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WO2025099184A1 - Partie inférieure à canaux multiples destinée à un dispositif de transfert de fluide, et dispositif de transfert de fluide - Google Patents

Partie inférieure à canaux multiples destinée à un dispositif de transfert de fluide, et dispositif de transfert de fluide Download PDF

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Publication number
WO2025099184A1
WO2025099184A1 PCT/EP2024/081564 EP2024081564W WO2025099184A1 WO 2025099184 A1 WO2025099184 A1 WO 2025099184A1 EP 2024081564 W EP2024081564 W EP 2024081564W WO 2025099184 A1 WO2025099184 A1 WO 2025099184A1
Authority
WO
WIPO (PCT)
Prior art keywords
channel
channels
housing
carrier element
channel lower
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2024/081564
Other languages
German (de)
English (en)
Inventor
Anne RÜßMANN
Holger Link
Peter Molitor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eppendorf SE
Original Assignee
Eppendorf SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eppendorf SE filed Critical Eppendorf SE
Publication of WO2025099184A1 publication Critical patent/WO2025099184A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/023—Adapting objects or devices to another adapted for different sizes of tubes, tips or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/028—Modular arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons

Definitions

  • the invention relates to a multi-channel lower part for a fluid transmission device and to a fluid transmission device with such a multi-channel lower part according to the preamble of the independent patent claims.
  • the invention relates to a multi-channel lower part for a multi-channel fluid transmission device, which is designed to accommodate a different number of channels in one and the same housing.
  • Multi-channel fluid transfer devices are, in particular, multi-channel pipettes and multi-channel dispensers designed for the calibrated aspiration of liquids and/or the subsequent dispensing of the liquids into containers.
  • the multi-channel fluid transfer device is held in the hand of an operator during the aspiration and dispensing of the liquid.
  • a multi-channel fluid transfer device has an upper part in which the operating elements and the mechanics or electronics required for aspirating the liquid are located, as well as a multi-channel lower part with several parallel dispensing channels designed to aspirate and/or dispense a liquid.
  • multi-channel lower parts of pipettes are known, with which 6, 8, 12, 16, or 24 samples can be aspirated or dispensed simultaneously.
  • EP 2 190 582 B1 discloses a multi-channel pipetting system for the calibrated aspiration of liquids and the subsequent dispensing of the liquids into containers.
  • the sampling pipettes can be held in the operator's hand while aspirating and dispensing the liquid, or they can be included as part of an automated system.
  • the multi-channel pipette comprises a body forming a handle and a base having a plurality of parallel aspiration channels for a liquid. Cones are formed at one end of the aspiration channels protruding from the housing to accommodate a pipette tip in each of the aspiration channels.
  • Patent application DE 102006 031 460 A1 discloses a pipetting device for dosing liquids with a multi-channel lower part, which has a plurality of parallel receiving channels for a liquid.
  • the receiving channels are each by a piston that can be moved within the receiving channel, with the different pistons being controlled by a common piston actuator.
  • the device is designed to receive eight equal amounts of liquid and release them again in a controlled manner in a subsequent process step.
  • the object of the invention is to reduce the variety of variants of a multi-channel pipette or a multi-channel dispenser and thus to simplify production and reduce costs.
  • a multi-channel lower part for a fluid transmission device comprising a housing in which several parallel channels for receiving a fluid are arranged, each channel comprising a cylinder which is delimited in the axial direction by a displaceable piston, one end section of the displaceable piston being received in a piston actuator such that, upon displacement of the piston actuator, the pistons are each displaced by the same distance.
  • a first receptacle for a first carrier element is formed on the housing, in which a plurality of channels are received, and a second receptacle for a second carrier element is formed on the housing, in which a different number of channels is received than the first carrier element.
  • the first carrier element and the second carrier element can each be reversibly and detachably fixed in the housing.
  • the carrier elements are preferably made of a plastic which is dimensionally stable under typical autoclave conditions (120-130°C, steam, pressure).
  • An example of such a plastic is PEEK, but the design is not limited to this plastic.
  • the support element can also be made of a metal, particularly steel, aluminum, or copper, or can be designed in a hybrid construction that includes a metal as the support and a plastic as the injection molding/overmolding of molded parts.
  • the multi-channel lower part according to the invention for a fluid transmission system makes it possible to create different variants with a reduced number of housings.
  • an 8-channel and a 16-channel variant or a 12-channel and a 24-channel variant can be represented with the same housing.
  • the number of housing variants and thus also the injection molding tools required to manufacture the housings can be halved.
  • the smaller number of housing variants results in additional synergy effects such as reduced setup times or a complete elimination of tool changes, higher quantities per housing variant and thus lower production costs.
