combination with a beauty device, there was little difference compared to when the beauty device was not used, and it was confirmed that the moisturizing effect was slightly reduced (Comparative Example 1).

Furthermore, when a topical composition containing negatively charged solubilized micelles (Preparation Example 1) was used, an even more excellent moisturizing effect was confirmed, suggesting a greater penetration effect of oil-soluble ingredients (Example 1).

[2-1] Preparation of topical compositions (Preparation Examples 3 to 15, and Comparative Preparation Examples 2 and 3)
In Preparation Examples 3 to 15 and Comparative Preparation Examples 2 and 3, the components were blended in the compositions shown in Tables 2 to 6, respectively, to prepare topical compositions.

In Table 2, the following materials were used for each component.
Ionic surfactant 2: Pellicer (registered trademark) L-30 (manufactured by Asahi Kasei Corporation, 30% by mass aqueous solution of sodium dilauramidoglutamide lysine)
Nonionic surfactant 1: Same as above Nonionic surfactant 2: PYROTER CPI-40 (manufactured by Nippon Emulsion Co., Ltd., PCA isostearate PEG-40 hydrogenated castor oil)
Nonionic surfactant 3: A mixture of Sunsoft (registered trademark) Q-12Y-C (manufactured by Taiyo Kagaku Co., Ltd., polyglyceryl-10 laurate) and Sunsoft (registered trademark) Q-17Y-C (manufactured by Taiyo Kagaku Co., Ltd., polyglyceryl-10 oleate). The blending ratio is 1:3 by mass.
Oil-soluble component 2: CEH (Cetyl ethylhexanoate, manufactured by Kokyu Alcohol Kogyo Co., Ltd.)
Water-soluble component (low molecular weight component 2): AJIDEW (registered trademark) N-50 (manufactured by Ajinomoto Co., Inc., 50% by mass aqueous solution of PCA-Na)
Water-soluble component (polymer component 2): Natrosol (registered trademark) 250HHR PC (hydroxyethyl cellulose, manufactured by Ashland)
Water-soluble component (polymer component 3): Hi-Aqua (registered trademark) C (manufactured by JinWoo Bio, sodium hyaluronate)
Water-soluble component (polymer component 4): Kimica Algin I-3 (manufactured by Kimica Co., Ltd., sodium alginate)
Water-soluble component (polymer component 5): GENU (registered trademark) pectin USP-H (manufactured by CP Kelco, pectin)
Water-soluble component (polymer component 6): GENUVISCO (registered trademark) carrageenan type PJ-JPE (manufactured by CP Kelco, carrageenan)
Water-soluble component (polymer component 7): UniqSens SFE system (manufactured by CP Kelco, a mixture of pectin/xanthan gum/carrageenan, with a mass ratio of 6:3:1)
Water-soluble component (polymer component 8): Tremoist (registered trademark) TP (manufactured by Nippon Fine Chemical Co., Ltd., Tremella fuciformis polysaccharide)
・Antiseptic aid: Pentylene glycol (manufactured by Kokyu Alcohol Kogyo Co., Ltd.)
・Water (purified water)

[2-2] Use of topical composition (Examples 3a to 15a and Comparative Examples 2a and 3a)
In Examples 3a to 15a and Comparative Examples 2a and 3a, the topical preparation compositions prepared in the above section [1-2] were used, but the evaluations were carried out in the same manner as in the above section [2-1]. The topical preparation compositions used and the results are shown in Table 2.

As shown in Table 2, it was found that when topical compositions containing solubilized micelles (topical compositions of Preparation Examples 3 to 15) were used in conjunction with a beauty device, they were able to further enhance the moisturizing effect compared to when no beauty device was used (Examples 3a to 15a). This suggests that the oil-soluble ingredients in the solubilized micelles effectively penetrate deep into the skin.

On the other hand, when topical compositions not containing solubilizing micelles (topical compositions of Comparative Preparation Examples 2 and 3) were used in conjunction with a cosmetic device, it was confirmed that the moisturizing effect was either slightly reduced (Comparative Example 2a) or significantly reduced (Comparative Example 3a) compared to when no cosmetic device was used.

