WO2024078373A1 - Use of jojoba oil in preparation of e-liquid of electronic cigarette - Google Patents

Abstract

The present invention relates to a use of jojoba oil in preparation of e-liquid of an electronic cigarette. The jojoba oil is used as a solvent in the process of preparing the e-liquid of an electronic cigarette. The present invention has the beneficial effects that the jojoba oil, which is used as a solvent of the e-liquid of an electronic cigarette to replace propylene glycol and glycerol or reduce the usage thereof, has no toxicity, has the functions of carrying and atomizing nicotine, can well protect the lung, bronchial and tracheal cells, has no stimulation effect on skin, and shows high resistance to rancidity.

Description

Application of jojoba oil in preparing electronic cigarette liquid Technical Field

The invention belongs to the technical field of electronic cigarette liquid preparation, and particularly relates to application of jojoba oil in preparing electronic cigarette liquid.

Background technique

Electronic cigarettes, or electronic nicotine delivery systems (ENDS), are rapidly gaining popularity at home and abroad. Since electronic cigarettes do not involve tobacco combustion, nicotine (nicotine) and other ingredients are atomized before inhalation. Compared with traditional cigarettes, although non-combustion can reduce the exposure of electronic cigarette users to toxic substances, users and non-users will still be exposed to aerosols containing electronic cigarette liquid ingredients.

E-cigarette liquid, or e-cigarette oil, consists of solvents, sometimes called humectants or stabilizers, as its largest component. The purpose of solvents in e-cigarette liquid formulations is to keep other chemical ingredients such as nicotine and flavorings in suspension, enhance the absorption of wicking materials in the device, and produce atomized smoke plumes. Currently, the two most common solvents used in e-cigarette liquids are propylene glycol and glycerol (glycerol). The U.S. FDA classifies propylene glycol as "generally recognized as safe" (GRAS) in Subchapter B on Food and Human Consumption, which can be used for ingestion but not for atomization. It defines maximum levels for consumer products, such as 2.5% in frozen dairy products, up to 97% in flavorings and seasonings, and 2% in all other food categories. Glycerol is also classified as "generally recognized as safe" in the same subchapter, but no maximum level is defined. Instead, the substance is generally recognized as safe when used in accordance with good manufacturing practices. Propylene glycol and glycerol can be present in e-cigarette liquids in different proportions, generally accounting for 80% to 95% of the volume of e-cigarette liquid. Propylene glycol and glycerol are three-carbon compounds with two and three alcohol groups, respectively. The additional alcohol group on glycerol contributes to higher boiling point, viscosity, aerosol density, and lower vapor pressure compared to propylene glycol. Many e-cigarette merchants do not compare propylene glycol and glycerol by these measures, but instead compare them based on consumer-relevant criteria such as throat feel, residue buildup, and flavor intensity. Glycerol can add flavor to e-liquids and produce a lot of aerosol. These solvents are often found in e-liquid formulations as a mixture, with common propylene glycol:glycerol ratios of 10:90, 20:80, 50:50, and 80:20, although many other ratios exist on the market.

The ratio of propylene glycol to glycerol affects many aspects of the e-cigarette experience, such as nicotine production, e-liquid consumption, and the production of toxic thermal decomposition products. Both propylene glycol and glycerol are airway irritants. Nebulized propylene glycol and glycerol can cause oral and throat irritation and dry cough. Acute inhalation of high-powered propylene glycol/glycerol aerosols can cause airway epithelial damage and a sustained decrease in transcutaneous oxygen tension in young smokers. Glycerol can increase the efficacy of inhalants. It is hygroscopic and can draw water into bronchial secretions and reduce their viscosity. It has been reported that glycerol and propylene glycol do not cause cytotoxic effects when human embryonic stem cells, mouse neural stem cells, and human lung fibroblasts are exposed to several e-cigarette refill solutions. However, the repeated and potentially long-term inhalation of glycerol vapor associated with e-cigarette use is different from exposure at the cellular level, and the currently available data are insufficient to determine long-term safety. [Priscilla Callahan-Lyon, Electroniccigarettes:

