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WO2022245099A1 - Crème mélangée contre la teigne animale ayant un jus de citron mélangé avec une formulation de crème et méthode de préparation - Google Patents

Crème mélangée contre la teigne animale ayant un jus de citron mélangé avec une formulation de crème et méthode de préparation Download PDF

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Publication number
WO2022245099A1
WO2022245099A1 PCT/KR2022/007037 KR2022007037W WO2022245099A1 WO 2022245099 A1 WO2022245099 A1 WO 2022245099A1 KR 2022007037 W KR2022007037 W KR 2022007037W WO 2022245099 A1 WO2022245099 A1 WO 2022245099A1
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mixed
cream
lemon juice
ringworm
cream formulation
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PCT/KR2022/007037
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English (en)
Korean (ko)
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김드보라
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Definitions

  • the present invention relates to a mixed cream for animal ringworm in which a cream formulation is mixed with lemon juice and a manufacturing method.
  • Toothpaste which is mainly a cream formulation, is used on a toothbrush for the purpose of cleaning and polishing teeth, and is sold in powder, cream, and liquid formulations. Toothpaste consists of an abrasive for mechanical cleaning of teeth (a) and a humectant (b) that prevents toothpaste from drying and solidifying when exposed to air as essential components, including a foaming agent (c), binder (d), and additives. (f) It is made of a cream formulation containing purified water and the like, and brings oral hygiene effects such as oral washing and plaque removal. Recently, it is also being made to bring about medical effects such as tooth decay prevention or periodontal disease treatment by adding medicinal agents.
  • dermatophytosis occurs as shown in FIG. 1 as a skin disease commonly known as 'fungal skin disease' or 'ringworm' among companions raising cats or dogs.
  • Dermatophytosis a skin disease that affects both dogs and cats, is caused by infection with dermatophytes, or fungi.
  • Representative fungi causing dermatophytosis include Trichophyton, Microsporum, and Epidermophyton, among which Microsporum canis is known as the most common infectious agent. It is a disease so common that there is a story that cats get it at least once in their lives, and it is highly likely to recur and takes a long time to treat.
  • dermatophytosis Cats with dermatophytosis develop scabs and dandruff (keratin) on the skin, and circular hair loss. Also, because it is accompanied by severe itching, you may scratch your skin or lick your hair excessively. Since dermatophytosis is literally a fungal skin disease, it can be infected anywhere in the environment where fungi live. However, it is not uncommon for healthy adult cats to become infected, and most cases occur in young or immunocompromised cats. Even if symptoms of dermatophytosis appear, life is not greatly affected, but there is a high probability of contagion to other cats.
  • dermatophytosis is a representative 'common disease' that can be transmitted to humans, so if a cat has the disease, the owner should be careful as well.
  • Cats whose whole body is covered with soft and abundant hair do not need to be bathed frequently because they manage their hair themselves through the grooming shown in FIG. However, depending on the cat's grooming ability, it is necessary to adjust the bathing cycle or to manage the coat through regular brushing. If the skin is damp or not properly managed, the cat is more likely to get a skin disease, so as a preventive measure, a neck cover is sometimes put on the neck as shown in FIG. 3, but there is no significant difference in the effect.
  • Dermatophytosis more commonly known as 'Ringworm' among cat owners, means 'round worms', that is, ring-shaped worms, as the name suggests, but in reality, it is not a skin disease caused by worms such as parasites, but ringworms. It is named because of the appearance of round skin lesions.
  • This skin disease caused by mold fungi is transmitted through direct or indirect contact with an environment or organisms containing mold spores. It is also called 'cat athlete's foot' because it is the same as athlete's foot in humans.
  • Cat fungal dermatosis is a representative symptom of partial circular hair loss on the body and severe scabs or dead skin cells.
  • the hair loss lesions may be red as a whole, accompanied by extreme itching, and cats suffering from itching may scratch or lick the skin severely.
  • Fungal skin disease mainly occurs severely in young cats with weak immunity. It is said that even adult cats can get it if their immunity is weakened due to disease or stress, or in the case of elderly cats with weak physical strength.
