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WO2025127179A1 - Dispositif de stimulation du nerf vague - Google Patents

Dispositif de stimulation du nerf vague Download PDF

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Publication number
WO2025127179A1
WO2025127179A1 PCT/KR2023/020404 KR2023020404W WO2025127179A1 WO 2025127179 A1 WO2025127179 A1 WO 2025127179A1 KR 2023020404 W KR2023020404 W KR 2023020404W WO 2025127179 A1 WO2025127179 A1 WO 2025127179A1
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WO
WIPO (PCT)
Prior art keywords
stimulation
mode
state
vagus nerve
pattern
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Pending
Application number
PCT/KR2023/020404
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English (en)
Korean (ko)
Inventor
문병종
홍기환
김종운
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Neurive Co Ltd
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Neurive Co Ltd
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Filing date
Publication date
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Publication of WO2025127179A1 publication Critical patent/WO2025127179A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M21/02—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36034—Control systems specified by the stimulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36036—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the outer, middle or inner ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0072—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus with application of electrical currents

Definitions

  • the present invention relates to a device for stimulating the vagus nerve, and more specifically, to a vagus nerve stimulator capable of applying various modes.
  • the vagus nerve is one of the cranial nerves and corresponds to the 10th cranial nerve.
  • the vagus nerve originates from the brain and is distributed across the face, chest, and abdomen. It is a mixed nerve that includes parasympathetic nerve fibers and is involved in the control of parasympathetic nerves that act on the heart, lungs, and digestive tract. It is the longest and has the most complex structure among the 12 pairs of cranial nerves and includes both sensory nerve fibers and motor nerve fibers.
  • vagus nerve stimulation devices for treating epilepsy and depression have been approved by the U.S. Food and Drug Administration (FDA), and they target the cervical branch located in the neck for stimulation.
  • FDA U.S. Food and Drug Administration
  • this cervical branch electrical stimulation of the vagus nerve cannot be used in the area of self-treatment by the general public because it involves making an incision directly on the skin, exposing the cervical branch of the vagus nerve, winding an electrical coil around the outside, and installing a microchip.
  • the human ear is the main path through which the vagus nerve passes, and since the vagus nerve is located close to the skin, it is considered a body part where electrical stimulation can be applied from the outside to the vagus nerve.
  • oriental medicine a method of treating diseases through acupuncture on the ear is applied, and since the ear is where the auricular branch of the vagus nerve is distributed, it can be seen that stimulation of the vagus nerve is used for treatment.
  • acupuncture cannot be applied by ordinary people.
  • vagus nerve stimulation devices that apply electrical stimulation by contacting the ear with electrodes have been developed and are being advanced, but the specific form of stimulation to which these vagus nerve stimulation devices are applied is limited.
  • the present invention is intended to solve the problems of the above-mentioned prior art and to provide a vagus nerve stimulation device that can apply various modes.
  • the vagus nerve stimulation device comprises: a stimulation unit including an electrode that is worn on at least one of the left and right ears and applies electrical stimulation to the vagus nerve of the external ear; a control unit that transmits an electrical stimulation signal for generating an electrical stimulation to the stimulation unit; and a mode selection unit that allows a user to select a mode of stimulation, wherein the mode selection unit includes a plurality of modes in which an electrical stimulation signal including a stimulation pattern constituting a frequency of a stimulation pulse and an application form of the stimulation is preset, the control unit stores information on the electrical stimulation signal corresponding to each mode and transmits an electrical stimulation signal corresponding to the mode selected by the user to the stimulation unit, and the mode selection unit is characterized in that it includes a tension relaxation mode, a concentration mode, and a sleep induction mode.
  • the above-mentioned tension relaxation mode has a stimulation pattern that continuously applies a stimulation pulse of 10 to 30 Hz for a predetermined period of time.
  • the above-mentioned focused mode has a stimulation pattern in which a stimulation pulse of 25 to 40 Hz is sequentially applied in an ON state where stimulation is applied and an OFF state where stimulation is not applied, and it is preferable that the length of each of the ON state and the OFF state be 1 to 2 seconds.