humanhealtheffects, TobControl.2014May;23(Suppl2):1136–1140】. It has been reported that both propylene glycol and glycerol form toxic aldehydes when heated. Propylene glycol can also cause irritation of the eyes, throat, mucous membranes and respiratory tract and peripheral airway constriction. Acute inhalation exposure to aerosolized propylene glycol in humans can cause throat discomfort, coughing and a decrease in forced expiratory volume in 1 second/forced vital capacity (FEV1). Relevant experiments have shown that rabbits exposed to propylene glycol aerosol for only 2 hours showed evidence of tracheal goblet cell degeneration. Although rats are relatively resistant to short-term exposure to aerosolized propylene glycol, long-term exposure has been shown to increase the number of nasal goblet cells and mucin content, irritate the nasal and ocular mucosa, and cause laryngeal squamous metaplasia. 【aurenF.

Pulmonary toxicity of e-cigarettes. Am J Physiol Lung Cell Mol Physiol. 2017 Aug 1; 313(2): L193–L206.】. A study observed the effects of 1,2-propylene glycol, the main component of e-cigarette liquid, on the early development of zebrafish. The zebrafish embryos were exposed to 1.25% or 2.5% 1,2-propylene glycol from 6 to 72 hours after fertilization. Experimental observations showed that exposure to 1,2-propylene glycol did not significantly affect mortality. At 48 hours, the hatching success rate of embryos exposed to 2.5% 1,2-propylene glycol was significantly reduced, but no significant difference was found at 72 hours. In addition, exposure to 1,2-propylene glycol reduced growth and increased the incidence of angina, pericardial edema, and yolk sac edema. Most importantly, exposure of zebrafish development to 1.25% 1,2-propylene glycol resulted in hyperactive swimming behavior in the larvae. This study shows that 1,2-propylene glycol has adverse effects on the early development of zebrafish.

2-Propanediolimpact early development of Zebrafifish (Daniorerio) and induces hyperactivity. Zebrafifish (2017). 14, 216-222].

Since the largest components of e-cigarette liquid are solvents propylene glycol and glycerin, and propylene glycol and glycerin have the above-mentioned defects, long-term use may have adverse effects on users.

Jojoba oil is extracted from a widely used medicinal plant that is cultivated worldwide. Jojoba oil consists of almost 98% pure wax (mainly wax esters, small amounts of free fatty acids, alcohols and hydrocarbons), sterols and vitamins. The main components of the sterol part are cholesterol, β-sitosterol, campesterol, stigmasterol and isoflavonesterol. The fat-soluble vitamins are mainly vitamin D and its derivatives, α, γ and δ tocopherols, of which γ-tocopherol accounts for about 79% of these compounds. Other fat-soluble vitamins, such as vitamin A, are also found, and there is almost no triglyceride, so it is widely called liquid wax rather than oil or fat. Crude jojoba oil obtained directly from seeds by cold pressing or solvent extraction, without any modification, produces golden or light yellow oil. It has a pleasant, slightly nutty flavor. Jojoba oil has high thermal and oxidative stability; therefore, due to the presence of natural antioxidants (α, γ and δ tocopherols), the oil shows high resistance to rancidity. Jojoba oil has a long history in folklore as a treatment for a variety of ailments, such as skin and scalp disorders, superficial wounds, sore throats, obesity, and cancer; for improving liver function, boosting immunity, and promoting hair growth. Extensive research on jojoba oil has revealed a wide range of pharmacological applications, including antioxidant, anti-acne and anti-psoriatic, anti-inflammatory, antifungal, antipyretic, analgesic, antibacterial, and anti-hyperglycemic activities. In addition, jojoba oil is widely used in the pharmaceutical industry, particularly in cosmetics for topical, transdermal, and parenteral preparations, but is not currently used in e-cigarette liquids.

technical problem

In view of the shortcomings of the prior art, the purpose of the present invention is to provide an application of jojoba oil to replace or reduce propylene glycol and glycerin as a solvent for electronic cigarette liquid. Jojoba oil has the function of carrying nicotine and can well protect the lungs, bronchial and tracheal cells, and can be used as a solvent in the preparation of electronic cigarette liquid.

Technical Solutions

To achieve the above-mentioned purpose of the invention, the technical solution provided by the present invention is: an application of jojoba oil in the preparation of electronic cigarette liquid, in the process of preparing the electronic cigarette liquid, jojoba oil is used as a solvent.