  • the treatment period for fungal dermatosis is as short as 2 to 4 weeks and as long as several months. At first glance, symptoms may seem to improve, but treatment should not be stopped prematurely. This is because if the fungal spores reappear and the symptoms recur, the treatment in the meantime may be in vain.
  • the treatment of dermatophytosis of animals is to apply disinfectant or take antifungal agents, but even if disinfectants are applied, the duration of effect is shortened through grooming, etc., and antifungal agents are resistant when taken for a long time. There are difficulties in treatment such as occurrence or side effects.
  • the present invention is to solve the problem of ringworm in animals, and an object of the present invention is to provide a mixed cream, which is a mixture of lemon juice, a natural ingredient, and a cream formulation having wettability, foaming properties, and binding properties, for healing and symptomatic relief of ringworm in animals.
  • a mixed cream which is a mixture of lemon juice, a natural ingredient, and a cream formulation having wettability, foaming properties, and binding properties, for healing and symptomatic relief of ringworm in animals.
  • the present invention is characterized by mixing 500 parts by weight of a cream formulation containing 500 to 1000 parts of lemon juice, an abrasive (a), a humectant (b), a foaming agent (c), a binder (d), an additive (f) and purified water
  • a cream formulation containing 500 to 1000 parts of lemon juice, an abrasive (a), a humectant (b), a foaming agent (c), a binder (d), an additive (f) and purified water
  • a cream formulation containing 500 to 1000 parts of lemon juice, an abrasive (a), a humectant (b), a foaming agent (c), a binder (d), an additive (f) and purified water
  • an animal ringworm mixed cream in which lemon juice is mixed with a cream formulation having
  • the present invention also adds 500 parts by weight of a cream formulation containing an abrasive (a), a humectant (b), a foaming agent (c), a binder (d), an additive (f) and purified water to 500 to 1000 parts by volume of lemon juice; While mixing it, stop mixing when the inside is filled with bubbles and the volume ratio is 1000 to 1500; wait for air bubbles to disappear; Provided is a method for manufacturing animal ringworm mixed cream in which lemon juice is mixed with a cream formulation in which the mixed cream is transferred to a separate container and aged for 12 to 24 hours in sequence.
  • the present invention mixes lemon juice, which is a natural ingredient, with a cream formulation having wettability, foaming properties and bonding properties for animal ringworm healing and symptom relief, reducing stimulation of the affected area and antibacterial properties when the mixed cream is applied to the ringworm area. to provide.
  • cream formulation is added to lemon juice, mixed and aged, and lemon juice is uniformly dispersed in the cream formulation during mixing, so the mixed and matured mixed cream reduces the stimulation of lemon and delays the initial reaction such as grooming of cats. , while delaying, it performs initial sterilization function peculiar to lemon to maintain sterilization and ringworm healing function even during grooming.
  • the mixed cream in which lemon juice is dispersed in the cream formulation forms a non-irritating form, reducing the feeling of rejection of ringworm-infected animals such as cats.
  • Figure 3 is a picture of filling the neck cover to prevent grooming of the cat.
  • the present invention is characterized by mixing 500 parts by weight of a cream formulation containing 500 to 1000 parts of lemon juice, an abrasive (a), a humectant (b), a foaming agent (c), a binder (d), an additive (f) and purified water
  • a cream formulation containing 500 to 1000 parts of lemon juice, an abrasive (a), a humectant (b), a foaming agent (c), a binder (d), an additive (f) and purified water
  • a cream formulation containing 500 to 1000 parts of lemon juice, an abrasive (a), a humectant (b), a foaming agent (c), a binder (d), an additive (f) and purified water
  • an animal ringworm mixed cream in which lemon juice is mixed with a cream formulation having
  • a cream formulation containing an abrasive (a) and a humectant (b) as basic components, to which a foaming agent (c), a binder (d) and an additive (f) are added or a fluorine component is further added is used.
  • the abrasive (a) is precipitated calcium carbonate, calcium hydrogen phosphate, calcium sulfate, magnesium carbonate, magnesium chloride, hydrous alumina, hydrous silica (silicon dioxide), hydrous silicic acid, precipitated silica, silica gel, zirconium silicate, aluminum silicate, calcium pyrophosphate and insoluble metaphosphate salts, and usually includes one or two or more of these.
  • These abrasives should have a uniform particle size of approximately 1 to 20 ⁇ m, a shape that is not too sharp, and a hardness of about 3 degrees Mohs' hardness.
  • the tongue serves as a toothbrush brush for scabs caused by wounds of ringworm, etc., so that the scabs fall off well during grooming.
