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WO2023096360A1 - Procédé de commande de stimulation complexe et dispositif de stimulation complexe - Google Patents

Procédé de commande de stimulation complexe et dispositif de stimulation complexe Download PDF

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Publication number
WO2023096360A1
WO2023096360A1 PCT/KR2022/018654 KR2022018654W WO2023096360A1 WO 2023096360 A1 WO2023096360 A1 WO 2023096360A1 KR 2022018654 W KR2022018654 W KR 2022018654W WO 2023096360 A1 WO2023096360 A1 WO 2023096360A1
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WIPO (PCT)
Prior art keywords
ears
stimulation
frequency
electrical stimulation
electrodes
Prior art date
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Ceased
Application number
PCT/KR2022/018654
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English (en)
Korean (ko)
Inventor
송재준
김국한
정용호
최혁
홍기환
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Neurive Co Ltd
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Neurive Co Ltd
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Publication date
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Priority to US18/712,446 priority Critical patent/US20250010071A1/en
Priority to EP22899042.0A priority patent/EP4438105A4/fr
Publication of WO2023096360A1 publication Critical patent/WO2023096360A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36034—Control systems specified by the stimulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H23/00—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
    • A61H23/02—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive
    • A61H23/0218—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive with alternating magnetic fields producing a translating or oscillating movement
    • A61H23/0236—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive with alternating magnetic fields producing a translating or oscillating movement using sonic waves, e.g. using loudspeakers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36036—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the outer, middle or inner ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/10—Characteristics of apparatus not provided for in the preceding codes with further special therapeutic means, e.g. electrotherapy, magneto therapy or radiation therapy, chromo therapy, infrared or ultraviolet therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/16—Physical interface with patient
    • A61H2201/1602—Physical interface with patient kind of interface, e.g. head rest, knee support or lumbar support
    • A61H2201/165—Wearable interfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/50—Control means thereof
    • A61H2201/5007—Control means thereof computer controlled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2205/00—Devices for specific parts of the body
    • A61H2205/02—Head
    • A61H2205/027—Ears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0027—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the hearing sense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0072—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus with application of electrical currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]

Definitions

  • the present invention relates to a method for controlling a composite stimulus in which various stimuli are simultaneously added, and more particularly, to a method for controlling a composite stimulus in which an electrical stimulus to the vagus nerve and an auditory stimulus to the ear are simultaneously added.
  • the vagus nerve is one of the cranial nerves and corresponds to the 10th cranial nerve.
  • the vagus nerve is a mixed nerve that comes out of the brain and is distributed over the face, chest, and abdomen, and includes parasympathetic nerve fibers. It is involved in the control of the parasympathetic nerve that acts on the heart, lungs, and digestive tract. It has the longest and most complex structure among the 12 pairs of cranial nerves, and includes both sensory nerve fibers and motor nerve fibers.
  • vagus nerve stimulation devices for the treatment of epilepsy and depression have been approved by the US Food and Drug Administration (FDA), and they target the cervical branches located in the neck.
  • FDA US Food and Drug Administration
  • such electrical stimulation of the cervical branch of the vagus nerve directly incises the skin, exposes the cervical branch of the vagus nerve, winds a coil, which is an electrical element, and mounts a microchip on the outside, so that it can be used in the field of self-treatment by the general public. can't
  • a vagus nerve stimulation device for treating epilepsy and depression affects the brain by controlling nerve signals entering the brain, and is based on neuromodulation.
  • Neuromodulation is a physiological process in which a given neuron uses one or more chemicals to modulate a diverse population of neurons, unlike synaptic transmission, in which neurotransmitters are released from axon terminals by targeting fast-acting receptors on one particular partner neuron. there is.
  • a method for improving the function of the nervous system or reducing chronic pain using such neuromodulation a method of applying electrical stimulation or chemical stimulation to the nervous system is being studied.
