WO2024135395A1 - Cosmetic preparation - Google Patents

Abstract

A cosmetic preparation comprising (A) a surfactant based on a polyglycerin/fatty acid ester, (B) an aliphatic alcohol having 8-40 carbon atoms, (C) one or more compounds selected from among compounds represented by general formula (1) (wherein R1, R3, R4, and R6 are each independently a C1-C3 alkyl group and R2 and R5 are each independently a hydrogen atom or a C1-C3 alkyl group) and pharmacologically acceptable salts thereof, (D) a thickener having a structure represented by general formula (2) (wherein R7 and R8 are each independently a hydrogen atom or a C1-C3 alkyl group), and (E) water.

Description

Cosmetics

The present invention relates to cosmetics. More specifically, it relates to stable cosmetics that have a whitening effect.

In order to use cosmetics comfortably, the feel when applied to the skin is important. For example, oil-in-water emulsion cosmetics have a viscous state with a smooth surface, and when applied to the skin, they can suppress the evaporation of water from the skin and give the skin a moist feel.

Patent Document 1 describes an oil-in-water emulsion composition that is a blend of glycerin, water, polar oil, and polyglycerol fatty acid ester, and explains that it has excellent feel when used and blends well with makeup.

On the other hand, pyrimidylpyrazole compounds are known as topical skin preparations with excellent whitening effects. For example, Patent Document 2 describes that pyrimidylpyrazole compounds are effective in suppressing melanin production in skin pigment cells and are useful as whitening agents.

JP 2007-153754 A Patent No. 4586108

The above-mentioned polyglycerol fatty acid esters are highly safe and have low irritation, and cosmetics containing them have a good feel on the skin. However, when a pyrimidylpyrazole compound is added to a cosmetic containing polyglycerol fatty acid esters and higher alcohols in an attempt to impart a whitening effect, the uniformity of the cosmetic gradually breaks down, and ultimately separation occurs.

The present invention was made in consideration of the above circumstances. The object of the present invention is to provide a stable cosmetic product that has a whitening effect.

The present invention is as follows:

<<Aspect 1>> (A) a polyglycerol fatty acid ester surfactant,
(B) an aliphatic alcohol having 8 to 40 carbon atoms;
(C) a compound represented by the following general formula (1):
(In general formula (1), R ₁ , R ₃ , R ₄ , and R ₆ are each independently an alkyl group having 1 to 3 carbon atoms, and R ₂ and R ₅ are each independently a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.)
and pharmacologically acceptable salts thereof,
(D) a compound represented by the following general formula (2):
(In general formula (2), R ₇ and R ₈ are each independently a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.)
and (E) water.
<<Aspect 2>> The cosmetic according to aspect 1, wherein _R7 and _R8 in the general formula (2) are methyl groups.
<Embodiment 3> The component (D) is,
The cosmetic preparation according to aspect 2, wherein the copolymer is one or more selected from the group consisting of a copolymer of ammonium acryloyldimethyltaurate and N-vinylpyrrolidone, and a copolymer of sodium acryloyldimethyltaurate, dimethylacrylamide, and methylenebisacrylamide.
<<Aspect 4>> The cosmetic preparation according to aspect 1, wherein the HLB value of the component (A) is 10 or more and 17 or less.
<Embodiment 5> The component (C) is
A compound in which R ₁ , R ₃ , R ₄ , and R ₆ in the general formula (1) are methyl groups, and R ₂ and R ₅ are hydrogen atoms;
The cosmetic preparation according to aspect ₁ , which is one or more selected from a compound in which R ₁ , R ₂ , R ₃ , R ₄ , and R ₆ in the general formula (1) are methyl groups and R ₅ is a hydrogen atom, and a compound in which R 1 , R ₃ , R ₄ , and R ₆ in the general formula (1) are methyl groups and R ₂ and R ₅ are ethyl groups.
<Embodiment 6> The component (C) is,
A compound in which R ₁ , R ₃ , R ₄ , and R ₆ in the general formula (1) are methyl groups, and R ₂ and R ₅ are hydrogen atoms;
The cosmetic preparation according to aspect 2, which is one or more selected from a compound in which R ₁ , R ₂ , R ₃ , R ₄ , and R ₆ in the general formula (1) are methyl groups and R ₅ is a hydrogen atom, and a compound in which R ₁ , R ₃ , R ₄ , and R ₆ in the general formula (1) are methyl groups and R ₂ and R ₅ are ethyl groups.
<Embodiment 7> The component (C) is,
A compound in which R ₁ , R ₃ , R ₄ , and R ₆ in the general formula (1) are methyl groups, and R ₂ and R ₅ are hydrogen atoms;
The cosmetic preparation according to aspect 3, which is one or more selected from a compound in which R ₁ , R ₂ , R ₃ , R ₄ , and R ₆ in the general formula (1) are methyl groups and R ₅ is a hydrogen atom, and a compound in which R ₁ , R ₃ , R ₄ , and R ₆ in the general formula (1) are methyl groups and R ₂ and R ₅ are ethyl groups.
Aspect 8: The cosmetic preparation according to any one of aspects 1 to 7, further comprising (F) an oil component.
<Aspect 9> The cosmetic according to any one of aspects 1 to 7, wherein the mass ratio of the component (D) relative to the total mass of the cosmetic is 0.1 mass% or more and 0.5 mass% or less.
Aspect 10: The cosmetic preparation according to any one of aspects 1 to 7, which is a cream, a sunscreen, a foundation, a milky lotion, or a beauty serum.