  • the humectant (b) is a base component essential for making an ointment formulation, which prevents drying and solidification when exposed to air and provides gloss to the surface of a paste, such as glycerin, sorbitol, polyethylene glycol, and propylene glycol.
  • a paste such as glycerin, sorbitol, polyethylene glycol, and propylene glycol.
  • glycerin, sorbitol, polyethylene glycol, and propylene glycol include one or more
  • lemon juice of strong acidity (pH 2) since lemon juice of strong acidity (pH 2) is dispersed in an ointment-type cream formulation, it functions to increase the time that lemon juice stays on the skin without the stinging caused by acid felt by animals, and to prevent solidification to increase the duration of the medicinal effect. function to prolong
  • the foaming agent (c) enhances the feeling of use, helps in cleaning action, speeds up the dispersion and penetration of other active agents, and reduces interfacial tension so that scabs caused by ringworm can easily fall off.
  • anionic surfactants such as sodium lauryl sulfate and sodium methyl cocoyl tarurate are mainly used, and depending on the characteristics of the formulation, nonionic surfactants such as polyoxyethylene, polyoxypropylene copolymer, and polyoxyethylene cured Castor oil, polyoxyethylene sorbitan fatty acid ester and the like are additionally used, including one or two or more of them.
  • the binder (d) prevents separation of the powdery solid component and the liquid component, and any water-soluble polymer may be used.
  • Commonly used ingredients include carboxymethyl cellulose sodium (CMC-Na) synthesized from tree cellulose, carrageenan extracted from seaweed, and xanthan gum obtained from microbial metabolism, including one or two or more of these. .
  • the lemon juice dispersed in the cream formulation functions so as not to be separated from the cream to provide a uniform sterilization effect when applied.
  • fluorine component (e) water-soluble fluorides such as sodium monofluorophosphate, sodium fluoride, amine fluoride, and tin fluoride are used.
  • a cationic surfactant or the like may be used.
  • the fluorine component is not directly related to ringworm treatment, but an indirect effect of protecting animal teeth through grooming can be expected.
  • the additive (f) is a water-soluble salt such as sodium chloride or sodium bicarbonate having a high osmotic pressure, aminocaproic acid having a hemostatic effect, allantoin derivatives such as allantoin chlorohydroxyaluminum, and tocopherol acetate, tocopherol acetate (vitamin E), Vitamins such as ascorbic acid (vitamin C) are used, and one or more of these additives may be used.
  • flavoring agents, sweetening agents, coloring agents, preservatives, and the like may be used as additional additives.
  • Fruit extracts and methyl salicylate, natural flavors such as calendula extract, rosemary extract, natural lemon flavor B30405, citrus mix flavor HF62946, etc. may be used as flavoring agents, and saccharin sodium, steviol glycosides, etc. may be most used as sweeteners.
  • titanium oxide or the like for producing a white color may be used as a pigment.
  • the most characteristic component of the present invention is mixing by adding 500 parts by weight of a cream formulation to 500 to 1000 parts by volume of lemon juice. If the lemon juice is less than 500 parts by volume, the ringworm healing effect is low, and if it exceeds 1000 parts by volume, there is no difference in the healing effect, but there are cats who avoid it because of strong stimulation.
  • Lemon juice in the present invention contains 5-6% citric acid, is acidic, and has a pH of about 2.2. It is a mixture of two or more flavonoids, and its main component is 3'hesperidin, a methylated derivative of hesperidin that is insoluble in water. Vitamin P contained in lemon is a yellow-orange powder with little or no odor and is easily soluble in water. Relatively stable, but hygroscopic.
  • vitamin P acts as a stabilizer for capillaries, and lack of vitamin P causes purpura, and capillaries show a decrease in resistance to blood and an increase in permeability to plasma proteins, so it is called vitamin P (Permiability), which means permeability. It was built. Vitamin P has an anti-inflammatory effect on all symptoms with abnormal vascular permeability, such as hemorrhagic nephritis and acute hepatitis.
  • vitamin C and vitamin P components are dispersed in the cream formulation to have anti-inflammatory action, and pH 2.2 of the lemon juice itself or dispersed in the cream formulation and matured are used.
  • the acidic sting is neutralized in the cream formulation so that it functions in a non-irritating state, reducing the feeling of rejection, and at the same time, the strong acid sterilization action relieves and heals the symptoms of ringworm in animals is considered to contribute to
