[go: up one dir, main page]

WO2025190611A1 - Composition de soin buccal contenant du zinc à faible astringence - Google Patents

Composition de soin buccal contenant du zinc à faible astringence

Info

Publication number
WO2025190611A1
WO2025190611A1 PCT/EP2025/054144 EP2025054144W WO2025190611A1 WO 2025190611 A1 WO2025190611 A1 WO 2025190611A1 EP 2025054144 W EP2025054144 W EP 2025054144W WO 2025190611 A1 WO2025190611 A1 WO 2025190611A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
zinc
toothpaste
percent
sodium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2025/054144
Other languages
English (en)
Inventor
Federico BRICCHI
Adam John Limer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unilever Global IP Ltd
Unilever IP Holdings BV
Conopco Inc
Original Assignee
Unilever Global IP Ltd
Unilever IP Holdings BV
Conopco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Global IP Ltd, Unilever IP Holdings BV, Conopco Inc filed Critical Unilever Global IP Ltd
Publication of WO2025190611A1 publication Critical patent/WO2025190611A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts

Definitions

  • the present invention is concerned with toothpaste compositions having an improved sensory profile.
  • Zinc salts have been used in some oral care compounds for a number of years.
  • US 5470 561 discloses an anti-plaque mouthwash comprising a zinc salt and triclosan.
  • the composition may also comprise glycine and has a pH of between 4 and 8, preferably between 5 and 7, the preferred pH being 6.
  • GBA-2 052 978 discloses a toothpaste comprising zinc salts with glycine and having a pH from 4.5 to 8.0.
  • Toothpaste compositions comprising zinc are disclosed in WO0612977.
  • the toothpaste comprises water, a zinc salt, a chelating agent for the zinc.
  • US 5632 972 discloses a method for minimising damage to gingival and periodontal tissue by delivering a first component comprising zinc and a second component comprising a bicarbonate.
  • US2014170084 discloses that certain zinc salts when added to toothpastes comprising catechins prevent darkening of the colour of the toothpaste.
  • the present application has found that the foam quality of the product, and astringency of toothpaste compositions comprising zinc can be improved by the use of specified surfactants.
  • the present invention relates to a toothpaste composition
  • a toothpaste composition comprising: i) 0.05 to 4 wt% of the total composition of a zinc salt selected from zinc citrate or zinc sulphate and ii) 0.5 to 10 wt% of the total composition of a sodium olefin sulfonate surfactant.
  • a further second of the invention is the use of sodium olefin sulfonate surfactant to mitigate the astringency of a toothpaste composition comprising a zinc salt.
  • a third aspect of the invention relates to a composition comprising sodium olefin sulfonate for use in a method to mitigate the astringency of a toothpaste composition comprising a zinc salt.
  • the composition is a toothpaste.
  • a composition is not intentionally swallowed for purposes of systemic administration of therapeutic agents, but is applied to the oral cavity, used to treat the oral cavity and then expectorated.
  • a cleaning implement such as a toothbrush, usually by applying it to the bristles of the toothbrush and then brushing the accessible surfaces of the oral cavity.
  • composition is a product which, during the normal course of usage, is not for the purpose of systemic administration or intentionally swallowed but is rather retained in the oral cavity for a time sufficient to contact substantially all of the dental surfaces and/or oral tissues for the purposes of oral activity.
  • the toothpaste is in the form of an extrudable semi-solid such as a cream, paste or gel (or mixture thereof).
  • Compositions according to the invention comprise a zins salt consisting of zinc citrate and/or zinc sulphate (zinc sulphate heptahydrate) are particularly preferred.
  • the level of zinc salt is from 0.05 to 4 wt% of the total composition. More preferably the level of zinc salt is from 0.1 wt% to 3.5wt% of the total composition, it is particularly preferred if the salt is a zinc sulphate its level is from 0.1 to 1 wt% of the total composition. If the zinc salt is a zinc citrate its level is from 1 to 3.5 wt% of the total composition
  • the composition further comprises glycine.
  • the level of glycine is from is from 1.5 wt% to 4 wt%, more preferably 2 wt% to 3.5 wt% of the total composition.
  • compositions of the invention comprise a sodium olefin sulfonate surfactant, preferbaly the the sodium olefin sulfpnate is sodium C14-C16 olefin sulfonate.
