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WO2021158193A1 - Dispositif de mesure de gaz sanguin - Google Patents

Dispositif de mesure de gaz sanguin Download PDF

Info

Publication number
WO2021158193A1
WO2021158193A1 PCT/TR2020/051492 TR2020051492W WO2021158193A1 WO 2021158193 A1 WO2021158193 A1 WO 2021158193A1 TR 2020051492 W TR2020051492 W TR 2020051492W WO 2021158193 A1 WO2021158193 A1 WO 2021158193A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood
blood gas
measuring device
gas measuring
measurement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/TR2020/051492
Other languages
English (en)
Inventor
Ayse Filiz KOC
Gizem Gul KOC
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cukurova Universitesi
Original Assignee
Cukurova Universitesi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cukurova Universitesi filed Critical Cukurova Universitesi
Publication of WO2021158193A1 publication Critical patent/WO2021158193A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6824—Arm or wrist
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/685—Microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient; User input means
    • A61B5/746—Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms

Definitions

  • the invention relates to a blood gas measuring device that provides reading of blood and determining blood gas parameters with the help of a sensor by piercing the skin with needles.
  • Arterial blood gas is one of the parameters guiding treatment in the follow-up of patients. Blood gas is measured by evaluating the blood sample taken from the patient's arteries and / or veins into a heparinized syringe in the laboratory. It is an invasive procedure that requires intervention. Currently, blood gas measurement is performed with separate systems and under laboratory conditions, but there is no system where all parameters are combined and wearable for personal medicine.
  • the invention has been characterized by micro needle electrodes (1), electronic components (2) and battery (3).
  • micro needle electrodes (1), electronic components (2) and battery (3) As a result of detailed researches, it is necessary to take a blood sample from the patient's artery for blood gas measurements. In addition, it is necessary to take arterial blood repeatedly for blood gas measurement at certain intervals deemed appropriate by the physician for the follow-up of the patient. It was seen that these blood samples were sent to the laboratory and studied on a blood gas analyzer, and a device that provides rapid and easy measurement, which takes continuous measurement at the same time without need of taking blood from the patient over and over, has been introduced.
  • the device has lab-on-a-chip technology developed with biosensor infrastructure.
  • potentiometric measurements based on the determination of the potential transformation occurring as a result of the chemical reaction on the electrode surface will be taken with the help of micro-needle electrodes (1), which provide specific binding to the analyte that they want to measure on the electrode surface.
  • Ag / AgCI electrode is used both as a pH measurement and as a reference electrode.
  • Carbon dioxide and bicarbonate measurement is made by bidirectional reaction of carbonic anhydrase enzyme immobilized on the working electrode surface. Oxygen measurement is made with the help of an oxygen electrode.
  • data are transferred to the electronic components (2) unit. The transferred data are calculated by means of software embedded on the electronic components (2) and the partial pressure and percentages are calculated and transmitted to the wristband screen, the user phone and the following physician phone for display purposes using at least one of the communication protocols.
  • the device will be worn on the wrist.
  • the micro-needle electrodes (1) inside the device which are designed not to cause pain, pierce the skin only once, and the potential change of blood gas parameters (pH, PaC02, HC03, Pa02 and Sa02) is read by the sensors and the blood gas parameters are based on the process of determining the gas parameters.
  • pH, PaC02, HC03, Pa02 and Sa02 levels which are checked during routine blood count, are evaluated and the parameters are reflected on the screen of the wristband worn by the patient.
  • the values measured by the chip and wristband attached to the headset will be updated to the phones with an appropriate software, and the attention of the patient and / or his relatives will be tried to be drawn with a warning alarm in values outside the normal limits given in Table 1.
  • these records will be transferred to the phone of the physician who follows the patient simultaneously. Thanks to the light battery (3), the device is applied in suitable parts of the body for the measurement of arterial blood pressure.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un dispositif de mesure de gaz sanguin qui permet de lire des données du sang et de déterminer des paramètres de gaz sanguin à l'aide d'un capteur en perçant la peau avec des aiguilles.
PCT/TR2020/051492 2020-02-04 2020-12-31 Dispositif de mesure de gaz sanguin Ceased WO2021158193A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR202001677 2020-02-04
TR2020/01677 2020-02-04

Publications (1)

Publication Number Publication Date
WO2021158193A1 true WO2021158193A1 (fr) 2021-08-12

Family

ID=77199583

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2020/051492 Ceased WO2021158193A1 (fr) 2020-02-04 2020-12-31 Dispositif de mesure de gaz sanguin

Country Status (1)

Country Link
WO (1) WO2021158193A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100204556A1 (en) * 2009-02-12 2010-08-12 Keimar, Inc. Physiological parameter sensors
US20150257685A1 (en) * 2014-03-13 2015-09-17 Sano Intelligence, Inc. System for monitoring body chemistry
US20190223770A1 (en) * 2018-01-24 2019-07-25 Bela Malik Biological sample extraction and detection system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100204556A1 (en) * 2009-02-12 2010-08-12 Keimar, Inc. Physiological parameter sensors
US20150257685A1 (en) * 2014-03-13 2015-09-17 Sano Intelligence, Inc. System for monitoring body chemistry
US20190223770A1 (en) * 2018-01-24 2019-07-25 Bela Malik Biological sample extraction and detection system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
C. H. AHN ET AL.: "Disposable smart lab on a chip for point-of-care clinical diagnostics", PROCEEDINGS OF THE IEEE, vol. 92, no. 1, 2004, pages 154 - 173, XP011105296, DOI: 10.1109/JPROC.2003.820548 *

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