Preferably, the components of the electronic cigarette liquid include 5 to 98 parts by weight of jojoba oil.

Preferably, the components of the electronic cigarette liquid include 65 to 95 parts by weight of jojoba oil.

Preferably, the components of the electronic cigarette liquid include 20 to 60 parts by weight of jojoba oil and 10 to 35 parts by weight of propylene glycol or glycerol or a mixture of the two.

Preferably, the components of the electronic cigarette liquid further include 1 to 20 parts of limonene and 0.5 to 10 parts of linalool by weight.

Preferably, the components of the electronic cigarette liquid also include 1 to 10 parts by weight of ethyl vanillin.

Preferably, the components of the electronic cigarette liquid further include 0.5 to 30 parts of nicotine or 1 to 20 parts of tobacco extract by weight.

Preferably, the electronic cigarette liquid is composed of the following components by weight: 80-95 parts of jojoba oil, 0.5-30 parts of nicotine, 2-10 parts of limonene, 0.5-5 parts of linalool, 1-2 parts of leaf alcohol, 5-10 parts of methyl cinnamate, and 1-5 parts of ethyl vanillin.

Preferably, the electronic cigarette liquid is composed of the following components by weight: 70-90 parts of jojoba oil, 3-10 parts of tobacco extract, 5-10 parts of limonene, 1-5 parts of linalool, 1-3 parts of leaf alcohol, 5-10 parts of methyl cinnamate, 2.5-5 parts of benzoic acid, and 2-5 parts of ethyl vanillin.

Preferably, the electronic cigarette liquid is composed of the following components by weight: 65-85 parts of jojoba oil, 5-20 parts of limonene, 1-5 parts of linalool, 1-3 parts of leaf alcohol, 5-10 parts of methyl cinnamate, 1-5 parts of ethyl vanillin, 0.5-3 parts of N,2,3-trimethyl-2-isopropylbutyramide, and 1-2 parts of peppermint oil.

In the present invention, the content of jojoba oil can generally account for 5 to 98 parts by weight of the electronic cigarette liquid, wherein when jojoba oil replaces propylene glycol or glycerol (glycerol) and is used as the only solvent, the content of jojoba oil can account for 65 to 95 parts by weight of the electronic cigarette liquid. In addition, jojoba oil is used as the main solvent, and the content of propylene glycol or glycerol (glycerol) is reduced and used as an auxiliary solvent to reduce the harmful performance while improving the solubility performance. At this time, the content of jojoba oil can account for 20 to 60 parts by weight of the electronic cigarette liquid, and propylene glycol or glycerol or a mixture of the two is reduced to 10 to 35 parts.

The crude jojoba oil obtained directly from the seeds by cold pressing or solvent extraction, without any modification, produces a golden or light yellow oil. It has a pleasant, slightly nutty flavor. Jojoba oil has high thermal and oxidative stability; therefore, the oil exhibits high resistance to rancidity due to the presence of natural antioxidants (alpha, gamma and delta tocopherols).

In the toxicity study of jojoba oil in the present invention, when crude jojoba oil was fed to mice, no acute toxicity was found; that is, the LD50 exceeded 160 g/kg. In the eye irritation test of rabbits, jojoba oil refined after deodorization or deodorization and discoloration caused some reversible conjunctival irritation 1 hour after oiling. After 24 hours of eye application, the reversal effect was completely eliminated. In guinea pigs aged 15 and 30 days, patch tests did not cause pathological inflammation. After 30 days of local application, mild swelling of the epidermis occurred, which was lighter than liquid paraffin and more obvious than olive oil. However, the effect on animal skin was reversible, which may be caused by the occlusive nature of the oil film. In addition, extended daily subcutaneous injections in rats did not lead to any histopathological changes in blood or urine analysis. Only a slight local reversible granuloma reaction occurred in the injection area, indicating that jojoba oil is slightly irritating. Patch tests on humans did not find allergic reactions, except in patients with allergies. Prick tests of people exposed to jojoba oil for two years earlier showed no allergic reactions to either the crude or refined oil. In the Ames test, a mixture of jojoba oil and hydrogenated jojoba wax was non-mutagenic and non-irritating to the skin in both activated and inactivated forms.