  • the application of the vagus nerve stimulation device and the deep brain stimulation device described above is very limited because a device for applying electrical stimulation to a nerve is directly attached to a nerve inside the human body.
  • Methods of directly influencing the brain from outside the body include magnetic stimulation in which a magnetic field applied from outside the head activates the brain and transcranial electrical stimulation in which electricity sent through electrodes attached to the transcranial cranial cortex is activated.
  • Transcranial magnetic stimulation and transcranial electrical stimulation have the effect of directly affecting the brain in a non-invasive way, but have limitations in that the area of the brain to be stimulated is limited to the vicinity of the skull.
  • the present invention is to solve the problems of the prior art described above, and in controlling the electrical stimulation for stimulating the vagus nerve, a control method capable of improving the effect of vagus nerve stimulation by adding acoustic stimulation affecting the brain together Its purpose is to provide
  • a method for controlling a complex stimulation is a method for controlling a complex stimulation device having an electrical stimulation unit including electrodes in contact with human ears and a sound output unit for stimulating hearing using sound waves.
  • the sound output unit generates sound waves having different frequencies in both ears, and controls a frequency difference between sound waves applied to both ears based on the frequency of electrical stimulation applied to the electrodes.
  • the sound waves applied to both ears are controlled so that the frequency difference between the frequency of the electric stimulation applied to the electrodes and the sound waves applied to both ears is the same.
  • a frequency difference between electrical stimulation applied to electrodes in contact with both ears may be 5 Hz or more.
  • the frequency of electrical stimulation applied to the electrode is preferably in the range of 10 to 120 Hz.
  • the strength of the electrical stimulation applied to the electrode is preferably in the range of 3 to 80 V.
  • the pulse width of the electrical stimulation applied to the electrode is preferably in the range of 10 to 250 ⁇ s.
  • a complex stimulation device includes two electrodes each contacting the vagus nerve located in both ears; Two sound output units that stimulate hearing in both ears, respectively; and a control unit for controlling electrical stimulation applied to the electrodes and sound waves output from the sound output unit, wherein the control unit controls each sound output unit to generate sound waves of different frequencies, but the sound waves applied to both ears It is characterized in that the frequency difference between the electrodes is controlled based on the frequency of electrical stimulation applied to the electrodes.
  • control unit controls to apply electrical stimulation of the same frequency to both ears or only one of both ears
  • the control unit controls both ears so that the frequency difference between the frequency of the electrical stimulation applied to the electrodes and the sound wave applied to both ears is the same. It controls the sound waves applied to the ear.
  • control unit controls electrical stimulation of different frequencies to be applied to the electrodes of both ears
  • the control unit determines that the frequency difference between the frequency difference between the electrical stimulation applied to the electrodes in contact with each vagus nerve and the sound waves applied to both ears Control the sound waves applied to both ears to be the same.
  • the present invention configured as described above is superior in that it can improve the efficiency of electrical stimulation for the vagus nerve by stimulating the brain with two stimuli by adding acoustic stimulation together when stimulating the vagus nerve through an electrode in contact with the ear. It works.
  • 1 is a diagram for explaining control elements of electrical stimulation applied to the vagus nerve.
  • FIG. 2 is a diagram for explaining the configuration of a vagus nerve stimulation device according to an embodiment of the present invention.
  • vagus nerve stimulation device 100 left wearing part
  • first and second are used to distinguish one component from another, and the scope of rights should not be limited by these terms.
  • a first element may be termed a second element, and similarly, a second element may be termed a first element.
  • 1 is a diagram for explaining control elements of electrical stimulation applied to the vagus nerve.
  • Electrical stimulation for stimulating the vagus nerve is controlled in the form of a pulse wave, and intensity (V), pulse width (PW), and frequency (F) can be controlled.
  • V intensity
  • PW pulse width
  • F frequency
  • the general frequency term and unit Hz are used only for alternating current
  • pulse frequency and pps pulse frequency and pps (pulses per second) are used as a unit for pulse current, but for pulse waves
  • frequency and Hz can be used, and frequency and Hz are also used in this specification.