  • the level of sodium olefin sulfonate surfactant is from 0.5 to 10.0 wt% of the total composition, more preferably from 0.75 to 7 wt%, more preferably from 1 to 5 wt%.
  • a further aspect of the invention is the use the use of sodium olefin sulfonate surfactant to mitigate the astringency of a toothpaste composition comprising a zinc salt compared with a composition not comprising sodium olefin sulfonate.
  • the sodium olefine surfactant comprises at least 50wt% of the total surfactant present in the composition, more preferably at least 75 wt%, most preferably at least 99 wt%.
  • Compositions according to the invention preferably comprise particulate abrasive materials such as silicas, aluminas, calcium carbonates, dicalciumphosphates, calcium pyrophosphates, hydroxyapatites, trimetaphosphates, insoluble hexametaphosphates and so on, including agglomerated particulate abrasive materials, usually in amounts between 3 and 60% by weight of the toothpaste composition.
  • particulate abrasive materials such as silicas, aluminas, calcium carbonates, dicalciumphosphates, calcium pyrophosphates, hydroxyapatites, trimetaphosphates, insoluble hexametaphosphates and so on, including agglomerated particulate abrasive materials, usually in amounts between 3 and 60% by weight of the toothpaste composition.
  • the composition particularly a toothpaste, comprises a silica based abrasive.
  • the preferred abrasive silicas used in the present invention is a silica with a low refractive index. It may be used as the sole abrasive silica, or in conjunction with a low level of other abrasive silicas, e.g. those according to EP 236070.
  • suitable low refractive index abrasive silicas e.g. having an R.l.
  • composition particularly if a toothpaste, preferably comprises an inorganic or a natural or synthetic thickener or gelling agent in proportions of about 0.10 to about 15% by weight depending on the material chosen.
  • thickeners in the dentifrice compositions of the present invention form an extrudable, shape-retaining product which can be squeezed from a tube onto a toothbrush and will not fall between the bristles of the brush but rather, will substantially maintain its shape thereon.
  • Suitable thickeners or gelling agents useful in the practice of the present invention include inorganic thickening silicas such as amorphous silicas available from Huber Corporation under the trade designation Zeodent 165, Irish moss, iota-carrageenan, gum tragacanth, and polyvinylpyrrolidone.
  • inorganic thickening silicas such as amorphous silicas available from Huber Corporation under the trade designation Zeodent 165, Irish moss, iota-carrageenan, gum tragacanth, and polyvinylpyrrolidone.
  • composition according to the invention will generally contain further ingredients to enhance performance and/or consumer acceptability, in addition to the ingredients specified above.
  • additional calcium-containing abrasives for example calcium phosphate abrasive, e.g., tricalcium phosphate, hydroxyapatite or dicalcium phosphate dihydrate or calcium pyrophosphate, and/or silica abrasives, sodium metaphosphate, potassium metaphosphate, aluminum silicate, calcined alumina, or other siliceous materials, or combinations thereof are used.
  • calcium phosphate abrasive e.g., tricalcium phosphate, hydroxyapatite or dicalcium phosphate dihydrate or calcium pyrophosphate
  • silica abrasives sodium metaphosphate, potassium metaphosphate, aluminum silicate, calcined alumina, or other siliceous materials, or combinations thereof are used.
  • the toothpaste composition according to the invention may comprise sodium bicarbonate at a level from 0.1 wt% to 5 wt%, preferably 0.1 wt% to 1 wt% of the total composition.
  • Compositions according to the invention may comprise a poyol such as propyleneglycol, xylitol, and lactitol.
  • Glycerol is a preferred polyol
  • sorbitol is particularly preferred.
  • Composition of the invention may comprise 0.5 to 5 wt% of the total composition of an antimicrobial quaternary ammonium material.
  • Preferred antimicrobial quaternary ammonium material are cetylpyridinium chloride (CPC), CPC-claybenzalkonium chloride, tetradecylpyridinium chloride (TPC), N-tetradecyl-4-ethylpyridinium chloride (TDEPC).
  • Particularly preferred is a cetylpyridium chloride clay complex.
  • the composition may comprise a natural or synthetic thickener or gelling agent in proportions of about 0.10 to about 5% by weight depending on the material chosen.
  • compositions according to the invention may comprise a polymeric deposition aid.
  • the composition comprises acid anhydride polymers, particularly preferred are co-polymers of maleic anhydride with methyl vinylether, in which the anhydride moiety may be in a partially or fully hydrolysed or alcoholysed form.