The jojoba oil in the present invention can volatilize at 200-250° C. to produce atomized vapor like smoke. Nicotine and shredded tobacco extract containing nicotine can be well soluble in jojoba oil. Nicotine can also be atomized with the jojoba oil and volatilized with the smoke, exerting physiological and pharmacological effects similar to those of nicotine when smoking. Therefore, jojoba oil can be used instead of propylene glycol and glycerin as a solvent for electronic cigarette liquid containing nicotine, and can also be used as a solvent for electronic cigarette liquid without nicotine.

The present invention selects jojoba oil as the solvent of the e-cigarette liquid, mainly based on the fact that the oil has a protective effect on the lungs. Chinese scientists recently (2021) published a research report in "Pharmaceutics", proving that jojoba oil has a good protective effect on lung injury. The title of their paper is "Inhalable Jojoba Oil Dry Nanoemulsion Powders for the Treatment of Lipopolysaccharide-or H2O2-Induced Acute Lung Injury" (Guoli Zhang, Pharmaceutics

2021,13,486.), they prepared dry nanoemulsions (JNDs) with jojoba oil, observed and measured their properties and simulated lung deposition through animal experiments, and then observed their anti-acute lung injury effects through animal experiments. The researchers established a rat acute lung injury (ALI) model by intratracheally administering lipopolysaccharide (LPS) or hydrogen peroxide (H2O2) to rats. Jojoba oil dry nanoemulsions and dexamethasone (DXM) solution were also administered to rats. The pathological state of lung tissue was examined. The results showed that jojoba oil dry nanoemulsions had a higher anti-inflammatory effect on LPS-induced acute lung injury in rats than dexamethasone, with a decrease in total protein content, and downregulation of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and NF-κBp65. Jojoba oil dry nanoemulsion also showed higher anti-inflammatory and antioxidant effects on H2O2. Compared with dexamethasone, it eliminated reactive oxygen species (ROS), increased superoxide dismutase (SOD), reduced lipid peroxide malondialdehyde (MDA) and glutathione (GSH), and inhibited the expression of caspase-3 in rats with acute lung injury induced by lipopolysaccharide. In addition, it alleviated the bleeding and infiltration of inflammatory cells in two rat acute lung injury models. Jojoba oil dry nanoemulsion is a promising natural oil-containing inhalable drug for the treatment of acute lung injury induced by LPS or H2O2 in rats. Therefore, it can be considered that the use of jojoba oil as a solvent for electronic cigarette liquid is suitable and has a protective effect on acute lung injury. Therefore, the use of jojoba oil as a solvent for electronic cigarette liquid will be of great significance to the development of electronic cigarette liquid products in the future.

The present invention adds limonene and linalool to jojoba oil as a solvent for electronic cigarette liquid, which can improve the taste and flavor of the electronic cigarette liquid, especially without the feeling of dry throat, without residue accumulation and increasing the flavor intensity. At the same time, it also has the effects of increasing memory, improving thinking, anti-anxiety and anti-depression by increasing nicotine. Limonene is a monoterpene of Rubiaceae, which has biological properties such as anti-oxidation, anti-inflammatory, anti-cancer, anti-injury and gastric protection. In recent years, since limonene can reduce oxidative stress and inflammatory response and regulate cell apoptosis and death, studying its pharmacological effects in various chronic diseases has aroused great interest. There are literature reports that limonene can interact with GABA at A receptors and produce an anti-anxiety effect by increasing the concentration of GABA in the brain. Limonene can also directly act on the central nervous system and olfactory nerves to restore the imbalance of monoamine transmitters and play a role in improving mood and anti-depression. Linalool is also a monoterpene that acts on the central nervous system. It has shown anticonvulsant and sedative effects in both animals and humans. The effects of linalool are related to the serotonergic pathway. It regulates monoamine neurotransmitters in brain tissue through a different pathway from limonene, thereby producing an antidepressant effect. Studies have shown that the antidepressant-like effect of linalool is exerted through the interaction between postsynaptic 5-HT and the serotonergic pathway. In addition, it is also related to the α receptors of the adrenergic system and the D1 receptors of the dopaminergic system.