[2-3] Use of topical composition (Examples 3b, 4b, 6b, 7b, and 9b to 15b)
In Examples 3b, 4b, 6b, 7b, and 9b to 15b, evaluation was performed in the same manner as in [2-1] above, except that the topical preparation compositions prepared in [1-2] above and the following cosmetic devices were used. The topical preparation compositions used and the results are shown in Table 3.
Beauty equipment: Facial beauty device (Yaman Corporation, Bright Lift EX HRF50 equivalent)
Energy emitted from the beauty device: 70 kHz single-wave electroosmotic wave (MSMP: Multi-Spike Moist Pulse Wave)
Beauty device output conditions: Output mode is 1 (1 out of 5 levels)

As shown in Table 3, it was found that topical compositions containing solubilized micelles (topical compositions of Preparation Examples 3, 4, 6, 7, and 9-15) can further enhance moisturizing effects when used in conjunction with a beauty device compared to when no beauty device is used (Examples 3b, 4b, 6b, 7b, and 9b-15b).

[2-4] Use of topical composition (Examples 3c to 5c, 8c and 14c)
In Examples 3c to 5c, 8c, and 14c, the evaluation was carried out in the same manner as in [2-1] above, except that the topical preparation compositions prepared in [1-2] above and the following cosmetic devices were used. The topical preparation compositions used and the results are shown in Table 4.
Beauty equipment: Facial beauty device (Yaman Corporation, Bright Lift EX HRF50 equivalent)
Energy emitted from the beauty device: 1.5KHz square wave electrorepulsion Beauty device output conditions: Output level is 1 (1 out of 5 levels)

As shown in Table 4, it was found that the topical preparation compositions containing solubilized micelles (topical preparation compositions of Preparation Examples 3 to 5, 8c, and 14) could further enhance the moisturizing effect when used in combination with a cosmetic device compared to when no cosmetic device was used (Examples 3c to 5c, 8c, and 14c).
In particular, when topical preparation compositions containing solubilized micelles formed by a surfactant containing an ionic surfactant (topical preparation compositions of Preparation Examples 3, 4, 8, and 14) were used, the difference in the improvement rate of stratum corneum moisture content when used in combination with a cosmetic device was confirmed to be greater than when a topical preparation composition containing solubilized micelles formed by a surfactant not containing an ionic surfactant (topical preparation composition of Preparation Example 5) was used. This is thought to indicate that the energy emitted from the cosmetic device generates electrical repulsion against the ionic surfactant, thereby further penetrating the solubilized micelles into the skin by electrorepulsion. In particular, when a topical preparation composition containing a low-molecular-weight component as a water-soluble component (topical preparation composition of Preparation Example 8) was used, the difference in the improvement rate of stratum corneum moisture content was confirmed to be particularly large. This is thought to indicate that the low-molecular-weight component as a water-soluble component adheres to the solubilized micelles, and when the solubilized micelles penetrate into the skin by electrorepulsion, the low-molecular-weight component also penetrates into the skin.

[2-5] Use of topical composition (Examples 3d, 6d, and 14d)
In Examples 3d, 6d, and 14d, the evaluation was carried out in the same manner as in [2-1] above, except that the topical preparation compositions prepared in [1-2] above and the following cosmetic devices were used. The topical preparation compositions used and the results are shown in Table 5.
Beauty equipment: Facial beauty device (Yaman Corporation, Bright Lift EX HRF50 equivalent)
Energy emitted from the beauty device: 1KHz medium frequency EMS
Beauty device output conditions: Output level is 5 (5 out of 1 to 5)

As shown in Table 5, it was found that the topical preparation compositions containing solubilized micelles (topical preparation compositions of Preparation Examples 3, 6, and 14) can further enhance the moisturizing effect when used in combination with a cosmetic device compared to when no cosmetic device is used (Examples 3d, 6d, and 14d).

