[go: up one dir, main page]

WO2024215161A1 - Composition cosmétique contenant de la zn-porphyrine et de la lignine, destinée à bloquer les rayons ultraviolets - Google Patents

Composition cosmétique contenant de la zn-porphyrine et de la lignine, destinée à bloquer les rayons ultraviolets Download PDF

Info

Publication number
WO2024215161A1
WO2024215161A1 PCT/KR2024/005007 KR2024005007W WO2024215161A1 WO 2024215161 A1 WO2024215161 A1 WO 2024215161A1 KR 2024005007 W KR2024005007 W KR 2024005007W WO 2024215161 A1 WO2024215161 A1 WO 2024215161A1
Authority
WO
WIPO (PCT)
Prior art keywords
lignin
ultraviolet rays
cream
cosmetic composition
lotion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/KR2024/005007
Other languages
English (en)
Korean (ko)
Inventor
한성옥
고영진
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea University Research and Business Foundation
Original Assignee
Korea University Research and Business Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020230111821A external-priority patent/KR20240152717A/ko
Application filed by Korea University Research and Business Foundation filed Critical Korea University Research and Business Foundation
Publication of WO2024215161A1 publication Critical patent/WO2024215161A1/fr
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Definitions

  • the present invention relates to a cosmetic composition for blocking ultraviolet rays comprising zinc-porphyrin and lignin.
  • UV-C Short-wave ultraviolet rays
  • UV-B medium-wave ultraviolet rays
  • UV-A long-wave ultraviolet rays
  • UV blockers currently used in the cosmetics industry can be largely divided into inorganic UV blockers and organic UV blockers.
  • organic UV blockers refer to substances that absorb ultraviolet rays and exhibit a blocking effect by trapping solar energy within molecules
  • inorganic UV blockers refer to substances that have physical properties that reflect and disperse ultraviolet rays and act only on the surface without being absorbed into the skin.
  • Organic UV blockers have better spreadability than inorganic UV blockers, but their UV blocking effect is minimal, so inorganic UV blockers are generally preferred.
  • inorganic UV blockers such as titanium dioxide can cause discomfort due to a sticky feeling when applied to the skin, and can also make the skin look white or cloudy and shiny due to a whitish appearance.
  • a technology to control inorganic UV blockers into nano-sized particles has been in the spotlight to enhance the UV blocking effect.
  • the inventors of the present invention attempted to develop a sunscreen having excellent ultraviolet absorption effects, and confirmed that the ultraviolet absorption effect over a wide spectrum was enhanced when Zn-porphyrin produced from a recombinant microorganism and lignin derived from biomass were mixed, thereby completing the present invention.
  • UV-A Ultraviolet rays
  • UV-B 280–320 nm
  • UVC 100–280 nm
  • UV-B is mostly absorbed by the ozone layer and only a small portion reaches the surface of the earth, but it burns the skin and sometimes penetrates the skin tissue and can even cause skin cancer in severe cases.
  • UV-C is completely absorbed by the ozone layer in the stratosphere. Therefore, cosmetic compositions for UV protection must effectively block UV-A and UV-B, that is, ultraviolet rays with a wavelength range of 280 to 400 nm.
  • the purpose of the present invention is to provide a cosmetic composition for blocking ultraviolet rays having an excellent ultraviolet ray blocking effect.
  • another object of the present invention is to provide a method for protecting skin from damage caused by ultraviolet rays, comprising the step of topically applying the composition to an object in an effective amount.
  • the present invention provides a cosmetic composition for blocking ultraviolet rays containing zinc-porphyrin and lignin as effective ingredients.
  • the present invention also provides a method for protecting skin from damage caused by ultraviolet rays, comprising the step of topically applying the composition to a subject in an effective amount.
  • the cosmetic composition for blocking ultraviolet rays according to the present invention can effectively block UV-A and UV-B rays harmful to the human body, and has the effect of significantly increasing ultraviolet ray blocking efficiency compared to the case where zinc-porphyrin or lignin is used alone.
  • FIG. 1 is a diagram showing the results of evaluating the UV blocking performance of a Zn-PP cream according to one embodiment of the present invention (a: results of checking the absorbance of the Zn-PP cream, b: results of checking the transmittance of the Zn-PP cream, c: results of checking the rhodamine B photodecomposition of the Zn-PP cream, d: results of checking the hydroxyl radical scavenging activity of the Zn-PP cream).
