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WO2022006865A1 - 穿戴式超声神经刺激装置及系统 - Google Patents

穿戴式超声神经刺激装置及系统 Download PDF

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Publication number
WO2022006865A1
WO2022006865A1 PCT/CN2020/101386 CN2020101386W WO2022006865A1 WO 2022006865 A1 WO2022006865 A1 WO 2022006865A1 CN 2020101386 W CN2020101386 W CN 2020101386W WO 2022006865 A1 WO2022006865 A1 WO 2022006865A1
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WO
WIPO (PCT)
Prior art keywords
ultrasonic
wearable
nerve stimulation
ultrasonic transducer
stimulation device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2020/101386
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English (en)
French (fr)
Inventor
郑海荣
牛丽丽
钟永盛
孟龙
邹俊杰
黄小伟
易沙沙
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen Institute of Advanced Technology of CAS
Original Assignee
Shenzhen Institute of Advanced Technology of CAS
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Filing date
Publication date
Application filed by Shenzhen Institute of Advanced Technology of CAS filed Critical Shenzhen Institute of Advanced Technology of CAS
Priority to PCT/CN2020/101386 priority Critical patent/WO2022006865A1/zh
Publication of WO2022006865A1 publication Critical patent/WO2022006865A1/zh
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy

Definitions

  • the application belongs to the technical field of medical equipment, and in particular relates to a wearable ultrasonic nerve stimulation device and system.
  • Physical brain stimulation neuromodulation technology provides an effective clinical treatment method for patients with brain function diseases.
  • Medical ultrasound is a non-invasive diagnosis and treatment technology that can form a focal point in the human body that is an oblong shape. This feature also enables him to obtain good spatial accuracy and target specific areas of tissue. Medical ultrasound can be divided into high-intensity focused ultrasound and low-intensity focused ultrasound. High-intensity focused ultrasound is a treatment method that directly damages the lesion, while low-intensity focused ultrasound also plays an important role in the field of neuromodulation.
  • the examiner needs to hold the ultrasonic transducer, which is a waste of manpower and inconvenient to operate, and the examinee needs to lie on the bed more often, unable to move freely and it is difficult to match the operation of the ultrasonic transducer. position, which can easily lead to large operating errors.
  • the embodiments of the present application provide a wearable ultrasonic nerve stimulation device and system to at least solve the problems that the current ultrasonic transducer is inconvenient to operate and difficult to match with the examinee, which easily leads to operation errors.
  • a wearable ultrasonic nerve stimulation device including: a wearable component; an ultrasonic transducer for outputting an ultrasonic nerve stimulation signal; and a connection structure for connecting the wearable component and all The ultrasonic transducer is used to adjust the relative position between the wearable component and the ultrasonic transducer.
  • a wearable ultrasonic nerve stimulation system comprising: the above-mentioned wearable ultrasonic nerve stimulation device; a display; wherein, the ultrasonic transducer in the wearable ultrasonic nerve stimulation device The device is used to collect neural image information; the display is used to display the neural image information.
  • the wearer can wear the wearable component like clothes to receive the neurostimulation operation, the wearer can move freely to obtain a better ultrasonic medical experience, and the wearable component and the ultrasonic exchange
  • the transducers are connected by a connection structure, and the relative position between the wearable component and the ultrasonic transducer can be adjusted through the connection structure, so that the ultrasonic transducer has a large operating position range, and the operation error can be reduced.
  • FIG. 1 shows a schematic structural diagram of an example of a wearable ultrasonic nerve stimulation device according to an embodiment of the present application
  • FIG. 2 shows a schematic structural diagram of an example of a wearable ultrasonic nerve stimulation device according to an embodiment of the present application
  • FIG. 3 shows a structural block diagram of an example of a wearable ultrasonic nerve stimulation system according to an embodiment of the present application.
  • ultrasound technology is used to stimulate human tissue, and several effects are produced to cause changes in diseased tissue, so as to achieve the purpose of treatment.
  • These ultrasonic effects are mainly thermal effects, mechanical effects and cavitation effects.
  • part of the sound energy is absorbed by the medium due to the viscosity and thermal conductivity of the medium during the propagation of the ultrasonic wave, and the result is converted into heat energy and causes the local temperature to rise.
  • certain reactions occur, such as vasodilation, accelerated blood circulation, and increased tissue metabolism, thereby promoting the absorption and dissipation of pathological products.
  • the mechanical effect of particle vibration in the medium causes acceleration, rotation, and rushing vibrations of some fine tissues, thus playing a massage role and enhancing the semi-permeable membrane. It also has a good effect on the material exchange of cells and tissue nutrition.
  • cavitation In the stimulation mechanism of the cavitation effect, during the propagation of ultrasonic waves, when sufficient ultrasonic intensity encounters some liquid tissues in the human body, cavitation will be generated, which can generate high-intensity micro shock waves, which can change or destroy lesions tissue for therapeutic purposes.
  • the wearable ultrasonic nerve stimulation device and system disclosed in the embodiments of the present application mainly relate to the structure or connection relationship of each component in the wearable ultrasonic nerve stimulation device or system, and various effects can be used.
  • the stimulatory mechanism of action should not be limited here.
  • the term “if” may be contextually interpreted as “when” or “once” or “in response to determining” or “in response to detecting” .
  • the phrases “if it is determined” or “if the [described condition or event] is detected” may be interpreted, depending on the context, to mean “once it is determined” or “in response to the determination” or “once the [described condition or event] is detected. ]” or “in response to detection of the [described condition or event]”.
  • the mobile terminals described in the embodiments of the present application include, but are not limited to, other portable devices such as mobile phones, laptop computers or tablet computers with touch-sensitive surfaces (eg, touch screen displays and/or touch pads).
  • other portable devices such as mobile phones, laptop computers or tablet computers with touch-sensitive surfaces (eg, touch screen displays and/or touch pads).
  • touch-sensitive surfaces eg, touch screen displays and/or touch pads.
  • the above-described devices are not portable communication devices, but rather desktop computers with touch-sensitive surfaces (eg, touch screen displays and/or touch pads).
  • FIG. 1 shows a schematic structural diagram of an example of a wearable ultrasonic nerve stimulation device according to an embodiment of the present application.
  • the wearable ultrasonic nerve stimulation device 100 includes a wearable component 110 , a connecting structure 120 and an ultrasonic transducer 130 .
  • the wearable part 110 can be designed in the style of a top (or vest) to facilitate wearing by the wearer, for example, the wearable part 110 is provided with a neck hole 2 and a shoulder hole 3, so that the neck hole 2 is used for The wearer's neck passes through, and the shoulder holes 3 are used for the wearer's upper limbs to pass through. It should be understood that the wearable component 110 can also be designed in other styles, for example, the wearable component 110 can also be designed in a pants or backpack style, and so on.
  • the ultrasonic transducer 130 may output an ultrasonic nerve stimulation signal, and the working parameters (eg, power, frequency, waveform, etc.) of the ultrasonic nerve stimulation signal may be preset, and may be a variety of ultrasonic nerve stimulation signals. It should be understood that an ultrasonic transducer (also referred to as an ultrasonic probe) is an important part of medical ultrasonic equipment, which can perform conversion between electrical and mechanical energy.