[2-6] Use of topical composition (Examples 6e and 14e)
In Examples 6e and 14e, evaluation was carried out in the same manner as in [2-1] above, except that the topical preparation compositions prepared in [1-2] above and the following cosmetic devices were used. The topical preparation compositions used and the results are shown in Table 6.
Beauty equipment: Facial beauty device (Yaman Corporation, Bright Lift EX HRF50 equivalent)
Energy emitted from beauty devices: 10Hz low-frequency EMS
Beauty device output conditions: Output level is 3 (3 out of 1 to 5)

As shown in Table 6, it was found that the topical preparation compositions containing solubilized micelles (topical preparation compositions of Preparation Examples 6 and 14) can further enhance the moisturizing effect when used in combination with a cosmetic device compared to when no cosmetic device is used (Examples 6e and 14e).

The zeta (ζ) potential of the topical composition containing the charged solubilized micelles of the present invention was measured using a zeta potential measuring device (manufactured by Anton Paar, product names LITESIZER 500, SurPASS 3) to confirm whether an electric double layer was formed at the solubilized micelle interface by counterions to the surface charge, resulting in a potential difference (ion concentration gradient).

In Table 7, the following materials were used for each component.
Ionic surfactant 2: Pellicer (registered trademark) L-30 (manufactured by Asahi Kasei Corporation, 30% by mass aqueous solution of sodium dilauramidoglutamide lysine)
Nonionic surfactant 2: PYROTER CPI-40 (manufactured by Nippon Emulsion Co., Ltd., PCA isostearate PEG-40 hydrogenated castor oil)
Oil-soluble component 3: NIKKOL VC-IP (manufactured by Nikko Chemicals Co., Ltd., ascorbyl tetrahexyldecanoate)
Oil-soluble component 4: Natural vitamin E (manufactured by Tama Biochemical Co., Ltd., tocopherol)
・Antiseptic aid: Pentylene glycol (manufactured by Kokyu Alcohol Kogyo Co., Ltd.)
・Water (purified water)
Comparative Example 4, which was a topical composition containing solubilized micelles prepared with uncharged nonionic surfactant 2, had a zeta potential (mV) close to zero (no zeta potential). On the other hand, the topical compositions containing solubilized micelles prepared with charged ionic surfactant 2 (Examples 16 and 17) had zeta potentials as shown in Table 7.
Furthermore, when an external preparation composition containing charged solubilized micelles with a zeta potential (Example 16) was diluted 20 times to form an external preparation composition (Example 17, Formulation Example 5), the ζ (zeta) potential actually became larger. As shown in Table 7, the external preparation composition containing charged solubilized micelles of the present invention retains a zeta potential even when diluted, indicating that an electric double layer is formed by counter ions to the surface charge, resulting in a potential difference.

<1> Topical Preparation Composition (Comparison of Moisturizing Feeling between Topical Preparation Composition Containing Charged Solubilizing Micelles (Example 17) and Topical Preparation Composition Containing Uncharged Solubilizing Micelles (Comparative Example 5))
(1) The inside of the panelist's forearm was washed with a detergent, rinsed with water to remove any remaining detergent, and excess water was wiped off with tissue.
(2) After 10 minutes had passed since the above step (1), the topical composition containing charged solubilized micelles (Example 17) and the topical composition containing uncharged solubilized micelles (Comparative Example 5) were applied to separate areas within a measurement area (approximately 5 cm square) on the inner side of the panelist's forearm.
(3) Next, the beauty device was applied to the measurement area on the inner forearm of each panelist for 90 seconds. The beauty device used was an RF facial device (Yaman Co., Ltd., Photoplus Shiny M18YL equivalent). After that, the remaining topical composition on the skin was wiped off with a tissue, and the moisturizing feeling of the skin was measured by sensory evaluation, and the panelist selected the one with the highest moisturizing feeling (high moisturizing feeling was A, low moisturizing feeling was B). The panelists were 10 people.
As shown in Table 8, the positively or negatively charged solubilized micelles of the present invention significantly enhanced the moisturizing sensation.

