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WO2025172966A1 - Composition stable, procédés et utilisations associés - Google Patents

Composition stable, procédés et utilisations associés

Info

Publication number
WO2025172966A1
WO2025172966A1 PCT/IB2025/051692 IB2025051692W WO2025172966A1 WO 2025172966 A1 WO2025172966 A1 WO 2025172966A1 IB 2025051692 W IB2025051692 W IB 2025051692W WO 2025172966 A1 WO2025172966 A1 WO 2025172966A1
Authority
WO
WIPO (PCT)
Prior art keywords
seq
previous
composition according
acid
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/IB2025/051692
Other languages
English (en)
Inventor
Diana Isabel PEREIRA GUIMARÃES
Ana Isabel SÁ LOUREIRO
Artur Manuel Cavaco Paulo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Solfarcos Solucoes Farmaceuticas E Cosmeticas Lda
Original Assignee
Solfarcos Solucoes Farmaceuticas E Cosmeticas Lda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP24201443.9A external-priority patent/EP4603151A1/fr
Application filed by Solfarcos Solucoes Farmaceuticas E Cosmeticas Lda filed Critical Solfarcos Solucoes Farmaceuticas E Cosmeticas Lda
Publication of WO2025172966A1 publication Critical patent/WO2025172966A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A61K8/553—Phospholipids, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A61K2800/31—Anhydrous

