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WO2024078373A1 - Utilisation d'huile de jojoba dans la préparation d'un e-liquide de cigarette électronique - Google Patents

Utilisation d'huile de jojoba dans la préparation d'un e-liquide de cigarette électronique Download PDF

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Publication number
WO2024078373A1
WO2024078373A1 PCT/CN2023/123137 CN2023123137W WO2024078373A1 WO 2024078373 A1 WO2024078373 A1 WO 2024078373A1 CN 2023123137 W CN2023123137 W CN 2023123137W WO 2024078373 A1 WO2024078373 A1 WO 2024078373A1
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WIPO (PCT)
Prior art keywords
parts
jojoba oil
electronic cigarette
cigarette liquid
preparation
Prior art date
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Ceased
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PCT/CN2023/123137
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English (en)
Chinese (zh)
Inventor
林光榕
吴铁
吴怡
戚怡
叶华
邹丽宜
郑周荧
李康
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Huizhou Happy Vaping Technology Ltd
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Huizhou Happy Vaping Technology Ltd
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Filing date
Publication date
Application filed by Huizhou Happy Vaping Technology Ltd filed Critical Huizhou Happy Vaping Technology Ltd
Publication of WO2024078373A1 publication Critical patent/WO2024078373A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
    • A24B15/26—Use of organic solvents for extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

Definitions

  • the invention belongs to the technical field of electronic cigarette liquid preparation, and particularly relates to application of jojoba oil in preparing electronic cigarette liquid.
  • Electronic cigarettes, or electronic nicotine delivery systems are rapidly gaining popularity at home and abroad. Since electronic cigarettes do not involve tobacco combustion, nicotine (nicotine) and other ingredients are atomized before inhalation. Compared with traditional cigarettes, although non-combustion can reduce the exposure of electronic cigarette users to toxic substances, users and non-users will still be exposed to aerosols containing electronic cigarette liquid ingredients.
  • E-cigarette liquid or e-cigarette oil
  • e-cigarette liquid consists of solvents, sometimes called humectants or stabilizers, as its largest component.
  • solvents in e-cigarette liquid formulations are to keep other chemical ingredients such as nicotine and flavorings in suspension, enhance the absorption of wicking materials in the device, and produce atomized smoke plumes.
  • the two most common solvents used in e-cigarette liquids are propylene glycol and glycerol (glycerol).
  • the U.S. FDA classifies propylene glycol as "generally recognized as safe" (GRAS) in Subchapter B on Food and Human Consumption, which can be used for ingestion but not for atomization.
  • GRAS generally recognized as safe
  • Glycerol is also classified as "generally recognized as safe" in the same subchapter, but no maximum level is defined. Instead, the substance is generally recognized as safe when used in accordance with good manufacturing practices.
  • Propylene glycol and glycerol can be present in e-cigarette liquids in different proportions, generally accounting for 80% to 95% of the volume of e-cigarette liquid.
  • Propylene glycol and glycerol are three-carbon compounds with two and three alcohol groups, respectively.
  • the additional alcohol group on glycerol contributes to higher boiling point, viscosity, aerosol density, and lower vapor pressure compared to propylene glycol.
  • Many e-cigarette merchants do not compare propylene glycol and glycerol by these measures, but instead compare them based on consumer-relevant criteria such as throat feel, residue buildup, and flavor intensity.
  • Glycerol can add flavor to e-liquids and produce a lot of aerosol. These solvents are often found in e-liquid formulations as a mixture, with common propylene glycol:glycerol ratios of 10:90, 20:80, 50:50, and 80:20, although many other ratios exist on the market.
  • the ratio of propylene glycol to glycerol affects many aspects of the e-cigarette experience, such as nicotine production, e-liquid consumption, and the production of toxic thermal decomposition products.
  • Both propylene glycol and glycerol are airway irritants. Nebulized propylene glycol and glycerol can cause oral and throat irritation and dry cough. Acute inhalation of high-powered propylene glycol/glycerol aerosols can cause airway epithelial damage and a sustained decrease in transcutaneous oxygen tension in young smokers.