  • FIG. 2 is a diagram showing the results of evaluating the UV blocking performance of a cream containing Zn-PP and/or lignin according to one embodiment of the present invention (a: results of confirming absorbance of a cream containing Zn-PP and/or lignin, b: results of confirming transmittance of a cream containing Zn-PP and/or lignin).
  • the present invention relates to a cosmetic composition for blocking ultraviolet rays, comprising zinc-porphyrin and lignin as active ingredients.
  • the zinc-porphyrin may be included at a concentration of 1 to 12% (w/v), preferably at a concentration of 3 to 10% (w/v), and more preferably at a concentration of 9 to 10% (w/v), but is not limited thereto.
  • the zinc-porphyrin may be produced from recombinant Corynebacterium glutamicum in which the heme biosynthesis pathway is engineered to produce zinc-porphyrin, and preferably, Corynebacterium glutamicum in which HemA, HemL, AlaS, DtxR, HemE and HrtBA genes are overexpressed, but is not limited thereto.
  • Zn-porphyrin as used in the present invention means Zn-coproporphyrin III or Zn-uroporphyrin III.
  • the molecular formula of Zn-coproporphyrin III is C 36 H 38 N 4 O 8 Zn +2 , the IUPAC name is zinc;3-[8,13,18-tris(2-carboxyethyl)-3,7,12,17-tetramethyl-21,24-dihydroporphy-rin-2-yl]propanoic acid, and it has a molecular weight of 720.1 g/mol.
  • the molecular formula of Zn-uroporphyrin III is C 40 H 38 N 4 O 16 Zn +2 , the IUPAC name is zinc;3-[7,12,18-tris(2-carboxyethyl)-3,8,13,17-tetrakis(carboxymethyl)-21,24-dihydroporphyrin-2-yl]propanoic acid, and it has a molecular mass of 896.1 g/mol.
  • the zinc-porphyrin may be represented by chemical formula 1 or chemical formula 2.
  • the lignin may be included at a concentration of 1 to 12% (w/v), preferably at a concentration of 3 to 10% (w/v), and more preferably at a concentration of 9 to 10% (w/v), but is not limited thereto.
  • the above lignin may be at least one selected from the group consisting of native lignin, lignosulfonate, dealkaline lignin, alkaline lignin, organosolv lignin, hydrolysis lignin, kraft lignin, soda lignin, steam explosion lignin, and dilute acid lignin, but is not limited thereto.
  • lignosulfonate used in the present invention, also called sulfite lignin, refers to lignin produced in the sulfite pulping process.
  • dealkaline lignin as used in the present invention means lignin produced from lignosulfonate produced from coniferous and deciduous trees through sodium sulfite treatment, through chemical modification such as partial desulfonation, oxidation, hydrolysis and demethylation.
  • alkaline lignin used in the present invention refers to the dealkalized lignin having its pH value adjusted to an alkaline range (pH8.0-10.0), and having higher water solubility than dealkalized lignin.
  • organic solvent lignin used in the present invention refers to lignin produced through a chemical pretreatment method in the bioethanol production process.
  • Representative methods for extracting organic solvent lignin include a method of extraction using an alcohol organic solvent process and a method of extraction using an acid organic solvent process.
  • the “cosmetic composition” of the present invention can be manufactured by including a cosmetically effective amount of the zinc-porphyrin and lignin of the present invention described above and a cosmetically acceptable carrier.
  • cosmetically effective amount means an amount sufficient to achieve the UV protection efficacy of the composition of the present invention described above.
  • the external form of the cosmetic composition contains a cosmetically or dermatologically acceptable medium or base. It may be provided in any formulation suitable for topical application, for example in the form of a solution, a gel, a solid, a pasty anhydrous product, an emulsion obtained by dispersing an oil phase in an aqueous phase, a suspension, a microemulsion, a microcapsule, a microgranule or a vesicular dispersion of ionic (liposomes) and nonionic type, or in the form of a cream, a skin, a lotion, a powder, an ointment, a spray or a concealer stick.
  • These compositions can be prepared according to methods conventional in the art.
  • the composition according to the invention can also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant.
  • the cosmetic composition according to one embodiment of the present invention is not particularly limited in its formulation, and may be formulated as cosmetics such as, for example, a softening toner, an astringent toner, a nourishing toner, a nourishing cream, a massage cream, an essence, an eye cream, an eye essence, a cleansing cream, a cleansing foam, a cleansing water, a pack, a powder, a body lotion, a body cream, a body oil, and a body essence.