Below is a formulation example, manufacturing method, conditions of use, and results when another topical composition according to the present invention is used in a facial beauty device.

(Formulation example 1: Lotion)
A lotion was prepared according to the following recipe using a method similar to that of the above example, and used for 90 seconds using a beauty device (facial beauty device, manufactured by Ya-man Corporation, equivalent to Bright Lift EX HRF50) under the following conditions.
Energy emitted from the beauty device: 1.5KHz square wave electrorepulsion Beauty device output conditions: Output level is 1 (1 out of 5 levels)
The preparation method was similar to that of the above-mentioned example. The cosmetic composition having this formulation also had the excellent properties according to the present invention.
Ingredients Amount (mass%)
(1) Butylene glycol (BG) 8.0
(2)PYROTER CPI-40 2.2
(3) Trehalose 2.0
(4) Methylgluceth-10 2.0
(5) Niacinamide 2.0
(6) Pentylene glycol 1.5
(7) Glycerin 1.0
(8) Sodium polystyrene sulfonate 1.0
(9) Pellicer (registered trademark) L-30 0.9
(10) 1,2-hexanediol 0.5
(11) Sodium citrate 0.05
(12) Retinol palmitate 0.1
(13) Bakuchiol 0.1
(14) Ascorbyl tetrahexyldecanoate 0.1
(15) Tocopherol 0.1
(16) ARGIRELINE (registered trademark) YOUth peptide oil solution MB 0.1
(17) DERMAXYL® 0.1
(18) Hydroxyacetophenone 0.3
(19) PEG-60 hydrogenated castor oil 0.3
(20) Carbomer 0.2
(21) PEG-7 glyceryl coconut oil fatty acid 0.15
(22) Glycyrrhizic acid 2K 0.1
(23) Citric acid 0.1
(24) Potassium hydroxide 0.1
(25) Water remainder
Total 100.00

(Formulation Example 2: Serum)
A beauty essence was prepared according to the following formulation and the same manufacturing method as in the above example, and used for 90 seconds using a beauty device (facial beauty device, manufactured by YA-MAN Corporation, equivalent to Bright Lift EX HRF50) under the following conditions.
Energy emitted from the beauty device: 1KHz medium frequency EMS
Beauty device output conditions: Output level is 5 (5 out of 1 to 5)
The cosmetic composition of this formulation also had the excellent properties according to the present invention.
Ingredients Amount (mass%)
(1)BG 7.5
(2) Glycerin 5.0
(3) Diglycerin 2.5
(4)PYROTER CPI-40 2.2
(5) Dipropylene glycol (DPG) 2.0
(6) Betaine 2.0
(7) Niacinamide 2.0
(8) Trehalose 2.0
(9) Pentylene glycol 1.5
(10) Pellicer (registered trademark) L-30 0.9
(11) 1,2-hexanediol 0.5
(12) Hydroxyacetophenone 0.3
(13) Retinol palmitate 0.1
(14) Bakuchiol 0.1
(15) Ascorbyl tetrahexyldecanoate 0.1
(16) Tocopherol 0.1
(17) ARGIRELINE (registered trademark) YOUth peptide oil solution MB 0.1
(18) DERMAXYL® 0.1
(19) Hydroxyacetophenone 0.3
(20) Xanthan gum 0.3
(21) PEG-60 hydrogenated castor oil 0.2
(22) Glycyrrhizic acid 2K 0.1
(23) Sodium citrate 0.1
(24) Citric acid 0.05
(25) Water remainder
Total 100.00

