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WO2025030050A3 - Analogues de coiffe et leurs méthodes d'utilisation - Google Patents

Analogues de coiffe et leurs méthodes d'utilisation Download PDF

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Publication number
WO2025030050A3
WO2025030050A3 PCT/US2024/040611 US2024040611W WO2025030050A3 WO 2025030050 A3 WO2025030050 A3 WO 2025030050A3 US 2024040611 W US2024040611 W US 2024040611W WO 2025030050 A3 WO2025030050 A3 WO 2025030050A3
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WO
WIPO (PCT)
Prior art keywords
substituted
cap
unsubstituted
methods
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/040611
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English (en)
Other versions
WO2025030050A2 (fr
Inventor
Chanfeng Zhao
Chunping Xu
Paul Theodore LUDFORD
Russell Donovan Cousins
Hengyuan Lang
Alexandre V. Lebedev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trilink Biotechnologies LLC
Original Assignee
Trilink Biotechnologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trilink Biotechnologies LLC filed Critical Trilink Biotechnologies LLC
Publication of WO2025030050A2 publication Critical patent/WO2025030050A2/fr
Publication of WO2025030050A3 publication Critical patent/WO2025030050A3/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Sont présentement décrits de nouveaux analogues de coiffe et compositions, ainsi que des méthodes d'utilisation de ceux-ci. Est également décrite une molécule d'ARN comprenant une coiffe à l'extrémité 5', la coiffe à l'extrémité 5' comportant un analogue de coiffe tel que présentement décrit. L'invention concerne également des méthodes d'induction d'un effet thérapeutique chez un sujet, les méthodes comprenant une étape d'administration au sujet d'une molécule analogique ou d'ARN de coiffe comprenant l'analogue de coiffe tel que présentement décrit.
PCT/US2024/040611 2023-08-03 2024-08-01 Analogues de coiffe et leurs méthodes d'utilisation Pending WO2025030050A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202363530592P 2023-08-03 2023-08-03
US63/530,592 2023-08-03
US202463651047P 2024-05-23 2024-05-23
US63/651,047 2024-05-23

Publications (2)

Publication Number Publication Date
WO2025030050A2 WO2025030050A2 (fr) 2025-02-06
WO2025030050A3 true WO2025030050A3 (fr) 2025-03-06

Family

ID=92457021

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/040611 Pending WO2025030050A2 (fr) 2023-08-03 2024-08-01 Analogues de coiffe et leurs méthodes d'utilisation

Country Status (1)

Country Link
WO (1) WO2025030050A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023033551A1 (fr) * 2021-08-31 2023-03-09 한미정밀화학 주식회사 Analogue de coiffe d'arnm et son utilisation
WO2023056044A1 (fr) * 2021-10-01 2023-04-06 Modernatx, Inc. Polynucléotides codant la relaxine pour le traitement de la fibrose et/ou d'une maladie cardiovasculaire
WO2023073190A1 (fr) * 2021-10-28 2023-05-04 BioNTech SE Constructions d'arn et leurs utilisations
WO2024044741A2 (fr) * 2022-08-26 2024-02-29 Trilink Biotechnologies, Llc Procédé efficace de production d'oligonucléotides coiffés en 5' hautement purifiés

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2370478A1 (fr) 1999-03-24 2000-09-28 Serge L. Beaucage N-acylphosphoramidites et leur utilisation dans la synthese d'oligonucleotides
DE602007013223D1 (de) 2006-06-01 2011-04-28 Trilink Biotechnologies San Diego Chemisch modifizierte oligonukleotidprimer zur nukleinsäureamplifikation
PL215513B1 (pl) 2008-06-06 2013-12-31 Univ Warszawski Nowe boranofosforanowe analogi dinukleotydów, ich zastosowanie, czasteczka RNA, sposób otrzymywania RNA oraz sposób otrzymywania peptydów lub bialka

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023033551A1 (fr) * 2021-08-31 2023-03-09 한미정밀화학 주식회사 Analogue de coiffe d'arnm et son utilisation
WO2023056044A1 (fr) * 2021-10-01 2023-04-06 Modernatx, Inc. Polynucléotides codant la relaxine pour le traitement de la fibrose et/ou d'une maladie cardiovasculaire
WO2023073190A1 (fr) * 2021-10-28 2023-05-04 BioNTech SE Constructions d'arn et leurs utilisations
WO2024044741A2 (fr) * 2022-08-26 2024-02-29 Trilink Biotechnologies, Llc Procédé efficace de production d'oligonucléotides coiffés en 5' hautement purifiés

Also Published As

Publication number Publication date
WO2025030050A2 (fr) 2025-02-06

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