  • 500 to 1000 parts by weight (500 to 1000 ml) of lemon juice contains precipitated silica and hydrated silica as an abrasive (a), and sorbitol as a wetting agent (b), and a foaming agent ( c) Sodium Lauryl Sulfate, Sodium Methyl Cocoyl Taurate, Sodium Carboxymethyl Cellulos (CMC-Na) as Binder (d), Sodium Monofluorophosphate as Fluorine Component (e) 500 parts by weight (500 mg) of a cream formulation containing monofluorophosphate), sodium metaphosphate, steviol glycoside as a sweetener among additives (f), titanium dioxide as a colorant, etc., and the remaining amount containing purified water ) was added, and mixed in a blender to achieve 1200 to 1500 volumes (ml) to increase the volume, and the cream formulation of the present invention was carried out at the component ratios shown in Table 1. 500 g of cream formulation was added to 500 ml of initial lemon juice,
  • Example 1 Example 2
  • Example 3 Example 4
  • Example 5 abrasive (a) precipitated silica 20.0 - - - 10.0 calcium monohydrogen phosphate - - 35.0 - - Hydrous Alumina - - 5.0 - 5.0 precipitated calcium carbonate - 30.0 - 35.0 15.0 silica gel 5.0 - - - - humectant (b) Agriglycerin (98%) - 5.0 10.0 25.0 - Sorbitol aqueous solution (70%) 60.0 20.0 20.0 - 33.0 xylitol - - 5.0 - 3.0
  • Foaming agent c) sodium lauryl sulfate 2.0 2.0 2.0 2.0 2.0 binder
  • Cream formulation 500 parts by weight; g) Lemon juice (by volume; ml) Days of recovery from ringworm date of hair growth
  • Example 1 500 4 days 8 days
  • Example 2 700 4 days 8 days
  • Example 3 1000 3 days 7 days
  • Example 4 500 4 days 8 days
  • Example 5 1000 3 days 7 days
  • the mixed cream of the present invention was applied to the ringworm area, for example, as in Example 4, when the cream formulation was mixed with lemon juice and mixed, the eyes It was confirmed that a remarkable healing effect occurred.
  • Examples 4 and 5 of Table 2 did not contain fluorine, and it was confirmed that there was no difference in treatment period compared to Example 3 containing fluorine in the ringworm healing effect of the present invention.
  • 500 parts by weight of a cream formulation is added to 500 to 1000 volumes of lemon juice and mixed with a mixer, and when bubbles fill the inner space of the mixer to 1200 to 1500 ml, the lemon juice is uniformly mixed with the cream formulation.
  • the cream formulation includes a humectant (b), a foaming agent (c), and a binder (d)
  • the humectant (b) maintains the cream form and prevents drying and solidification when applied to ringworm skin so that the sterilization effect is maintained,
  • the dead skin cells that are separated from the skin are still moistened with lemon juice to prevent secondary infection.
  • the foaming agent (c) acts as a surfactant, reducing the surface tension of the lemon juice to evenly spread wounds on ringworm skin. Regardless of the condition, lemon juice is dispersed to improve the function of killing fungi on the ringworm skin.
  • the binding agent (d) functions to prevent separation of inorganic and organic powder components and lemon juice, as in the present invention, even when lemon juice is mixed in an amount of 500 to 1000 parts, it maintains a binding state and maintains a sterilizing function even during grooming, and the skin concerned to have anti-inflammatory function, sterilizes ringworm-generating fungi that cause ringworm-generated cat skin, and at the same time, lemon juice performs anti-inflammatory function on cat ringworm-generated skin to restore cat ringworm-generated skin. do.
  • Example 4 when a mixed cream mixed with lemon juice and cream formulation as in Example 4 is applied to the ringworm affected area of a cat two or three times a day, the visible recovered affected area and the contaminated area around it are recovered after 3 days. While recovering, it was confirmed as shown in the photo in Table 3 that the keratin fell off along with the hair and became clean, and the downy hair grew over 7 days.
  • the affected area If the affected area is in contact with the cat's mouth, simply apply the liquid to clean the falling hairs and dead skin cells on its own, and the affected area will be completely healed in about 3 days. If the affected area is out of reach of cats, just as the scab on the wound falls off on its own, and as if peeling off the skin, carefully comb out the hair and dead skin cells that are entangled with the drug with a fine comb and clean up the affected area to extend the healing period. can prevent
  • the mixed cream of the present invention which is made by mixing cream formulation and lemon juice, maintains viscosity, so that the liquid component (mixed cream) is attached to the spores. Since it is buried together, it is judged to prevent the normal activity of spores. It is conceivable that the bacteria were reverse contaminated with the mixed solution of the present invention. This is because the reverse-contaminated fungi cannot cause disease.
  • the mixed cream for animal ringworm in which the cream formulation is mixed with lemon juice according to the present invention and the manufacturing method are very useful inventions for treating ringworm in animals and alleviating symptoms, and thus have great industrial applicability.