The invention adds limonene and linalool to the jojoba oil solvent, which can enhance the beneficial effects of nicotine in the electronic cigarette liquid. At the same time, in terms of pharmacy, the distribution of nicotine can be more uniform, the electronic atomization can be more thorough, the carbonization residue can be extremely small, and the taste and flavor can be better. The invention is the best companion for preparing the electronic cigarette liquid with jojoba oil.

After limonene and linalool are added to the jojoba oil solvent of the present invention, leaf alcohol, menthol, vanillin, ethyl vanillin, N,2,3-trimethyl-2-isopropylbutyramide and other substances are added, nicotine may not be added, and we can also obtain a product with a flavor and taste similar to that of an electronic cigarette liquid containing nicotine. We call this product "nicotine-free electronic smoking cessation liquid". The electronic smoking cessation liquid does not contain nicotine, but has the effects of nicotine in inhibiting monoamine oxidase, promoting monoamine neurotransmitters such as acetylcholine, 5-hydroxytryptamine and dopamine to play beneficial physiological functions, improving thinking, stabilizing emotions and preventing depression symptoms.

The electronic cigarette liquid prepared by the present invention using jojoba oil as a solvent meets the quality requirements of the electronic cigarette liquid after pharmaceutical testing. After animal experimental observation, mice continuously smoked the electronic cigarette liquid of the present invention for 2 months, twice a day, each time for 1 hour, and no toxic reaction was found. Pathological examination of the heart, lung and brain tissues did not find any pathological morphological changes. Studies have shown that the electronic cigarette liquid prepared by the technical solution of the present invention will not cause toxicity to mice smoking continuously for 2 months.

Beneficial Effects

The present invention uses jojoba oil as a solvent to prepare electronic cigarette liquid, which solves the defects of using propylene glycol and glycerol as solvents, especially the adverse effects that long-term use may have on users. The jojoba oil used to replace or reduce propylene glycol and glycerol as the solvent of the electronic cigarette liquid proposed by the present invention is non-toxic, has the function of carrying and atomizing nicotine, and can have a good protective effect on the lungs, bronchial and tracheal cells, has no irritating effect on the skin, and shows high resistance to rancidity. In addition, the present invention adds limonene and linalool to jojoba oil as a solvent for the electronic cigarette liquid, which can improve the taste and flavor of the electronic cigarette liquid, especially without the feeling of dry throat, without residue accumulation and increasing the flavor intensity. At the same time, it also has the effects of increasing nicotine to increase memory, improve thinking, and resist anxiety and depression.

The electronic cigarette liquid prepared according to the technical solution of the embodiment of the present invention meets the quality requirements of the electronic cigarette liquid after pharmaceutical testing. According to animal experimental observations, mice smoked the electronic cigarette liquid of the present invention for 2 months, twice a day, 1 hour each time, and no toxic reaction was found. Pathological examination of the heart, lung and brain tissues did not find any pathological morphological changes. Studies have shown that the electronic cigarette liquid prepared by the technical solution of the present invention will not cause toxicity to mice smoking continuously for 2 months.

Best Mode for Carrying Out the Invention

The present invention describes an application of jojoba oil in preparing electronic cigarette liquid, that is, in the process of preparing the electronic cigarette liquid, jojoba oil is used as a solvent.

One embodiment of the present invention is that the components of the electronic cigarette liquid include 5 to 98 parts of jojoba oil used as a solvent, and other components include 1 to 20 parts of limonene, 0.5 to 10 parts of linalool, 1 to 10 parts of ethyl vanillin, 0.5 to 30 parts of nicotine or 1 to 20 parts of tobacco extract. Specifically, jojoba oil can be selected from 51 to 59 parts, or 61 to 69 parts, or 71 to 79 parts, or 81 to 85 parts, or 86 to 90 parts, or 91 to 98 parts; nicotine can be selected from 0.5 to 5 parts, or 6 to 10 parts, or 11 to 20 parts, or 21 to 30 parts; tobacco extract can be selected from 1 to 10 parts, or 11 to 20 parts; limonene can be selected from 1 to 5 parts, or 6 to 9 parts, or 11 to 20 parts; linalool can be selected from 0.6 to 3 parts, or 3 to 6 parts, or 7 to 9 parts; ethyl vanillin can be selected from 1 to 4 parts, or 5 to 7 parts, or 8 to 10 parts.