Definitions

  • the present disclosure relates to a stable and safe emulsified waterless composition, namely a pharmaceutical or cosmetic composition, to enhance specific attributes of the skin, hair, nail, and/or scalp.
  • This stable composition has a better shelf stability, moisturizing, antioxidant, antimicrobial properties and promotes microbiome balance on the skin and scalp.
  • Stable compositions often face challenges related to instability, susceptibility to oxidation, and microbial contamination, which can compromise their efficacy and safety.
  • the present disclosure addresses these challenges by providing a stable emulsified composition with enhanced moisturizing, antioxidant and antimicrobial properties, suitable for various cosmetic/pharmaceutical applications.
  • a stable emulsified composition namely a pharmaceutical or cosmetic composition, is disclosed herein, formulated to provide enhanced stability, antioxidant benefits, and antimicrobial properties for application on skin, hair, nails, and/or scalp.
  • the composition comprises a carefully selected blend of emulsifiers, antioxidants, and antimicrobial agents, ensuring the stability of the emulsion over time and promoting skin health.
  • the present disclosure pertains to stable emulsified waterless composition
  • a green solvent which can be a naturally occurring product, a mixture of them or a NAtural Deep Eutectic Solvent (NADES), serving as a solvent itself or to extract bioactive compounds, along with an emulsifier (e.g. phospholipids), an oil phase, and at least one soluble auxiliary, such as a diol.
  • NADES NAtural Deep Eutectic Solvent
  • the composition of the present disclosure may further include a peptide, a cosmetic/pharmaceutic component, or a combination thereof, with the intent of addressing and enhancing specific attributes of hair, nail, scalp, and skin.
  • the stable emulsified composition disclosed herein can be formulated into various skincare, haircare, nail care, and scalp care products, including but not limited to lotions, creams, serums, shampoos, conditioners, and treatments. Its stability, antioxidant activity, and antimicrobial efficacy make it suitable for use in a wide range of cosmetic/pharmaceutic formulations, catering to diverse consumer needs.
  • NADES are a type of solvent formed by mixing two or more naturally occurring compounds at a certain ratio, resulting in a eutectic mixture with unique properties. They are gaining attention as environmentally friendly alternatives to traditional solvents in various applications, including pharmaceuticals, cosmetics, and green chemistry with high efficiency in extracting natural components.
  • the present disclosure relates to a stable emulsified composition, comprising: a bioactive mixture; a phospholipid as an emulsifier; and di-alcohol as a solvent; wherein bioactive mixture comprises a green solvent as NADES and an active cosmetic compound; wherein the NADES is a mixture of lactic acid and glycerol.
  • the composition does not comprise water.
  • Phospholipids are used as skin-friendly emulsifier agents. They help to repair and restore our skin's natural protective barrier. They mimic the lamellar structure of the extracellular matrix and form a protective layer, preventing water loss from the skin. Phospholipids themselves can be used as a powerful cosmetic /pharmaceutic active ingredient for skin protection and skin rejuvenation, and as a carrier system for cosmetic/pharmaceutic active ingredients improving their skin interaction, resulting in a long-lasting cosmetic effect.
  • the oil phase influences the final characteristics of a cosmetic/pharmaceutical product, including its spreading behaviour and sensory properties. It can provide also antioxidant and antimicrobial properties.
  • the stable emulsified composition of the present disclosure provides enhanced stability, antioxidant benefits, and antimicrobial properties for application on skin, hair, nails, and/or scalp. Unexpectedly, the composition of the present disclosure also promotes microbiome balance on the skin and scalp, leveraging the synergistic interaction between green solvents, active cosmetic/pharmaceutical compound, and phospholipids for improved dermatological health and aspect.
  • the cosmetic composition may comprise:
  • the phospholipid is selected from a list consisting of: phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidic acid, lecithin including unsaturated as well as hydrogenated phospholipids, or mixtures thereof.
  • the phospholipid is selected from a list consisting of: phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, lecithin or mixtures thereof; lecithin.
  • the phospholipid is selected from a list consisting of: phosphatidylcholine and /or lecithin.