  • the ultrasonic transducer 130 may integrate an ultrasonic generating function, so that the ultrasonic transducer 130 can independently and autonomously generate a driving signal (electrical signal) and output a corresponding ultrasonic nerve stimulation signal (acoustic signal). ).
  • the ultrasonic transducer 130 may be electrically connected with an ultrasonic generator, and the ultrasonic generator (also referred to as an ultrasonic driving power source), which can convert commercial power into an ultrasonic transducer Matching high-frequency alternating current signals (for example, ultrasonic electrical signals of various parameter types) to drive the ultrasonic transducer to work.
  • the ultrasonic transducer can output a corresponding ultrasonic nerve stimulation signal (acoustic signal) according to the driving signal generated by the ultrasonic generator.
  • connection structure 120 connects the wearable part 110 and the ultrasonic transducer 130 , and the relative position between the wearable part 110 and the ultrasonic transducer 130 can be adjusted through the connection structure 120 . It should be understood that with regard to the adjustment direction of the relative position, it may be limited or diverse (eg, it may be adjusted at any angle with respect to the wearable component 110 ).
  • the wearer when the wearer uses the wearable ultrasonic nerve stimulation device, the wearer does not need to lie down, and only needs to put on the wearable parts like clothes.
  • the operation is simple and convenient, and the patient has a large of free space.
  • the relative position between the wearable component and the ultrasonic transducer can be adjusted through the connection structure, so that the ultrasonic transducer can have more action positions, and the operation error can be reduced.
  • the "wearer” or “user” of the wearable ultrasonic nerve stimulation device or system may be various identities, such as a doctor, a patient, and the like. References to the terms “doctor” and “patient” elsewhere in this document are for example only, and are not intended to be limiting, for example, in some situations a wearer may wear a wearable ultrasonic nerve stimulation device to conduct Stimulation operation, where the wearer is both the doctor and the patient.
  • FIG. 2 shows a schematic structural diagram of an example of a wearable ultrasonic nerve stimulation device according to an embodiment of the present application.
  • the wearable component 110 is a collapsible wearable component.
  • the wearable component can be adapted to the body or body shape of different wearers, thereby expanding the application range of the wearable nerve stimulation device.
  • the wearable part 110 may further include a retractable part 4 and a fixing screw 5 , and the retractable part 4 can be adjusted according to the size of different human bodies, so that the wearable part 110 can be adapted to different groups of people.
  • the size of the wearable component 110 can be fixed by the fixing screw 5 .
  • some soft materials such as sponge can be added to the inner surface of the wearable part 110 (which can be made of metal or carbon material, etc.) to reduce additional damage to the wearable part, for example, when the wearable part 110 is
  • the vest can play a role in protecting the shoulders and chest.
  • connection structure 120 is a retractable connection structure.
  • the connecting structure 120 includes a spring 7 and a support rod 8 , and the support rod 8 can be telescopically adjusted to different positions along the direction of the support rod 8 through the spring 7 .
  • the connecting structure 120 includes a connecting rod, and a first connecting member and a second connecting member disposed on the connecting rod.
  • the position of the wearable component relative to the connecting rod can be adjusted through the first connecting member, and the position of the ultrasonic transducer 130 relative to the connecting rod can be adjusted through the second connecting member. Therefore, the relative position between the wearable component and the ultrasonic transducer can be adjusted by adjusting the connecting piece provided on the connecting rod, so that the ultrasonic transducer has a larger operating position range.
  • the first connector includes a ball axle module for securing the connecting rod to the wearable component.
  • the ball shaft module has a free rotation function, so that the connecting rod can be driven by the ball shaft module to rotate, and the ball shaft module can adopt a variety of structures, for example, the ball shaft structure in the current car mobile phone bracket can be used. Unlimited. Therefore, by means of the ball-shaft connection, the connecting rod in multiple directions can be realized, which is helpful for positioning the ultrasonic transducer on the connecting rod to the required precise position.
  • corresponding ball axle modules may be respectively provided at a preset number of positions of the wearable component. Therefore, the ball axis module at a suitable position can be selected to fix the connecting rod according to the actual needs of ultrasonic stimulation, thereby expanding the position range of the connecting rod and the ultrasonic transducer.
  • the connecting rod may include a spring 7 , a supporting rod 8 , a movable rod 9 and a fixing screw 13
  • the first connecting member may include a ball axle module 6
  • the ball axis module 6 can be disposed on the wearable component 110
  • the support rod 8 can be fixed to the ball axis module 6 through the spring 7
  • the support rod 8 can be telescopically adjusted to different directions along the support rod 8 through the spring 7 Location.
  • the movable rod 9 can move relative to the supporting rod 8, for example, the supporting rod 8 can be a hollow structure, so that the movable rod 9 can move up and down in the supporting rod 8, and the movable rod 9 can also rotate relative to the supporting rod 8 (for example, rotate 360 degrees) ), and the movable rod 9 can be fixed to the support rod 8 by operating the corresponding fixing screws 13 when the movable rod 9 is adjusted to the desired position.
  • the supporting rod 8 can be a hollow structure, so that the movable rod 9 can move up and down in the supporting rod 8, and the movable rod 9 can also rotate relative to the supporting rod 8 (for example, rotate 360 degrees) ), and the movable rod 9 can be fixed to the support rod 8 by operating the corresponding fixing screws 13 when the movable rod 9 is adjusted to the desired position.
  • the ball axis module 6 may be similar to the structure of a vehicle mobile phone bracket, and has a free rotation function, so that the support rod 8 can be adjusted to different directions along with the ball axis module 6 .
  • the ball axle module includes an inner movable ball (not shown), an outer fixed ball (not shown) and a screw (not shown), and the inner movable ball can be rotated relative to the outer fixed ball and adjusted to a suitable When turning the screw, the outer fixed ball is tightened to fix the position of the inner movable ball.
  • the outer surface of the inner movable ball and the inner surface of the outer fixed ball may also be frosted or provided with concave and convex points, so as to increase the friction between the two balls and facilitate fixing the ball axle module at any position.
  • different positions of the wearable component 110 may be provided with a plurality of corresponding ball axis modules 6 , and the position of the ultrasonic stimulation may be adjusted according to the position of the ultrasonic stimulation.
  • the support rod 8 is arranged on the ball axis module at the corresponding position according to the requirements, which can meet the personalized ultrasound treatment requirements.
  • the second connector includes an ultrasonic transducer fixing module, which is used to rotate and adjust the position of the ultrasonic transducer.
  • the ultrasonic transducer fixing module can also adopt a ball shaft structure. In this way, an ultrasonic transducer with a larger position range can be realized, which is favorable for positioning the ultrasonic transducer to a required precise position.
  • the ultrasonic transducer fixing module and the connecting rod are connected by a rotating shaft, so that the ultrasonic transducer fixing module can move around the rotating shaft. Therefore, the steering of the ultrasonic transducer can be adjusted to multiple directions through the rotating shaft member, and the ultrasonic transducer in more directions can be realized, which is more favorable for positioning the ultrasonic transducer to the required position.
  • the second connector may include an ultrasonic transducer fixing module 15, and the ultrasonic transducer 130 is fixed by the ultrasonic transducer fixing module 15, and the ultrasonic transducer fixing module 15 has a rotation function,
  • the ultrasonic transducer fixing module 15 can fix the ultrasonic transducer 130 through a ball shaft module, so that the ultrasonic transducer 130 can rotate at multiple angles.
  • the ultrasonic transducer 130 may employ piezoelectric material or flexible transducer material, or the like.
  • the second connecting member may further include a spring 10 , a support rod 11 , a movable rod 12 , a fixing screw 13 and a handle-shaped screw 14 .
  • the support rod 11 is connected with the movable rod 9 through the handle-shaped screw 14, so that the support rod 11 can move around the handle-shaped screw 14 to adjust the support rod 11 and the ultrasonic transducer fixing module 15 to various directions.
  • the shaped screw 14 can also be replaced with other various types of rotating shaft members, so that the ultrasonic transducer fixing module 15 can move around the rotating shaft member, which is not limited herein.
  • the spring 10 may be arranged inside the support rod 11 so that the support rod 11 has the function of retracting and retracting back and forth.
  • the movable rod 12 can move relative to the support rod 11, for example, the support rod 11 can be a hollow structure, so that the movable rod 12 can move up and down in the support rod 11, and the movable rod 12 can also rotate relative to the support rod 11 (for example, rotate 360 degrees) ), and when the movable rod 12 is adjusted to a desired position, the movable rod 12 can be fixed to the support rod 11 by operating the corresponding fixing screws 13 , and one end of the movable rod 12 can also be connected with the ultrasonic transducer fixing module 15 . Therefore, by adjusting the positions of the support rod 8 and the movable rod 9, the position of the ultrasonic transducer fixing module 15 can be adjusted accordingly.
  • the movable rods (eg, 9 and 12 ) and the support rods (eg, 8 and 11 ) are cylindrical rod bodies, and the movable rods can freely rotate 360° relative to the support rods.
  • the support rod can be hollow, so the movable rod can slide up and down, far and near in the support rod to adjust the position according to actual needs.
  • the surface of the support rod may be frosted or provided with concave and convex points, which is beneficial for the fixing screw to firmly fix the support rod and the movable rod.
  • the movable rod and support rod can be selected from materials such as metal or carbon fiber.
  • the wearable ultrasonic nerve stimulation device is further provided with an arm rest 16 .
  • the arm rests 16 may be disposed on one side or the left and right sides of the wearable component 110 , so that the wearer can place his arms on the arm rests 16 when performing ultrasonic therapy on the wearer.
  • the wearable neurostimulation device may include a preset number of electrode devices (or electrode pads), which are provided on the wearable component (eg, vest) or connecting structure, and pass through the electrodes
  • the device may collect physiological feedback signals from the wearer of the wearable component (eg, the patient).
  • the signal transmission line connecting the electrode device is flexible, so that it can be adjusted freely according to the setting position of the electrode device. Therefore, the electrode device is directly arranged on the wearable component or the connection structure, which facilitates finding the electrode device in time and facilitates the collection process of the stimulation effect data of the wearable nerve stimulation device.
  • the type of physiological feedback signal should not be limited here, and may be determined according to the required stimulation effect data.
  • the wearable nerve stimulation device may include a preset number or a plurality of electrode devices 20 .
  • the electrode device 20 is disposed on the wearable component 110, so that the electrode device 20 can be integrated with the wearer to facilitate finding. It should be understood that the electrode device 20 can also be arranged at other positions of the wearable ultrasonic nerve stimulation device, for example, arranged on the connecting rod.
  • the signal transmission line connected to the electrode device 20 can be flexible, which facilitates the adjustment of the position of the electrode device.
  • the wearer's physiological feedback signals for example, brain electrical signals
  • changes in the wearer's physiological signals before and after ultrasound modulation are collected through the electrode device, so as to understand the effect of ultrasound therapy.
  • a retractable connecting rod that can rotate relative to the ball shaft of the wearable component
  • a ball shaft module that can fix the connecting rod in multiple positions
  • an ultrasonic transducer that can rotate and adjust the position of the ultrasonic transducer
  • the device fixing module helps to meet the needs of individualized precise nerve stimulation of different wearers.
  • the wearable component and the ultrasonic transducer are integrated into a whole, so that the wearer's freedom of movement is not restricted during the entire operation process of performing ultrasonic therapy on the wearer.
  • the shaft module, support rod, movable rod and ultrasonic transducer fixing module can be adjusted in multi-angle, multi-dimensional, high and low, far and near according to the specific position of the ultrasonic stimulation, which helps to adjust the ultrasonic transducer to a variety of desired location.
  • peripheral nerves including facial nerves, cervical vagus nerves, etc.
  • Central Nervous System a system for delivering ultrasound to peripheral nerves.
  • peripheral nerves including facial nerves, cervical vagus nerves, etc.
  • Central Nervous System a system for delivering ultrasound to peripheral nerves.
  • peripheral nerves including facial nerves, cervical vagus nerves, etc.
  • Central Nervous System a system for delivering ultrasound to peripheral nerves.
  • peripheral nerves including facial nerves, cervical vagus nerves, etc.
  • Central Nervous System Central Nervous System
  • FIG. 3 shows a structural block diagram of an example of a wearable ultrasonic nerve stimulation system according to an embodiment of the present application.
  • the wearable ultrasonic nerve stimulation system 300 includes the wearable ultrasonic nerve stimulation device 100 and a display 320 .
  • the wearable ultrasonic nerve stimulation device 100 includes a wearable component 110, an ultrasonic transducer 130 and a connecting structure 120, so that the wearer can receive the ultrasonic non-invasive treatment process like wearing clothes, which can improve the medical experience of ultrasonic stimulation.
  • the ultrasound transducer 130 may collect nerve image information, the display 320 may display the nerve image information, and the ultrasound transducer 130 may also output an ultrasound nerve stimulation signal.
  • the ultrasonic transducer may adopt various types, and may perform different operation processes according to different operating parameters (for example, driving signals used to define the power, frequency, and waveform of the ultrasonic signal, etc.).
  • driving signals used to define the power, frequency, and waveform of the ultrasonic signal, etc.
  • the image detection function or the ultrasound diagnosis function
  • the regulation and stimulation function is performed under the action of some driving signals (eg, the second driving signal).
  • the doctor can view the neural image information on the display through the ultrasonic transducer in the first working mode (for example, under the action of the first driving signal).
  • the specific position of the target point can be clearly seen on the display, which facilitates precise stimulation of the ultrasonic transducer under the second working mode (for example, under the action of the second driving signal).
  • the wearable ultrasonic nerve stimulation system 300 may further include an ultrasonic generator 330 electrically connected to the ultrasonic transducer 130 .
  • the ultrasonic generator 330 can generate driving signals (eg, corresponding to various types of operating parameters), and the ultrasonic transducer 130 can perform corresponding functional operations according to the driving signals input by the ultrasonic generator 330 , such as ultrasonic Detection function or ultrasound stimulation function.
  • the ultrasonic transducer 130 can collect nerve image information according to the first driving signal generated by the ultrasonic generator (for example, to explore the specific positions of the central nervous system and peripheral nerves such as the subcutaneous nerve and the vagus nerve, and the information generated by the ultrasonic generator
  • the second driving signal of the device outputs the ultrasonic nerve stimulation signal, so as to realize the function of precise positioning of the target point.
  • the ultrasonic generator 330 may receive a user operation to update the drive signal in a preset drive signal set, where the preset drive signal set includes a first drive signal and a second drive signal. Thereby, the switching of ultrasonic detection and ultrasonic stimulation functions can be realized by a user operation for the ultrasonic generator.
  • the function of the ultrasonic generator 330 ie, the function of generating a driving signal for the ultrasonic transducer
  • the user can directly operate the ultrasonic transducer by To realize the switch between the ultrasonic detection function and the ultrasonic stimulation function.
  • a preset number of electrode devices are provided on the wearable component or the connecting rod, and the display 320 may display the feedback result corresponding to the physiological feedback signal.
  • a plurality of electrode devices are connected to a receiver (such as a mobile terminal such as a computer and special equipment) through an elastic signal transmission cable. After the receiver performs signal filtering and conversion operations to obtain feedback results, the receiver The corresponding feedback results are displayed on the display of the .
  • the operator can view the effect of nerve stimulation in real time (for example, the effect of ultrasonic regulation of peripheral nerves) through the display, which facilitates timely correction of the stimulation plan and ensures high quality nerve stimulation process.
  • nerve stimulation for example, peripheral nerves
  • the operator can view the effect of nerve stimulation in real time (for example, the effect of ultrasonic regulation of peripheral nerves) through the display, which facilitates timely correction of the stimulation plan and ensures high quality nerve stimulation process.
  • various types of feedback signals can also be captured in various ways, so that the operator can view and evaluate the effect of nerve stimulation in real time, such as EMG, eye movement and brain CT (Computed Tomography, electronic computed tomography), MR (Magnetic Resonance, magnetic resonance) imaging and other signals.
  • a wearable ultrasonic stimulation nerve and brain wave feedback system which has the advantages of non-invasiveness, convenience and accuracy, and can meet the needs of personalized ultrasonic non-invasive treatment and operation. It will be appreciated that due to the non-invasive nature of ultrasound stimulation, ultrasound can be applied to peripheral nerve stimulation targeting different nerve nuclei in the central nervous system and different organs (eg, heart, spleen, liver, pancreas, gallbladder), and by Stimulating different organ targets can intervene in related diseases.
  • organs eg, heart, spleen, liver, pancreas, gallbladder
  • the nerve stimulation device in the embodiment of the present application is wearable, and the use process is simple and convenient, so that the person being stimulated can move freely, and the target point (ie, the nerve position) can be stimulated more quickly, accurately and individually, so that the While increasing compliance, it can also improve the efficiency and success of ultrasound stimulation of peripheral nerves.
  • the facial nerve and the cervical vagus nerve can be stimulated non-invasively, quickly and accurately through the ultrasonic transducer, and the electroencephalogram, electromyography, eye movement can be used simultaneously.
  • imaging means to provide real-time feedback on the effect of stimulation, which perfectly realizes the closed-loop stimulation and regulation of the ultrasonic nervous system.
  • the disclosed apparatus/terminal device and method may be implemented in other manners.
  • the apparatus/terminal device embodiments described above are only illustrative.
  • the division of the modules or units is only a logical function division. In actual implementation, there may be other division methods, such as multiple units. Or components may be combined or may be integrated into another system, or some features may be omitted, or not implemented.
  • the shown or discussed mutual coupling or direct coupling or communication connection may be through some interfaces, indirect coupling or communication connection of devices or units, and may be in electrical, mechanical or other forms.
  • the units described as separate components may or may not be physically separated, and components displayed as units may or may not be physical units, that is, may be located in one place, or may be distributed to multiple network units. Some or all of the units may be selected according to actual needs to achieve the purpose of the solution in this embodiment.
  • each functional unit in each embodiment of the present application may be integrated into one processing unit, or each unit may exist physically alone, or two or more units may be integrated into one unit.
  • the above-mentioned integrated units may be implemented in the form of hardware, or may be implemented in the form of software functional units.
  • the integrated modules/units if implemented in the form of software functional units and sold or used as independent products, may be stored in a computer-readable storage medium.
  • the present application can implement all or part of the processes in the methods of the above embodiments, and can also be completed by instructing the relevant hardware through a computer program.
  • the computer program can be stored in a computer-readable storage medium, and the computer When the program is executed by the processor, the steps of the foregoing method embodiments can be implemented.
  • the computer program includes computer program code, and the computer program code may be in the form of source code, object code, executable file or some intermediate form, and the like.
  • the computer-readable medium may include: any entity or device capable of carrying the computer program code, recording medium, U disk, removable hard disk, magnetic disk, optical disk, computer memory, read-only memory (ROM, Read-Only Memory) , Random Access Memory (RAM, Random Access Memory), electric carrier signal, telecommunication signal and software distribution medium, etc. It should be noted that the content contained in the computer-readable media may be appropriately increased or decreased according to the requirements of legislation and patent practice in the jurisdiction, for example, in some jurisdictions, according to legislation and patent practice, the computer-readable media Electric carrier signals and telecommunication signals are not included.

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Abstract

本申请实施例提供了一种穿戴式超声神经刺激装置及系统，涉及医学设备技术领域，该装置包括：可穿戴部件；超声换能器，用于输出超声神经刺激信号；连接结构，连接所述可穿戴部件和所述超声换能器，且用于调整所述可穿戴部件与所述超声换能器之间的相对位置。由此，佩戴者可以像穿衣服一样去穿戴可穿戴部件来接受神经刺激操作，佩戴者能够自由活动而得到较佳的超声医疗体验，并且超声换能器具有较大的操作位置范围，可以降低操作误差。

Description

穿戴式超声神经刺激装置及系统 技术领域
本申请属于医学设备技术领域，尤其涉及一种穿戴式超声神经刺激装置及系统。
 背景技术
物理性脑部刺激神经调控技术（电刺激、磁刺激等）为脑功能疾病患者提供了一种有效的临床治疗手段。
随着超声技术的发展，医学超声是一种无创诊疗技术，能够人体内形成聚焦点呈长椭圆形，这种特性也使得他获得良好的空间精度，靶向作用于特定区域组织。医学超声可以分为高强度聚焦超声和低强度聚焦超声，高强度聚焦超声是一种直接损毁病灶的治疗方式，而低强度聚焦超声在神经调控领域也起着重要作用。
但是，目前在使用超声无创医疗技术时，需要检查者手持超声换能器，浪费人力且操作不便，而被检查者更多时候需要躺在床上，无法自由活动且难以匹配超声换能器的操作位置，易导致较大的操作误差。
 技术问题
有鉴于此，本申请实施例提供了一种穿戴式超声神经刺激装置及系统，以至少解决目前超声换能器操作不便且难以与被检查者匹配而易导致操作误差的问题。
 技术解决方案
根据本申请实施例的一方面，提供了一种穿戴式超声神经刺激装置，包括：可穿戴部件；超声换能器，用于输出超声神经刺激信号；连接结构，连接所述可穿戴部件和所述超声换能器，且用于调整所述可穿戴部件与所述超声换能器之间的相对位置。
根据本申请实施例的另一方面，提供了一种穿戴式超声神经刺激系统，包括：如上述的穿戴式超声神经刺激装置；显示器；其中，所述穿戴式超声神经刺激装置中的超声换能器用于采集神经图像信息；所述显示器用于显示所述神经图像信息。
 有益效果
本申请实施例采用的上述至少一个技术方案能够达到以下有益效果：
在本申请的穿戴式神经刺激装置中，佩戴者可以像穿衣服一样去佩戴可穿戴部件来接受神经刺激操作，佩戴者能够自由活动而得到较佳的超声医疗体验，并且可穿戴部件和超声换能器之间通过连接结构连接，通过连接结构能够调整可穿戴部件与超声换能器之间的相对位置，使得超声换能器具有较大的操作位置范围，可以降低操作误差。
 附图说明
为了更清楚地说明本申请实施例中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本申请的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。
图1示出了根据本申请实施例的穿戴式超声神经刺激装置的一示例的结构示意图；
图2示出了根据本申请实施例的穿戴式超声神经刺激装置的一示例的结构示意图；
图3示出了根据本申请实施例的穿戴式超声神经刺激系统的一示例的结构框图。
 本发明的实施方式
目前应用超声技术对人体组织进行刺激作用，通过产生几种效应来引起病变组织的改变,从而达到治疗的目的。这些超声所产生的效应主要是热效应、机械效应和空化效应。
在热效应的刺激作用机制中，超声波在传播过程中，由于媒质的粘滞性、导热性等引起部分的声能被媒质所吸收，结果转化为热能，并导致局部温度上升。组织受到这种热效应后，产生了某些反应，例如血管扩张、血液循环加快、组织代谢增高，从而促进病理产物的吸收消散。
在机械效应的刺激作用机制中，超声波在传播过程中，媒质中质点振动的机械效应引起某些细微组织的加速度、旋转、冲流等振动，从而起到按摩的作用，并增强了半透膜的弥散（即增强了通透性）、细胞的代谢功能和细胞的活力，对细胞的物质交换、组织营养也产生了较良好的影响。
在空化效应的刺激作用机制中，超声波在传播过程中，足够的超声强度遇到人体中某些液性组织时，将产生空化，能产生强度很高的微冲击波，可以改变或者破坏病变组织，从而达到治疗目的。
应理解的是，于本申请实施例中所公开的穿戴式超声神经刺激装置及系统，主要涉及在穿戴式超声神经刺激装置或系统中各个组成部件的结构或连接关系，并可以采用各种效应的刺激作用机制，在此应不加限制。
以下描述中，为了说明而不是为了限定，提出了诸如特定系统结构、技术之类的具体细节，以便透彻理解本申请实施例。然而，本领域的技术人员应当清楚，在没有这些具体细节的其它实施例中也可以实现本申请。在其它情况中，省略对众所周知的系统、装置、电路以及方法的详细说明，以免不必要的细节妨碍本申请的描述。
为了说明本申请所述的技术方案，下面通过具体实施例来进行说明。
应当理解，当在本说明书和所附权利要求书中使用时，术语“包括”指示所描述特征、整体、步骤、操作、元素和/或组件的存在，但并不排除一个或多个其它特征、整体、步骤、操作、元素、组件和/或其集合的存在或添加。
还应当理解，在此本申请说明书中所使用的术语仅仅是出于描述特定实施例的目的而并不意在限制本申请。如在本申请说明书和所附权利要求书中所使用的那样，除非上下文清楚地指明其它情况，否则单数形式的“一”、“一个”及“该”意在包括复数形式。
还应当进一步理解，在本申请说明书和所附权利要求书中使用的术语“和/或”是指相关联列出的项中的一个或多个的任何组合以及所有可能组合，并且包括这些组合。
如在本说明书和所附权利要求书中所使用的那样，术语“如果”可以依据上下文被解释为“当...时”或“一旦”或“响应于确定”或“响应于检测到”。类似地，短语“如果确定”或“如果检测到[所描述条件或事件]”可以依据上下文被解释为意指“一旦确定”或“响应于确定”或“一旦检测到[所描述条件或事件]”或“响应于检测到[所描述条件或事件]”。
具体实现中，本申请实施例中描述的移动终端包括但不限于诸如具有触摸敏感表面(例如，触摸屏显示器和/或触摸板)的移动电话、膝上型计算机或平板计算机之类的其它便携式设备。还应当理解的是，在某些实施例中，上述设备并非便携式通信设备，而是具有触摸敏感表面(例如，触摸屏显示器和/或触摸板)的台式计算机。
另外，在本申请的描述中，术语“第一”、“第二”、“第三”等仅用于区分描述，而不能理解为指示或暗示相对重要性。
图1示出了根据本申请实施例的穿戴式超声神经刺激装置的一示例的结构示意图。
如图1所示，穿戴式超声神经刺激装置100包括可穿戴部件110、连接结构120和超声换能器130。
具体地，可穿戴部件110可以被设计成上衣（或，背心）样式，以方便佩戴者穿戴，例如可穿戴部件110设置有颈部孔2和肩部孔3，使得颈部孔2用于供佩戴者的颈部穿过，以及肩部孔3用于供佩戴者的上肢穿过。应理解的是，可穿戴部件110还可以被设计成其他样式，例如可穿戴部件110还可以被设计成裤子或者背包样式，等等。
超声换能器130可以输出超声神经刺激信号，超声神经刺激信号的工作参数（例如，功率、频率和波形等）可以是预先设定的，并可以是多样化的超声神经刺激信号。应理解的是，超声换能器（也被称为，超声探头）是医学超声仪器设备的重要组成部分，其能完成在电能与机械能之间转换。
在本申请实施例的一些示例中，超声换能器130可以集成了超声发生功能，使得在超声换能器130能够独立自主地产生驱动信号（电信号）并输出相应的超声神经刺激信号（声信号）。在本申请实施例的另一些示例中，超声换能器130可以与超声发生器电连接，超声发生器（也被称为，超声波驱动电源），其可以将市电转换成与超声换能器相匹配的高频交流电信号（例如，各种参数类型的超声波电信号），以驱动超声波换能器工作。进而，超声换能器可以根据超声发生器所产生的驱动信号输出相应的超声神经刺激信号（声信号）。
连接结构120连接可穿戴部件110和超声换能器130，并且通过连接结构120可以调整可穿戴部件110与超声换能器130之间的相对位置。应理解的是，关于相对位置的调整方向，其可以是限制性的或多样化的（例如，可与可穿戴部件110之间呈任意角度的方向进行调整）。
在一些应用场景下，在佩戴者使用该穿戴式超声神经刺激装置时，佩戴者不需要躺下，并只需要像穿衣服一样穿上可穿戴部件即可，操作简单、便捷，患者具有较大的自由活动空间。此外，通过连接结构能够调整可穿戴部件与超声换能器之间的相对位置，使得超声换能器能够具有更多的作用位置，可以降低操作误差。
需说明的是，在本文中，穿戴式超声神经刺激装置或系统的“佩戴者”或“用户”可以是各种身份，例如医生、患者等。在本文其他部分中所提及的术语“医生”和“患者”仅用作示例，并不旨在对身份的限制，例如在一些情形下佩戴者可以佩戴穿戴式超声神经刺激装置来对自己进行刺激操作，此时佩戴者既是医生又是患者。
图2示出了根据本申请实施例的穿戴式超声神经刺激装置的一示例的结构示意图。
在本申请实施例的一些示例中，可穿戴部件110为可收缩式穿戴部件。由此，使得穿戴部件能够适配不同的佩戴者的身材或体型，扩大了穿戴式神经刺激装置的应用范围。结合图2中的示例，可穿戴部件110还可以包括可收缩部4和固定螺钉5，可收缩部4可以根据不同人体型大小调节，使可穿戴部件110适应于不同人群，在可收缩部4调节到合适位置时，可以通过固定螺钉5来固定可穿戴部件110的大小。通过背心穿戴在佩戴者身上，能使超声换能器与佩戴者整合为一体，在进行超声刺激神经（例如，外周神经）时，整个过程不会约束佩戴者的自由活动空间。
此外，为了增加舒适性，可以在可穿戴部件110（其可以采用金属或碳材料等）的内面加用一些海绵等软性材料，以减少可穿戴部位的额外损伤，例如当可穿戴部件110是背心时可以起到保护肩部和胸部的作用。
在本申请实施例的一些示例中，连接结构120为可伸缩式连接结构。由此，可以沿着连接结构的方向来伸缩调整可穿戴部件110与超声换能器130之间的相对位置。结合图2中的示例，连接结构120包括弹簧7和支撑杆8，通过弹簧7可以将支撑杆8伸缩调节至沿着支撑杆8方向上的不同位置。
在本申请实施例的一些示例中，连接结构120包括连接杆，以及设置于连接杆的第一连接件和第二连接件。这里，通过第一连接件可以调节可穿戴部件相对于连接杆的位置，以及通过第二连接件可以调节超声换能器130相对于连接杆的位置。由此，可以通过调节连接杆上所设置的连接件来调整可穿戴部件与超声换能器之间的相对位置，使得超声换能器具有更大的操作位置范围。
在一些实施方式中，第一连接件包括球轴模块，其用于将连接杆固定于可穿戴部件。这里，球轴模块具有自由旋转功能，使得连接杆能够被球轴模块带动而进行旋转，并且球轴模块可以采用多样化的结构，例如可以采用目前车载手机支架中的球轴结构，在此应不加限制。由此，通过球轴连接的方式，可以实现在多方向上的连接杆，有助于将连接杆上的超声换能器定位到所需求的精准位置。
进一步地，在可穿戴部件的预设数量个位置可以分别设置有相应的球轴模块。由此，可以根据超声刺激的实际需求而选择在适宜位置处的球轴模块来固定连接杆，扩大了连接杆及超声换能器的位置范围。
结合图2中的示例，连接杆可以包括弹簧7、支撑杆8、活动杆9和固定螺钉13，第一连接件可以包括球轴模块6。具体地，球轴模块6可以设置在可穿戴部件110上，支撑杆8可以通过弹簧7固定至球轴模块6，通过弹簧7可以将支撑杆8伸缩调节至沿着支撑杆8方向上的不同位置。活动杆9可以相对支撑杆8进行活动，例如支撑杆8可以是中空结构，使得活动杆9在支撑杆8内上下移动，并活动杆9还可以相对支撑杆8进行旋转（例如，旋转360度），并且在活动杆9被调节到期望位置时可以通过操作相应的固定螺钉13以将活动杆9固定至支撑杆8。
需说明的是，球轴模块6可以是类似于车载手机支架结构，具有自由旋转功能，使得支撑杆8可随着球轴模块6而被调节到不同的方向。示例性地，球轴模块包括内活动球（未示出）和外固定球（未示出）和螺钉（未示出），内活动球可以相对外固定球而进行旋转，并在调节到适宜方向时通过旋转螺钉使外固定球收紧，从而固定内活动球的位置。优选地，内活动球的外表面和外固定球的内表面还可以是磨砂的或设有凹凸点，从而增加两个球之间的摩擦力，并有利于在任意位置固定球轴模块。
在一些实施方式中，在可穿戴部件110的不同位置（例如，图2中背心的上下左右的四个边角位置）可以设有相应的多个球轴模块6，并且可以根据超声刺激的位置需求而将支撑杆8设置在相应位置的球轴模块上，可以满足个性化的超声治疗需求。
在本申请实施例的一些示例中，第二连接件包括超声换能器固定模块，用于旋转调节超声换能器的位置，例如超声换能器固定模块也可以采用球轴结构。由此，可以实现具有更大的位置范围的超声换能器，有利于将超声换能器定位到所需求的精准位置。
进一步地，超声换能器固定模块与连接杆之间通过转轴件相连接，以使得超声换能器固定模块能够绕着转轴件移动。由此，通过转轴件可以将超声换能器转向调节至多个方向，能够实现在更多方向上的超声换能器，更有利于将超声换能器定位到所需求的位置。
继续参照图2中的示例，第二连接件可以包括超声换能器固定模块15，通过超声换能器固定模块15来固定超声换能器130，且超声换能器固定模块15具有旋转功能，以旋转调节或改变超声换能器130的角度或方向，例如超声换能器固定模块15可以通过球轴模块来固定超声换能器130，使得超声换能器130能够多角度旋转。在一些实施方式中，超声换能器130可以采用压电材料或者柔性换能器材料等。
在一些实施方式中，第二连接件还可以包括弹簧10、支撑杆11、活动杆12、固定螺钉13和把形螺钉14。这里，支撑杆11通过把形螺钉14与活动杆9连接，使得支撑杆11能够绕着把形螺钉14移动，以将支撑杆11和超声换能器固定模块15调节至各种方向。应理解的是，还可以将把形螺钉14替换为其他各种类型的转轴件，使得超声换能器固定模块15能够绕着转轴件移动，在此可不加限制。弹簧10可以是被设置在支撑杆11内部，使得支撑杆11具有来回伸缩的功能。活动杆12可以相对支撑杆11进行活动，例如支撑杆11可以是中空结构，使得活动杆12在支撑杆11内上下移动，并活动杆12还可以相对支撑杆11进行旋转（例如，旋转360度），并且在活动杆12被调节到期望位置时可以通过操作相应的固定螺钉13以将活动杆12固定至支撑杆11，活动杆12的一端还可以与超声换能器固定模块15连接。因此，通过调节支撑杆8和活动杆9的位置，可以相应地调整超声换能器固定模块15的位置。
在本申请实施例的一些实施方式中，活动杆（例如，9和12）和支撑杆（例如，8和11）是圆柱杆体，活动杆能相对支撑杆随意旋转360°。此外，支撑杆可以是中空的，故活动杆可以根据实际需要而在支撑杆内上下、远近滑动来调整位置。同时，支撑杆表面可以是磨砂的或设有凹凸点，有利于固定螺钉牢靠固定支撑杆和活动杆。在材料选型的示例中，活动杆和支撑杆可以选用金属或碳纤维等材料。
在本申请实施例的一些示例中，穿戴式超声神经刺激装置中还设置有臂托16。具体地，臂托16可以被设置在可穿戴部件110的一侧或左右两侧，使得在对佩戴者进行超声治疗时，佩戴者可以将手臂放置在臂托16上。
在本申请实施例的一些示例中，穿戴式神经刺激装置可以包括预设数量个电极器（或，电极片），其被设置在可穿戴部件（例如，背心）或连接结构上，并且通过电极器可以采集可穿戴部件的佩戴者（例如，患者）的生理反馈信号。优选地，连接电极器的信号传输线是具有弹性的，使得可以根据电极器的设置位置而随意调节。由此，电极器直接被设置在可穿戴部件或连接结构上，方便及时找到电极器，便于实施对穿戴式神经刺激装置的刺激效果数据的采集过程。应理解的是，针对生理反馈信号的类型在此应不加限制，并可以是依据所需求的刺激效果数据来确定的。
结合图2中的示例，穿戴式神经刺激装置可以包括预设数量个或多个电极器20。电极器20是被设置在可穿戴部件110上的，使得电极器20能够与佩戴者整合为一体而便于寻找。应理解的是，电极器20还可以被设置在穿戴式超声神经刺激装置的其他位置，例如设置在连接杆上。此外，电极器20所连接的信号传输线可以是具有弹性的，方便了调整电极器的位置。通过电极器采集可穿戴部件的佩戴者的生理反馈信号（例如，脑电信号），例如在超声调控前后佩戴者生理信号的变化量，便于了解超声治疗的效果。
在本申请实施例中，通过能够相对可穿戴部件球轴旋转的可伸缩式连接杆、可以在多个位置固定连接杆的球轴模块，以及能够旋转调节超声换能器的位置的超声换能器固定模块，有助于满足不同佩戴者的个体化的神经精准刺激的需求。
通过本申请实施例所提供的穿戴式超声神经刺激装置，将可穿戴部件与超声换能器结合成一整体，使得在对佩戴者进行超声治疗的整个操作过程不会约束佩戴者的活动自由。此外，具有能上下移动、旋转360°的活动杆和多角度旋转的球轴模块和超声换能器固定模块等，实现了超声换能器任意位置、多角度和多维度方向的调节，并且球轴模块、支撑杆、活动杆及超声换能器固定模块等都能根据超声刺激的具体位置而多角度、多维度及高低、远近地进行调节，有助于将超声换能器调节至多样化的期望位置。
应理解的是，针对于本文中所描述的术语“神经”的类型可不作限制，其可以是各种能够通过超声技术进行作用的神经，例如外周神经（包括面部面神经、颈部迷走神经等）或中枢神经系统。作为示例，当将超声无创医疗技术作用到外周神经时，针对一些疾病的治疗过程可以取得较佳的临床效果，外周神经与器官功能和疾病密切相关，而超声调控外周神经能有效干预炎症、高血压、糖尿病、肥胖以及胃肠道等疾病。
图3示出了根据本申请实施例的穿戴式超声神经刺激系统的一示例的结构框图。
如图3所示，穿戴式超声神经刺激系统300包括穿戴式超声神经刺激装置100及显示器320。具体地，穿戴式超声神经刺激装置100包括可穿戴部件110、超声换能器130和连接结构120，这样佩戴者可以像穿衣服一样去接受超声无创治疗过程，可以提升超声刺激的医疗体验。
具体地，超声换能器130可以采集神经图像信息，显示器320可以显示神经图像信息，并且超声换能器130还可以输出超声神经刺激信号。
在本申请实施例中，超声换能器可以采用各种类型，并且可以根据不同的工作参数（例如，用于定义超声波信号的功率、频率及波形等等）的驱动信号来执行不同的操作过程，例如基于一些驱动信号（例如，第一驱动信号）的作用下执行图像检测功能（或，超声诊断功能），在一些驱动信号（例如，第二驱动信号）的作用下执行调控刺激功能。
在本申请实施例的一些应用场景中，患者穿上可穿戴部件之后，医生通过在第一工作模式（例如，第一驱动信号作用）下的超声换能器可以在显示器上看到神经图像信息，可以清楚地在显示器上看到靶点的具体位置，便于在第二工作模式（例如，第二驱动信号作用）下的超声换能器进行精准刺激。
在本申请实施例的一些示例中，穿戴式超声神经刺激系统300还可以包括与超声换能器130电连接的超声发生器330。具体地，超声发生器330可以产生（例如，对应各种工作参数类型的超声波的）驱动信号，超声换能器130可以根据超声发生器330所输入的驱动信号来进行相应的功能操作，例如超声检测功能或超声刺激功能。具体地，超声换能器130可以根据超声发生器所产生的第一驱动信号采集神经图像信息（例如，探查中枢神经系统及皮下面神经、迷走神经等外周神经的具体位置，以及根据超声发生器所产生的第二驱动信号输出超声神经刺激信号，实现目标靶点精准定位的作用。
在本申请实施例的一些示例中，超声发生器330可以接收用户操作而在预设的驱动信号集中更新驱动信号，预设的驱动信号集包括第一驱动信号和第二驱动信号。由此，可以通过针对超声发生器的用户操作来实现切换超声检测和超声刺激功能。在本申请实施例的另一些示例中，超声发生器330的功能（即产生针对超声波换能器的驱动信号的功能）被集成在超声换能器130中，用户可以直接通过操作超声换能器来实现切换超声检测功能和超声刺激功能。
在本申请实施例的一些示例中，在可穿戴部件或连接杆上设置有预设数量个电极器（例如，图2中的20），显示器320可以显示生理反馈信号所对应的反馈结果。作为示例，多个电极器通过弹性的信号传输线缆连接至接收器（诸如计算机、专用设备之类的移动终端），由接收器进行信号滤波及转换等操作而得到反馈结果之后，在接收器的显示器上显示相应的反馈结果。由此，在对神经（例如，外周神经）进行刺激的同时，操作者可以通过显示器来实时查看神经刺激的效果（例如，超声调控外周神经的效果），便于及时矫正刺激方案，可以保障高质量的神经刺激过程。
需说明的是，除了可以将电极器阵列所采集的信号作为反馈信号之外，还可以多种方式来捕获各种类型的反馈信号，以使得操作者能实时查看并评估神经刺激的效果，例如肌电、眼动及颅脑CT（Computed Tomography, 电子计算机断层扫描）、MR（Magnetic Resonance, 核磁共振）影像学等信号。
通过本申请实施例，提供了一种穿戴式超声刺激神经及脑电波反馈系统，具备无创、便捷、准确的优点，能够满足个性化超声无创治疗及操作的需求。应理解的是，由于超声刺激的无创性，所以超声能应用到针对中枢神经系统中的不同神经核团及不同器官（例如，心脏、脾脏、肝脏、胰腺、胆囊）的外周神经刺激，并且通过刺激不同器官靶点能够干预相关疾病。此外，本申请实施例中的神经刺激装置是穿戴式的，使用过程简单、便捷，使得被刺激者能自由活动，且能够更快速、准确及个体化刺激靶点（即，神经位置），使得在增加依从性的同时，还可以提高超声刺激外周神经的效率和成功率。
在本申请实施例的一些应用场景下，在患者佩戴上可穿戴部件之后，通过超声换能器能够无创、快速且精准地刺激面部面神经和颈部迷走神经，同时利用脑电、肌电、眼动、以及影像学手段等信号对刺激的效果进行实时反馈，完美实现了超声神经系统的闭环刺激与调控。