  • the above sleep induction mode has a stimulation pattern in which a HIGH state in which a relatively strong stimulus is applied and a LOW state in which a relatively weak stimulus is applied are sequentially applied with a stimulation pulse of 1 to 10 Hz, and it is preferable that the stimulation intensity of the LOW state is 30 to 60% of the stimulation intensity of the HIGH state, and the length of each of the HIGH state and the LOW state is 1 to 2 seconds.
  • the above mode selection unit may set a 'basic mode' used for a specific purpose in daily life as a higher mode, and may include a tension relaxation mode, a concentration mode, and a sleep induction mode as lower modes of the 'basic mode'.
  • the above motion sickness prevention mode has a stimulation pattern that sequentially applies RAMP UP, in which the stimulation intensity sequentially increases in multiple levels, and RAMP DOWN, in which the stimulation intensity sequentially decreases in multiple levels, with stimulation pulses of 30 to 60 Hz, and the stimulation intensity of each level is configured such that the difference between each stage is uniform, with level 0 set to 0% and the highest level set to 100%, and the time for performing each level can be 1 to 3 seconds each.
  • the above mode selection unit further includes a depression response mode, and the depression response mode has a stimulation pattern in which a stimulation pulse of 25 to 40 Hz is sequentially applied in an ON state in which stimulation is applied and an OFF state in which stimulation is not applied, and the length of each of the ON state and the OFF state can be 0.1 to 0.5 seconds.
  • the above mode selection unit further includes an ADHD response mode
  • the ADHD response mode has a stimulation pattern in which a HIGH state in which a relatively strong stimulus and a LOW state in which a relatively weak stimulus are applied are sequentially applied with a stimulation pulse of 5 to 80 Hz, and the stimulation intensity of the LOW state is 30 to 60% of the stimulation intensity of the HIGH state, and the length of each of the HIGH state and the LOW state is configured to be 1 to 10 seconds, but the application time may be determined randomly.
  • the above mode selection unit further includes a PTSD response mode, and the PTSD response mode has a stimulation pattern in which a stimulation pulse of 5 to 15 Hz is sequentially applied in an ON state in which a stimulation is applied and an OFF state in which a stimulation is not applied, and the length of each of the ON state and the OFF state can be 1 to 2 seconds.
  • the above mode selection unit may further include a 'symptom response mode' used for the purpose of symptom relief for a specific symptom as a higher mode, and may include a depression response mode, an ADHD response mode, and a PTSD response mode as lower modes of the 'symptom response mode'.
  • a 'symptom response mode' used for the purpose of symptom relief for a specific symptom as a higher mode, and may include a depression response mode, an ADHD response mode, and a PTSD response mode as lower modes of the 'symptom response mode'.
  • the present invention configured as described above, has multiple operation modes specialized for specific purposes, so that the effect of electric stimulation is improved through a mode according to the user's purpose of use.
  • Figure 1 is a schematic diagram illustrating the structure of a vagus nerve stimulation device according to an embodiment of the present invention.
  • FIG. 2 is a drawing for explaining information about an electrical stimulation signal in a vagus nerve stimulation device according to an embodiment of the present invention.
  • FIG. 3 is a drawing for explaining a stimulation pattern of a tension relaxation mode applied to a vagus nerve stimulation device according to an embodiment of the present invention.
  • FIG. 4 is a drawing for explaining a stimulation pattern of a focused mode applied to a vagus nerve stimulation device according to an embodiment of the present invention.
  • FIG. 5 is a drawing for explaining a stimulation pattern of a sleep induction mode applied to a vagus nerve stimulation device according to an embodiment of the present invention.
  • FIG. 6 is a drawing for explaining a stimulation pattern of an anti-motion sickness mode applied to a vagus nerve stimulation device according to an embodiment of the present invention.
  • FIG. 7 is a drawing for explaining a stimulation pattern of a depression response mode applied to a vagus nerve stimulation device according to an embodiment of the present invention.