  • stimulation treatment using electrical stimulation it is common to perform stimulation treatment with various types of treatment waveforms by controlling intensity (V), pulse width (PW), and frequency (F).
  • the control of such electric stimulation is to adjust so that the strength of the stimulation felt by the user is not too strong or too weak, and is also adjusted for the purpose of increasing the efficiency of the stimulation through change rather than continuously applying a constant stimulation.
  • the inventors of the present invention have developed a neuromodulation technique using the vagus nerve in developing a neuromodulation technique for activating brain functions.
  • a neuromodulation technique using the vagus nerve in developing a neuromodulation technique for activating brain functions.
  • Transcranial magnetic stimulation or transcranial electrical stimulation has the property of stimulating the cerebral cortex from the outside, but in the case of the vagus nerve stimulation according to the present invention, it stimulates the deep part of the brain via the vagus nerve, the 10th cranial nerve, so that the brainstem and deep cerebral is a technique that can effectively stimulate
  • the non-invasive vagus nerve stimulation of the present invention stimulates the cerebral cortex via the Nucleus tractus solitarius, Locus Cceruleus, and Nucleus basalis to improve the neural plasticity of the cerebrum, thereby providing new It can enhance learning ability by promoting the formation of synapses. Changes in cerebral synapses by acoustic stimulation can induce synergy with the improvement of cerebral plasticity by the non-invasive vagus nerve stimulation of the present invention, thereby improving the therapeutic effect.
  • the inventors of the present invention confirmed that when electrical stimulation is applied to the vagus nerve of the ear and acoustic stimulation is applied to the auditory nerve, brain activation proceeds actively under some conditions. Then, as a result of experimenting with various conditions in order to find specific conditions in which brain activation is induced, it was confirmed that there is a relationship between the frequency of electrical stimulation and the frequency of acoustic stimulation.
  • control range of the electrical stimulation that can be applied to the vagus nerve of the ear is the intensity (V) in the range of 3 to 80V, the frequency (F) in the range of 10 to 120Hz, and the pulse width (PW) in the range of 10 to 250 ⁇ s.
  • the control range of electrical stimulation was determined in consideration of the range of electrical stimulation that can be applied to human nerves and the range that can be handled by non-experts.
  • the inventors of the present invention configure the frequency of the acoustic stimulation applied to the left ear and the right ear differently, but the frequency difference of the acoustic stimulation A method of linking the frequency of electrical stimulation applied to the vagus nerve of the ear was derived.
  • the vagus nerve is a pathway that transmits nerve signals between various organs of the human body and the brain. Electrical stimulation to the vagus nerve is transmitted to the brain along nerve fibers, and electrical stimulation to the vagus nerve affects a wide network of the brain. It is widely known that At this time, if the frequency of the electrical stimulation applied to the vagus nerve of the ear and the frequency of the acoustic signal applied to the auditory nerve are adjusted, the effect of the electrical stimulation on the brain and the effect of the acoustic signal on the brain cause an interaction, resulting in an electrical stimulation applied to the vagus nerve. It is believed that the effect of
  • the frequency of the acoustic stimulation applied to the left ear and the right ear is configured differently, but the specific method of linking the frequency difference of the acoustic stimulation to the frequency of the electrical stimulation applied to the vagus nerve of the ear is largely divided into two types.
  • the first method is suitable for a case in which electrical stimulation of the same frequency is applied to both ears or only one of both ears.
  • applying the same electrical stimulation to both ears does not mean that they are physically identical, and is a concept that includes slight errors according to the configuration of the device by applying the same conditions to the two electrodes.
  • the frequency of the electrical stimulation applied to the electrodes of both ears or one ear is the same, the frequency of the acoustic stimulation applied to the left and right ears is configured differently, but the frequency difference between the acoustic stimulation applied to both ears is controlled to be the same as the frequency of the electrical stimulation By doing so, the effect of electrical stimulation on the vagus nerve is improved.