  • a softening toner such as, for example, a softening toner, an astringent toner, a nourishing toner, a nourishing cream, a massage cream, an essence, an eye cream, an eye essence, a cleansing cream, a cleansing foam, a cleansing water, a pack, a powder, a body lotion, a body cream, a body oil, and a body essence.
  • the cosmetic composition of the present invention is in the form of a paste, cream or gel, animal fiber, plant fiber, wax, paraffin, starch, tragacanth, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component.
  • the cosmetic composition of the present invention is in the form of a powder or spray
  • lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and particularly in the case of a spray, a propellant such as chlorofluorohydrocarbon, propane/butane or dimethyl ether may be additionally included.
  • a solvent, a solvating agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid ester of sorbitan.
  • liquid diluents such as water, ethanol or propylene glycol
  • suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tragacanth, etc. can be used as carrier components.
  • an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, an isethionate, an imidazolinium derivative, methyl taurate, a sarcosinate, a fatty acid amide ether sulfate, an alkyl amidobetaine, an aliphatic alcohol, a fatty acid glyceride, a fatty acid diethanolamide, a vegetable oil, a linolenic derivative, or an ethoxylated glycerol fatty acid ester may be used as a carrier component.
  • the cosmetic composition of the present invention can be applied to cosmetics such as skin, lotion, cream, essence, pack, foundation, color cosmetics, sunscreen, two-way cake, face powder, compact, makeup base, skin cover, eye shadow, lipstick, lip gloss, lip fix, eyebrow pencil, toner, and cleansing agents such as shampoo and soap.
  • cosmetics such as skin, lotion, cream, essence, pack, foundation, color cosmetics, sunscreen, two-way cake, face powder, compact, makeup base, skin cover, eye shadow, lipstick, lip gloss, lip fix, eyebrow pencil, toner, and cleansing agents such as shampoo and soap.
  • a cosmetic composition according to one embodiment of the present invention may further include functional additives and components included in general cosmetic compositions in addition to the zinc-porphyrin and lignin.
  • the functional additives may include components selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, high molecular peptides, high molecular polysaccharides, sphingolipids, and seaweed extracts.
  • the cosmetic composition of the present invention may also contain ingredients included in general cosmetic compositions, if necessary.
  • the contained ingredients may include oil components, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, bactericides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, fragrances, blood circulation promoters, cooling agents, antiperspirants, purified water, etc.
  • the present invention provides a method for protecting skin from damage caused by ultraviolet radiation, comprising the step of topically applying the composition to a subject in an effective amount.
  • E. coli DH5 ⁇ for replication was performed using LB medium at 37°C and 200 rpm.
  • Corynebacterium glutamicum ATCC 14067 was pre-cultured in 20 ml of BHISG medium (medium containing 37 g BHI, 91 g sorbitol, and 2 g glucose per L) to secure the cell number.
  • BHISG medium medium containing 37 g BHI, 91 g sorbitol, and 2 g glucose per L
  • the culture was centrifuged at 4,000 rpm for 10 min to separate the cells, and the separated cells were pre-cultured once more in 200 ml of BHISG medium to secure the cell number for 2 L of the main culture.
  • Flask cultures were performed in CGXY10 medium (42 g/L 3-morpholinopropanesulfonic acid (MOPS), 40 g/L glucose, 20 g/L ( NH4 ) 2SO4 , 5 g/L urea, 10 g/L yeast extract, 1 g/L KH2PO4 , 1 g/L K2HPO4 , 250 mg/L MgSO4 ⁇ 7H2O , 10 mg/L FeSO4 ⁇ 7H2O, 10 mg /L CaCl2 , 1 mg /L ZnSO4 ⁇ 7H2O , 0.31 mg/ L CuSO4 ⁇ 5H2O , 200 ⁇ g/L biotin, 100 ⁇ g/L MnSO4 ⁇ H2O , and 20 ⁇ g/L NiCl2 ⁇ 6H 2 O) was used at 30°C, 200 rpm for 24 or 48 h.
  • MOPS 3-morpholinopropanesulfonic acid
  • Fed-batch fermentation was performed as follows. All wild-type and recombinant Corynebacterium stored at cryogenic temperature were streaked on BHISG agar plates and cultured at 30°C for 24 h. One colony was then inoculated into 20 mL of BHISG medium and pre-cultured at 30°C, 200 rpm for 16 h. The first pre-cultured cell was inoculated into a 1000 mL shake flask containing 200 mL of BHISG medium and pre-cultured at 30°C, 200 rpm for 16 h.
  • the second pre-cultured cells were inoculated into a 6-L fermentor containing CGXY10 medium excluding 2-L 3-morpholinopropanesulfonic acid (MOPS) at an optical density at 600 nm (OD 2).
