WO2025132929A9 - Sels d'avatrombopag - Google Patents
Sels d'avatrombopagInfo
- Publication number
- WO2025132929A9 WO2025132929A9 PCT/EP2024/087614 EP2024087614W WO2025132929A9 WO 2025132929 A9 WO2025132929 A9 WO 2025132929A9 EP 2024087614 W EP2024087614 W EP 2024087614W WO 2025132929 A9 WO2025132929 A9 WO 2025132929A9
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- salts
- avatrombopag
- relates
- hydrogenmalonate
- hydrogenmaleate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/145—Maleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne un procédé amélioré de préparation de la forme C d'hydrogénomaléate d'avatrombopag à partir d'un mélange d'acétone et d'eau, ainsi que les nouveaux sels d'avatrombopag, leurs formes cristallines et leur préparation. Les sels sont choisis parmi les sels d'hydrogénomaléate, de fumarate, de sulfate, de bésylate et de tosylate.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP23218326.9 | 2023-12-19 | ||
| EP23218326 | 2023-12-19 | ||
| EP23219403.5 | 2023-12-21 | ||
| EP23219403 | 2023-12-21 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO2025132929A2 WO2025132929A2 (fr) | 2025-06-26 |
| WO2025132929A3 WO2025132929A3 (fr) | 2025-09-12 |
| WO2025132929A9 true WO2025132929A9 (fr) | 2025-11-13 |
Family
ID=94238300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2024/087614 Pending WO2025132929A2 (fr) | 2023-12-19 | 2024-12-19 | Sels d'avatrombopag |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2025132929A2 (fr) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1319967C (zh) | 2002-01-18 | 2007-06-06 | 安斯泰来制药有限公司 | 2－酰基氨基噻唑衍生物或其盐 |
| JP4317818B2 (ja) | 2002-09-30 | 2009-08-19 | アステラス製薬株式会社 | ２−アシルアミノチアゾール誘導体の新規な塩 |
| JP2014144916A (ja) | 2011-08-03 | 2014-08-14 | Astellas Pharma Inc | ２−アシルアミノチアゾール化合物の結晶 |
| CN106749226B (zh) | 2017-03-15 | 2019-12-20 | 广东赛拓医药科技有限公司 | 一种avatrombopag马来酸盐晶型C的制备方法 |
| CN112409350B (zh) | 2020-11-27 | 2023-12-19 | 上海迪赛诺生物医药有限公司 | 一种马来酸阿伐曲泊帕晶型c的制备方法 |
| CN116135854A (zh) | 2021-11-16 | 2023-05-19 | 四川科伦药物研究院有限公司 | 2-酰基氨基噻唑衍生物马来酸盐晶型的制备方法 |
-
2024
- 2024-12-19 WO PCT/EP2024/087614 patent/WO2025132929A2/fr active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2025132929A3 (fr) | 2025-09-12 |
| WO2025132929A2 (fr) | 2025-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
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