  • Preferred copolymers include Gantrez(R) polymers such as:
  • Gantrez S-95 molecular weight 216,000; free acid
  • Gantrez S-96 molecular weight 700,000; free acid
  • Gantrez S-97 molecular weight 1,500,000; free acid
  • Gantrez MS-955 molecular weight 1,060,000; calcium/sodium salt.
  • Particularly preferred co-polymers of maleic acid and methyl vinylether have a molecular weight of 1,000,000 or greater and an especially preferred material is Gantrez S-97.
  • compositions according to the invention may comprise a tooth whitening agent.
  • the whitening agent preferably comprises a green and/or a blue pigment.
  • a pigment is generally understood to be a shade/material which is insoluble in the relevant medium, at the relevant temperature. This is in contrast to dyes which are soluble.
  • the "relevant medium” is human saliva, the liquid medium in which the composition is used, at the temperature of the oral cavity during brushing of the teeth, i.e. up to 37 Degrees C. As a reasonable approximation, the relevant medium may be considered to be water and the relevant temperature to be 25 Degrees C.
  • the blue pigment is Pigment Blue 15, more preferably Pigment Blue 15:1, 15:2, 15:3, 15:4, 15:5 or 15:6, most preferably 15:1.
  • a preferred pigment is blue pigment is Phthalocyanine Blue Pigment, Cl No. 74160, blue covarine.
  • the preferred Green pigment is Phthalocyanine Green, preferably Phthalocyanine Green CI-74260.
  • the total level of pigment in the composition is from 0.01 wt% to 3 wt, more preferably from 0.02 to 2 wt%.
  • composition is a toothpaste it may be a dual phase paste, with the whitening pigments present in one phase.
  • compositions according to the invention may comprise water-soluble or sparingly water-soluble sources of metal salts
  • zinc ions such as zinc chloride, zinc acetate, zinc gluconate, zinc sulphate, zinc fluoride, zinc citrate, zinc lactate, zinc oxide, zinc monoglycerolate, zinc tartrate, zinc pyrophosphate and zinc maleate
  • stannous ions such as stannous fluoride and stannous chloride.
  • compositions according to the invention may comprise oral care enzyme systems such as hydrogen peroxide producing enzyme systems (e.g. the oxidoreductase enzyme glucose oxidase), amyloglucosidase, dextranase and/or mutanase, (optionally in the presence of zinc ion providing compounds and/or 8- hydroxyquinoline derivatives), lactoperoxidase, lactoferrin, lysozyme and mixtures thereof.
  • hydrogen peroxide producing enzyme systems e.g. the oxidoreductase enzyme glucose oxidase
  • amyloglucosidase e.g. the oxidoreductase enzyme glucose oxidase
  • dextranase and/or mutanase e.g. the oxidoreductase enzyme glucose oxidase
  • mutanase e.g. the mutanase
  • lactoperoxidase e.g. the
  • Compositions of the invention may comprise fluoride sources such as sodium fluoride, stannous fluoride, sodium monofluorophosphate, zinc ammonium fluoride, tin ammonium fluoride, calcium fluoride, cobalt ammonium fluoride and mixtures thereof.
  • Fluoride ion sources may be added to the compositions at a level of about 0.001 wt. percent to about 10 wt. percent, e.g., from about 0.003 wt. percent to about 5 wt. percent, 0.01 wt. percent to about 1 wt., or about 0.05 wt. percent.
  • the stannous fluoride is present in an amount of 0.1 wt. percent to 2 wt.
  • Fluoride ion sources may be added to the compositions at a level of about 0.001 wt. percent to about 10 wt. percent, e.g., from about 0.003 wt. percent to about 5 wt. percent, 0.01 wt. percent to about 1 wt., or about 0.05 wt. percent.
  • weights of fluoride salts to provide the appropriate level of fluoride ion will obviously vary based on the weight of the counter ion in the salt, and one of skill in the art may readily determine such amounts.
  • the fluoride source is a fluoride salt present in an amount of 0.1 wt. percent to 2 wt. percent (0.1 wt percent -0.6 wt. percent) of the total composition weight (e.g., sodium fluoride (e.g., about 0.32 wt. percent).
  • the total composition weight e.g., sodium fluoride (e.g., about 0.32 wt. percent).
  • Some embodiments of the invention are free from fluoride sources, that is the composition comprises less than 0.01 wt% of a fluoride source.
  • a preferred class of oral care active for inclusion in the compositions of the invention includes agents for the remineralisation of teeth.
  • remineralisation in the context of the present invention means the in situ generation of hydroxyapatite on teeth.
  • a specific example of a suitable agent for the remineralisation of teeth is a mixture of a calcium source and a phosphate source which, when delivered to the teeth results in the in situ generation of hydroxyapatite on teeth.