(Formulation Example 3: Beauty Serum)
A beauty essence was prepared according to the following formulation and the same manufacturing method as in the above example, and used for 90 seconds using a beauty device (facial beauty device, manufactured by YA-MAN Corporation, equivalent to Bright Lift EX HRF50) under the following conditions.
Energy emitted from beauty devices: 10Hz low-frequency EMS
Beauty device output conditions: Output level is 3 (3 out of 1 to 5)
The cosmetic composition of this formulation also had the excellent properties according to the present invention.
Ingredients Amount (mass%)
(1) Curerex-Galacto 10.0
(2) KGK Fermented Collagen Water 10.0
(3)BG 7.5
(4) Glycerin 3.0
(5) Diglycerin 2.5
(6)PYROTER CPI-40 2.2
(7)DPG 2.0
(8) Betaine 2.0
(9) Niacinamide 2.0
(10) Gaturin® Expression AF 2.0
(11) Trehalose 2.0
(12) Pentylene glycol 1.5
(13) Pellicer (registered trademark) L-30 0.9
(14) Ascorbyl phosphate magnesium 0.5
(15) 1,2-hexanediol 0.5
(16) Hydroxyacetophenone 0.3
(17) PRODEW® 600 0.1
(18) Retinol palmitate 0.1
(19) NIKKOL® Tocoretinoate-10 0.1
(20) Ascorbyl tetrahexyldecanoate 0.1
(21) Tocopherol 0.1
(22) ARGIRELINE (registered trademark) YOUth peptide oil solution MB 0.1
(23) DERMAXYL® 0.1
(24) 3-O-ethyl ascorbic acid 0.1
(25) Spring Mint 0.05
(26) BARPULL® G 0.05
(27) Hyalobel 0.05
(28) Hyalo Oligo 0.05
(29)HA booster 0.05
(30) Hydrolyzed collagen 0.05
(31) BAOLIFT 0.05
(32)NovoRetin 0.01
(33) FILMEXCEL® 0.01
(34) Argireline® Amplified peptide solution C 0.01
(35) NIKKOL® Retinol H1 0.01
(36) FLEXAN® 0.01
(37) Pullulan 0.01
(38) Hyaluronic Acid Crosspolymer Na-2 SF100 0.01
(39) MATRIXYL 3000 0.01
(40) ARGIRELINE® peptide 0.01
(41) SYN-AKE® 0.01
(42) SYN-COLL (registered trademark) 0.01
(43)ChroNOline 0.01
(44) IDEALIFT® MBAL 0.01
(45) PROGELINE 0.01
(46) Ceramide NP 0.01
(47) Ceramide NG 0.01
(48) Ceramide AS 0.01
(49) SymWhite® 377 0.01
(50) Sodium Ascorbyl Phosphate 0.01
(51) APPRECIER (registered trademark) 0.01
(52) TPNa® 0.01
(53) Ascorbyl glucoside 0.01
(54) Radical Sponge (registered trademark) N 0.01
(55) Moistfullerene (registered trademark) N 0.01
(56)ALGAKTIV GenoFix Day 0.01
(57)ALGAKTIV RetinART 0.01
(58) Tremella fuciformis polysaccharide 0.01
(59) Caffeine 0.01
(60) Inositol 0.01
(61) Panax ginseng root extract 0.01
(62) Hydroxyacetophenone 0.3
(63) Xanthan gum 0.3
(64) PEG-60 hydrogenated castor oil 0.2
(65) Glycyrrhizic acid 2K 0.1
(66) Sodium citrate 0.1
(67) Citric acid 0.05
(68)EDTA-2Na 0.05
(69) Ethanol 0.1
(70) Phenoxyethanol 0.3
(71) Water remainder
Total 100.00