  • FIG. 8 is a drawing for explaining a stimulation pattern of an ADHD response mode applied to a vagus nerve stimulation device according to an embodiment of the present invention.
  • FIG. 9 is a drawing for explaining a stimulation pattern of a PTSD response mode applied to a vagus nerve stimulation device according to an embodiment of the present invention.
  • first the first component
  • second the second component
  • first component the first component
  • first component the second component
  • first component the second component
  • Figure 1 is a schematic diagram illustrating the structure of a vagus nerve stimulation device according to an embodiment of the present invention.
  • the vagus nerve stimulation device equipped with a user identification function of the present embodiment includes a stimulation unit (10), a control unit (20), and a mode selection unit (300).
  • the stimulation unit (10) includes one or more electrodes that contact a predetermined location to apply electrical stimulation to the vagus nerve located in the user's ear, and may be structured such that the electrodes are formed on a wearable device worn by the user so that the electrodes maintain contact with the user's ear.
  • the electrode includes at least one electrode on one side of the ear, and may include, for example, an electrode inserted into the external auditory canal and an electrode contacting the conchae of the auricle.
  • the specific configuration of the electrode is not particularly limited, and any structure of the electrode for general vagus nerve stimulation may be applied as long as it does not impair the characteristics of the present invention.
  • the wearable device is usually provided in two pieces, one for each ear, but may be configured to be worn on only one ear.
  • each piece may be configured to be completely separate, or may be configured to be connected through a separate connecting member.
  • the control unit (20) is a component that transmits an electrical stimulation signal for generating electrical stimulation to the electrode of the stimulation unit.
  • the present invention provides electrical stimulation to the vagus nerve of the ear through electrodes for symptom relief of a specific symptom or for other purposes, and the control unit (20) stores information on the electrical stimulation signal and transmits it to the stimulation unit (10) so that the electrical stimulation is performed through the electrodes.
  • the information on the electrical stimulation signal can be applied to all the contents of a general vagus nerve stimulation device, and the present invention is characterized in that it includes information on a plurality of modes having a specific purpose. In order to explain the information on the electrical stimulation signal, the stimulation pulse and the stimulation pattern are explained separately.
  • FIG. 2 is a drawing for explaining information about an electrical stimulation signal in a vagus nerve stimulation device according to an embodiment of the present invention.
  • Electrical stimulation through electrodes is performed by applying current, and the form of current application can be expressed as a stimulation pulse since it is applied in the form of a pulse wave.
  • the form of stimulation application configured by controlling the intensity of the stimulation pulse or stopping the stimulation can be expressed as a stimulation pattern.
  • the electrical stimulation mode specified in the present invention is distinguished by an electrical stimulation signal composed of a stimulation pulse and a stimulation pattern.
  • the stimulation pulse can be treated in the same way as the current applied to the electrode, and the intensity of the stimulation pulse and the intensity of the stimulation pattern can be treated in the same way as the intensity of the current. Meanwhile, in indicating the stimulation pattern, only the plus area is indicated for the convenience of expression, but this does not mean that the electrical stimulation in the minus area is excluded.
  • the mode selection unit (300) is a component that allows the user to select the type of electrical stimulation, and the specific configuration for selecting and inputting the type of electrical stimulation is not particularly limited.
  • the vagus nerve stimulation device of this embodiment has multiple modes that can be selected from the mode selection unit (300), and specifically includes a tension relaxation mode, a concentration mode, a sleep induction mode, a motion sickness prevention mode, a depression response mode, an ADHD response mode, a PTSD response mode, etc.
  • Each mode selectable from the mode selection unit (300) has an electric stimulation signal having the characteristics of a preset stimulation pulse and stimulation pattern, which are stored in advance in the control unit (20).
  • the control unit (20) transmits an electric stimulation signal reflecting the characteristics of the stored mode to the electrode, thereby performing electric stimulation on the user.
  • the electric stimulation signal set for each mode is set based on whether a stable or excited state is required from the user in each situation and the frequency of brain waves required in each situation.
  • each mode is described.
  • the application time of each mode can be adjusted according to the individual's condition based on a predetermined basic time, and in this embodiment, 15 minutes is set as the basic time.