  • remineralising calcium sources include, for example, calcium phosphate, calcium gluconate, calcium oxide, calcium lactate, calcium glycerophosphate, calcium carbonate, calcium hydroxide, calcium sulphate, calcium carboxymethyl cellulose, calcium alginate, calcium salts of citric acid, calcium silicate and mixtures thereof.
  • the remineralising calcium source is calcium silicate.
  • the amount of remineralising calcium source(s) (e.g. calcium silicate) in the composition of the invention typically ranges from 1 to 30%, preferably from 5 to 20% by total weight remineralising calcium source based on the total weight of the toothpaste composition.
  • remineralising phosphate sources include, for example, monosodium dihydrogen phosphate, disodium hydrogen phosphate, sodium pyrophosphate, tetrasodium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, potassium dihydrogenphosphate, trisodium phosphate, tripotassium phosphate and mixtures thereof.
  • the remineralising phosphate source is a mixture of trisodium phosphate and sodium dihydrogen phosphate.
  • the amount of remineralising phosphate source(s) (e.g. trisodium phosphate and sodium dihydrogen phosphate) in the composition of this invention typically ranges from 2 to 15%, preferably from 4 to 10% by total weight remineralising phosphate source based on the total weight of the toothpaste composition.
  • the oral care compositions comprise an effective amount of one or more antibacterial agents, for example comprising an antibacterial agent selected from halogenated diphenyl ether (e.g.
  • triclosan triclosan
  • triclosan monophosphate e.g., rosemary extract, tea extract, magnolia extract, thymol, menthol, eucalyptol, geraniol, carvacrol, citral, hinokitol, magnolol, ursolic acid, ursic acid, catechol, methyl salicylate, epigallocatechin gallate, epigallocatechin, gallic acid, miswak extract, sea-buckthorn extract), bisguanide antiseptics (e.g., chlorhexidine, alexidine or octenidine), quaternary ammonium compounds (e.g., cetylpyridinium chloride (CPC), CPC-claybenzalkonium chloride, tetradecylpyridinium chloride (TPC), N-tetradecyl-4-ethylpyridinium chloride (TDEPC)), phenolic antiseptics, hexetidine furanone
  • One or more additional antibacterial or preservative agents may optionally be present in the composition in a total amount of from about 0.01 wt. percent to about 0.5 wt. percent, optionally about 0.05 wt. percent to about 0.1 wt. percent or about 0.3 percent, by total weight of the composition.
  • the oral care compositions also comprise at least one flavorant, useful for example to enhance taste of the composition.
  • Any orally acceptable natural or synthetic flavorant can be used, including without limitation essential oils and various flavoring aldehydes, esters, alcohols, and similar materials, tea flavors, vanillin, sage, marjoram, parsley oil, spearmint oil, cinnamon oil, oil of Wintergreen, peppermint oil, clove oil, bay oil, anise oil, eucalyptus oil, citrus oils, fruit oils, sassafras and essences including those derived from lemon, orange, lime, grapefruit, apricot, banana, grape, apple, strawberry, cherry, pineapple, etc., bean-and nut-derived flavors such as coffee, cocoa, cola, peanut, almond, etc., adsorbed and encapsulated flavorants and the like.
  • ingredients that provide fragrance and/or other sensory effect in the mouth, including cooling or warming effects.
  • Such ingredients illustratively include menthol, carvone, menthyl acetate, menthyl lactate, camphor, eucalyptus oil, eucalyptol, anethole, eugenol, cassia, oxanone, a-irisone, , thymol, linalool, benzaldehyde, cinnamaldehyde, N-ethyl-p-menthan-3-carboxamine, N, 2, 3- trimethyl-2- isopropylbutanamide, 3- (1-menthoxy) -propane-1, 2-diol, cinnamaldehyde glycerol acetal (CGA), menthone glycerol acetal (MGA) and the like.
  • One or more flavorants are optionally present in a total amount of from about 0.01 wt. percent to about 5 wt. percent, for example, from about 0.03 wt. percent to about 2.5 wt. percent, optionally about 0.05 wt. percent to about 1 .5 wt. percent, further optionally about 0.1 wt. percent to about 0.3 wt. percent and in some embodiments in various embodiments from about 0.01 wt. percent to about 1 wt. percent, from about 0.05 to about 2 percent, from about 0.1 percent to about 2.5 percent, and from about 0.1 to about 0.5 percent by total weight of the composition.
  • the oral care compositions comprise at least one sweetener, useful for example to enhance taste of the composition.