  • the amount of an active cosmetic compound ranges from 0.01 to 10 % (w/w).
  • the amount of an active cosmetic/pharmaceutic compound ranges from 0.01 to 5 % (w/w).
  • the amount of an active cosmetic/pharmaceutic compound ranges from 0.5 to 2 % (w/w).
  • the at least two components of the bioactive mixture are selected from a list consisting of : lactic acid, glycolic acid, decanoic acid, citric acid, maleic acid, malic acid, oxalic acid, tartaric acid, oleic acid, palmitic acid, enanthic acid, formic acid, caprylic acid, ethylene glycol, propylene glycol, glycine, glycerol, glucose, transcutol, menthol, sodium lactate, sodium acetate, sodium citrate, xylitol and sorbitol more preferably lactic acid, glycolic acid, glycine, glycerol, ethylene glycol and propylene glycol, choline chloride, or mixtures thereof.
  • the di-alcohol is selected from a list consisting of: 1,2- Propanediol; 1,3-Propanediol; 1,2-Butanediol; 1,3-Butanediol; 1,4-Butanediol; 2,3-Butanediol; 1,2- Hexanediol; 1,6-Hexanodiol; 1,5-Pentanediol; 1,2-Octanediol; 1,8-Octanediol; 1,2-Decanediol; 1,10- Decanediol; Methylpropanediol; 2-Butyl-2-ethyl-1,3-propanediol, Isopentyldiol and Ethane-1,2-diol or mixtures thereof.
  • the di-alcohol is selected from a list consisting of: 1,2- Propanediol; 1,3-Propanediol; 1,2-Butanediol; 1,3-Butanediol; 1,4-Butanediol; 2,3-Butanediol; 1,2- Hexanediol; 1,6-Hexanodiol; more preferably 1,3-Propanediol, 1,2-Butanediol and 1,2-Hexanediol, or mixtures thereof.
  • composition may further comprise a peptide preferably at least a peptide 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from a list consisting of:
  • SEQ ID No 556 EEMQRR
  • SEQ ID No 557 MGWCTASVPPQCYG
  • SEQ. ID No 558 ATAKAWLKGIGAGAGAGA;
  • SEQ ID No 560 GGVCGPSPPCITTATAKAWLKGI;
  • SEQ ID No 561 GGVCGPSPPCITTGAGAGAGATAKAWLKGI;
  • SEQ ID No 563 ATAKAWLKGIAGAGAGAGGVCGPSPPCITT;
  • SEQ ID No 564 GGVCGPSPPCITTATAKAWLKGIRRQMEE;
  • SEQ ID No 566 GGVCGPSPPCITTRRQMEE
  • SEQ ID No 584 GGVCGPSPPCITTGAGAGAGARRQMEE;
  • SEQ ID No 586 RRQMEEGGVCGPSPPCITTGRKKRRQRRRPPQ;
  • SEQ ID No 569 ATAKAWLKGIMGWCTASVPPQCYG;
  • SEQ ID No 570 RRQMEEMGWCTASVPPQCYG;
  • SEQ ID No 2 GGVCGPSPPCITTVPGVGVPGVGVPGVGVPGVGVPGVGVPGVG;
  • SEQ ID No 4 GGVCGPSPPCITTGGRPSDSYGAPGGGN;
  • SEQ ID No 573 GGVCGPSPPCITTRCAERCSEASIQDRCLKYCGICCEK;
  • SEQ ID No 574 GGVCGPSPPCITTGTYGNKDECPCYRDMKNSKGKGKCP;
  • SEQ ID No 572 GGVCGPSPPCITTGTCYINDDEGCTKRCQGIYIYRREAVMGHC;
  • SEQ ID No 576 RQIKIWFQNRRMKWKK
  • SEQ ID No 578 LLIILRRRRIRKQAHAHSK
  • SEQ ID No 579 GVCGPSPPCITTDRDDQAAWFSQY
  • SEQ. ID No 581 GGVCGPSPPCITTERSRSSDGKSSSQVNRSRHENTSQVPLQESRTRKRRGSRVSQDRDSEGH;
  • the amount peptide ranges from 0.0001 % to 20 % (w/w).
  • the amount peptide ranges from 0.001% to 5 % (w/w).
  • the amount peptide ranges from 0.1% to about 1% (w/w).
  • the green solvent is a natural deep eutectic solvent.
  • the composition does not contain water.
  • composition may further comprise at least one excipient suitable for dermatological use.
  • the at least one excipient suitable for dermatological use may be selected from the following list: preservative, thickener, organic polymer, humectant, silicone, oil, fragrance, vitamin, buffer, antimicrobial agent, antibacterial agent, disinfectant, chelating agent or mixtures thereof.
  • the at least one excipient suitable for dermatological use is selected from the following list: ethanol, benzyl alcohol, diol molecule, urea, ammonium thioglycolate, thioanisole, tris(hydroxymethyl)aminomethane, phosphate buffer, sodium hydroxide, sodium chloride, citrate buffer, or a combination of two or more thereof.
  • An aspect of the present disclosure relates to the use of the composition as described in the present disclosure as an antimicrobial agent against infection.
  • the composition as described in the present disclosure may be used against infections of Trichophyton mentagrophytes strain, and/or toenails infections.
  • the composition may be a pharmaceutical or a cosmetic composition.
  • An aspect of the present disclosure relates to the use of the composition described in the present disclosure in skin, nail, hair or scalp treatment; namely for the prevention or treatment of diseases or disorders in skin, nail, hair or scalp (human or animal).
  • An aspect of the present disclosure relates to the use of the composition described in the present disclosure in skin, nail, hair or scalp treatment (human or animal).
  • An aspect of the present disclosure relates to the use of the composition described in the present disclosure for the manufacture of a medicament for the prevention or treatment of diseases or disorders in skin, nail, hair or scalp (human or animal).