The present invention provides a stable cosmetic product that has a whitening effect. The cosmetic product of the present invention is preferably used, for example, as a whitening cream.

Cosmetics
The cosmetic composition of the present invention comprises:
(A) a polyglycerol fatty acid ester surfactant (hereinafter, simply referred to as a "fatty acid ester surfactant");
(B) an aliphatic alcohol having 8 to 40 carbon atoms (hereinafter, simply referred to as "aliphatic alcohol");
(C) one or more compounds selected from the compounds represented by the above general formula (1) and pharmacologically acceptable salts thereof (hereinafter, these may be collectively referred to as "pyrimidylpyrazole compounds");
(D) a thickener having a structure represented by the above general formula (2) (hereinafter, sometimes referred to as "AMPS thickener"), and (E) water.

The cosmetic composition of the present invention may further contain (F) oil in addition to the above components (A) to (E).

The inventors conducted a detailed study on the phenomenon in which the uniformity of a cosmetic formulation containing a polyglycerol fatty acid ester and a higher alcohol is destroyed when pyrimidylpyrazole compounds are added to the cosmetic formulation.

In homogeneous cosmetics, for example, a surfactant (e.g., polyglycerol fatty acid ester) and a higher alcohol form a bilayer structure, and water is trapped between the hydrophilic groups of this layered structure to form a network in water, resulting in a gel state and a uniform appearance. When oil is included along with the surfactant and higher alcohol, the oil is emulsified in the gel, forming a homogeneous oil-in-water emulsion called "α-gel."

Cosmetics containing the α-gel structure have the advantage that the sensation of use can be adjusted appropriately over a wide range, from a refreshing sensation to a slightly rich sensation.

However, when pyrimidylpyrazole compounds are further added to this cosmetic in an α-gel state, it is presumed that the pyrimidylpyrazole compounds act on the layered structure of the bilayer membrane, destroying this layered structure and destroying the uniform state of the cosmetic.

The inventors discovered that when an AMPS thickener is added to a cosmetic formulation containing a polyglycerol fatty acid ester and a higher alcohol, the cosmetic formulation maintains its homogeneous state and maintains its α-gel state even when pyrimidylpyrazole compounds are further added, and thus arrived at the present invention.

It is not clear why the addition of the above thickeners allows the cosmetic to maintain a uniform state even when pyrimidylpyrazole compounds are blended, but it is speculated that the taurine-derived structure of the AMPS thickener blocks the effect of pyrimidylpyrazole compounds on the laminated structure of the bilayer membrane.