Another embodiment of the present invention is that the components of the electronic cigarette liquid include 20 to 60 parts of jojoba oil used as a solvent, 10 to 35 parts of propylene glycol or glycerol or a mixture of propylene glycol and glycerol, and other components include 1 to 20 parts of limonene, 0.5 to 10 parts of linalool, 1 to 10 parts of ethyl vanillin, 0.5 to 30 parts of nicotine or 1 to 20 parts of tobacco extract. Specifically, jojoba oil can be selected from 21 to 29 parts, or 31 to 39 parts, or 41 to 49 parts, or 51 to 59 parts; nicotine can be selected from 0.5 to 5 parts, or 6 to 10 parts, or 11 to 20 parts, or 21 to 30 parts; tobacco extract can be selected from 1 to 10 parts, or 11 to 20 parts; limonene can be selected from 1 to 5 parts, or 6 to 9 parts, or 11 to 20 parts; linalool can be selected from 0.6 to 3 parts, or 3 to 6 parts, or 7 to 9 parts; ethyl vanillin can be selected from 1 to 4 parts, or 5 to 7 parts, or 8 to 10 parts.

Another embodiment of the present invention is that the electronic cigarette liquid is composed of the following components by weight: 80-95 parts of jojoba oil as a solvent, and other components include 0.5-30 parts of nicotine, 2-10 parts of limonene, 0.5-5 parts of linalool, 1-2 parts of leaf alcohol, 5-10 parts of methyl cinnamate, and 1-5 parts of ethyl vanillin.

Another embodiment of the present invention is that the electronic cigarette liquid is composed of the following components by weight: 70-90 parts of jojoba oil as a solvent, other components including 3-10 parts of tobacco extract, 5-10 parts of limonene, 1-5 parts of linalool, 1-3 parts of leaf alcohol, 5-10 parts of methyl cinnamate, 2.5-5 parts of benzoic acid, and 2-5 parts of ethyl vanillin.

Another embodiment of the present invention is that the electronic cigarette liquid is composed of the following components by weight: 65-85 parts of jojoba oil as a solvent, other components including 5-20 parts of limonene, 1-5 parts of linalool, 1-3 parts of leaf alcohol, 5-10 parts of methyl cinnamate, 1-5 parts of ethyl vanillin, 0.5-3 parts of N,2,3-trimethyl-2-isopropylbutyramide, and 1-2 parts of peppermint oil.

Embodiments of the present invention

The present invention will be described in detail below through specific embodiments.

Example 1

The formula and preparation method of the electronic cigarette liquid using jojoba oil as a solvent and containing nicotine are as follows: take 80.5g of jojoba oil, then add 1.5g of nicotine, 5g of limonene, 5g of linalool, 1g of leaf alcohol, 5g of methyl cinnamate, and 2g of ethyl vanillin to the jojoba oil, and heat appropriately to fully dissolve.

Example 2

The formula and preparation method of the electronic cigarette liquid using jojoba oil as a solvent and containing nicotine are as follows: take 50g of jojoba oil, then add 25g of glycerol, 1.5g of nicotine, 8g of limonene, 5g of linalool, 1.5g of leaf alcohol, 7g of methyl cinnamate, and 2g of ethyl vanillin to the jojoba oil, and heat appropriately to fully dissolve.

In this embodiment, jojoba oil is used as the main solvent component, and glycerol is added as the auxiliary solvent component.

Example 3

Another formula and preparation method of electronic cigarette liquid using jojoba oil as a solvent and containing nicotine is as follows: take 78g of jojoba oil, then add 1.5g of nicotine, 5g of limonene, 5g of linalool, 1g of leaf alcohol, 5g of methyl cinnamate, 2.5g of benzoic acid, and 2g of ethyl vanillin to the jojoba oil, and heat appropriately to fully dissolve.