  • MOPS 2-L 3-morpholinopropanesulfonic acid
  • Fed-batch fermentation was performed in a 6-L fermentor at 30°C, 250–600 rpm, and pH was maintained at 7.0.
  • Isopropyl ⁇ -d-1-thiogalactopyranoside (1 mM) and ethambutol at a concentration of 25 mg/L were added after 0 h of flask culture and 6 h of fed-batch fermentation.
  • Zinc-porphyrin (Zn-PPs) was purified using preparative HPLC from Agela Technologies. Zinc porphyrin in the supernatant was purified using HP-20 Column (1500 g + 220 g) as the stationary phase and distilled water and 100% methanol as the mobile phase. The purification was performed at a flow rate of 100 ml/min for 220 minutes, and 75% purity zinc porphyrin was obtained under these conditions.
  • UV protection performance test was conducted by applying each cream evenly to a glass slide (Marienfeld-SupeRior, Germany) attached with a transfer tape (3M corporation, Germany). After drying the sample in a dark room for 30 minutes, UV absorbance and transmittance were measured using a Cary Series UV-VIS-NIR spectrophotometer 5000 (Agilent Technologies, USA) at 1 nm intervals in the wavelength range of 290–400 nm, and the in vitro SPF value was calculated using the following formula:
  • the critical wavelength ( ⁇ c) is the wavelength at which the absorbance integral curve first reaches a ratio (R) greater than 0.9, and R was calculated using the following formula:
  • UV-A/UV-B ratio was calculated using the following formula:
  • the UV blocking properties were determined by evaluating the degree of decomposition of rhodamine B under UV irradiation.
  • the residual rhodamine B (%) was calculated using the following equation:
  • a t Absorbance of the solution after exposure at 554 nm
  • Hydroxyl radical scavenging activity was measured using a modified 2-deoxyribose oxidation method.
  • a s Absorbance of the sample at 520 nm
  • a c Absorbance of the control group at 520 nm
  • the critical wavelength of the Zn-PPS cream is 392.0 nm, which fully satisfies the requirements of a broad-spectrum UV blocker.
  • the Zn-PP cream showed greater absorption in the UV-A region with a UV-A/UV-B ratio of 1.17 ⁇ 0.04.
  • the Zn-PP cream also showed excellent ability to prevent photodegradation of rhodamine B under UV light (Fig. 1c).
  • the Zn-PP cream at a concentration of 4% (w/v) was found to have the highest photoprotective effect among the samples with more than 60% of rhodamine B remaining.
  • all concentrations of the Zn-PP cream showed hydroxyl radical scavenging activity, and the hydroxyl radical scavenging activity increased as the concentration increased (Fig. 1d).
  • the SPF values of the AL, DL, and OL creams at a concentration of 4% (w/v) containing only lignin were 2.04 ⁇ 0.13, 2.48 ⁇ 0.18, and 2.79 ⁇ 0.77, respectively, which were lower than that of the Zn-PP cream.
  • the critical wavelengths were estimated to be 379.67 ⁇ 0.58, 382.0 ⁇ 1.0, and 386.33 ⁇ 2.08, respectively, indicating that they were broad-spectrum UV blockers.
  • the AL, DL, and OL creams had relatively lower UV-A/UV-B ratios of 0.46 ⁇ 0.02, 0.49 ⁇ 0.02, and 0.71 ⁇ 0.01, respectively, compared to the Zn-PP cream, and showed higher absorption and lower transmittance in the UV-B region than in the UV-A region (Fig. 6).
  • ALZP, DLZP, and OLZP creams all showed complementarity in the UV-B region (Fig. 2a), and the lowest transmittance was observed (Fig. 2b).
  • the SPF values of ALZP, DLZP, and OLZP all increased by more than 1.5 times, and among them, OLZP cream showed the highest SPF value.
  • the critical wavelengths of ALZP, DLZP, and OLZP were similar to that of the Zn-PPs cream, and the UV-A/UV-B ratios of ALZP, DLZP, and OLZP creams were 0.93 ⁇ 0.02, 0.89 ⁇ 0.02, and 0.88 ⁇ 0.04, which were 2.02, 1.81, and 1.24 times higher than those of AL, DL, and OL creams, respectively.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne une composition cosmétique contenant de la Zn-porphyrine et de la lignine, destinée à bloquer les rayons ultraviolets. La composition cosmétique destinée à bloquer les rayons ultraviolets, selon la présente invention, peut bloquer efficacement les UV-A et les UV-B, qui sont nocifs pour le corps humain et, par rapport à l'utilisation séparée de Zn-porphyrine ou de lignine, présente une efficacité de blocage des ultraviolets significativement accrue.
PCT/KR2024/005007 2023-04-13 2024-04-15 Composition cosmétique contenant de la zn-porphyrine et de la lignine, destinée à bloquer les rayons ultraviolets Pending WO2024215161A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2023-0048636 2023-04-13
KR20230048636 2023-04-13
KR1020230111821A KR20240152717A (ko) 2023-04-13 2023-08-25 아연-포르피린 및 리그닌을 포함하는 자외선 차단용 화장료 조성물
KR10-2023-0111821 2023-08-25