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Abstract

La présente invention concerne une crème mélangée contre la teigne animale et une méthode de préparation, caractérisée en ce que 500 à 1000 parties en volume de jus de citron sont mélangées avec 500 parties en poids d'une formulation de crème contenant un abrasif (a), un agent mouillant (b), un agent moussant (c), un liant (d), un additif (f) et de l'eau purifiée.
PCT/KR2022/007037 2021-05-21 2022-05-17 Crème mélangée contre la teigne animale ayant un jus de citron mélangé avec une formulation de crème et méthode de préparation Ceased WO2022245099A1 (fr)

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KR10-2021-0065531 2021-05-21
KR1020210065531A KR20220157691A (ko) 2021-05-21 2021-05-21 레몬즙에 크림제형을 혼합한 동물 링웜 혼합크림 및 제조방법

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Citations (5)

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Publication number Priority date Publication date Assignee Title
JP2010528098A (ja) * 2007-05-31 2010-08-19 シントピックス グループ パブリック リミティド カンパニー ジアルキル・スルホスクシナート及びカルバニリド抗菌剤を含んでなる抗菌製剤
KR20120021909A (ko) * 2010-08-20 2012-03-09 임미경 기능성 치약 조성물 및 그 제조방법
KR101154500B1 (ko) * 2005-08-11 2012-06-13 주식회사 엘지생활건강 구강 조성물
JP2015503520A (ja) * 2011-12-21 2015-02-02 コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ ガラートおよびガラミドを含む組成物
KR101784028B1 (ko) * 2010-03-12 2017-10-10 닛신 오일리오그룹 가부시키가이샤 피부외용 조성물, 화장료 및 세정제

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101154500B1 (ko) * 2005-08-11 2012-06-13 주식회사 엘지생활건강 구강 조성물
JP2010528098A (ja) * 2007-05-31 2010-08-19 シントピックス グループ パブリック リミティド カンパニー ジアルキル・スルホスクシナート及びカルバニリド抗菌剤を含んでなる抗菌製剤
KR101784028B1 (ko) * 2010-03-12 2017-10-10 닛신 오일리오그룹 가부시키가이샤 피부외용 조성물, 화장료 및 세정제
KR20120021909A (ko) * 2010-08-20 2012-03-09 임미경 기능성 치약 조성물 및 그 제조방법
JP2015503520A (ja) * 2011-12-21 2015-02-02 コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ ガラートおよびガラミドを含む組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Adopt this home remedy if you are troubled with ringworm", 16 May 2020 (2020-05-16), pages 1 - 2, XP093005398, Retrieved from the Internet <URL:https://english.newstracklive.com/news/home-remedies-for-ringworm-sc115-nu612-ta294-1092811-1.html> [retrieved on 20221206] *

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