  • An aspect of the present disclosure relates to a method for treating or preventing of diseases or disorders in skin, nail, hair or scalp in a subject (human or animal), the method comprising administering the composition of the present disclosure.
  • the composition may further comprise a propellant, a fragrance, an oil, or mixture thereof.
  • composition of the present disclosure may be used in hair or scalp treatment.
  • composition of the present disclosure may be used as a cosmetic product; namely as a cosmetic for hair, nails, skin or scalp.
  • the composition of the present disclosure may be a shampoo, a lotion, a serum, a cream, a conditioner, a foam, an elixir, an oil, an aerosol or a mask comprising the cosmetic composition described in the present disclosure.
  • the components of the described cosmetic composition may be enriched with active components for sensations of warm, cold, freshness, relaxing, pain relive, lightness and well-being, preferably selected from a list comprising: a peptide, icilin, menthol, carboxylated icilin, carboxylated menthol, baicalin, curcumin, caffeine, or mixtures thereof, among others.
  • Another aspect of the present disclosure relates to the use of a cosmetic composition as described in the present disclosure as a cosmetic product, namely as a cosmetic for hair, nails, skin or scalp.
  • a cosmetic composition as described in the present disclosure as a cosmetic product, namely as a cosmetic for hair, nails, skin or scalp.
  • Figure 1 Schematic representation of a stable formulation comprising a green solvent, a phospholipid as an emulsifier, an oil phase, and at least one soluble auxiliary, such as a diol.
  • Figure 2 Assessment of the stability of an emulsified formulation by centrifugation (1100 g, 30 minutes at room temperature) by visual inspection.
  • Figure 3 Antimicrobial activity of a formulation with the composition of Example 2 against Trichophyton mentagrophytes strain, Candida parapsilosis, Klebsiella pneumoniae, and Staphylococcus aureus by disc-diffusion antibiotic susceptibility.
  • Figure 4 Visual inspection of the anti-fungal activity of a formulation in toenails with the composition of Example 2.
  • the present disclosure provides a stable emulsified composition
  • a green solvent can be a naturally occurring product, a mixture of natural solvents, or a Natural Deep Eutectic Solvent (NADES), serving either as a solvent or as a medium to extract bioactive compounds.
  • NADES Natural Deep Eutectic Solvent
  • the emulsifier such as phospholipids, ensures the stability of the emulsion, while the oil phase delivers essential moisturizing properties.
  • the composition may further include a peptide, a cosmetic component, or a combination thereof to target and enhance specific attributes of hair, nails, scalp, and skin. This composition provides long-lasting stability, antioxidant benefits, and antimicrobial properties, making it suitable for various cosmetic applications.
  • a stable emulsified composition with enhanced stability, antioxidant benefits, and antimicrobial properties for application on skin, hair, nails, and/or scalp comprises a carefully selected blend of emulsifiers (e.g., phospholipids), antioxidants, and antimicrobial agents, ensuring the stability of the emulsion over time and promoting skin, hair, nails, and/or scalp health.
  • emulsifiers e.g., phospholipids
  • antioxidants e.g., phospholipids
  • antimicrobial agents ensuring the stability of the emulsion over time and promoting skin, hair, nails, and/or scalp health.
  • a stable emulsified composition comprising a bioactive mixture, a phospholipid as an emulsifier, an oil component and at least one diol with enhanced stability, moisturizing effect, antioxidant benefits, and antimicrobial properties for application on skin, hair, nails, and/or scalp.
  • the composition comprises a carefully selected blend of emulsifiers, antioxidants, and antim
  • Example 1 it was prepared an emulsified composition with:
  • NADES 20% (w/w) of a thymol and carvacrol solution in NADES as a bioactive mixture (where NADES is glycerol:lactic acid, 4:1 mass ratio);
  • SEQ. ID No 8 GGVCGPSPPCITT.
  • Fig. 2 illustrates the visual inspection of the stability analysis conducted using centrifugation.
  • the visual inspection focuses on identifying potential signs of instability, such as phase separation, creaming, sedimentation, or changes in texture and homogeneity.
  • the images in Fig. 2 provide a clear comparison of the formulation before and after centrifugation and no signs of instability are observed.
  • NADES is glycerol:lactic acid, 4:1 molar ratio
  • FIG. 3 the images of the in vitro antimicrobial susceptibility test are displayed, illustrating the results of the experiment. These images provide a visual representation of the antimicrobial activity, highlighting differences in the size and clarity of the inhibition zones, which correlate with the potency of a formulation with the composition of Example 2.
