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WO2025132929A3 - Sels d'avatrombopag - Google Patents

Sels d'avatrombopag

Info

Publication number
WO2025132929A3
WO2025132929A3 PCT/EP2024/087614 EP2024087614W WO2025132929A3 WO 2025132929 A3 WO2025132929 A3 WO 2025132929A3 EP 2024087614 W EP2024087614 W EP 2024087614W WO 2025132929 A3 WO2025132929 A3 WO 2025132929A3
Authority
WO
WIPO (PCT)
Prior art keywords
salts
avatrombopag
relates
hydrogenmalonate
hydrogenmaleate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2024/087614
Other languages
English (en)
Other versions
WO2025132929A9 (fr
WO2025132929A2 (fr
Inventor
Michal HEGEDUS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthon BV
Original Assignee
Synthon BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon BV filed Critical Synthon BV
Publication of WO2025132929A2 publication Critical patent/WO2025132929A2/fr
Publication of WO2025132929A3 publication Critical patent/WO2025132929A3/fr
Publication of WO2025132929A9 publication Critical patent/WO2025132929A9/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé amélioré de préparation de la forme C d'hydrogénomaléate d'avatrombopag à partir d'un mélange d'acétone et d'eau, ainsi que les nouveaux sels d'avatrombopag, leurs formes cristallines et leur préparation. Les sels sont choisis parmi les sels d'hydrogénomaléate, de fumarate, de sulfate, de bésylate et de tosylate.
PCT/EP2024/087614 2023-12-19 2024-12-19 Sels d'avatrombopag Pending WO2025132929A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP23218326.9 2023-12-19
EP23218326 2023-12-19
EP23219403 2023-12-21
EP23219403.5 2023-12-21

Publications (3)

Publication Number Publication Date
WO2025132929A2 WO2025132929A2 (fr) 2025-06-26
WO2025132929A3 true WO2025132929A3 (fr) 2025-09-12
WO2025132929A9 WO2025132929A9 (fr) 2025-11-13

Family

ID=94238300

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2024/087614 Pending WO2025132929A2 (fr) 2023-12-19 2024-12-19 Sels d'avatrombopag

Country Status (1)

Country Link
WO (1) WO2025132929A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013018362A1 (fr) * 2011-08-03 2013-02-07 Astellas Pharma Inc. Cristaux de composé de 2-acylaminothiazole

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2416304T3 (es) 2002-01-18 2013-07-31 Astellas Pharma Inc. Derivado de 2-acilaminotiazol o sal del mismo
JP4317818B2 (ja) 2002-09-30 2009-08-19 アステラス製薬株式会社 ２−アシルアミノチアゾール誘導体の新規な塩
CN106749226B (zh) 2017-03-15 2019-12-20 广东赛拓医药科技有限公司 一种avatrombopag马来酸盐晶型C的制备方法
CN112409350B (zh) 2020-11-27 2023-12-19 上海迪赛诺生物医药有限公司 一种马来酸阿伐曲泊帕晶型c的制备方法
CN116135854A (zh) 2021-11-16 2023-05-19 四川科伦药物研究院有限公司 2-酰基氨基噻唑衍生物马来酸盐晶型的制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013018362A1 (fr) * 2011-08-03 2013-02-07 Astellas Pharma Inc. Cristaux de composé de 2-acylaminothiazole

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DEEPAK GUPTA ET AL: "Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations", MOLECULES, vol. 23, no. 7, 14 July 2018 (2018-07-14), pages 1719, XP055718934, DOI: 10.3390/molecules23071719 *

Also Published As

Publication number Publication date
WO2025132929A9 (fr) 2025-11-13
WO2025132929A2 (fr) 2025-06-26

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