However, the present invention is not bound by any particular theory.

The components that make up the cosmetic of the present invention will be explained below in order.

(A) Polyglycerol fatty acid ester surfactant
The component (A) in the cosmetic of the present invention is a polyglycerol fatty acid ester surfactant. The fatty acid ester surfactant (A) is blended in the cosmetic of the present invention to form a bilayer structure together with the fatty alcohol (B) described below, and to trap water between the hydrophilic groups in this layer structure, thereby making the cosmetic into a gel state with a uniform appearance.

(A) The fatty acid ester surfactant may be a compound in which a fatty acid is ester-bonded to one or both ends of polyglycerin.

The degree of polymerization of the polyglycerol may be 4 or more, 5 or more, 6 or more, or 8 or more, and may be 20 or less, 18 or less, 15 or less, or 12 or less.

The number of carbon atoms in the fatty acid may be 6 or more, 8 or more, 10 or more, 12 or more, 14 or more, or 16 or more, and may be 24 or less, 22 or less, 20 or less, 18 or less, 15 or less, 12 or less, or 10 or less. The number of carbon atoms in this fatty acid includes the carbon of the carboxyl group.

The fatty acid may be a saturated or unsaturated fatty acid. The alkyl group of the fatty acid may be linear or branched. In one embodiment of the invention, the alkyl group of the fatty acid is saturated and linear. In another embodiment of the invention, the alkyl group of the fatty acid is saturated and branched. In yet another embodiment of the invention, the alkyl group of the fatty acid is unsaturated and linear. In yet another embodiment of the invention, the alkyl group of the fatty acid is unsaturated and branched.

The fatty acid ester surfactant (A) in the cosmetic of the present invention may be one or more selected from, for example, polyglyceryl-10 caprate, polyglyceryl-6 caprylate, polyglyceryl-10 laurate, polyglyceryl-10 myristate, polyglyceryl-10 dimyristate, polyglyceryl-10 stearate, polyglyceryl-10 distearate, polyglyceryl-10 diisostearate, etc. In the above, the number added after the word "polyglyceryl" indicates the degree of polymerization of polyglycerin.

(A) The HLB value of the fatty acid ester surfactant may be 10 or more, 12 or more, 14 or more, or 16 or more, and may be 17 or less, 15 or less, 14 or less, 13 or less, or 12 or less.

(B) Aliphatic Alcohol
Component (B) in the cosmetic of the present invention is an aliphatic alcohol having a carbon number of 8 to 40. The aliphatic alcohol (B) is blended in the cosmetic of the present invention to form a bilayer structure together with the above-mentioned component (A), and to trap water between the hydrophilic groups in this layer structure, thereby making the cosmetic into a gel state with a uniform appearance.

(B) The carbon number of the aliphatic alcohol is 8 or more, and may be 10 or more, 12 or more, 14 or more, or 16 or more. Also, the carbon number is 40 or less, and may be 36 or less, 32 or less, 28 or less, 26 or less, or 24 or less.

The (B) fatty alcohol may be linear or branched. In one embodiment of the present invention, the (B) fatty alcohol is saturated and linear. In another embodiment of the present invention, the (B) fatty alcohol is saturated and branched. In yet another embodiment of the present invention, the (B) fatty alcohol is unsaturated and linear. In yet another embodiment of the present invention, the (B) fatty alcohol is unsaturated and branched.

The fatty alcohol (B) in the cosmetic of the present invention may be one or more selected from lauryl alcohol, myristyl alcohol, palmityl alcohol (cetanol), stearyl alcohol, behenyl alcohol, etc. A mixture of palmityl alcohol and stearyl alcohol, which is commercially available as "cetearyl alcohol", may also be used as the fatty alcohol (B) in the cosmetic of the present invention.

(C) Pyrimidylpyrazole compounds
The component (C) in the cosmetic of the present invention is a compound represented by the following general formula (1):
(In general formula (1), R ₁ , R ₃ , R ₄ , and R ₆ are each independently an alkyl group having 1 to 3 carbon atoms, and R ₂ and R ₅ are each independently a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.)
and pharmacologically acceptable salts thereof.