  • the frequency difference between the acoustic stimulation applied to the left ear and the right ear is controlled to be 20 Hz.
  • the frequency range of the acoustic stimulation is not particularly limited as long as the same difference as the frequency of the electrical stimulation can be obtained, and a desirable acoustic frequency range can be applied by reflecting the technical details of the acoustic stimulation that have been studied.
  • the second method is suitable for cases where the frequencies of electrical stimulation applied to both ears are different.
  • stimulation treatment using electrical stimulation it is common to perform stimulation treatment with various types of treatment waveforms by controlling intensity (V), pulse width (PW), and frequency (F).
  • the control of such electric stimulation is to adjust so that the strength of the stimulation felt by the user is not too strong or too weak, and is also adjusted for the purpose of increasing the efficiency of the stimulation through change rather than continuously applying a constant stimulation.
  • the inventor of the present invention studied the effect on the brain by neuromodulation in applying electrical stimulation to the vagus nerve of the ear, and unlike transcranial magnetic stimulation or transcranial electrical stimulation, indirectly stimulated the brain to developed a way to activate it.
  • the process of stimulating the vagus nerve of both ears when electrical stimulation of different frequencies is applied to both ears, it was confirmed that the activation of the brain proceeds actively, and furthermore, acoustic stimulation applied to the left and right ears It was confirmed that the effect of electrical stimulation on the vagus nerve was improved by configuring the frequency of the vagus nerve differently, but controlling the frequency difference between the acoustic stimulation applied to both ears to be the same as the frequency difference of the electrical stimulation. At this time, when the frequency difference between the electrical stimulation applied to both ears is 5 Hz or more, the effect of inducing brain activation by the frequency difference of the electrical stimulation is shown.
  • the difference between the frequencies of the acoustic stimulation applied to the left and right ears is controlled to be 10 Hz.
  • the frequency range of the acoustic stimulation is not particularly limited as long as the same frequency difference as that of the electrical stimulation can be obtained, and a desirable acoustic frequency range can be applied by reflecting the technical details of the acoustic stimulation that have been studied so far. there is.
  • FIG. 2 is a diagram for explaining the configuration of a vagus nerve stimulation device according to an embodiment of the present invention.
  • the vagus nerve stimulation device 10 of the present invention includes a left wearing part 100 worn on the user's left ear and a right wearing part 200 worn on the right ear, and the left wearing part 100 and the right wearing part 200 ) Electrodes 110 and 210 and sound output units 120 and 220 for applying electrical stimulation to the vagus nerve of the ear are respectively formed.
  • the specific structure of the left wearing part 100 and the right wearing part 200 can be variously applied within a range that does not impair the characteristics of the present invention.
  • the left wearable part 100 and the right wearable part 200 may be separately worn, and at this time, the structure for fixing the wearable part to the user's ear is not limited. For example, it may be fixed to the ear by a structure inserted into the ear canal, or it may be fixed to the ear by a separate fixing means such as an ear hook, and the shape of the fixing means may be applied without limitation to the extent that the characteristics of the present invention are not impaired.
  • connection part structurally connecting the left wearable part 100 and the right wearable part 200 may be further included, and the structure of the connection part may be applied without limitation in a conventional form, such as when located on the head side and when located on the back neck side.
  • the left wearable part 100 and the right wearable part 200 may be fixed to the wearer's ear by the elasticity of the connection part, or may be fixed to the ear by a separate fixing means.
  • the specific structure of the electrodes 110 and 210 formed on the left wearable part 100 and the right wearable part 200 can also be applied in various ways within a range that does not impair the characteristics of the present invention.
  • the position and shape of contact with the ear to stimulate the vagus nerve can be variously applied to the existing technology, and can be formed to contact the Cymba concha of the ear or inserted into the ear canal to make contact. there is.