  • Sweetening agents among those useful herein include dextrose, polydextrose, sucrose, maltose, dextrin, dried invert sugar, mannose, xylose, ribose, fructose, levulose, galactose, corn syrup, partially hydrolyzed starch, hydrogenated starch hydrolysate, ethanol, sorbitol, mannitol, xylitol, maltitol, isomalt, aspartame, neotame, saccharin and salts thereof (e.g. sodium saccharin), sucralose, dipeptide-based intense sweeteners, cyclamates, dihydrochalcones.
  • sweetening agents include dextrose, polydextrose, sucrose, maltose, dextrin, dried invert sugar, mannose, xylose, ribose, fructo
  • One or more sweeteners are optionally present in a total amount depending strongly on the particular sweetener (s) selected, but typically 0.005 wt. percent to 5 wt. percent, by total weight of the composition, optionally 0.005 wt. percent to 0.2 wt. percent, further optionally 0.05 wt. percent to 0.1 wt. percent by total weight of the composition.
  • the oral care compositions further comprise an agent that interferes with or prevents bacterial attachment, e.g., ethyl lauroyl arginiate (ELA), solbrol or chitosan, as well as plaque dispersing agents such as enzymes (papain, glucoamylase, etc.).
  • an agent that interferes with or prevents bacterial attachment e.g., ethyl lauroyl arginiate (ELA), solbrol or chitosan
  • EVA ethyl lauroyl arginiate
  • solbrol solbrol
  • chitosan e.g., chitosan
  • plaque dispersing agents such as enzymes (papain, glucoamylase, etc.).
  • composition according the invention will comprise further ingredients which are common in the art, such as: antimicrobial agents, e.g. chlorhexidine, sanguinarine extract, metronidazole, quaternary ammonium compounds, such as cetylpyridinium chloride; cetylpyridium chloride clay complex bis- guanides, such as chlorhexidine digluconate, hexetidine, octenidine, alexidine; and halogenated bisphenolic compounds, such as 2,2' methylenebis-(4-chloro-6-bromophenol); anti-inflammatory agents such as ibuprofen, flurbiprofen, aspirin, indomethacin etc.; anti-caries agents such as sodium- and stannous fluoride, aminefluorides, sodium monofluorophosphate, sodium trimeta phosphate and casein; plaque buffers such as urea, calcium lactate, calcium glycerophosphate and strontium polyacrylates; vitamins such as Vitamins A
  • starch starch, sucrose, water or water/alcohol systems etc.
  • additional surfactants such as anionic, nonionic, cationic and zwitterionic or amphoteric surfactants
  • polymeric compounds which can enhance the delivery of active ingredients such as antimicrobial agents can also be included
  • buffers and salts to buffer the pH and ionic strength of the oral care composition e.g. bleaching agents such as peroxy compounds e.g. potassium peroxydiphosphate, effervescing systems such as sodium bicarbonate/citric acid systems, colour change systems, and so on.
  • bleaching agents such as peroxy compounds e.g. potassium peroxydiphosphate, effervescing systems such as sodium bicarbonate/citric acid systems, colour change systems, and so on.
  • Toothpaste compositions were prepared as described in Table 1.
  • the product was assessed for astringency using an expert sensory panel of 25 people.
  • the astringency was measured after 1 , 5 and 10 minutes of application of the toothpaste.
  • the differences shown in table 2 below are all considered statistically significant (they are on 1-10 scale), less is better.
  • a Kruss dynamic foam analyser was used to agitate which following a standard method was used to agitate the product and generate foam.
  • Example of the invention has more foam and the foam is denser, giving an enhanced sensory attribute compared with the comparative Example.
  • Examples 2 and B were assessed for astringency using an expert sensory panel of 25 people. The astringency was measured after 1 , 5 and 10 minutes of application of the toothpaste. The differences shown in table 6 below are all considered statistically significant (they are on 1-10 scale), less is better. Table 6
  • a Kruss dynamic foam analyser was used to agitate which following a standard method was used to agitate the product and generate foam.
  • the foam height and bubble size were measured as in Tables 7 and 8. A higher proportion of the bubbles are small, which implies a denser foam.
  • Example 2 of invention has more foam and the foam is denser, giving an enhanced sensory attribute over comparative Example B.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition de dentifrice comprenant un sel de zinc et un tensioactif de sulfonate d'oléfine de sodium.
PCT/EP2025/054144 2024-03-15 2025-02-17 Composition de soin buccal contenant du zinc à faible astringence Pending WO2025190611A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP24163863 2024-03-15
EP24163863.4 2024-03-15