These pyrimidylpyrazole compounds (C) are blended into the cosmetic of the present invention to impart a whitening effect to the cosmetic.

The alkyl group having 1 to 3 carbon atoms for R ₁ to R ₆ may be, for example, a methyl group, an ethyl group, an n-propyl group, an isopropyl group, or a cyclopropyl group, in particular a methyl group or an ethyl group, and typically a methyl group.

In one embodiment of the present invention, R ₁ , R ₃ , R ₄ , and R ₆ in the above general formula (1) are all methyl groups. In another embodiment of the present invention, R ₂ and R ₅ in the above general formula (1) are all hydrogen atoms. In yet another embodiment of the present invention, R ₁ , R ₃ , R ₄ , and R ₆ in the above general formula (1) are all methyl groups, and R ₂ and R ₅ are all hydrogen atoms.

In one embodiment of the present invention, R ₁ , R ₂ , R ₃ , R ₄ , and R ₆ in the above general formula (1) are all methyl groups. In another embodiment of the present invention, R ₅ in the above general formula (1) is a hydrogen atom. In yet another embodiment of the present invention, R ₁ , R ₂ , R ₃ , R ₄ , and R ₆ in the above general formula (1) are all methyl groups and R ₅ is a hydrogen atom.

In one embodiment of the present invention, _R2 and _R5 in the above general formula (1) are all ethyl groups. In another embodiment of the present invention, _R1 , _R2 , _R3 , _R4 , and _R6 in the above general formula (1) are all methyl groups, and _R2 and _R5 are all ethyl atoms.

The component (B) in the present invention is
2-(3,5-dimethylpyrazol-1-yl)-4,6-dimethylpyrimidine,
The compound may be one or more compounds selected from 2-(3,5-dimethylpyrazol-1-yl)-4,5,6-trimethylpyrimidine, and 5-ethyl-2-(4-ethyl-3,5-dimethylpyrazol-1-yl)-4,6-dimethylpyrimidine, and pharmacologically acceptable salts thereof.

The pharmacologically acceptable salt of the compound represented by the above general formula (1) may be, for example, an acid addition salt of the compound represented by the above general formula (1). The acid in the acid addition salt may be an inorganic acid or an organic acid. The inorganic acid may be, for example, hydrochloric acid (hydrochloric acid), hydrobromic acid, sulfuric acid, phosphoric acid, etc., and the organic acid may be, for example, acetic acid, propionic acid, citric acid, lactic acid, oxalic acid, maleic acid, fumaric acid, succinic acid, tartaric acid, methanesulfonic acid, etc.

The compound represented by the above general formula (1) can be synthesized by a known method and is also available as a commercial product. A representative method for synthesizing the compound represented by the above general formula (1) is disclosed, for example, in the above-mentioned Patent Document 2.

(D) AMPS thickener
The component (D) in the cosmetic composition of the present invention is a compound represented by the following general formula (2):
(In general formula (2), R ₇ and R ₈ are each independently a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.)
It is a thickener (AMPS thickener) having a structure represented by the following formula:

The (D) AMPS thickener is believed to have the function of stably maintaining the laminated structure of the bilayer membrane formed by the above-mentioned (A) fatty acid ester surfactant and (B) fatty alcohol over a wide pH range. In addition, by blending the (D) AMPS thickener in cosmetics, a refreshing feeling can be obtained.

The alkyl groups having 1 to 3 carbon atoms of _R7 and _R8 in the above general formula (2) may each independently be a methyl group, an ethyl group, an n-propyl group, or an i-propyl group. In one embodiment of the present invention, both _R7 and _R8 in the general formula (2) are methyl groups.

