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WO2025203989A1 - Vaisseau sanguin artificiel et trousse de vaisseau sanguin artificiel - Google Patents

Vaisseau sanguin artificiel et trousse de vaisseau sanguin artificiel

Info

Publication number
WO2025203989A1
WO2025203989A1 PCT/JP2025/000507 JP2025000507W WO2025203989A1 WO 2025203989 A1 WO2025203989 A1 WO 2025203989A1 JP 2025000507 W JP2025000507 W JP 2025000507W WO 2025203989 A1 WO2025203989 A1 WO 2025203989A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood vessel
artificial blood
hole
retaining ring
artificial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/JP2025/000507
Other languages
English (en)
Japanese (ja)
Inventor
島村　和男
繁 宮川
浩禎 桝田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Osaka NUC
Original Assignee
Osaka University NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osaka University NUC filed Critical Osaka University NUC
Publication of WO2025203989A1 publication Critical patent/WO2025203989A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts

Definitions

  • the present invention relates to an artificial blood vessel and an artificial blood vessel kit, which are used to treat aortic aneurysms and the like.
  • Aortic aneurysms are diseases that can lead to sudden death if they rupture, and are classified as true aneurysms caused by arteriosclerosis, which occur in elderly people, and dissecting aneurysms, which occur in relatively young people. Both types of aneurysms have a high mortality rate if left untreated, so prophylactic treatments are available, such as artificial blood vessel replacement, in which the aneurysm is surgically removed and replaced with an artificial blood vessel, or aneurysm exclusion, in which a self-expanding artificial blood vessel (stent graft) is placed via an endovascular approach to block blood flow to the aneurysm. Examples of endovascular approaches are shown in Patent Documents 1 and 2.
  • the difficulty and risk of these treatments vary greatly depending on the location of the aortic aneurysm, and it is known that the risk of treatment is particularly high in the aortic arch. This is primarily due to the anatomical characteristics of the aortic arch. In other words, because the aortic arch runs from the anterior chest to the posterior chest, it is difficult to approach using surgical treatment alone. Furthermore, because branches to the brain (the brachiocephalic artery, left common carotid artery, and left subclavian artery) branch off from the aortic arch, it is difficult to maintain adequate cerebral blood flow using only an endovascular approach.
  • the thickness of the tubular portion 41 and flange portion 42 of the main body member 31 is approximately 0.5 to 1 mm, and the axial length of the tubular portion 41 is approximately 5 to 8 mm.
  • the thickness of the washer member 32 is approximately 0.5 to 4 mm, and if a thick-walled portion 322 is provided on the inner peripheral side as shown in Figure 8, the thickness of the thin-walled portion 321 on the outer peripheral side can be reduced. In either case, the minimum thickness should be set to a level that ensures strength and provides adhesion and stability.
  • the inner diameter of the tubular portion 41 is determined depending on the inner diameter of the origin of the left subclavian artery 6c, and is, for example, approximately 8 to 10 mm.
  • the outer diameter of the flange portion 42 and washer member 32 is, for example, approximately 15 to 20 mm.
  • Figure 7 shows an example of a retaining ring 22A when washers 33a and 33b are used.
  • washers 33a and 33b is expected to improve strength and adhesion, and is also advantageous for increasing the thickness of the retaining ring 22A to ensure a sufficient landing zone.
  • the cylindrical portion 41A and flange portion 42A of the main body member 31A need only be thick enough to ensure strength.
  • Figure 8 shows an example of a retaining ring 22B that achieves thickness without using a washer.
  • a washer member 32B has a thin portion 321 and a thick portion 322, and the thick portion 322 ensures the overall thickness.
  • the cylindrical portion 41B and flange portion 42B of the main body member 31B only need to be thick enough to ensure strength.
  • the outer edge that comes into contact with the periphery of the hole 21 or the inner surface that comes into contact with the outer periphery of the small-diameter stent graft 13 may be made elastically deformable so as to expand or deform.
  • an elastically deformable annular spring may be attached to the outer or inner periphery of the tubular portion 41 of the retaining ring 22.
  • Figure 9 shows an example of a first artificial blood vessel 12D with two holes 21, 21 and retaining rings 22, 22.
  • the first artificial blood vessel 12D is used, for example, when preserving the left common carotid artery 6b and the left subclavian artery 6c in the aortic arch 5b.
  • the number and positions of the holes 21 and retaining rings 22 can be selected depending on the position, such as the zone classification, in which the first artificial blood vessels 12, 12D are to be placed.
  • an artificial blood vessel kit for such hybrid treatment can be prepared by combining and setting various sizes of first artificial blood vessels 12, small-diameter stent grafts 13, retaining rings 22, and washers 33a, 33b. Furthermore, various sizes of main artificial blood vessels 11 and small-diameter artificial blood vessels 11a, 11b can also be combined. Additionally, a crimping tool can be prepared as an additional piece of equipment and supplies required for the procedure.
  • first artificial blood vessels 12 of various sizes with retaining rings 22 attached may be prepared as artificial blood vessels for hybrid treatment.
  • the above-described embodiment provides an artificial blood vessel kit and artificial blood vessel suitable for use in hybrid treatment. Furthermore, it is possible to easily obtain landmarks when performing catheter manipulation in hybrid treatment, facilitating and stabilizing the insertion of the small-diameter stent graft 13 and wires. Furthermore, improved adhesion and bonding between the origin of the small-diameter stent graft 13 and the fenestration 21 reduces the risk of blood leakage, which is expected to improve the long-term survival rate of patients.
  • the overall or individual configurations, structures, shapes, dimensions, and materials of the main artificial blood vessel 11, small-diameter artificial blood vessels 11a, 11b, first artificial blood vessel 12, 12D, small-diameter stent graft 13, retaining rings 22, 22A, 22B, washers 33a, 33b, and other equipment and tools, as well as the content, sequence, and timing of hybrid treatment, can be modified as appropriate in accordance with the spirit of the present invention.