  • Glycerol can increase the efficacy of inhalants. It is hygroscopic and can draw water into bronchial secretions and reduce their viscosity.
  • rats are relatively resistant to short-term exposure to aerosolized propylene glycol, long-term exposure has been shown to increase the number of nasal goblet cells and mucin content, irritate the nasal and ocular mucosa, and cause laryngeal squamous metaplasia. ⁇ aurenF.
  • 1,2-propylene glycol has adverse effects on the early development of zebrafish.
  • e-cigarette liquid Since the largest components of e-cigarette liquid are solvents propylene glycol and glycerin, and propylene glycol and glycerin have the above-mentioned defects, long-term use may have adverse effects on users.
  • Jojoba oil is extracted from a widely used medicinal plant that is cultivated worldwide.
  • Jojoba oil consists of almost 98% pure wax (mainly wax esters, small amounts of free fatty acids, alcohols and hydrocarbons), sterols and vitamins.
  • the main components of the sterol part are cholesterol, ⁇ -sitosterol, campesterol, stigmasterol and isoflavonesterol.
  • the fat-soluble vitamins are mainly vitamin D and its derivatives, ⁇ , ⁇ and ⁇ tocopherols, of which ⁇ -tocopherol accounts for about 79% of these compounds.
  • Other fat-soluble vitamins, such as vitamin A are also found, and there is almost no triglyceride, so it is widely called liquid wax rather than oil or fat.
  • jojoba oil is widely used in the pharmaceutical industry, particularly in cosmetics for topical, transdermal, and parenteral preparations, but is not currently used in e-cigarette liquids.
  • the purpose of the present invention is to provide an application of jojoba oil to replace or reduce propylene glycol and glycerin as a solvent for electronic cigarette liquid.
  • Jojoba oil has the function of carrying nicotine and can well protect the lungs, bronchial and tracheal cells, and can be used as a solvent in the preparation of electronic cigarette liquid.
  • the technical solution provided by the present invention is: an application of jojoba oil in the preparation of electronic cigarette liquid, in the process of preparing the electronic cigarette liquid, jojoba oil is used as a solvent.
  • the components of the electronic cigarette liquid include 5 to 98 parts by weight of jojoba oil.
  • the components of the electronic cigarette liquid include 65 to 95 parts by weight of jojoba oil.
  • the components of the electronic cigarette liquid include 20 to 60 parts by weight of jojoba oil and 10 to 35 parts by weight of propylene glycol or glycerol or a mixture of the two.
  • the components of the electronic cigarette liquid further include 1 to 20 parts of limonene and 0.5 to 10 parts of linalool by weight.
  • the components of the electronic cigarette liquid also include 1 to 10 parts by weight of ethyl vanillin.
  • the components of the electronic cigarette liquid further include 0.5 to 30 parts of nicotine or 1 to 20 parts of tobacco extract by weight.
  • the electronic cigarette liquid is composed of the following components by weight: 80-95 parts of jojoba oil, 0.5-30 parts of nicotine, 2-10 parts of limonene, 0.5-5 parts of linalool, 1-2 parts of leaf alcohol, 5-10 parts of methyl cinnamate, and 1-5 parts of ethyl vanillin.
  • the electronic cigarette liquid is composed of the following components by weight: 70-90 parts of jojoba oil, 3-10 parts of tobacco extract, 5-10 parts of limonene, 1-5 parts of linalool, 1-3 parts of leaf alcohol, 5-10 parts of methyl cinnamate, 2.5-5 parts of benzoic acid, and 2-5 parts of ethyl vanillin.
  • the electronic cigarette liquid is composed of the following components by weight: 65-85 parts of jojoba oil, 5-20 parts of limonene, 1-5 parts of linalool, 1-3 parts of leaf alcohol, 5-10 parts of methyl cinnamate, 1-5 parts of ethyl vanillin, 0.5-3 parts of N,2,3-trimethyl-2-isopropylbutyramide, and 1-2 parts of peppermint oil.