The AMPS thickener (D) in the cosmetic composition of the present invention is, for example,
A copolymer of ammonium acryloyldimethyltaurate and N-vinylpyrrolidone,
Copolymer of sodium acryloyldimethyltaurate, dimethylacrylamide and methylenebisacrylamide,
(acrylamide/sodium acryloyldimethyltaurate) copolymer,
(dimethylacrylamide/sodium acryloyldimethyltaurate) crosspolymer,
(hydroxyethyl acrylate/sodium acryloyldimethyltaurate) copolymer,
(Sodium acrylate/sodium acryloyldimethyltaurate) copolymer,
Ammonium acryloyldimethyltaurate/beheneth-25 methacrylate crosspolymer,
(Sodium acrylate/acryloyldimethyltaurine/dimethylacrylamide) crosspolymer, etc., and one or more types selected from these may be used.

(E) Water
The cosmetic preparation of the present invention contains water as a solvent.

(F) Oil
The cosmetic of the present invention may further contain an oil component (F) in addition to the above-mentioned components (A) to (E). As the oil component (F), an oil component that is usually used in the fields of cosmetics, pharmaceuticals, etc. may be appropriately selected and used.

(F) The oil may be selected from solid oils that are solid at room temperature (25°C) and liquid oils that are liquid at the same temperature.

Solid oils include, for example, solid oils and fats such as cacao butter, coconut oil, horse tallow, hardened coconut oil, palm oil, hydrogenated palm oil, beef tallow, mutton tallow, hardened beef tallow, palm kernel oil, lard, beef bone fat, Japan wax kernel oil, hardened fat, cow's foot fat, Japan wax, and hardened castor oil; beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, Japanese laurel wax, whale wax, montan wax, bran wax, lanolin, kapok wax, lanolin acetate, sugarcane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol, Examples of waxes include lanolin ether, POE lanolin alcohol acetate, POE cholesterol ether, and POE hydrogenated lanolin alcohol ether; hydrocarbon waxes such as polyethylene wax, paraffin wax, ceresin, petrolatum, microcrystalline wax, Lunacera, and ozokerite; fatty acid glyceryl ethers such as monostearyl glycerin ether (batyl alcohol); and fatty acid glycerides such as acetoglyceride and tri-2-heptylundecanoic acid glyceride. One or more selected from these may be used.

Liquid oils include liquid fats and oils, ester oils, hydrocarbon oils, silicone oils, etc., and one or more selected from these may be used.

Liquid oils and fats include, for example, avocado oil, evening primrose oil, camellia oil, turtle oil, macadamia nut oil, sunflower oil, almond oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, camellia oil, sugar squalane, castor oil, linseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, Chinese tung oil, Japanese tung oil, jojoba seed oil, germ oil, etc., and one or more selected from these may be used.

Ester oils include, for example, cetyl octanoate, cetyl 2-ethylhexanoate, hexyldecyl dimethyloctanoate, ethyl laurate, hexyl laurate, isopropyl myristate, 2-hexyldecyl myristate, myristyl myristate, octyldodecyl myristate, isopropyl palmitate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, and 2-heptylundecyl palmitate. , butyl stearate, isocetyl stearate, isocetyl isostearate, decyl oleate, dodecyl oleate, oleyl oleate, myristyl lactate, cetyl lactate, diisostearyl malate, cholesteryl 12-hydroxystearate, castor oil fatty acid methyl ester, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, 2-ethylhexyl succinate, diisobutyl adipate, 2-hexyl adipate Cyldecyl, di-2-heptylundecyl adipate, diisopropyl sebacate, di-2-ethylhexyl sebacate, cetyl ethylhexanoate, ethylene glycol di-2-ethylhexanoate, neopentyl glycol dicaprate, neopentyl glycol dioctanoate, acetoglyceride, glycerin di-2-heptylundecanoate, tricaprylin, glycerin trioctanoate, glycerin tri-2-ethylhexanoate, glycerin trimyristate, glycerin triisopalmitate, glyceride tri-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentaerythritol tetraoctanoate, pentaerythrityl tetraethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, etc. may be used, and one or more selected from these may be used.

Examples of the hydrocarbon oil include liquid paraffin, ozokerite, squalene, pristane, polybutene, hydrogenated polybutene, etc., and one or more selected from these may be used.