(Formulation example 4: Beauty gel)
According to the following recipe, a beauty gel was prepared by a manufacturing method similar to that of the above example, and used for 90 seconds using a beauty device (facial beauty device, manufactured by Ya-man Corporation, equivalent to Photoplus Shiny M18YL).
Energy emitted from the beauty device: 1MHz radio frequency (RF)
Beauty device output conditions: Output level is 3 (3 out of 1 to 3 levels)
The cosmetic composition of this formulation also had the excellent properties according to the present invention.
Ingredients Amount (mass%)
(1)BG 7.5
(2) Glycerin 5.0
(3) Pentylene glycol 2.5
(4)PYROTER CPI-40 2.2
(5) Diglycerin 2.0
(6) Niacinamide 2.0
(7) Pellicer (registered trademark) L-30 0.9
(8) Carbomer 0.5
(9) 1,2-hexanediol 0.5
(10) Retinol palmitate 0.1
(11) Bakuchiol 0.1
(12) Ascorbyl tetrahexyldecanoate 0.1
(13) Tocopherol 0.1
(14) ARGIRELINE (registered trademark) YOUth peptide oil solution MB 0.1
(15) DERMAXYL® 0.1
(16) Hydroxyacetophenone 0.3
(17) Potassium hydroxide 0.25
(18) Glycyrrhizic acid 2K 0.1
(19) Sodium citrate 0.05
(20) Citric acid 0.01
(21) Water remainder
Total 100.00

(Formulation Example 5: Beauty Serum)
A beauty essence was prepared according to the following formulation using a manufacturing method similar to that of the above example, and used for 90 seconds using a beauty device (facial beauty device, manufactured by Ya-man Corporation, equivalent to Photoplus Shiny M18YL).
Energy emitted from the beauty device: 1MHz radio frequency (RF)
Beauty device output conditions: Output level is 3 (3 out of 1 to 3 levels)
The cosmetic composition of this formulation also had the excellent properties according to the present invention.
Ingredients Amount (mass%)
(1)BG 7.5
(2) Glycerin 5.0
(3) Diglycerin 2.5
(4)PYROTER CPI-40 0.0365
(5) Dipropylene glycol (DPG) 2.0
(6) Pentylene glycol 1.5
(7) Pellicer (registered trademark) L-30 0.0455
(8) 1,2-hexanediol 0.5
(9) Hydroxyacetophenone 0.3
(10) Retinol palmitate 0.0015
(11) Bakuchiol 0.0015
(12) Ascorbyl tetrahexyldecanoate 0.0015
(13) Tocopherol 0.0015
(14) ARGIRELINE (registered trademark) YOUth peptide oil solution MB 0.0015
(15) DERMAXYL (registered trademark) 0.0015
(16) Hydroxyacetophenone 0.3
(17) Xanthan gum 0.3
(18) PEG-60 hydrogenated castor oil 0.2
(19) Sodium citrate 0.1
(20) Citric acid 0.05
(21) Water remainder
Total 100.00

The method of using the topical composition of this embodiment allows the oil-soluble ingredients in the topical composition to penetrate effectively, and has industrial applicability.

10 Solubilizing micelle (10' Negatively charged solubilizing micelle)
2 surfactant 4 oil-soluble component 6 water-soluble component M beauty device E energy (E' negative electrical energy)
L: Stratum corneum S: Body surface (skin surface)

Claims (9)

A topical composition containing water and a solubilized micelle in which an oil-soluble component is encapsulated in a surfactant is applied to the body surface;
A method for using the topical composition, comprising applying energy to the body surface to which the topical composition has been applied using a beauty device, thereby causing the solubilized micelles to penetrate from the body surface to its interior. The method for using the topical composition according to claim 1, wherein the solubilizing micelles are positively or negatively charged. The method for using the topical composition according to claim 1 or 2, wherein the topical composition further contains a water-soluble component, and the water-soluble component is attached to the solubilizing micelle via the surfactant. The composition contains water and a solubilizing micelle in which a surfactant encapsulates an oil-soluble component,
An external preparation composition to be used in combination with a beauty device. The topical composition according to claim 4, wherein the solubilizing micelles are positively or negatively charged. The topical composition according to claim 4 or 5, further comprising a water-soluble component, the water-soluble component being attached to the solubilizing micelle via the surfactant. The topical composition according to claim 4, wherein the content of the surfactant is 15% by mass or less based on 100% by mass of the topical composition. The topical composition according to claim 4, wherein the content of the oil-soluble component is 11% by mass or less based on 100% by mass of the topical composition. The topical composition according to claim 6, wherein the content of the water-soluble component is 40% by mass or less based on 100% by mass of the topical composition.