Publications (1)

Publication Number Publication Date
WO2025190611A1 true WO2025190611A1 (fr) 2025-09-18

Family

ID=90366399

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2025/054144 Pending WO2025190611A1 (fr) 2024-03-15 2025-02-17 Composition de soin buccal contenant du zinc à faible astringence

Country Status (1)

Country Link
WO (1) WO2025190611A1 (fr)

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1373003A (en) * 1971-01-28 1974-11-06 Unilever Ltd Dentifrice composition
US5470561A (en) 1991-12-11 1995-11-28 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Mouthwash compositions
US5632972A (en) 1994-06-30 1997-05-27 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Method for treating gingival and periodontal tissues
WO2006012977A1 (fr) 2004-08-03 2006-02-09 Unilever N.V. Composition
EP1837009B1 (fr) * 2006-03-22 2009-05-13 The Procter and Gamble Company Compositions à base de zinc pour l'administration orale
DE102010063720A1 (de) * 2010-12-21 2011-06-16 Lr Health & Beauty Systems Gmbh Silberhaltige Zahnpflegezusammensetzung
US20140170084A1 (en) 2011-06-17 2014-06-19 Prasun Bandyopadhyay Oral care composition
WO2016156161A1 (fr) * 2015-03-30 2016-10-06 Unilever Plc Compositions solides pour l'hygiène bucco-dentaire
US20190307657A1 (en) * 2017-02-10 2019-10-10 Evonik Degussa Gmbh Oral care composition containing at least one biosurfactant and fluoride
WO2021013283A1 (fr) * 2019-07-19 2021-01-28 Dr. Kaschny Healthcare GmbH Produit d'hygiène buccale contenant de la caféine et de la l-lysine comme agent anti-amertume