  • the modular design can achieve significant cost reductions.
  • the modular design of the multi-channel lower section using different support elements enables easy replacement of components during servicing, so that, for example, in the case of internal repairs, the costs of replacing the defective component(s) can be reduced.
  • the first support element has a first number of channels and the second support element has twice that number.
  • the distance between the center axes of the channels accommodated in the first support element is twice as large as the distance between the center axes of the channels accommodated in the second support element.
  • the distance between the center axes of the channels in the first support element is 9 mm
  • the distance between the center axes of the channels in the second support element is 4.5 mm.
  • Distances of 4.5 mm and 9 mm are typical for test tubes or plates that are filled or wetted with a liquid using a pipette or dispenser. Accordingly, a distance of the center axes of 4.5 mm for the support element with twice the number of channels and a distance of 9 mm for the support element with the single number of channels is particularly advantageous in order to enable particularly efficient and effective laboratory operation.
  • the first support element and/or the second support element can be fixed in the housing receptacle by means of a snap-in connection.
  • a snap-in connection is generally reversibly detachable, allowing for quick and uncomplicated replacement in the event of incorrect assembly or the installation of a faulty support element.
  • cones for receiving pipette tips are arranged in an axial extension and coaxial with the channels, with each cone being spring-loaded by a cone spring.
  • cone springs can limit the operating forces, thereby reducing the risk of damage to the pipette tip.
  • the limited force required is perceived as pleasant by the user of the fluid transfer system and prevents rapid fatigue during a large number of fluid transfer operations.
  • the conical springs are arranged concentrically to the channels in the first support element and parallel to the channels in the second support element. This allows for a particularly compact design of the first support element. Since the distances between the channels in the first support element are correspondingly large, a concentric arrangement of the conical springs is easily possible.
  • a retaining clip is provided for locking one of the support elements, which can be connected to the housing or a receptacle connected to the housing.
  • a retaining clip can be manufactured particularly easily and cost-effectively and enables secure fixation of the support element in the receptacle(s) of the housing.
  • the first receptacle is identical to the second receptacle.
  • the multi-channel lower parts differ only in the support elements, the number of channels and pistons, and the design of the piston actuator. This allows for particularly simple production and assembly of the multi-channel lower parts.
  • a second aspect of the invention relates to a multi-channel fluid transfer device with an upper part and such a multi-channel lower part, wherein the upper part has an operating element which is configured to displace a piston actuator of the multi-channel lower part in the axial direction via a transfer element and thus to displace a plurality of pistons in the channels in order to receive a liquid.
  • Such multi-channel fluid transfer devices can be manufactured particularly cost-effectively due to the small number of variants of the multi-channel lower parts. Furthermore, a particularly high quality can be achieved since no additional setup times and associated breaks and restarts in injection molding processes for producing the housing of the multi-channel lower part are necessary. This allows the production of a particularly high-quality fluid transfer device.
  • the multi-channel fluid transfer device is a multi-channel pipette or a multi-channel dispenser.
  • multi-channel pipettes or multi-channel dispensers are used in laboratories. These can be held in one hand and operated with one hand. This allows a large number of samples to be processed and/or manipulated simultaneously in a simple manner.
  • a further aspect of the invention relates to a method for producing such a multi-channel fluid transmission device, the method comprising the following steps: producing a housing of a multi-channel lower part, producing a support element for such a multi-channel lower part, inserting cylinders into the support element, inserting pistons into the cylinders, fixing the pistons in the piston actuator, fixing the support element in the housing
  • Figure 1 shows a multi-channel fluid transfer device
  • Figure 2 shows a sectional view of a multi-channel
  • Figure 3 shows a first recording for a multi-channel
  • Fluid transfer device for accommodating eight channels
  • Figure 4 shows a second recording for a multi-channel
  • Fluid transfer device for accommodating 16 channels
  • Figure 5 shows a further sectional view of a multi-channel
  • Figure 1 shows a fluid transfer device 100 in the form of a multi-channel pipette 102 with an upper part 10 and a multi-channel lower part 20, which is reversibly detachably connected to the upper part 10.
  • An operating element 12, in particular an operating button 16, is provided on the upper part 10, with which a liquid can be taken up into the fluid transfer device 100 in a first process step and released again in a later process step.
  • the upper part 10 comprises a housing 14, in which a transfer rod (not shown) is arranged, with which a A mechanical connection is established between the operating element 12 and the multi-channel lower part 20.
  • a finger hook 18 is formed on the upper part 10, with which the fluid transfer device can rest on a finger of the operator to facilitate holding and operating the fluid transfer device 100.
