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WO2001031057A3 - Double-strand nucleic acid probes and the use thereof - Google Patents

Double-strand nucleic acid probes and the use thereof Download PDF

Info

Publication number
WO2001031057A3
WO2001031057A3 PCT/EP2000/010209 EP0010209W WO0131057A3 WO 2001031057 A3 WO2001031057 A3 WO 2001031057A3 EP 0010209 W EP0010209 W EP 0010209W WO 0131057 A3 WO0131057 A3 WO 0131057A3
Authority
WO
WIPO (PCT)
Prior art keywords
double
nucleic acid
strand nucleic
acid probes
nucleic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/010209
Other languages
German (de)
French (fr)
Other versions
WO2001031057A2 (en
Inventor
Jochen Muth
Norbert Windhab
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Research and Technologies GmbH and Co KG
Original Assignee
Aventis Research and Technologies GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Research and Technologies GmbH and Co KG filed Critical Aventis Research and Technologies GmbH and Co KG
Priority to EP00969512A priority Critical patent/EP1226272A2/en
Priority to AU79201/00A priority patent/AU7920100A/en
Priority to CA002387567A priority patent/CA2387567A1/en
Priority to JP2001533192A priority patent/JP2003512081A/en
Priority to KR1020027005181A priority patent/KR20020065488A/en
Priority to BR0015240-4A priority patent/BR0015240A/en
Publication of WO2001031057A2 publication Critical patent/WO2001031057A2/en
Publication of WO2001031057A3 publication Critical patent/WO2001031057A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The invention relates to electronically-isolable double-strand nucleic acid probes and use thereof for rapid and easy detection of interactions between double-stranded nucleic acids and factors which interact with them either by mediated or direct means. The invention further relates to the production of said double-strand nucleic acids.
PCT/EP2000/010209 1999-10-22 2000-10-17 Double-strand nucleic acid probes and the use thereof Ceased WO2001031057A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP00969512A EP1226272A2 (en) 1999-10-22 2000-10-17 Double-strand nucleic acid probes and the use thereof
AU79201/00A AU7920100A (en) 1999-10-22 2000-10-17 Double-strand nucleic acid probes and the use thereof
CA002387567A CA2387567A1 (en) 1999-10-22 2000-10-17 Double-stranded nucleic acid probes and their use
JP2001533192A JP2003512081A (en) 1999-10-22 2000-10-17 Double-stranded nucleic acid probes and their use
KR1020027005181A KR20020065488A (en) 1999-10-22 2000-10-17 Double-strand nucleic acid probes and the use thereof
BR0015240-4A BR0015240A (en) 1999-10-22 2000-10-17 Double-stranded nucleic acid probes and their application

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19950969A DE19950969A1 (en) 1999-10-22 1999-10-22 Double-stranded nucleic acid probes and their use
DE19950969.7 1999-10-22

Publications (2)

Publication Number Publication Date
WO2001031057A2 WO2001031057A2 (en) 2001-05-03
WO2001031057A3 true WO2001031057A3 (en) 2001-12-27

Family

ID=7926558

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/010209 Ceased WO2001031057A2 (en) 1999-10-22 2000-10-17 Double-strand nucleic acid probes and the use thereof

Country Status (8)

Country Link
EP (1) EP1226272A2 (en)
JP (1) JP2003512081A (en)
KR (1) KR20020065488A (en)
AU (1) AU7920100A (en)
BR (1) BR0015240A (en)
CA (1) CA2387567A1 (en)
DE (1) DE19950969A1 (en)
WO (1) WO2001031057A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004033476A1 (en) * 2002-10-11 2004-04-22 Ahram Biosystems Inc. Target detection system having a conformationally sensitive probe comprising a nucleic acid based signal transducer
WO2004106545A1 (en) * 2003-05-28 2004-12-09 Innogenetics N.V. Methods for enhanced detection using surface sensitive techniques.
JP5352742B2 (en) * 2009-08-07 2013-11-27 オームクス コーポレーション Enzymatic redox-change chemical elimination (E-TRACE) immunoassay
US8877022B2 (en) * 2011-06-21 2014-11-04 National Taiwan University Biosensor
JP6584986B2 (en) * 2016-03-18 2019-10-02 株式会社東芝 Nucleic acid detection method
US11840715B2 (en) 2020-06-30 2023-12-12 Microsoft Technology Licensing, Llc Microelectrode array with a switchable hydrophilic surface