Examples of silicone oils include linear polysiloxanes such as dimethylpolysiloxane (also called "dimethicone"), methylphenylpolysiloxane, and diphenylpolysiloxane; cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane; amino-modified polysiloxanes, polyether-modified polysiloxanes, alkyl-modified polysiloxanes, and fluorine-modified polysiloxanes; and one or more selected from these may be used.

Other Ingredients
The cosmetic preparation of the present invention may further contain other components in addition to the above-mentioned components (A) to (E) and the optional component (F).

Other components include, for example, surfactants other than component (A), thickeners other than component (D), moisturizers, defoamers, cooling agents, pH adjusters, chelating agents, preservatives, antioxidants, colorants, fragrances, stabilizers, etc.

《Amount of each ingredient》
The blending amount of the fatty acid ester surfactant (A) in the cosmetic of the present invention, expressed as the mass ratio of the fatty acid ester surfactant (A) relative to the total mass of the cosmetic, may be 1.0 mass% or more, 1.5 mass% or more, 2.0 mass% or more, or 2.5 mass% or more, and may be 10.0 mass% or less, 8.0 mass% or less, 6.0 mass% or less, 5.0 mass% or less, 4.0 mass% or less, or 3.0 mass% or less.

The amount of (B) fatty alcohol in the cosmetic of the present invention may be, as a mass ratio of (B) fatty alcohol to the total mass of the cosmetic, 0.5 mass% or more, 1.0 mass% or more, 1.5 mass% or more, 2.0 mass% or more, or 2.5 mass% or more, and may be 12.0 mass% or less, 10.0 mass% or less, 8.0 mass% or less, 6.0 mass% or less, 5.0 mass% or less, or 4.0 mass% or less.

In addition, in the cosmetic of the present invention, the blending ratio of (A) fatty acid ester surfactant and (B) fatty alcohol, expressed as the mass ratio of (B) fatty alcohol to the total mass of both, may be 10 mass% or more, 15 mass% or more, 20 mass% or more, 25 mass% or more, 30 mass% or more, 40 mass% or more, or 50 mass% or more, and may be 75 mass% or less, 70 mass% or less, 65 mass% or less, 60 mass% or less, 55 mass% or less, or 50 mass% or less.

The amount of the (C) pyrimidylpyrazole compounds in the cosmetic of the present invention may be, as a mass ratio of the (C) pyrimidylpyrazole compounds to the total mass of the cosmetic, 0.05 mass% or more, 0.10 mass% or more, 0.15 mass% or more, 0.20 mass% or more, or 0.25 mass% or more, and may be 1.0 mass% or less, 0.8 mass% or less, 0.6 mass% or less, 0.5 mass% or less, or 0.4 mass% or less.

The amount of the (D)AMPS thickener in the cosmetic of the present invention may be, as a mass ratio of the (D)AMPS thickener to the total mass of the cosmetic, 0.01 mass% or more, 0.03 mass% or more, 0.05 mass% or more, 0.07 mass% or more, 0.08 mass% or more, or 0.1 mass% or more, and may be 1.0 mass% or less, 0.8 mass% or less, 0.6 mass% or less, 0.5 mass% or less, or 0.3 mass% or less.

In addition, in the cosmetic of the present invention, the blending ratio of the (D) AMPS thickener to the total mass of the (A) fatty acid ester surfactant and the (B) fatty alcohol may be 0.1% by mass or more, 0.3% by mass or more, 0.5% by mass or more, 1.0% by mass or more, 1.5% by mass or more, or 2.0% by mass or more, and may be 12% by mass or less, 10% by mass or less, 8% by mass or less, 6% by mass or less, 5% by mass or less, 4% by mass or less, or 3% by mass or less.

When the cosmetic of the present invention contains (F) oil, the blending amount of the (F) oil may be 5% by mass or more, 10% by mass or more, 12% by mass or more, or 15% by mass or more, and may be 35% by mass or less, 30% by mass or less, 28% by mass or less, 25% by mass or less, 23% by mass or less, or 20% by mass or less, as a mass ratio of the (F) oil to the total mass of the cosmetic.