Example 4

The formula and preparation method of the electronic cigarette liquid using jojoba oil as a solvent and containing tobacco extract are as follows: take 75g of jojoba oil, then add 10g of tobacco extract, 5g of limonene, 2g of linalool, 1g of leaf alcohol, 5g of methyl cinnamate, and 2g of ethyl vanillin to the jojoba oil, and heat appropriately to fully dissolve.

Example 5

Another formula and preparation method of an electronic cigarette liquid using jojoba oil as a solvent and containing no nicotine is as follows: take 80 g of jojoba oil, then add 8 g of limonene, 1.5 g of linalool, 1 g of leaf alcohol, 5 g of methyl cinnamate, 1.5 g of ethyl vanillin, 1 g of N, 2, 3-trimethyl-2-isopropylbutyramide, and 2 g of peppermint oil to the jojoba oil, and heat appropriately to fully dissolve.

Example 6

In the above embodiments and examples of the present invention, relevant ingredients such as linalool, limonene, leaf alcohol, menthol, vanillin, ethyl vanillin, N,2,3-trimethyl-2-isopropylbutanamide, benzoic acid and other substances allowed to be added in the national electronic cigarette standards are added to the electronic cigarette liquid solution using jojoba oil as a solvent to improve the taste and flavor of the electronic cigarette liquid.

Industrial Applicability

The above description is only a preferred embodiment of the present invention. All equivalent changes and modifications made within the scope of the claims of the present invention should fall within the scope of the claims of the present invention.

Claims (10)

An application of jojoba oil in preparing electronic cigarette liquid is characterized in that jojoba oil is used as a solvent in the process of preparing the electronic cigarette liquid. The use of jojoba oil in the preparation of electronic cigarette liquid according to claim 1 is characterized in that the components of the electronic cigarette liquid include 5 to 98 parts of jojoba oil by weight. The use of jojoba oil in the preparation of electronic cigarette liquid according to claim 1 is characterized in that the components of the electronic cigarette liquid include 65 to 95 parts of jojoba oil by weight. The use of jojoba oil in the preparation of electronic cigarette liquid according to claim 1 is characterized in that the components of the electronic cigarette liquid include 20 to 60 parts of jojoba oil and 10 to 35 parts of propylene glycol or glycerol or a mixture of the two in parts by weight. The use of jojoba oil in the preparation of electronic cigarette liquid according to any one of claims 2 to 4 is characterized in that the components of the electronic cigarette liquid further include 1 to 20 parts of limonene and 0.5 to 10 parts of linalool by weight. The use of jojoba oil in the preparation of electronic cigarette liquid according to any one of claims 2 to 4 is characterized in that the components of the electronic cigarette liquid further include 1 to 10 parts by weight of ethyl vanillin. The use of jojoba oil in the preparation of electronic cigarette liquid according to any one of claims 2 to 4 is characterized in that the components of the electronic cigarette liquid further include 0.5 to 30 parts of nicotine or 1 to 20 parts of tobacco extract by weight. The use of jojoba oil in the preparation of electronic cigarette liquid according to claim 2 is characterized in that the electronic cigarette liquid is composed of the following components by weight: 80-95 parts of jojoba oil, 0.5-30 parts of nicotine, 2-10 parts of limonene, 0.5-5 parts of linalool, 1-2 parts of leaf alcohol, 5-10 parts of methyl cinnamate, and 1-5 parts of ethyl vanillin. The use of jojoba oil in the preparation of electronic cigarette liquid according to claim 2 is characterized in that the electronic cigarette liquid is composed of the following components by weight: 70-90 parts of jojoba oil, 3-10 parts of tobacco extract, 5-10 parts of limonene, 1-5 parts of linalool, 1-3 parts of leaf alcohol, 5-10 parts of methyl cinnamate, 2.5-5 parts of benzoic acid, and 2-5 parts of ethyl vanillin. The use of jojoba oil in the preparation of electronic cigarette liquid according to claim 2 is characterized in that the electronic cigarette liquid is composed of the following components by weight: 65-85 parts of jojoba oil, 5-20 parts of limonene, 1-5 parts of linalool, 1-3 parts of leaf alcohol, 5-10 parts of methyl cinnamate, 1-5 parts of ethyl vanillin, 0.5-3 parts of N,2,3-trimethyl-2-isopropylbutyramide, and 1-2 parts of peppermint oil.