  • the content of jojoba oil can generally account for 5 to 98 parts by weight of the electronic cigarette liquid, wherein when jojoba oil replaces propylene glycol or glycerol (glycerol) and is used as the only solvent, the content of jojoba oil can account for 65 to 95 parts by weight of the electronic cigarette liquid.
  • jojoba oil is used as the main solvent, and the content of propylene glycol or glycerol (glycerol) is reduced and used as an auxiliary solvent to reduce the harmful performance while improving the solubility performance.
  • the content of jojoba oil can account for 20 to 60 parts by weight of the electronic cigarette liquid, and propylene glycol or glycerol or a mixture of the two is reduced to 10 to 35 parts.
  • the jojoba oil in the present invention can volatilize at 200-250° C. to produce atomized vapor like smoke. Nicotine and shredded tobacco extract containing nicotine can be well soluble in jojoba oil. Nicotine can also be atomized with the jojoba oil and volatilized with the smoke, exerting physiological and pharmacological effects similar to those of nicotine when smoking. Therefore, jojoba oil can be used instead of propylene glycol and glycerin as a solvent for electronic cigarette liquid containing nicotine, and can also be used as a solvent for electronic cigarette liquid without nicotine.
  • the present invention selects jojoba oil as the solvent of the e-cigarette liquid, mainly based on the fact that the oil has a protective effect on the lungs.
  • Chinese scientists recently (2021) published a research report in "Pharmaceutics”, proving that jojoba oil has a good protective effect on lung injury.
  • the title of their paper is "Inhalable Jojoba Oil Dry Nanoemulsion Powders for the Treatment of Lipopolysaccharide-or H2O2-Induced Acute Lung Injury" (Guoli Zhang, Pharmaceutics
  • JNDs dry nanoemulsions
  • LPS lipopolysaccharide
  • H2O2 hydrogen peroxide
  • DXM dexamethasone
  • jojoba oil dry nanoemulsions had a higher anti-inflammatory effect on LPS-induced acute lung injury in rats than dexamethasone, with a decrease in total protein content, and downregulation of tumor necrosis factor- ⁇ (TNF- ⁇ ), interleukin-1 ⁇ (IL-1 ⁇ ), interleukin-6 (IL-6), and NF- ⁇ Bp65.
  • TNF- ⁇ tumor necrosis factor- ⁇
  • IL-1 ⁇ interleukin-1 ⁇
  • IL-6 interleukin-6
  • NF- ⁇ Bp65 NF- ⁇ Bp65
  • Jojoba oil dry nanoemulsion is a promising natural oil-containing inhalable drug for the treatment of acute lung injury induced by LPS or H2O2 in rats. Therefore, it can be considered that the use of jojoba oil as a solvent for electronic cigarette liquid is suitable and has a protective effect on acute lung injury. Therefore, the use of jojoba oil as a solvent for electronic cigarette liquid will be of great significance to the development of electronic cigarette liquid products in the future.
  • the present invention adds limonene and linalool to jojoba oil as a solvent for electronic cigarette liquid, which can improve the taste and flavor of the electronic cigarette liquid, especially without the feeling of dry throat, without residue accumulation and increasing the flavor intensity. At the same time, it also has the effects of increasing memory, improving thinking, anti-anxiety and anti-depression by increasing nicotine.
  • Limonene is a monoterpene of Rubiaceae, which has biological properties such as anti-oxidation, anti-inflammatory, anti-cancer, anti-injury and gastric protection. In recent years, since limonene can reduce oxidative stress and inflammatory response and regulate cell apoptosis and death, studying its pharmacological effects in various chronic diseases has aroused great interest.
  • limonene can interact with GABA at A receptors and produce an anti-anxiety effect by increasing the concentration of GABA in the brain.