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002981A1 (en) * 1989-08-25 1991-03-07 Amersham International Plc Assay method
WO1996040712A1 (en) * 1995-06-07 1996-12-19 California Institute Of Technology Nucleic acid mediated electron transfer
WO1997004129A1 (en) * 1995-07-14 1997-02-06 Biacore Ab Method for nucleic acid sequencing
WO1998020162A2 (en) * 1996-11-05 1998-05-14 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
WO1998031839A2 (en) * 1997-01-21 1998-07-23 President And Fellows Of Harvard College Electronic-property probing of biological molecules at surfaces
WO1999015893A1 (en) * 1997-09-22 1999-04-01 Aventis Research & Technologies Gmbh & Co. Kg Addressable modular recognition system, production mode and use
WO1999031275A1 (en) * 1997-12-15 1999-06-24 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand diagnostic biochip
DE19901761A1 (en) * 1999-01-18 1999-07-01 Gerhard Dr Hartwich Oligonucleotides tagged with photoinducible redox-active unit
WO2001013126A1 (en) * 1999-08-13 2001-02-22 Nanogen, Inc. Microelectronic molecular descriptor array devices, methods, procedures, and formats for combinatorial selection of intermolecular ligand binding structures and for drug screening

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998048275A1 (en) * 1997-04-22 1998-10-29 Thomas Schalkhammer Reinforced cluster optical sensors

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002981A1 (en) * 1989-08-25 1991-03-07 Amersham International Plc Assay method
WO1996040712A1 (en) * 1995-06-07 1996-12-19 California Institute Of Technology Nucleic acid mediated electron transfer
WO1997004129A1 (en) * 1995-07-14 1997-02-06 Biacore Ab Method for nucleic acid sequencing
WO1998020162A2 (en) * 1996-11-05 1998-05-14 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
WO1998031839A2 (en) * 1997-01-21 1998-07-23 President And Fellows Of Harvard College Electronic-property probing of biological molecules at surfaces
WO1999015893A1 (en) * 1997-09-22 1999-04-01 Aventis Research & Technologies Gmbh & Co. Kg Addressable modular recognition system, production mode and use
WO1999031275A1 (en) * 1997-12-15 1999-06-24 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand diagnostic biochip
DE19901761A1 (en) * 1999-01-18 1999-07-01 Gerhard Dr Hartwich Oligonucleotides tagged with photoinducible redox-active unit
WO2001013126A1 (en) * 1999-08-13 2001-02-22 Nanogen, Inc. Microelectronic molecular descriptor array devices, methods, procedures, and formats for combinatorial selection of intermolecular ligand binding structures and for drug screening

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ERSKINE SYMON G ET AL: "Reactions on the EcoRV restriction endonuclease with fluorescent oligodeoxynucleotides: Identical equilibrium constants for binding to specific and non-specific DNA.", JOURNAL OF MOLECULAR BIOLOGY, vol. 275, no. 5, 6 February 1998 (1998-02-06), pages 759 - 772, XP002173203, ISSN: 0022-2836 *
GAO HETIAN ET AL: "Stabilization of double-stranded oligonucleotides using backbone-linked disulfide bridges.", NUCLEIC ACIDS RESEARCH, vol. 23, no. 2, 1995, pages 285 - 292, XP002173239, ISSN: 0305-1048 *
HIBMA M H ET AL: "A NON-RADIOACTIVE ASSAY FOR THE DETECTION AND QUANTITATION OF A DNA BINDING PROTEIN", NUCLEIC ACIDS RESEARCH,GB,OXFORD UNIVERSITY PRESS, SURREY, vol. 22, no. 18, 11 September 1994 (1994-09-11), pages 3806 - 3807, XP000673300, ISSN: 0305-1048 *
OKAHATA YOSHIO ET AL: "Kinetic studies of sequence-specific binding of GCN4-bZIP peptides to DNA strands immobilized on a 27-MHz quartz-crystal microbalance.", BIOCHEMISTRY, vol. 37, no. 16, 21 April 1998 (1998-04-21), pages 5666 - 5672, XP002173202, ISSN: 0006-2960 *

Also Published As

Publication number Publication date
BR0015240A (en) 2002-07-16
EP1226272A2 (en) 2002-07-31
WO2001031057A2 (en) 2001-05-03
DE19950969A1 (en) 2001-05-10
AU7920100A (en) 2001-05-08
CA2387567A1 (en) 2001-05-03
KR20020065488A (en) 2002-08-13
JP2003512081A (en) 2003-04-02

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