Publications (1)

Publication Number Publication Date
WO2024215161A1 true WO2024215161A1 (fr) 2024-10-17

Family

ID=93059853

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2024/005007 Pending WO2024215161A1 (fr) 2023-04-13 2024-04-15 Composition cosmétique contenant de la zn-porphyrine et de la lignine, destinée à bloquer les rayons ultraviolets

Country Status (1)

Country Link
WO (1) WO2024215161A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190083182A (ko) * 2018-01-03 2019-07-11 동국대학교 산학협력단 리그닌 기반 자외선 차단용 화장료 조성물
KR20190109032A (ko) * 2018-03-16 2019-09-25 농업회사법인 주식회사 리치바이오 리그닌을 유효성분으로 포함하는 자외선 차단용 조성물
KR20190112096A (ko) * 2017-02-06 2019-10-02 쓰리스킨 에이에스 자외선 차단제 조성물
WO2021121647A1 (fr) * 2019-12-18 2021-06-24 Ramirez Rios Liliana Patricia Complexes métalliques de macrocycles et/ou d'isoprénoïdes et/ou de tétrapyrroles linéaires par mécanochimie (broyage ou mouture), procédé de préparation correspondant, écran solaire/correcteur de teint/absorbeur uv, matériau de revêtement auto-assemblé, matériau ou surfaces super-amphiphiles et coloration capillaire de ceux-ci ainsi que d'autres utilisations associées
KR20230041247A (ko) * 2021-09-17 2023-03-24 네이처코스텍 주식회사 왕겨로부터 추출된 리그닌을 포함하는 자외선 차단용 조성물