  • Limonene can also directly act on the central nervous system and olfactory nerves to restore the imbalance of monoamine transmitters and play a role in improving mood and anti-depression.
  • Linalool is also a monoterpene that acts on the central nervous system. It has shown anticonvulsant and sedative effects in both animals and humans. The effects of linalool are related to the serotonergic pathway. It regulates monoamine neurotransmitters in brain tissue through a different pathway from limonene, thereby producing an antidepressant effect.
  • the invention adds limonene and linalool to the jojoba oil solvent, which can enhance the beneficial effects of nicotine in the electronic cigarette liquid.
  • the distribution of nicotine can be more uniform, the electronic atomization can be more thorough, the carbonization residue can be extremely small, and the taste and flavor can be better.
  • the invention is the best companion for preparing the electronic cigarette liquid with jojoba oil.
  • the electronic smoking cessation liquid does not contain nicotine, but has the effects of nicotine in inhibiting monoamine oxidase, promoting monoamine neurotransmitters such as acetylcholine, 5-hydroxytryptamine and dopamine to play beneficial physiological functions, improving thinking, stabilizing emotions and preventing depression symptoms.
  • the electronic cigarette liquid prepared by the present invention using jojoba oil as a solvent meets the quality requirements of the electronic cigarette liquid after pharmaceutical testing.
  • Studies have shown that the electronic cigarette liquid prepared by the technical solution of the present invention will not cause toxicity to mice smoking continuously for 2 months.
  • the present invention uses jojoba oil as a solvent to prepare electronic cigarette liquid, which solves the defects of using propylene glycol and glycerol as solvents, especially the adverse effects that long-term use may have on users.
  • the jojoba oil used to replace or reduce propylene glycol and glycerol as the solvent of the electronic cigarette liquid proposed by the present invention is non-toxic, has the function of carrying and atomizing nicotine, and can have a good protective effect on the lungs, bronchial and tracheal cells, has no irritating effect on the skin, and shows high resistance to rancidity.
  • the present invention adds limonene and linalool to jojoba oil as a solvent for the electronic cigarette liquid, which can improve the taste and flavor of the electronic cigarette liquid, especially without the feeling of dry throat, without residue accumulation and increasing the flavor intensity. At the same time, it also has the effects of increasing nicotine to increase memory, improve thinking, and resist anxiety and depression.
  • the electronic cigarette liquid prepared according to the technical solution of the embodiment of the present invention meets the quality requirements of the electronic cigarette liquid after pharmaceutical testing. According to animal experimental observations, mice smoked the electronic cigarette liquid of the present invention for 2 months, twice a day, 1 hour each time, and no toxic reaction was found. Pathological examination of the heart, lung and brain tissues did not find any pathological morphological changes. Studies have shown that the electronic cigarette liquid prepared by the technical solution of the present invention will not cause toxicity to mice smoking continuously for 2 months.
  • the present invention describes an application of jojoba oil in preparing electronic cigarette liquid, that is, in the process of preparing the electronic cigarette liquid, jojoba oil is used as a solvent.
  • the components of the electronic cigarette liquid include 5 to 98 parts of jojoba oil used as a solvent, and other components include 1 to 20 parts of limonene, 0.5 to 10 parts of linalool, 1 to 10 parts of ethyl vanillin, 0.5 to 30 parts of nicotine or 1 to 20 parts of tobacco extract.
  • jojoba oil can be selected from 51 to 59 parts, or 61 to 69 parts, or 71 to 79 parts, or 81 to 85 parts, or 86 to 90 parts, or 91 to 98 parts; nicotine can be selected from 0.5 to 5 parts, or 6 to 10 parts, or 11 to 20 parts, or 21 to 30 parts; tobacco extract can be selected from 1 to 10 parts, or 11 to 20 parts; limonene can be selected from 1 to 5 parts, or 6 to 9 parts, or 11 to 20 parts; linalool can be selected from 0.6 to 3 parts, or 3 to 6 parts, or 7 to 9 parts; ethyl vanillin can be selected from 1 to 4 parts, or 5 to 7 parts, or 8 to 10 parts.