<pH of cosmetics>
The pH of the present invention may be in the range of 4 or more and 8 or less.

<<Production method of cosmetics>>
The cosmetic preparation of the present invention may be produced by mixing the components (A) to (E), the optional component (F), and other components that are blended as necessary, by an appropriate method. The temperature during mixing is, for example, 50° C. or higher and lower than 100° C., and preferably 60° C. or higher and 90° C. or lower.

When the cosmetic preparation of the present invention contains optional components other than the components (A) to (F), such as a moisturizing agent, an antifoaming agent, a cooling agent, a pH adjuster, a chelating agent, a preservative, an antioxidant, a colorant, a fragrance, a stabilizer, etc., the cosmetic preparation of the present invention can be, for example,
an emulsion phase consisting of each of the components (A) to (D) and (F) and a portion of the component (E);
The optional components and the main aqueous phase consisting of the remainder of component (E) may be prepared separately, and then the two are mixed together to prepare the composition.

In this case, the temperature when the components of the emulsion phase are mixed, the temperature when the components of the main aqueous phase are mixed, and the temperature when the emulsion phase and the main aqueous phase are mixed are all, for example, from 50°C to less than 100°C, and preferably from 60°C to 90°C.

<Use of cosmetics>
The cosmetic of the present invention may be a cosmetic for humans, and may be in any product form. The cosmetic of the present invention may be in any suitable form, such as a cream, emulsion, or the like.

The cosmetic composition of the present invention can be suitably applied to, for example, creams (e.g., skin creams), sunscreens (e.g., sunscreen emulsions), foundations (e.g., emulsion foundations), milk lotions, beauty serums, etc.

The cosmetics listed in Tables 1 to 3 below were manufactured and their stability was evaluated. The manufacturing and evaluation methods for the cosmetics were as follows:

<<Method of preparing a cosmetic product>>
The cosmetics of each Reference Example, Comparative Example, and Example were prepared as follows. First, ion-exchanged water (a part of component (E)), a glycerin fatty acid ester (component (A) or other glycerin fatty acid ester), component (B), component (C), a thickener (component (D) or other thickener), and component (F) shown in Tables 1 to 3 were mixed at 70 to 80°C to prepare an emulsion phase. In addition, ion-exchanged water (the remainder of component (E)), and the main aqueous phase components shown in Tables 1 to 3 were mixed at 70 to 80°C to prepare a main aqueous phase.

Then, while maintaining the liquid temperature at 70-80°C, the main aqueous phase was added to the emulsion phase and mixed, and then cooled to room temperature to obtain the cosmetic preparation.

<<Evaluation method for cosmetics>>
The obtained cosmetic was sealed in a sample bottle and allowed to stand for 5 days (120 hours) at 60° C. After standing for 5 days, the cosmetic was visually observed and evaluated according to the following criteria.
A: The water phase and the oil phase did not separate, and no creaming occurred (very good)
B: The water phase and the oil phase were not separated, and only slight creaming was observed (good).
C: The water phase and the oil phase did not separate, but creaming was observed (slightly poor)
D: Water phase and oil phase are separated (poor)

The amount of each component in Tables 1 to 3 is in "mass %." "Compound (C-1)" in component (C) means "2-(3,5-dimethylpyrazol-1-yl)-4,6-dimethylpyrimidine hydrochloride." In addition, the amount of component (E) (ion-exchanged water) that is "the remainder" means that the total amount of component (E) (ion-exchanged water) is appropriately changed to make the total amount of each cosmetic 100% by mass.

As can be seen from Table 1, the cosmetic composition of Reference Example 1, which does not contain the pyrimidylpyrazole compound (C), exhibited excellent stability even after being left to stand at 60°C for 5 days. Similarly, the cosmetic compositions of Reference Examples 2 to 5, which further contain a thickener in addition to the cosmetic composition of Reference Example 1, also exhibited excellent stability even after being left to stand at 60°C for 5 days.