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190112096A (ko) * 2017-02-06 2019-10-02 쓰리스킨 에이에스 자외선 차단제 조성물
KR20190083182A (ko) * 2018-01-03 2019-07-11 동국대학교 산학협력단 리그닌 기반 자외선 차단용 화장료 조성물
KR20190109032A (ko) * 2018-03-16 2019-09-25 농업회사법인 주식회사 리치바이오 리그닌을 유효성분으로 포함하는 자외선 차단용 조성물
WO2021121647A1 (fr) * 2019-12-18 2021-06-24 Ramirez Rios Liliana Patricia Complexes métalliques de macrocycles et/ou d'isoprénoïdes et/ou de tétrapyrroles linéaires par mécanochimie (broyage ou mouture), procédé de préparation correspondant, écran solaire/correcteur de teint/absorbeur uv, matériau de revêtement auto-assemblé, matériau ou surfaces super-amphiphiles et coloration capillaire de ceux-ci ainsi que d'autres utilisations associées
KR20230041247A (ko) * 2021-09-17 2023-03-24 네이처코스텍 주식회사 왕겨로부터 추출된 리그닌을 포함하는 자외선 차단용 조성물

Similar Documents

Publication Publication Date Title
CN102970961B (zh) 个人护理组合物
WO2013176435A1 (fr) Composition anti-vieillissement contenant de l'acide abiétique déshydrogéné comme principe actif
KR101565542B1 (ko) 거미줄 추출물을 함유하는 피부 리프팅 및 노화 방지용 화장료 조성물
WO2022245070A1 (fr) Nouveau peptide et composition cosmétique le comprenant
WO2024242394A1 (fr) Composition cosmétique bloquant les uv comprenant un matériau bloquant les uv consistant en un complexe organique-inorganique
CA2093563A1 (fr) Compositions cosmetiques renfermant une vitamine e polyethoxylee
KR101299024B1 (ko) 피부 미백 및 항산화용 화장료 조성물 및 그 제조방법
WO2024215161A1 (fr) Composition cosmétique contenant de la zn-porphyrine et de la lignine, destinée à bloquer les rayons ultraviolets
KR100920899B1 (ko) 블루로터스 추출물을 유효성분으로 함유하는 피부 보호용화장료 조성물
KR20240152717A (ko) 아연-포르피린 및 리그닌을 포함하는 자외선 차단용 화장료 조성물
KR102211099B1 (ko) 기능성 리포펩타이드를 포함하는 피부 개선용 화장료 조성물
EP1301165B1 (fr) Utilisation d'une allomelanine pour traiter l'inflammation ou l'irritation due à la dha et/ou un tensioactif
WO2021060714A1 (fr) Composition cosmétique pour prévenir le vieillissement de la peau et réduire les rides cutanées, comprenant un extrait de selaginella rossii warb.
KR100466379B1 (ko) 피부미백용 조성물
KR102862564B1 (ko) 리그닌 복합분체를 포함하는 자외선 차단용 화장료 조성물
WO2023277224A1 (fr) Composition antioxydante comprenant un extrait médicinal oriental contenant de l'aurea helianthus, et un extrait de plantes médicinales
RU2682963C2 (ru) Косметическое применение экстракта джимнемы сильвестра
KR20010018665A (ko) 죽여 추출물을 함유하는 화장료 조성물
KR101947062B1 (ko) 복합 식물 추출물을 유효 성분으로 포함하는 화장료 조성물
KR102579725B1 (ko) 곤충 추출물을 포함하는 화장료 조성물
KR102867289B1 (ko) 라즈베리씨오일 또는 발효 라즈베리씨오일을 포함하는 피지 항산화용 화장료 조성물
KR102699931B1 (ko) 치자, 작약 및 배롱나무 추출물을 포함하는 화장료 조성물 및 이의 제조방법
KR102814373B1 (ko) Eckmaxol을 유효성분으로 포함하는 항산화 또는 미백용 화장료 조성물
KR102868327B1 (ko) 자주개자리 종자 추출물을 유효성분으로 포함하는 자외선 차단용 및 자외선 차단 효과 부스팅용 조성물 및 자외선 차단제의 자외선 차단효과 부스팅 방법
KR20010018661A (ko) 소엽 추출물을 함유하는 화장료 조성물

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 24789101

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE