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WO2021201353A1 - Dispositif d'analyse de douleur - Google Patents

Dispositif d'analyse de douleur Download PDF

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Publication number
WO2021201353A1
WO2021201353A1 PCT/KR2020/013479 KR2020013479W WO2021201353A1 WO 2021201353 A1 WO2021201353 A1 WO 2021201353A1 KR 2020013479 W KR2020013479 W KR 2020013479W WO 2021201353 A1 WO2021201353 A1 WO 2021201353A1
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WIPO (PCT)
Prior art keywords
pain
subject
unit
stimulation
level
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Ceased
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PCT/KR2020/013479
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English (en)
Korean (ko)
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유승구
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Individual
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4824—Touch or pain perception evaluation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
    • A61B5/0051—Detecting, measuring or recording by applying mechanical forces or stimuli by applying vibrations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
    • A61B5/0053—Detecting, measuring or recording by applying mechanical forces or stimuli by applying pressure, e.g. compression, indentation, palpation, grasping, gauging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4824—Touch or pain perception evaluation
    • A61B5/4827—Touch or pain perception evaluation assessing touch sensitivity, e.g. for evaluation of pain threshold
    • A61B5/483—Touch or pain perception evaluation assessing touch sensitivity, e.g. for evaluation of pain threshold by thermal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4884—Other medical applications inducing physiological or psychological stress, e.g. applications for stress testing

Definitions

  • the present invention relates to a pain analysis device, and more particularly, to a pain analysis device capable of quantitatively and qualitatively analyzing the pain of a subject.
  • an appropriate treatment method can be selected according to the severity of the pain, and the patient's physical condition can be accurately identified.
  • the reality is that it is very difficult to qualitatively and quantitatively analyze pain because the degree of pain can be different for each person who feels pain, and the body reactions and biological signals that are expressed are varied.
  • the pain level was set using the current value for the pain threshold felt by the subject by giving electrical stimulation, or the pain level was estimated based on this by selecting the level of pain from the reference table.
  • a pain analysis apparatus for achieving the above object includes: a plurality of pain stimulation units capable of providing a plurality of pain stimulation; a pain stimulation driving unit for driving the plurality of pain stimulation units; a plurality of biosignal sensing units for sensing biosignals for each of the plurality of pain stimuli of the plurality of pain stimulation units; and increasing and providing the plurality of pain stimuli to a plurality of examinees, storing a plurality of pain thresholds for the plurality of pain stimuli and a plurality of biosignals for the plurality of pain thresholds, and thereafter, the plurality of biosignals and a controller configured to determine a degree of pain based on the plurality of bio-signals when receiving a plurality of bio-signals of the subject from the sensing unit.
  • a plurality of pain stimuli are provided to a subject who feels multiple pains, a plurality of biosignals for pain threshold are identified and stored, and a plurality of biosignals are measured for a subject who feels pain afterward, and the measured multiple biosignals are stored.
  • the degree of pain may be determined and provided in comparison with a plurality of stored bio-signals.
  • the plurality of pain stimulation units include an electrical stimulation unit that provides electrical stimulation to the subject, a tenderness stimulation unit that applies tender stimulation to the skin of the subject, a temperature stimulation unit that comes in contact with the subject to provide temperature stimulation, and vibration stimulation to the subject.
  • an electrical stimulation unit that provides electrical stimulation to the subject
  • a tenderness stimulation unit that applies tender stimulation to the skin of the subject
  • a temperature stimulation unit that comes in contact with the subject to provide temperature stimulation
  • vibration stimulation to the subject When at least one of the provided vibration stimulation units is included, it is preferable to provide various degrees of pain according to the types of pain stimulation of the examinee who feels pain.
  • control unit when setting the pain level based on the pain indication from the examinee for at least one of the electrical stimulation unit, the tenderness stimulation unit, the temperature stimulation unit, and the vibration stimulation unit, the pain level felt differently for each individual It is preferable because it is possible to grasp the range of the pain level and the pain level according to the biosignal can also be grasped, so that it is possible to provide a pain level with improved probabilistic accuracy.
  • control unit applies pain stimulation from at least one of the electrical stimulation unit, the tenderness stimulation unit, the temperature stimulation unit, and the vibration stimulation unit in a state in which a preset pain level is applied to the subject from the outside, and the at least one If the pain level is set using the plurality of biosignals at a time point when the pain stimulus of the patient exceeds the preset pain level, it is preferable that the type and region of the pain can be identified.
  • control unit can provide a more accurate pain level by organically updating the pain level based on data on a lot of pain.
  • the bio-signal sensing unit detects a body state including a breathing rate, a pulse rate, and a body temperature of an examinee and a test self-qualification, and the control unit, based on the body state received from the bio-signal detecting unit and the test subject's self-qualification
  • biosignals can be analyzed according to different conditions, states, constitutions and physiques for each subject, so it is preferable to provide various pain and pain levels according to various subjects.
  • the bio-signal detection unit includes: a skin conductivity detection unit for detecting the skin conductivity of the subject; a pulse detection unit for detecting a pulse of the subject; Respiratory sensing unit for detecting the respiration rate and respiration amount of the subject; a body temperature sensing unit for sensing the body temperature of the subject; Hormone sensing unit for detecting the test subject's hormone secretion; and a blood flow sensing unit for sensing the blood flow velocity of the examinee, it is preferable to detect various biosignals of the examinee to accurately determine the pain level.
  • the control unit stores the degree of pain for the skin conductivity of the subject, the pulse of the subject, the respiration rate and amount of the subject, the body temperature of the subject, the amount of hormone secretion of the subject and the blood flow rate of the subject, and the skin conductivity sensing unit,
  • the pulse sensing unit, the respiration sensing unit, the body temperature sensing unit, the hormone sensing unit and the blood flow sensing unit sensed by the subject's skin conductivity, the subject's pulse, the subject's respiration rate and respiration amount, the subject's body temperature, the subject's Analyzing the pain level of the examinee according to at least one of the hormone secretion amount and the blood flow velocity of the examinee can identify various biosignals for various pains, and based on this, it is preferable to more accurately calculate the pain level.
  • the biosignal detection unit includes a camera that captures the expression of the examinee, and the control unit detects the expression of the examinee to determine the degree of pain when the degree of pain of the examinee is set based on the expression of the examinee captured by the camera. It is desirable to be able to set
  • control unit can help the pain treatment of the examinee by estimating the pain location of the examinee based on the medical history of the examinee.
  • a plurality of pain stimuli are provided to an examinee who feels a plurality of pains, a plurality of bio-signals for a pain threshold are identified and stored, and a plurality of bio-signals are measured for a subject who feels pain afterward.
  • determining the pain level by comparing the bio-signals of the patient with a plurality of stored bio-signals, it is possible to grasp the pain close to the actual pain felt by the examinee. It works.
  • FIG. 1 is an exemplary view of a pain analysis device according to the present invention.
  • 2 is a graph showing changes in biosignals in response to pain stimulation.
  • 3 is an exemplary diagram of pain quantification through a pain threshold.
  • FIG. 4 is an exemplary view of a screen display of a pain level.
  • 5 is an exemplary view of estimation of pain level.
  • FIG. 6 is an exemplary diagram of a system for estimating the degree of pain.
  • FIG. 7 is a graph showing the amount of hormone secretion according to the size of the pain stimulus.
  • 9 is an exemplary table of biosignals for pain levels.
  • FIG. 1 is an exemplary diagram of a pain analysis device 1 according to the present invention
  • FIG. 2 is a graph showing a change in a biosignal in response to a pain stimulus
  • FIG. 3 is an exemplary diagram of pain quantification through a pain threshold
  • FIG. 4 is a screen display example of the pain level
  • Figure 5 is an example of the estimation of the degree of pain
  • Figure 6 is an example of a system for estimating the degree of pain
  • Figure 7 is a graph showing the amount of hormone secretion according to the size of the pain stimulus
  • 8 is a pain reference table for the examinee to select a pain level
  • FIG. 9 is an exemplary biosignal table for the pain level
  • FIG. 10 is a control block diagram.
  • the pain analysis apparatus 1 includes a pain stimulation unit 10 , a pain stimulation driving unit 20 , a biosignal sensing unit 30 , and a control unit 40 .
  • the pain stimulus unit 10 is a device capable of providing a plurality of pain stimuli.
  • the pain stimulation unit 10 includes an electrical stimulation unit 11 , a tenderness stimulation unit 12 , a temperature stimulation unit 13 , and a vibration stimulation unit 14 .
  • the electrical stimulation unit 11 is composed of electrodes, wires, bands, etc. attached to the body of the subject. It is provided so that it can be provided by adjusting and increasing or decreasing the electrical stimulation that is difficult to endure from the level of electrical stimulation that the body cannot feel with the electrode.
  • the tenderness stimulation unit 12 is provided to apply tenderness stimulation to the skin of the subject.
  • the tenderness stimulation unit 12 may be provided with a cylinder and a piston to apply tenderness to the body of the subject.
  • the part in contact with the body of the subject may have various shapes, such as a pointed shape, a round shape, a thin shape, a thick shape, and a wide shape.
  • the tenderness stimulation unit 12 may be provided to press only one part of the body of the subject, or to move and press several parts.
  • the temperature stimulation unit 13 is in contact with the subject to provide the temperature stimulation.
  • the temperature stimulation unit 13 may be provided as a thermoelectric element to provide a low temperature to a high temperature to the subject.
  • the vibration stimulation unit 14 provides vibration stimulation to the subject.
  • the vibration stimulator 14 is provided to shake a part of the body of the subject while being tilted.
  • the pain stimulation driving unit 20 is provided to drive the plurality of pain stimulation units 10 .
  • the pain stimulation driving unit 20 includes an electrical stimulation driving unit 21 , a tender stimulation driving unit 22 , a temperature stimulation driving unit 23 , and a vibration stimulation driving unit 24 .
  • the electrical stimulation driving unit 21 and the temperature stimulation driving unit 23 may be provided as a power supply to control the amount of current supplied to the electrical stimulation unit 11 and the temperature stimulation unit 13 .
  • the tenderness stimulation driving unit 22 may be provided as a hydraulic pressure supply unit for supplying hydraulic pressure to the tender stimulation portion 12 provided with a cylinder and a piston.
  • the tenderness stimulation unit 22 may be provided as a driving motor.
  • the biosignal detection unit 30 detects the body state including the breathing rate, pulse rate, and body temperature of the subject and the subject himself/herself.
  • the biosignal sensing unit 30 senses biosignals for each of the plurality of pain stimuli of the plurality of pain stimulation units 10 .
  • the biosignal detecting unit 30 may determine the body state including the respiration rate, pulse rate, and body temperature of the subject and the subject's own qualifications.
  • the biosignal sensing unit 30 includes a skin conductivity sensing unit 31, a pulse sensing unit 32, a respiration sensing unit 33, a body temperature sensing unit 34, a hormone sensing unit 35, and a blood flow sensing unit 36. It consists of a camera (37).
  • the skin conductivity detection unit 31 detects the skin conductivity of the subject.
  • the skin conductivity sensing unit 31 is attached to the skin of a subject to detect electrical resistance and measure the skin conductivity. As the pain increases, the skin conductivity tends to increase.
  • the pulse detection unit 32 detects the pulse of the subject.
  • the pulse detecting unit 32 may be attached to the skin of the subject to determine the speed of the pulse, the strength of the pulse, the regularity of the pulse, and the like.
  • Respiratory detection unit 33 is provided in the same shape as a mask to detect the respiration rate and respiration amount of the examinee.
  • the respiration sensing unit 33 may determine the cycle of one respiration, respiration amount, respiration rate, and regularity of respiration.
  • the body temperature sensing unit 34 detects the body temperature of the subject. It may be attached to the subject to detect a change in body temperature and transmit it to the controller 40 to be described later.
  • the hormone detecting unit 35 may be provided as a camera capable of detecting a specific hormone, or may be provided as a renal dialysis machine to draw blood from a test subject, detect the hormone, and then inject it again. Thereby, the hormone detecting unit 35 may detect the type of hormone and the amount of hormone secreted by the test subject.
  • the blood flow sensing unit 36 detects a blood flow volume and a blood flow velocity of the subject.
  • the blood flow detection unit 36 may be provided as a specific camera that can detect specific blood, or may be provided like a kidney dialysis machine to draw blood from a subject and put it back in again.
  • the camera 37 captures the facial expression of the subject.
  • the control unit 40 increases and provides a plurality of pain stimuli to a plurality of subjects, stores a plurality of pain thresholds for the plurality of pain stimuli and a plurality of biosignals for the plurality of pain thresholds, and then the plurality of biosignals When a plurality of bio-signals of the subject are received from the sensing units 31 to 37, a degree of pain is determined based on the plurality of bio-signals.
  • the control unit 40 determines the degree of pain based on the pain indication from the examinee with respect to at least one of the electrical stimulation unit 11, the tenderness stimulation unit 12, the temperature stimulation unit 13, and the vibration stimulation unit 14. set
  • the control unit 40 receives pain from at least one of the electrical stimulation unit 11, the tenderness stimulation unit 12, the temperature stimulation unit 13, and the vibration stimulation unit 14 while applying a preset pain level to the subject from the outside. Stimulation is applied, and the pain level is set using a plurality of biosignals when at least one pain stimulus exceeds a preset pain level.
  • the control unit 40 updates the stored pain level based on the pain indication obtained from the subject.
  • the control unit 40 determines the pain level based on the physical condition received from the biosignal sensing units 31 to 37 and the test subject's own qualifications.
  • the control unit 40 stores the degree of pain for the skin conductivity of the subject, the pulse of the subject, the respiration rate and amount of the subject, the body temperature of the subject, the amount of hormone secretion of the subject and the blood flow rate of the subject, and the skin conductivity sensing unit 31 , Pulse sensing unit 32, respiration sensing unit 33, body temperature sensing unit 34, hormone sensing unit 35 and blood flow sensing unit 36 to detect the subject's skin conductivity, the subject's pulse, the subject's respiration
  • the pain level of the subject is analyzed according to at least one of speed and respiration volume, body temperature of the subject, the amount of hormone secretion of the subject, and blood flow rate of the subject.
  • the control unit 40 sets the pain level of the examinee based on the expression of the examinee captured by the camera 37 .
  • the control unit 40 may estimate the pain location of the examinee based on the medical history history of the examinee.
  • FIG. 2 is a graph showing a change in a biosignal in response to a pain stimulus.
  • the biosignal changes in response to the pain stimulus.
  • the test subject senses the electrical stimulation by providing the electrical stimulation
  • the change in the biological signal can be detected by the biological signal detecting unit.
  • 3 is an exemplary diagram of pain quantification through a pain threshold.
  • Electrical stimulation is provided while the subject is already feeling pain. In this case, if the electrical stimulation is small, the subject does not feel the electrical stimulation, but if the electrical stimulation is increased and an electrical stimulation greater than the already felt pain is provided, the examinee feels the electrical stimulation and does not feel the pain that has already been felt. This can be used to quantify pain.
  • FIG. 5 is an exemplary diagram of estimating the pain level
  • FIG. 6 is an exemplary diagram of a system for estimating the pain level.
  • a pain stimulus is provided to an examinee who has already felt pain, and a plurality of bio-signals at the point in time at which the provided pain stimulus is felt are sensed and stored. Based on the stored biosignals, the pain can be analyzed and the pain level can be estimated.
  • the pain level is investigated before the pain level test for a plurality of subjects.
  • the intensity of the pain stimulus at the time of the pain threshold and the value of the biosignal are stored for a plurality of subjects. Accordingly, the range of the user's pain degree may be set according to the numerical range of the biosignal.
  • the pain level can be set by combining at least one of a plurality of biosignals, i.e., the skin conductance of the subject, the pulse of the subject, the respiration rate and amount of the subject, the body temperature of the subject, the amount of hormone secretion of the subject, and the blood flow rate of the subject. have.
  • weights are assigned to the weighted subject's skin conductivity, the subject's pulse , it is possible to set the pain level by combining at least one of the respiration rate and amount of respiration of the subject, body temperature of the subject, the amount of hormone secretion of the subject, and blood flow rate of the subject.
  • FIG. 7 is a graph showing the amount of hormone secretion according to the size of the pain stimulus.
  • the amount of hormone secretion may increase.
  • the type of hormone secretion may be different.
  • the pain level can also be set by combining the hormone secretion amount (A) or the hormone type at the time when the pain stimulus is first felt and the hormone secretion amount (B) or the hormone type secreted at the pain threshold.
  • 9 is an exemplary table of biosignals for pain levels.
  • a method for setting the pain level may be provided in various ways.
  • the biosignal value (A) at the time when the examinee first feels the pain stimulus the biosignal value (B) at the time of the pain threshold is stored, and then the pain level (C) can be set through various equations.
  • the pain level is set based on any one bio-signal, and the pain level is appropriately changed according to the change of the bio-signal.
  • the pain level can be set based on the distribution table for the biosignals of multiple subjects.
  • this is a method in which the minimum value of the biosignal is set to pain level 1, the maximum value of the biosignal is set to the pain level 100, and the intermediate biosignal value is set to an appropriate pain level.
  • the pain level is set by the first, second, and third methods.
  • the pain level can be set by the first, second, and third methods.
  • the pain level may be set by the first, second, and third methods using only 50% of the hormone secreted and 50% of the hormone secreted amount.
  • the estimation method for the pain site can also be estimated by the type of hormone secreted.
  • Skin conductance of the subject Pule of the subject, respiration rate and respiration volume of the subject, body temperature of the subject, the amount of hormone secretion of the subject and the blood flow rate of the test subject. It is also possible to determine the condition of organs, blood pressure, blood sugar, red blood cell count, white blood cell count, etc. and reflect it in the pain level.
  • a method of pain relief according to the degree of pain may also be suggested. For example, after identifying the pain level of a patient complaining of abdominal pain, a method for relieving pain may be suggested by attaching an electrode of a deep heat treatment device to the subject's stomach and treating the subject's core at a temperature of 42°C.
  • a plurality of pain stimuli are provided to a test subject who feels a plurality of pain, and a plurality of bio-signals for a pain threshold are identified and stored, and thereafter, a plurality of bio-signals for a test subject who feels pain are provided.
  • the degree of pain may be determined and provided by comparing a plurality of measured bio-signals with a plurality of stored bio-signals.
  • the plurality of pain stimulation units 10 include an electrical stimulation unit 11 that provides electrical stimulation to the subject, a tenderness stimulation unit 12 that applies tender stimulation to the subject's skin, and a temperature stimulation unit that contacts the subject to provide temperature stimulation. (13) and at least one of the vibration stimulation unit 14 for providing the vibration stimulation to the examinee, it is possible to provide various pain levels according to each type of pain stimulation of the examinee who feels pain.
  • At least one pain stimulus is applied to the subject while a preset pain level is being applied from the outside, and when the at least one pain stimulus exceeds the preset pain level, the pain level is set using a plurality of biosignals. The type, location, etc. can be identified. If the stored pain level is updated based on the pain indication obtained from the subject, it is possible to provide a more accurate pain level by organically updating the pain level based on the data on many pains.
  • the degree of pain is determined based on the physical condition of the subject and the subject's personality, so that the biosignals can be analyzed according to different conditions, states, constitutions, and physiques for each subject.
  • the pain level of the examinee is set based on the expression of the examinee captured by the camera, the pain level may be set by detecting the expression of the examinee. Based on the medical history history of the subject, it is possible to estimate the location of the subject's pain.

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  • Life Sciences & Earth Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Developmental Disabilities (AREA)
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  • Social Psychology (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

Un dispositif d'analyse de douleur comprend : une pluralité d'unités de stimulation de douleur permettant de fournir une pluralité de stimuli de douleur ; une unité d'actionnement de stimulation de douleur pour actionner la pluralité d'unités de stimulation de douleur ; une pluralité d'unités de détection de biosignal pour détecter des biosignaux pour chaque stimulus de douleur de la pluralité de stimuli de douleur de la pluralité d'unités de stimulation de douleur ; et un dispositif de commande pour augmenter et fournir une pluralité de stimuli de douleur à de multiples candidats, pour stocker une pluralité de seuils de douleur pour la pluralité de stimuli de douleur et une pluralité de biosignaux pour la pluralité de seuils de douleur, puis, lorsqu'une pluralité de biosignaux des candidats est reçue de la pluralité d'unités de détection de biosignal, pour déterminer le degré de douleur sur la base de la pluralité de biosignaux.
PCT/KR2020/013479 2020-04-01 2020-10-05 Dispositif d'analyse de douleur Ceased WO2021201353A1 (fr)

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KR1020200039753A KR102162054B1 (ko) 2020-04-01 2020-04-01 통증 분석 장치

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CN116195971A (zh) * 2021-12-01 2023-06-02 中国人民解放军空军特色医学中心 一种基于微表情分析的压力痛阈测量装置
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CN113057597B (zh) * 2021-03-25 2021-11-16 南通市第一人民医院 一种实时监测产妇生产过程中生理状态的方法及系统

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