  • An ejector button 13 can also be formed on the upper part 10 to facilitate ejecting pipette tips after use of the fluid transfer device 100.
  • the upper part 10 has a preferably tubular housing 14, from which an operating element 12, in particular a control knob 16, protrudes at one end face.
  • the operating element 12 serves to set a volume for the fluid transfer and/or to control the fluid intake and/or discharge through the multi-channel fluid transfer device 100. Furthermore, parts of the mechanics necessary for the fluid transfer and, if necessary, electronic components for controlling the multi-channel fluid transfer device are arranged in the upper part 10.
  • the multi-channel lower part 20 comprises a housing 22 with a first housing shell 24 and a second housing shell 26, which are connected to one another and form the housing 22.
  • the housing shells 24, 26 are separated at the side walls 21, 23 of the housing 22.
  • the multi-channel lower part 20 comprises a plurality of parallel channels 31, 32, 33, 34, 35, 36, 37, 38, each with a receiving volume 81, 82, 83, 84, 85, 86, 87, 88 for a fluid 40.
  • a pipette tip into which a liquid can be received, is attached to a cone 30 of the channels 31, 32, 33, 34, 35, 36, 37, 38.
  • an ejection frame 28 is provided which is mechanically connected to the ejector button 13 and, when the ejector button 13 is pressed, causes the pipette tips to be ejected from the cones 30 of the channels 31, 32, 33, 34, 35, 36, 37, 38.
  • FIG 2 shows a sectional view through a multi-channel lower part 20 according to the invention for a fluid transmission device 100.
  • the lower part 20 has a piston actuator 44, which is displaced by pressing the operating button 16 of the upper part in the axial direction against a return spring of the piston actuator 44 (not shown in Figure 2).
  • Receptacles for receiving a first end section 45, in particular a piston head 46, of a plurality of pistons 42 arranged parallel to one another are formed on the piston actuator 44.
  • the pistons 42 each have a piston rod, on which A sealing element is arranged at the end facing away from the first end section 45.
  • the sealing elements of the pistons 42 are each accommodated in a cylinder 39.
  • the multi-channel lower part 20 further comprises a first receptacle 50 for a first
  • Support element 52 in which a plurality of channels 31, 32, 33, 34, 35, 36, 37, 38 are accommodated.
  • the channels 31, 32, 33, 34, 35, 36, 37, 38 each comprise a cylinder 39 for receiving a fluid.
  • the cylinder 39 has a cone 30, which is formed on the side of the cylinder 39 facing away from the piston 42 and is designed to receive a pipette tip.
  • a spring seat 59 for receiving a conical spring 98 is formed on the cylinder 39.
  • the channels 31, 32, 33, 34, 35, 36, 37, 38 each comprise a conical spring 98, with which the respective cylinder 39 is spring-loaded in the support element 52.
  • a retaining clip 54 is provided, with which the carrier element 52 can be fixed to the receptacle 50 of the housing 22.
  • Figure 3 shows the support element 52 in a three-dimensional representation.
  • the support element has a seat 58, on which the cylinders 39 of the channels 31, 32, 33, 34, 35, 36, 37, 38 are positively received.
  • the support element 52 has spring seats 53, on which the conical springs 98 are received at their ends facing away from the spring seats 59.
  • the cone springs 98 are arranged concentrically to the cylinders 39 of the channels 31, 32, 33, 34, 35, 36, 37, 38 and enclose the respective cylinder 39.
  • Each cylinder 39 has a volume 90, 91, 92, 93, 94, 95, 96, 97 for receiving a fluid, in particular for receiving an air cushion, in order to be able to receive a liquid and subsequently dispense it again by means of a corresponding displacement of the fluid in pipette tips received on the cones 30.
  • Figure 4 shows a second support element 62 for a multi-channel lower part 20 according to the invention.
  • the second support element 62 can be received, as an alternative to the first support element 52, on the receptacle 50 or a further receptacle 60 in the housing 22 of the multi-channel lower part.
  • the second support element 62 is configured to accommodate twice the number of cylinders 39 compared to the first support element 52 and thus to form twice the number of channels 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86.
  • the center axes of the respective channels 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86 are spaced at half the distance from the channels 31, 32, 33, 34, 35, 36, 37, 38 accommodated in the first support element 52.
  • the distances between the center axes in the first support element 52 are preferably in the range of 8 mm to 10 mm, particularly preferably 9 mm, and the distances between the center axes in the second support element 62 at 4 mm to 5 mm, preferably at 4.5 mm.
  • a spring seat 59 for the conical springs 98 is formed on the carrier element 62, wherein the conical springs 98 in this embodiment are not arranged concentrically to the cylinders 39, but rather parallel to the cylinders 39, in order to enable conical springing for the cones 30 on the channels 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86 even in confined installation space.
  • Figure 5 shows a further sectional view of a multi-channel lower part 20 according to the invention.
  • the second carrier element 62 is fastened in the receptacle 50 or in the receptacle 60 of the housing 22.
  • channels 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86 with the associated cylinders 39 are accommodated in the support element 62.
  • the cylinders 39 of the channels 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86 are fixed in the support element 62 by a securing element 64.