  • the components of the electronic cigarette liquid include 20 to 60 parts of jojoba oil used as a solvent, 10 to 35 parts of propylene glycol or glycerol or a mixture of propylene glycol and glycerol, and other components include 1 to 20 parts of limonene, 0.5 to 10 parts of linalool, 1 to 10 parts of ethyl vanillin, 0.5 to 30 parts of nicotine or 1 to 20 parts of tobacco extract.
  • jojoba oil can be selected from 21 to 29 parts, or 31 to 39 parts, or 41 to 49 parts, or 51 to 59 parts; nicotine can be selected from 0.5 to 5 parts, or 6 to 10 parts, or 11 to 20 parts, or 21 to 30 parts; tobacco extract can be selected from 1 to 10 parts, or 11 to 20 parts; limonene can be selected from 1 to 5 parts, or 6 to 9 parts, or 11 to 20 parts; linalool can be selected from 0.6 to 3 parts, or 3 to 6 parts, or 7 to 9 parts; ethyl vanillin can be selected from 1 to 4 parts, or 5 to 7 parts, or 8 to 10 parts.
  • the electronic cigarette liquid is composed of the following components by weight: 80-95 parts of jojoba oil as a solvent, and other components include 0.5-30 parts of nicotine, 2-10 parts of limonene, 0.5-5 parts of linalool, 1-2 parts of leaf alcohol, 5-10 parts of methyl cinnamate, and 1-5 parts of ethyl vanillin.
  • the electronic cigarette liquid is composed of the following components by weight: 70-90 parts of jojoba oil as a solvent, other components including 3-10 parts of tobacco extract, 5-10 parts of limonene, 1-5 parts of linalool, 1-3 parts of leaf alcohol, 5-10 parts of methyl cinnamate, 2.5-5 parts of benzoic acid, and 2-5 parts of ethyl vanillin.
  • the electronic cigarette liquid is composed of the following components by weight: 65-85 parts of jojoba oil as a solvent, other components including 5-20 parts of limonene, 1-5 parts of linalool, 1-3 parts of leaf alcohol, 5-10 parts of methyl cinnamate, 1-5 parts of ethyl vanillin, 0.5-3 parts of N,2,3-trimethyl-2-isopropylbutyramide, and 1-2 parts of peppermint oil.
  • the formula and preparation method of the electronic cigarette liquid using jojoba oil as a solvent and containing nicotine are as follows: take 80.5g of jojoba oil, then add 1.5g of nicotine, 5g of limonene, 5g of linalool, 1g of leaf alcohol, 5g of methyl cinnamate, and 2g of ethyl vanillin to the jojoba oil, and heat appropriately to fully dissolve.
  • the formula and preparation method of the electronic cigarette liquid using jojoba oil as a solvent and containing nicotine are as follows: take 50g of jojoba oil, then add 25g of glycerol, 1.5g of nicotine, 8g of limonene, 5g of linalool, 1.5g of leaf alcohol, 7g of methyl cinnamate, and 2g of ethyl vanillin to the jojoba oil, and heat appropriately to fully dissolve.
  • jojoba oil is used as the main solvent component, and glycerol is added as the auxiliary solvent component.
  • Another formula and preparation method of electronic cigarette liquid using jojoba oil as a solvent and containing nicotine is as follows: take 78g of jojoba oil, then add 1.5g of nicotine, 5g of limonene, 5g of linalool, 1g of leaf alcohol, 5g of methyl cinnamate, 2.5g of benzoic acid, and 2g of ethyl vanillin to the jojoba oil, and heat appropriately to fully dissolve.
  • the formula and preparation method of the electronic cigarette liquid using jojoba oil as a solvent and containing tobacco extract are as follows: take 75g of jojoba oil, then add 10g of tobacco extract, 5g of limonene, 2g of linalool, 1g of leaf alcohol, 5g of methyl cinnamate, and 2g of ethyl vanillin to the jojoba oil, and heat appropriately to fully dissolve.