Landscapes

  • Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne une trousse de vaisseau sanguin artificiel et un vaisseau sanguin artificiel qui conviennent parfaitement à une utilisation dans des thérapies hybrides, et qui comprennent : un premier vaisseau sanguin artificiel (12) tubulaire et dont au moins une extrémité peut être suturée à un autre corps tubulaire ; un circlip (22) fixé à un orifice (fenestration) (21) disposé dans la paroi de vaisseau du premier vaisseau sanguin artificiel (12) et contenant des éléments radio-opaques ; et un second vaisseau sanguin artificiel (13) placé dans l'orifice du premier vaisseau sanguin artificiel (12). Le circlip (22) sert de marqueur pour des manipulations sous fluoroscopie, et retient le second vaisseau sanguin artificiel (13) dans la zone anastomotique après son insertion.
PCT/JP2025/000507 2024-03-25 2025-01-09 Vaisseau sanguin artificiel et trousse de vaisseau sanguin artificiel Pending WO2025203989A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2024-047688 2024-03-25
JP2024047688 2024-03-25

Publications (1)

Publication Number Publication Date
WO2025203989A1 true WO2025203989A1 (fr) 2025-10-02

Family

ID=97216278

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2025/000507 Pending WO2025203989A1 (fr) 2024-03-25 2025-01-09 Vaisseau sanguin artificiel et trousse de vaisseau sanguin artificiel

Country Status (1)

Country Link
WO (1) WO2025203989A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001503657A (ja) * 1996-11-08 2001-03-21 ハウザー，ラッセル，エイ． 径皮バイパス移植片および固着システム
JP2002518082A (ja) * 1998-06-10 2002-06-25 コンバージ メディカル， インコーポレイテッド 縫合なし吻合システム
JP2008526440A (ja) * 2005-01-13 2008-07-24 メドトロニック ヴァスキュラー インコーポレイテッド 分岐血管移植片の設計およびその配備方法
US20150073534A1 (en) * 2010-08-21 2015-03-12 Cook Medical Technologies Llc Prosthesis having pivoting fenestration
US20160184078A1 (en) * 2014-12-31 2016-06-30 Cordis Corporation Sectional Inserts for Trunk Section in Endoprosthesis for Aortic Aneurysm

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001503657A (ja) * 1996-11-08 2001-03-21 ハウザー，ラッセル，エイ． 径皮バイパス移植片および固着システム
JP2002518082A (ja) * 1998-06-10 2002-06-25 コンバージ メディカル， インコーポレイテッド 縫合なし吻合システム
JP2008526440A (ja) * 2005-01-13 2008-07-24 メドトロニック ヴァスキュラー インコーポレイテッド 分岐血管移植片の設計およびその配備方法
US20150073534A1 (en) * 2010-08-21 2015-03-12 Cook Medical Technologies Llc Prosthesis having pivoting fenestration
US20160184078A1 (en) * 2014-12-31 2016-06-30 Cordis Corporation Sectional Inserts for Trunk Section in Endoprosthesis for Aortic Aneurysm

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