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1373003A (en) * 1971-01-28 1974-11-06 Unilever Ltd Dentifrice composition
US5470561A (en) 1991-12-11 1995-11-28 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Mouthwash compositions
US5632972A (en) 1994-06-30 1997-05-27 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Method for treating gingival and periodontal tissues
WO2006012977A1 (fr) 2004-08-03 2006-02-09 Unilever N.V. Composition
EP1837009B1 (fr) * 2006-03-22 2009-05-13 The Procter and Gamble Company Compositions à base de zinc pour l'administration orale
DE102010063720A1 (de) * 2010-12-21 2011-06-16 Lr Health & Beauty Systems Gmbh Silberhaltige Zahnpflegezusammensetzung
US20140170084A1 (en) 2011-06-17 2014-06-19 Prasun Bandyopadhyay Oral care composition
WO2016156161A1 (fr) * 2015-03-30 2016-10-06 Unilever Plc Compositions solides pour l'hygiène bucco-dentaire
US20190307657A1 (en) * 2017-02-10 2019-10-10 Evonik Degussa Gmbh Oral care composition containing at least one biosurfactant and fluoride
WO2021013283A1 (fr) * 2019-07-19 2021-01-28 Dr. Kaschny Healthcare GmbH Produit d'hygiène buccale contenant de la caféine et de la l-lysine comme agent anti-amertume

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE GNPD [online] MINTEL; 28 February 2022 (2022-02-28), ANONYMOUS: "Complete Toothpaste", XP093198925, retrieved from https://www.gnpd.com/sinatra/recordpage/9415776/ Database accession no. 9415776 *
DATABASE GNPD [online] MINTEL; 28 February 2023 (2023-02-28), ANONYMOUS: "8 in 1 Toothpaste", XP093198953, retrieved from https://www.gnpd.com/sinatra/recordpage/10617084/ Database accession no. 10617084 *
DATABASE GNPD [online] MINTEL; 4 February 2021 (2021-02-04), ANONYMOUS: "Mild Mint Toothpaste with Fluoride", XP093198958, retrieved from https://www.gnpd.com/sinatra/recordpage/8462607/ Database accession no. 8462607 *

Similar Documents

Publication Publication Date Title
EP2934442B1 (fr) Produits de soin buccal comprenant un complexe halogénure de zinc tétrabasique/acide aminé
AU2014364436A1 (en) Dentifrice compositions comprising zinc oxide and zinc citrate
EP2793809B1 (fr) Compositions de soin orales
WO2022133221A1 (fr) Compositions de soins bucco-dentaires contenant des fluorures d'amine
EP3955883B1 (fr) Composition de soins personnels comprenant de la tétraméthylcurcumine et son procédé de production
AU2020337430B2 (en) Zinc phosphate containing compositions
WO2025190611A1 (fr) Composition de soin buccal contenant du zinc à faible astringence
WO2025153291A1 (fr) Composition de soin buccal
WO2025153301A1 (fr) Composition de soin buccal
WO2025233091A1 (fr) Composition de soin buccal comprenant de l'arginine ou des sels de celle-ci et de l'asparagine ou des sels de celle-ci
WO2024231022A1 (fr) Composition de soin buccal à goût amélioré comprenant du bicarbonate de sodium
WO2025190613A1 (fr) Composition de soin buccal ayant un dépôt de calcium amélioré
EP4420736A1 (fr) Composition de soin buccal
WO2024149491A1 (fr) Composition de soins buccodentaires
EP4483861A1 (fr) Composition de soin buccal comprenant un alkylpolyglucoside
EP4420737A1 (fr) Composition de soin buccal
WO2025180682A1 (fr) Composition de soin buccal
EP4420735A1 (fr) Composition de soin buccal
WO2024175393A1 (fr) Composition de dentifrice
WO2025176405A1 (fr) Composition de soin buccal
WO2025031689A1 (fr) Composition de soins buccaux
EP3952829B1 (fr) Procédé de préparation d'une composition de soins bucco-dentaires comprenant du gingerdiol
EP3955884B1 (fr) Composition de soins personnels comprenant de la piperlongumine et son procédé de production
WO2025228646A1 (fr) Composition de soins bucco-dentaires
RU2801309C2 (ru) Композиция для ухода за полостью рта

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 25705260

Country of ref document: EP

Kind code of ref document: A1

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)