  • Another formula and preparation method of an electronic cigarette liquid using jojoba oil as a solvent and containing no nicotine is as follows: take 80 g of jojoba oil, then add 8 g of limonene, 1.5 g of linalool, 1 g of leaf alcohol, 5 g of methyl cinnamate, 1.5 g of ethyl vanillin, 1 g of N, 2, 3-trimethyl-2-isopropylbutyramide, and 2 g of peppermint oil to the jojoba oil, and heat appropriately to fully dissolve.
  • relevant ingredients such as linalool, limonene, leaf alcohol, menthol, vanillin, ethyl vanillin, N,2,3-trimethyl-2-isopropylbutanamide, benzoic acid and other substances allowed to be added in the national electronic cigarette standards are added to the electronic cigarette liquid solution using jojoba oil as a solvent to improve the taste and flavor of the electronic cigarette liquid.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Health & Medical Sciences (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
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Abstract

La présente invention concerne une utilisation d'huile de jojoba dans la préparation d'un e-liquide d'une cigarette électronique. L'huile de jojoba est utilisée en tant que solvant dans le processus de préparation du e-liquide d'une cigarette électronique. La présente invention présente les effets bénéfiques suivants : l'huile de jojoba, laquelle est utilisée en tant que solvant du e-liquide d'une cigarette électronique pour remplacer le propylène glycol et le glycérol ou réduire son utilisation, ne présente pas de toxicité, a les fonctions de contenir et d'atomiser de la nicotine, peut bien protéger les cellules pulmonaires, bronchiques et trachéales, n'a pas d'effet de stimulation sur la peau, et présente une résistance élevée à la rancidité.
PCT/CN2023/123137 2022-10-10 2023-10-07 Utilisation d'huile de jojoba dans la préparation d'un e-liquide de cigarette électronique Ceased WO2024078373A1 (fr)

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CN202211232830.8 2022-10-10
CN202211232830.8A CN115736319A (zh) 2022-10-10 2022-10-10 荷荷巴油在制备电子烟烟液中的应用

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115736319A (zh) * 2022-10-10 2023-03-07 惠州市新泓威科技有限公司 荷荷巴油在制备电子烟烟液中的应用

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CN104905400A (zh) * 2015-04-29 2015-09-16 昆明理工大学 一种烟草保润剂及其制备方法
CN110506981A (zh) * 2019-09-12 2019-11-29 深圳雾芯科技有限公司 风味组合物及包含所述风味组合物的电子烟液
US20200128870A1 (en) * 2017-04-24 2020-04-30 Swedish Match North Europe Ab A flavoured moist oral pouched nicotine product comprising triglyceride
CN113558278A (zh) * 2021-08-23 2021-10-29 深圳芳芯科技有限公司 风味组合物及包含所述风味组合物的电子烟液
CN115736319A (zh) * 2022-10-10 2023-03-07 惠州市新泓威科技有限公司 荷荷巴油在制备电子烟烟液中的应用

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101264277A (zh) * 2008-04-16 2008-09-17 冯冲 一种控烟戒烟复方精油
CN104905400A (zh) * 2015-04-29 2015-09-16 昆明理工大学 一种烟草保润剂及其制备方法
US20200128870A1 (en) * 2017-04-24 2020-04-30 Swedish Match North Europe Ab A flavoured moist oral pouched nicotine product comprising triglyceride
CN110506981A (zh) * 2019-09-12 2019-11-29 深圳雾芯科技有限公司 风味组合物及包含所述风味组合物的电子烟液
CN113558278A (zh) * 2021-08-23 2021-10-29 深圳芳芯科技有限公司 风味组合物及包含所述风味组合物的电子烟液
CN115736319A (zh) * 2022-10-10 2023-03-07 惠州市新泓威科技有限公司 荷荷巴油在制备电子烟烟液中的应用

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