  • determining means determining if an element is present or not (for example, detection). These terms can include quantitative, qualitative or quantitative and qualitative determinations. Assessing can be relative or absolute. "Detecting the presence of” can include determining the amount of something present in addition to determining whether it is present or absent depending on the context.
  • the term "about” a number refers to that number plus or minus 10% of that number.
  • the term “about” a range refers to that range minus 10% of its lowest value and plus 10% of its greatest value.
  • pharmaceutically acceptable and “cosmetically acceptable” are used interchangeably and refer to those compounds, materials, compositions, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problems or complications commensurate with a reasonable benefit/risk ratio. More specifically, pharmaceutically acceptable refers to a material, compound, or composition which is suitable for use in contact with the skin, scalp, or hair. Pharmaceutically acceptable materials are known to those of ordinary skill in the art.
  • treatment or “treating” are used in reference to a pharmaceutical or other intervention regimen for obtaining beneficial or desired results in the recipient.
  • Beneficial or desired results include but are not limited to a therapeutic benefit and/or a prophylactic benefit.
  • a therapeutic benefit may refer to eradication or amelioration of symptoms or of an underlying disorder being treated.
  • a therapeutic benefit can be achieved with the eradication or amelioration of one or more of the physiological symptoms associated with the underlying disorder such that an improvement is observed in the subject, notwithstanding that the subject may still be afflicted with the underlying disorder.
  • treatment or “treating” refers to the therapeutic intervention, management, or alleviation of a disease, disorder, or condition in a subject.
  • a prophylactic effect includes delaying, preventing, or eliminating the appearance of a disease or condition, delaying or eliminating the onset of symptoms of a disease or condition, slowing, halting, or reversing the progression of a disease or condition, or any combination thereof.
  • a subject at risk of developing a particular disease, or to a subject reporting one or more of the physiological symptoms of a disease may undergo treatment, even though a diagnosis of this disease may not have been made.
  • values that are expressed as ranges can assume any specific value within the stated ranges in different embodiments of the invention, to the tenth of the unit of the lower limit of the range, unless the context clearly dictates otherwise. It is also to be understood that unless otherwise indicated or otherwise evident from the context and/or the understanding of one of ordinary skill in the art, values expressed as ranges can assume any subrange within the given range, wherein the endpoints of the subrange are expressed to the same degree of accuracy as the tenth of the unit of the lower limit of the range.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne une composition émulsifiée stable, à savoir une composition pharmaceutique ou cosmétique, comprenant un mélange bioactif, un phospholipide en tant qu'émulsifiant, un composant huileux et au moins un diol ayant une stabilité améliorée, un effet hydratant, des effets bénéfiques antioxydants et des propriétés antimicrobiennes pour une application sur la peau, les cheveux, les ongles et/ou le cuir chevelu. La composition comprend un mélange soigneusement sélectionné d'émulsifiants, d'antioxydants et d'agents antimicrobiens, assurant la stabilité de l'émulsion dans le temps et favorisant un traitement approprié pour les soins de santé et de beauté.
PCT/IB2025/051692 2024-02-16 2025-02-17 Composition stable, procédés et utilisations associés Pending WO2025172966A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PT119259 2024-02-16
PT11925924 2024-02-16
EP24201443.9 2024-09-19
EP24201443.9A EP4603151A1 (fr) 2024-02-16 2024-09-19 Composition cosmétique stable, procédés et utilisations associés

Publications (1)

Publication Number Publication Date
WO2025172966A1 true WO2025172966A1 (fr) 2025-08-21

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ID=94969610

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2025/051692 Pending WO2025172966A1 (fr) 2024-02-16 2025-02-17 Composition stable, procédés et utilisations associés

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WO (1) WO2025172966A1 (fr)

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