However, as can be seen in Table 2, the cosmetic of Comparative Example 1, in which the cosmetic of Reference Example 1 was blended with pyrimidylpyrazole compound (C), showed separation into an aqueous phase and an oil phase after being left to stand at 60°C for 5 days.

Also, as can be seen in Table 2, in the cosmetics of Comparative Examples 2 to 5, in which a thickener other than the specified component (D) of the present invention was blended with the cosmetic of Comparative Example 1, there was no improvement in stability after leaving the cosmetic at 60°C for 5 days, or if there was any, it was only slight.

In contrast, as can be seen in Table 3, the cosmetics of Examples 1 to 3, in which the cosmetic of Comparative Example 1 was blended with the thickening agent (D) specified in the present invention, were verified to have improved stability after being left at 60°C for 5 days.

Claims (10)

(A) a polyglycerol fatty acid ester surfactant,
(B) an aliphatic alcohol having 8 to 40 carbon atoms;
(C) a compound represented by the following general formula (1):
(In general formula (1), R ₁ , R ₃ , R ₄ , and R ₆ are each independently an alkyl group having 1 to 3 carbon atoms, and R ₂ and R ₅ are each independently a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.)
and pharmacologically acceptable salts thereof,
(D) a compound represented by the following general formula (2):
(In general formula (2), R ₇ and R ₈ are each independently a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.)
and (E) water. The cosmetic preparation according to claim 1 , wherein R ₇ and R ₈ in the general formula (2) are methyl groups. The component (D) is
The cosmetic preparation according to claim 2, which is one or more selected from the group consisting of a copolymer of ammonium acryloyldimethyltaurate and N-vinylpyrrolidone, and a copolymer of sodium acryloyldimethyltaurate, dimethylacrylamide, and methylenebisacrylamide. The cosmetic preparation according to claim 1, wherein the HLB value of component (A) is 10 or more and 17 or less. The component (C) is
A compound in which R ₁ , R ₃ , R ₄ , and R ₆ in the general formula (1) are methyl groups, and R ₂ and R ₅ are hydrogen atoms;
The cosmetic preparation according to claim 1, which is one or more selected from the group consisting of a compound in which R ₁ , R ₂ , R ₃ , R ₄ , and R ₆ in the general formula (1) are methyl groups and R ₅ is a hydrogen atom, and a compound in which R ₁ , R ₃ , R ₄ , and R ₆ in the general formula (1) are methyl groups and R ₂ and R ₅ are ethyl groups. The component (C) is
A compound in which R ₁ , R ₃ , R ₄ , and R ₆ in the general formula (1) are methyl groups, and R ₂ and R ₅ are hydrogen atoms;
The cosmetic preparation according to claim 2, which is one or more selected from the group consisting of a compound in which R ₁ , R ₂ , R ₃ , R ₄ , and R ₆ in the general formula (1) are methyl groups and R ₅ is a hydrogen atom, and a compound in which R ₁ , R ₃ , R ₄ , and R ₆ in the general formula (1) are methyl groups and R ₂ and R ₅ are ethyl groups. The component (C) is
A compound in which R ₁ , R ₃ , R ₄ , and R ₆ in the general formula (1) are methyl groups, and R ₂ and R ₅ are hydrogen atoms;
The cosmetic preparation according to claim 3, which is one or more selected from the group consisting of a compound in which R ₁ , R ₂ , R ₃ , R ₄ , and R ₆ in the general formula (1) are methyl groups and R ₅ is a hydrogen atom, and a compound in which R ₁ , R ₃ , R ₄ , and R ₆ in the general formula (1) are methyl groups and R ₂ and R ₅ are ethyl groups. The cosmetic preparation according to any one of claims 1 to 7, further comprising (F) an oil component. The cosmetic according to any one of claims 1 to 7, wherein the mass ratio of the component (D) to the total mass of the cosmetic is 0.1 mass% or more and 0.5 mass% or less. The cosmetic preparation according to any one of claims 1 to 7, which is a cream, a sunscreen, a foundation, a milky lotion, or a beauty serum.