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Devices For Use In Laboratory Experiments (AREA)

Abstract

L'invention concerne une partie inférieure (20) à canaux multiples destinée à un dispositif de transfert de fluide (100). La partie inférieure à canaux multiples (20) comprend : un logement (22) qui contient de multiples canaux parallèles (31-38) destinés à recevoir un fluide (40), chaque canal comprenant un cylindre (39) délimité axialement par un piston pouvant être déplacé (42), une partie d'extrémité du piston pouvant être déplacé (42) étant reçue dans un actionneur de piston (44) de sorte que le déplacement de l'actionneur de piston (44) provoque le déplacement de chacun des pistons (42) de la même distance. Le logement (22) comporte un premier réceptacle (50) destiné à un premier élément de support (52), qui contient une pluralité de canaux (31-38), et le logement (22) comporte un second réceptacle (60) destiné à un second élément de support (62), qui contient un nombre différent de canaux (71-86) que le premier élément de support (52). Le premier élément de support (52) et le second élément de support (62) sont chacun fixés de façon amovible et réversible dans le logement (22).
PCT/EP2024/081564 2023-11-10 2024-11-07 Partie inférieure à canaux multiples destinée à un dispositif de transfert de fluide, et dispositif de transfert de fluide Pending WO2025099184A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102023131370.3 2023-11-10
DE102023131370.3A DE102023131370B3 (de) 2023-11-10 2023-11-10 Mehrkanal-Unterteil für eine Fluidübertragungsvorrichtung sowie Fluidübertragungsvorrichtung

Publications (1)

Publication Number Publication Date
WO2025099184A1 true WO2025099184A1 (fr) 2025-05-15

Family

ID=93460428

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2024/081564 Pending WO2025099184A1 (fr) 2023-11-10 2024-11-07 Partie inférieure à canaux multiples destinée à un dispositif de transfert de fluide, et dispositif de transfert de fluide

Country Status (2)

Country Link
DE (1) DE102023131370B3 (fr)
WO (1) WO2025099184A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010019845A1 (en) * 1998-08-07 2001-09-06 Klaus Bienert Metering head for parallel processing of a plurality of fluid samples
DE102004003433A1 (de) * 2004-01-21 2005-08-25 Eppendorf Ag Pipettiervorrichtung mit einer Abwurfeinrichtung für Pipettenspitzen
DE102006031460A1 (de) 2006-07-07 2008-01-10 Eppendorf Ag Pipettiervorrichtung
US20090117009A1 (en) * 2007-11-02 2009-05-07 Richard Cote Multi-channel electronic pipettor
EP2190582B1 (fr) 2007-09-10 2016-02-17 Gilson Sas Pipette à canaux multiples comprenant un support de piston à guidage
DE202022104955U1 (de) * 2022-09-01 2022-09-15 Brand Gmbh + Co Kg Verdrängereinrichtung und Pipettiervorrichtung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7219567B2 (en) 2005-01-05 2007-05-22 Bio-Magnetics Ltd. Combinatorial pipettor device
KR102011496B1 (ko) 2017-10-24 2019-08-16 (주) 바이오팩트 자성입자를 이용한 핵산 정제용 멀티-웰 자성입자 파이펫터
WO2023206092A1 (fr) 2022-04-26 2023-11-02 广州国家实验室 Dispositif de transfert de liquide, dispositif de transfert de liquide multicanal, et procédé

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010019845A1 (en) * 1998-08-07 2001-09-06 Klaus Bienert Metering head for parallel processing of a plurality of fluid samples
DE102004003433A1 (de) * 2004-01-21 2005-08-25 Eppendorf Ag Pipettiervorrichtung mit einer Abwurfeinrichtung für Pipettenspitzen
DE102006031460A1 (de) 2006-07-07 2008-01-10 Eppendorf Ag Pipettiervorrichtung
EP2190582B1 (fr) 2007-09-10 2016-02-17 Gilson Sas Pipette à canaux multiples comprenant un support de piston à guidage
US20090117009A1 (en) * 2007-11-02 2009-05-07 Richard Cote Multi-channel electronic pipettor
DE202022104955U1 (de) * 2022-09-01 2022-09-15 Brand Gmbh + Co Kg Verdrängereinrichtung und Pipettiervorrichtung

Also Published As

Publication number Publication date
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