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WO2024253841A3 - Systems and methods for electrochemical sensors with reduced signal loss - Google Patents

Systems and methods for electrochemical sensors with reduced signal loss Download PDF

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Publication number
WO2024253841A3
WO2024253841A3 PCT/US2024/030618 US2024030618W WO2024253841A3 WO 2024253841 A3 WO2024253841 A3 WO 2024253841A3 US 2024030618 W US2024030618 W US 2024030618W WO 2024253841 A3 WO2024253841 A3 WO 2024253841A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
signal loss
reduced signal
systems
sensors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/030618
Other languages
French (fr)
Other versions
WO2024253841A2 (en
Inventor
Kaylyn LEUNG
Kevin Plaxco
Tod KIPPIN
Julian GERSON
Nicole EMMONS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California Berkeley
University of California San Diego UCSD
Original Assignee
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California Berkeley, University of California San Diego UCSD filed Critical University of California Berkeley
Publication of WO2024253841A2 publication Critical patent/WO2024253841A2/en
Publication of WO2024253841A3 publication Critical patent/WO2024253841A3/en
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3276—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/607—Detection means characterised by use of a special device being a sensor, e.g. electrode

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Electrochemical aptamer-based (EAB) sensors support the high-frequency, real-time monitoring of analyte in vivo. Methods for reducing the sensor drift during in vivo placements are described. EAB sensors with non-natural nucleic acid can be used to reduce sensor signal drift. The EAB sensors have improved stability and reduced signal loss.
PCT/US2024/030618 2023-06-06 2024-05-22 Systems and methods for electrochemical sensors with reduced signal loss Pending WO2024253841A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363506560P 2023-06-06 2023-06-06
US63/506,560 2023-06-06

Publications (2)

Publication Number Publication Date
WO2024253841A2 WO2024253841A2 (en) 2024-12-12
WO2024253841A3 true WO2024253841A3 (en) 2025-02-20

Family

ID=93794624

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/030618 Pending WO2024253841A2 (en) 2023-06-06 2024-05-22 Systems and methods for electrochemical sensors with reduced signal loss

Country Status (1)

Country Link
WO (1) WO2024253841A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8003374B2 (en) * 2003-03-25 2011-08-23 The Regents Of The University Of California Reagentless, reusable, bioelectronic detectors
US20190137436A1 (en) * 2016-04-29 2019-05-09 Board Of Trustees Of Michigan State University Embroidered electrochemical biosensors and related methods
US20200182820A1 (en) * 2017-06-01 2020-06-11 The Regents Of The University Of California Calibration-Free Measurement with Electrochemical Biosensors
US20210196161A1 (en) * 2017-10-30 2021-07-01 The Regents Of The University Of California Calibration Free In-Vivo Measurement of Analytes Using Electrochemical Sensors
WO2023034192A1 (en) * 2021-08-31 2023-03-09 Virginia Commonwealth University Self-calibrated electrochemical sensors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8003374B2 (en) * 2003-03-25 2011-08-23 The Regents Of The University Of California Reagentless, reusable, bioelectronic detectors
US20190137436A1 (en) * 2016-04-29 2019-05-09 Board Of Trustees Of Michigan State University Embroidered electrochemical biosensors and related methods
US20200182820A1 (en) * 2017-06-01 2020-06-11 The Regents Of The University Of California Calibration-Free Measurement with Electrochemical Biosensors
US20210196161A1 (en) * 2017-10-30 2021-07-01 The Regents Of The University Of California Calibration Free In-Vivo Measurement of Analytes Using Electrochemical Sensors
WO2023034192A1 (en) * 2021-08-31 2023-03-09 Virginia Commonwealth University Self-calibrated electrochemical sensors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MANA TANUSHREE, BHATTACHARYA BUDHADITYA, LAHIRI HIYA, MUKHOPADHYAY RUPA: "XNAs: A Troubleshooter for Nucleic Acid Sensing", ACS OMEGA, vol. 7, no. 18, 10 May 2022 (2022-05-10), US , pages 15296 - 15307, XP093240003, ISSN: 2470-1343, DOI: 10.1021/acsomega.2c00581 *

Also Published As

Publication number Publication date
WO2024253841A2 (en) 2024-12-12

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