  • the specific structure of the sound output units 120 and 220 formed on the left wearable part 100 and the right wearable part 200 can also be applied in various ways without impairing the characteristics of the present invention, and the technology used in headphones and earphones this may apply.
  • the electrodes 110 and 210 are inserted into the ear canal, it is preferable to form a hole through which sound can be transmitted to the inside of the electrodes 110 and 210.
  • the control unit 300 controls electrical stimulation applied to the vagus nerve through the electrodes 110 and 210 formed on the left wearable part 100 and the right wearable part 200 and acoustic stimulation output from the sound output units 120 and 220. configuration for control. At this time, the controller may control the electrical stimulation applied to the electrode 110 of the left wearable part 100 and the electrode 210 of the right wearable part 200 together or individually.
  • the control unit 300 may control the intensity (V), pulse width (PW), and frequency (F) of the electrical stimulation.
  • the control range of the electrical stimulation controlled by the control unit 300 is the intensity (V) in the range of 3 ⁇ 80V, the frequency (F) in the range of 10 ⁇ 120Hz, the pulse width (PW) is in the range of 10 ⁇ 250 ⁇ s.
  • control unit 300 controls the frequency of the acoustic stimulus output from the sound output unit 120 of the left wearable part 100 and the sound stimulus output from the sound output unit 220 of the right wearable part 200 to be different from each other.
  • the frequency difference between the acoustic stimulation applied to the left ear and the right ear can be controlled based on the frequency of the electrical stimulation applied to the electrodes 110 and 210.
  • the control unit 300 is the sound output unit of the left wearing part 100.
  • the frequency difference between the acoustic stimulus output from the 120 and the acoustic stimulus output from the acoustic output unit 220 of the right wearable part 200 may be controlled to be the same as the frequency of the electrical stimulus.
  • the control unit 300 controls the sound output unit 120 of the left wearing part 100.
  • the frequency difference between the sound stimulation output from the sound output unit 220 of the right wearable part 200 may be controlled to be the same as the frequency of the electrical stimulation.
  • the control unit 300 is the sound output unit of the left wearable part 100.
  • the frequency difference between the acoustic stimulus output from the 120 and the acoustic stimulus output from the acoustic output unit 220 of the right wearable part 200 may be controlled to be the same as the frequency difference between the electric stimulus.
  • the controller 300 controls the frequencies F of electrical stimulation applied to the vagus nerves of both ears differently, the difference in frequencies can be controlled to be 5 Hz or more.

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Abstract

La présente invention concerne un procédé de commande d'une stimulation complexe, qui est un procédé de commande d'un dispositif de stimulation complexe comportant une unité de stimulation électrique comprenant des électrodes en contact avec les oreilles d'un être humain et une unité de sortie sonore pour stimuler l'audition à l'aide d'ondes sonores, l'unité de sortie sonore générant des ondes sonores présentant différentes fréquences dans les deux oreilles, et commandant la différence de fréquence entre les ondes sonores appliquées aux deux oreilles sur la base des fréquences de stimulation électrique appliquées aux électrodes. La présente invention présente un excellent effet d'amélioration de l'efficacité de la stimulation électrique sur le nerf vague par stimulation du cerveau à l'aide de deux types de stimulation par ajout d'une stimulation acoustique conjointement à la stimulation du nerf vague à travers les électrodes en contact avec les oreilles.
PCT/KR2022/018654 2021-11-26 2022-11-23 Procédé de commande de stimulation complexe et dispositif de stimulation complexe Ceased WO2023096360A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US18/712,446 US20250010071A1 (en) 2021-11-26 2022-11-23 Method for controlling complex stimulation and complex stimulation device
EP22899042.0A EP4438105A4 (fr) 2021-11-26 2022-11-23 Procédé de commande de stimulation complexe et dispositif de stimulation complexe

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020210165569A KR102604276B1 (ko) 2021-11-26 2021-11-26 복합 자극의 제어 방법 및 복합 자극 장치
KR10-2021-0165569 2021-11-26

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