所属领域的技术人员可以清楚地了解到，为了描述的方便和简洁，仅以上述各功能单元、模块的划分进行举例说明，实际应用中，可以根据需要而将上述功能分配由不同的功能单元、模块完成，即将所述装置的内部结构划分成不同的功能单元或模块，以完成以上描述的全部或者部分功能。实施例中的各功能单元、模块可以集成在一个处理单元中，也可以是各个单元单独物理存在，也可以两个或两个以上单元集成在一个单元中，上述集成的单元既可以采用硬件的形式实现，也可以采用软件功能单元的形式实现。另外，各功能单元、模块的具体名称也只是为了便于相互区分，并不用于限制本申请的保护范围。上述系统中单元、模块的具体工作过程，可以参考前述方法实施例中的对应过程，在此不再赘述。
在上述实施例中，对各个实施例的描述都各有侧重，某个实施例中没有详述或记载的部分，可以参见其它实施例的相关描述。
本领域普通技术人员可以意识到，结合本文中所公开的实施例描述的各示例的单元及算法步骤，能够以电子硬件、或者计算机软件和电子硬件的结合来实现。这些功能究竟以硬件还是软件方式来执行，取决于技术方案的特定应用和设计约束条件。专业技术人员可以对每个特定的应用来使用不同方法来实现所描述的功能，但是这种实现不应认为超出本申请的范围。
在本申请所提供的实施例中，应该理解到，所揭露的装置/终端设备和方法，可以通过其它的方式实现。例如，以上所描述的装置/终端设备实施例仅仅是示意性的，例如，所述模块或单元的划分，仅仅为一种逻辑功能划分，实际实现时可以有另外的划分方式，例如多个单元或组件可以结合或者可以集成到另一个系统，或一些特征可以忽略，或不执行。另一点，所显示或讨论的相互之间的耦合或直接耦合或通讯连接可以是通过一些接口，装置或单元的间接耦合或通讯连接，可以是电性，机械或其它的形式。
所述作为分离部件说明的单元可以是或者也可以不是物理上分开的，作为单元显示的部件可以是或者也可以不是物理单元，即可以位于一个地方，或者也可以分布到多个网络单元上。可以根据实际的需要选择其中的部分或者全部单元来实现本实施例方案的目的。
另外，在本申请各个实施例中的各功能单元可以集成在一个处理单元中，也可以是各个单元单独物理存在，也可以两个或两个以上单元集成在一个单元中。上述集成的单元既可以采用硬件的形式实现，也可以采用软件功能单元的形式实现。
所述集成的模块/单元如果以软件功能单元的形式实现并作为独立的产品销售或使用时，可以存储在一个计算机可读取存储介质中。基于这样的理解，本申请实现上述实施例方法中的全部或部分流程，也可以通过计算机程序来指令相关的硬件来完成，所述的计算机程序可存储于一计算机可读存储介质中，该计算机程序在被处理器执行时，可实现上述各个方法实施例的步骤。其中，所述计算机程序包括计算机程序代码，所述计算机程序代码可以为源代码形式、对象代码形式、可执行文件或某些中间形式等。所述计算机可读介质可以包括：能够携带所述计算机程序代码的任何实体或装置、记录介质、U盘、移动硬盘、磁碟、光盘、计算机存储器、只读存储器（ROM，Read-Only Memory）、随机存取存储器（RAM，Random Access Memory）、电载波信号、电信信号以及软件分发介质等。需要说明的是，所述计算机可读介质包含的内容可以根据司法管辖区内立法和专利实践的要求进行适当的增减，例如在某些司法管辖区，根据立法和专利实践，计算机可读介质不包括电载波信号和电信信号。
以上所述实施例仅用以说明本申请的技术方案，而非对其限制；尽管参照前述实施例对本申请进行了详细的说明，本领域的普通技术人员应当理解：其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换；而这些修改或者替换，并不使相应技术方案的本质脱离本申请各实施例技术方案的精神和范围，均应包含在本申请的保护范围之内。

Claims (11)

  1. 一种穿戴式超声神经刺激装置，其特征在于，包括：
    可穿戴部件；
    超声换能器，用于输出超声神经刺激信号；
    连接结构，连接所述可穿戴部件和所述超声换能器，且用于调整所述可穿戴部件与所述超声换能器之间的相对位置。
  2. 如权利要求1所述的穿戴式超声神经刺激装置，其特征在于，所述可穿戴部件为可收缩式穿戴部件，和/或所述连接结构为可伸缩式连接结构。
  3. 如权利要求1所述的穿戴式超声神经刺激装置，其特征在于，所述连接结构包括连接杆，以及设置于所述连接杆的第一连接件和第二连接件，
    其中，所述第一连接件用于调节所述可穿戴部件相对于所述连接杆的位置，以及所述第二连接件用于调节所述超声换能器相对于所述连接杆的位置。
  4. 如权利要求3所述的穿戴式超声神经刺激装置，其特征在于，所述第一连接件包括：
    球轴模块，用于将所述连接杆固定于所述可穿戴部件，使得所述连接杆能够被所述球轴模块带动而进行旋转。
  5. 如权利要求3所述的穿戴式超声神经刺激装置，其特征在于，所述第二连接件包括：
    超声换能器固定模块，用于旋转调节所述超声换能器的位置。
  6. 如权利要求5所述的穿戴式超声神经刺激装置，其特征在于，所述超声换能器固定模块与所述连接杆之间通过转轴件相连接，以使得所述超声换能器固定模块能够绕着所述转轴件移动。
  7. 如权利要求1所述的穿戴式超声神经刺激装置，其特征在于，还包括：
    预设数量个电极器，设置在所述可穿戴部件或所述连接结构上，用于采集所述可穿戴部件的佩戴者的生理反馈信号。
  8. 如权利要求1-7中任一项所述的穿戴式超声神经刺激装置，其特征在于，所述可穿戴部件设置有颈部孔和肩部孔，所述颈部孔用于供佩戴者的颈部穿过，以及所述肩部孔用于供佩戴者的上肢穿过。
  9. 一种穿戴式超声神经刺激系统，其特征在于，包括：
    如权利要求1-8中任一项所述的穿戴式超声神经刺激装置；
    显示器；
    其中，所述穿戴式超声神经刺激装置中的超声换能器用于采集神经图像信息；
    所述显示器用于显示所述神经图像信息。
  10. 如权利要求9所述的穿戴式超声神经刺激系统，其特征在于，所述穿戴式超声神经刺激系统还包括：
    超声发生器，与所述超声换能器电连接，用于产生与所述超声换能器相匹配的驱动信号；
    其中，所述超声换能器用于根据所述超声发生器所产生的第一驱动信号采集神经图像信息，以及根据所述超声发生器所产生的第二驱动信号输出超声神经刺激信号。
  11. 如权利要求10所述的穿戴式超声神经刺激系统，其特征在于，所述超声发生器用于接收用户操作而在预设的驱动信号集中更新驱动信号，所述预设的驱动信号集包括所述第一驱动信号和所述第二驱动信号。
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CN111195397A (zh) * 2018-11-19 2020-05-26 乾智(上海)医疗科技有限公司 一种便携式超声治疗系统

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