  • FIG. 3 is a drawing for explaining a stimulation pattern of a tension relaxation mode applied to a vagus nerve stimulation device according to an embodiment of the present invention.
  • the tension-relieving middle frequency (TRMF) mode is a mode that can relieve tension by balancing the autonomic nervous system through parasympathetic nerve activation in a tense state where the sympathetic nerve is activated, and can achieve the effect of reducing stress.
  • TRMF tension-relieving middle frequency
  • a stimulation pulse of 10 to 30 Hz is continuously applied.
  • the intensity of the stimulation can be adjusted according to the user's current condition and personal characteristics such as sensitivity, and this is the same in all modes below.
  • the overall scale of the stimulation intensity can change over time depending on the user's sensitivity, etc., but the basic structure of the stimulation pattern is maintained.
  • FIG. 4 is a drawing for explaining a stimulation pattern of a focused mode applied to a vagus nerve stimulation device according to an embodiment of the present invention.
  • Concentration enhancement frequency activates the alpha wave band (8-13 Hz) of brain waves to improve study and work efficiency, enable the user to enter a state of mental concentration, and achieve the effect of maximizing memory and concentration.
  • a stimulation pulse of 25-40 Hz is applied, and the electrical stimulation is applied in a stimulation pattern in which the ON state where the stimulation is applied and the OFF state where the stimulation is not applied are sequentially applied, as shown in the figure.
  • the length of each ON state and OFF state is 1-2 seconds.
  • FIG. 5 is a drawing for explaining a stimulation pattern of a sleep induction mode applied to a vagus nerve stimulation device according to an embodiment of the present invention.
  • Sleep-Inducing Low Frequency (SILF) mode can achieve the effect of inducing sleep as well as the effect of relieving tension and making one feel comfortable by activating the delta and theta wave bands, which are low-frequency bands of brain waves below 8 Hz.
  • a stimulation pulse of 1 to 10 Hz is applied, and the electrical stimulation is applied in a stimulation pattern in which a HIGH state (state) in which a relatively strong stimulus is applied and a LOW state (state) in which a relatively weak stimulus is applied are sequentially applied, as shown in the figure.
  • the stimulation intensities of the HIGH and LOW states are such that the stimulation intensity of the LOW state is 30 to 60% of the stimulation intensity of the HIGH state, and the length of each of the HIGH and LOW states is configured to be the same in the range of 1 to 2 seconds.
  • FIG. 6 is a drawing for explaining a stimulation pattern of an anti-motion sickness mode applied to a vagus nerve stimulation device according to an embodiment of the present invention.
  • Motion sickness prevention high frequency (MHF) mode activates the high-frequency beta and gamma wave bands of brain waves to induce an arousal state, thereby reducing the occurrence of motion sickness.
  • a stimulation pulse of 30 to 60 Hz is applied, and the electrical stimulation is applied in a stimulation pattern that sequentially applies RAMP UP, in which the intensity of the stimulation sequentially increases to multiple levels, and RAMP DOWN, in which the intensity of the stimulation sequentially decreases to multiple levels, as shown in the figure.
  • the levels of RAMP UP and RAMP DOWN can be composed of three or more, and the time for each level to be performed is 1 to 3 seconds.
  • the stimulation intensity of each level is configured so that the difference between each stage is uniform, with level 0 set to 0% and the highest level set to 100%.
  • the maximum level of stimulation intensity can be adjusted according to the user's current status and personal characteristics such as sensitivity, as examined above.
  • FIG. 7 is a drawing for explaining a stimulation pattern of a depression response mode applied to a vagus nerve stimulation device according to an embodiment of the present invention.
  • Depression prevention High Frequency (DHF) mode lifts the mood of depressed users and induces an energetic and excited state.
  • a stimulation pulse of 25 to 40 Hz is applied, and the electrical stimulation is applied in a stimulation pattern in which the ON state where the stimulation is applied and the OFF state where the stimulation is not applied are sequentially applied, as shown in the figure.
  • the length of each ON state and OFF state is 0.1 to 0.5 seconds. Compared to the concentration mode, by quickly configuring the change between the ON state and the OFF state, the effect of inducing an energetic state can be obtained.
  • FIG. 8 is a drawing for explaining a stimulation pattern of an ADHD response mode applied to a vagus nerve stimulation device according to an embodiment of the present invention.
  • ADHD-relieving variable frequency (ARVF) mode is a mode for alleviating symptoms of ADHD such as decreased concentration and distraction.
  • a stimulation pulse of 5 to 80 Hz is applied, and electrical stimulation is applied in a stimulation pattern in which a relatively strong HIGH state and a relatively weak LOW state are sequentially applied, as shown in the figure.
  • the stimulation intensities of the HIGH and LOW states are such that the stimulation intensity of the LOW state is 30 to 60% of the stimulation intensity of the HIGH state, and the length of each HIGH and LOW state is 1 to 10 seconds, but the application time is randomly determined.
  • FIG. 9 is a drawing for explaining a stimulation pattern of a PTSD response mode applied to a vagus nerve stimulation device according to an embodiment of the present invention.
  • PTSD-relieving middle frequency is a mode that helps users suffering from PTSD to escape from the influence of past memories and their fears through a calming effect.
  • a stimulation pulse of 5 to 15 Hz is applied, and the electrical stimulation is applied in a stimulation pattern in which the ON state where the stimulation is applied and the OFF state where the stimulation is not applied are sequentially applied, as shown in the figure.
  • the length of each ON state and OFF state is 1 to 2 seconds.
  • the tension relief mode, concentration mode, sleep induction mode, motion sickness prevention mode, depression response mode, ADHD response mode, and PTSD response mode applied in this embodiment may be simply arranged at the same level in the mode selection unit (300), but may also be presented by grouping them into separate upper categories.
  • a 'basic mode' used for a specific purpose in daily life and a 'symptom response mode' used for the purpose of symptom relief for a specific symptom may be set as upper categories of individual modes
  • a tension relief mode, concentration mode, sleep induction mode, and motion sickness prevention mode may be arranged as sub-modes of the basic mode
  • a depression response mode, ADHD response mode, and PTSD response mode may be arranged as sub-modes of the symptom response mode.
  • the mode of the electric stimulation signal presented in the mode selection unit (300) and stored in the control unit (20) can be additionally downloaded through wired/wireless communication or added using a separate storage device.

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Abstract

La présente invention concerne un dispositif de stimulation du nerf vague. Le dispositif de stimulation du nerf vague comprend : une unité de stimulation comprenant une électrode portée sur au moins une de l'oreille gauche ou de l'oreille droite pour appliquer une stimulation électrique au nerf vague de l'oreille externe ; une unité de commande pour transmettre, à l'unité de stimulation, un signal de stimulation électrique pour générer une stimulation électrique ; et une unité de sélection de mode par laquelle un utilisateur sélectionne un mode de stimulation, l'unité de sélection de mode comprenant une pluralité de modes prédéfinis, chacun comprenant un signal de stimulation électrique qui comprend un modèle de stimulation constituant la fréquence d'une impulsion de stimulation et le type d'application d'une stimulation, l'unité de commande stockant des informations sur un signal de stimulation électrique correspondant à chaque mode et transmettant le signal de stimulation électrique correspondant à un mode sélectionné par un utilisateur à l'unité de stimulation, et l'unité de sélection de mode comprenant un mode de relaxation de tension, un mode de concentration et un mode d'induction du sommeil. La présente invention comporte une pluralité de modes de fonctionnement spécialisés dans un but spécifique, ce qui permet d'améliorer l'effet de stimulation électrique grâce à un mode sélectionné en fonction de l'objectif d'utilisation de l'utilisateur.
PCT/KR2023/020404 2023-12-12 2023-12-12 Dispositif de stimulation du nerf vague Pending WO2025127179A1 (fr)

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KR1020230179361A KR20250089743A (ko) 2023-12-12 2023-12-12 미주신경 자극장치

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