[go: up one dir, main page]

WO2021158193A1 - Blood gas measuring device - Google Patents

Blood gas measuring device Download PDF

Info

Publication number
WO2021158193A1
WO2021158193A1 PCT/TR2020/051492 TR2020051492W WO2021158193A1 WO 2021158193 A1 WO2021158193 A1 WO 2021158193A1 TR 2020051492 W TR2020051492 W TR 2020051492W WO 2021158193 A1 WO2021158193 A1 WO 2021158193A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood
blood gas
measuring device
gas measuring
measurement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/TR2020/051492
Other languages
French (fr)
Inventor
Ayse Filiz KOC
Gizem Gul KOC
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cukurova Universitesi
Original Assignee
Cukurova Universitesi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cukurova Universitesi filed Critical Cukurova Universitesi
Publication of WO2021158193A1 publication Critical patent/WO2021158193A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6824—Arm or wrist
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/685—Microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient; User input means
    • A61B5/746—Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms

Definitions

  • the invention relates to a blood gas measuring device that provides reading of blood and determining blood gas parameters with the help of a sensor by piercing the skin with needles.
  • Arterial blood gas is one of the parameters guiding treatment in the follow-up of patients. Blood gas is measured by evaluating the blood sample taken from the patient's arteries and / or veins into a heparinized syringe in the laboratory. It is an invasive procedure that requires intervention. Currently, blood gas measurement is performed with separate systems and under laboratory conditions, but there is no system where all parameters are combined and wearable for personal medicine.
  • the invention has been characterized by micro needle electrodes (1), electronic components (2) and battery (3).
  • micro needle electrodes (1), electronic components (2) and battery (3) As a result of detailed researches, it is necessary to take a blood sample from the patient's artery for blood gas measurements. In addition, it is necessary to take arterial blood repeatedly for blood gas measurement at certain intervals deemed appropriate by the physician for the follow-up of the patient. It was seen that these blood samples were sent to the laboratory and studied on a blood gas analyzer, and a device that provides rapid and easy measurement, which takes continuous measurement at the same time without need of taking blood from the patient over and over, has been introduced.
  • the device has lab-on-a-chip technology developed with biosensor infrastructure.
  • potentiometric measurements based on the determination of the potential transformation occurring as a result of the chemical reaction on the electrode surface will be taken with the help of micro-needle electrodes (1), which provide specific binding to the analyte that they want to measure on the electrode surface.
  • Ag / AgCI electrode is used both as a pH measurement and as a reference electrode.
  • Carbon dioxide and bicarbonate measurement is made by bidirectional reaction of carbonic anhydrase enzyme immobilized on the working electrode surface. Oxygen measurement is made with the help of an oxygen electrode.
  • data are transferred to the electronic components (2) unit. The transferred data are calculated by means of software embedded on the electronic components (2) and the partial pressure and percentages are calculated and transmitted to the wristband screen, the user phone and the following physician phone for display purposes using at least one of the communication protocols.
  • the device will be worn on the wrist.
  • the micro-needle electrodes (1) inside the device which are designed not to cause pain, pierce the skin only once, and the potential change of blood gas parameters (pH, PaC02, HC03, Pa02 and Sa02) is read by the sensors and the blood gas parameters are based on the process of determining the gas parameters.
  • pH, PaC02, HC03, Pa02 and Sa02 levels which are checked during routine blood count, are evaluated and the parameters are reflected on the screen of the wristband worn by the patient.
  • the values measured by the chip and wristband attached to the headset will be updated to the phones with an appropriate software, and the attention of the patient and / or his relatives will be tried to be drawn with a warning alarm in values outside the normal limits given in Table 1.
  • these records will be transferred to the phone of the physician who follows the patient simultaneously. Thanks to the light battery (3), the device is applied in suitable parts of the body for the measurement of arterial blood pressure.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to a blood gas measuring device that provides reading of blood and determining blood gas parameters with the help of a sensor by piercing the skin with needles.

Description

BLOOD GAS MEASURING DEVICE
TECHNICAL AREA
The invention relates to a blood gas measuring device that provides reading of blood and determining blood gas parameters with the help of a sensor by piercing the skin with needles.
BACKGROUND
Millions of people around the world experience various levels of lung problems, especially asthma and chronic obstructive pulmonary diseases. As a matter of fact, shortness of breath is seen in 15-18% of patients over the age of 40 and in 25-37% of patients over the age of 70. Arterial blood gas is one of the parameters guiding treatment in the follow-up of patients. Blood gas is measured by evaluating the blood sample taken from the patient's arteries and / or veins into a heparinized syringe in the laboratory. It is an invasive procedure that requires intervention. Currently, blood gas measurement is performed with separate systems and under laboratory conditions, but there is no system where all parameters are combined and wearable for personal medicine.
BRIEF DESCRIPTION OF THE INVENTION
Needles inside the device, which are designed not to cause pain, pierce the skin and allow the blood to be read by sensors and to determine blood gas parameters. Thus, pH, arterial blood oxygen (PaC02), bicarbonate (HC03), partial arterial oxygen pressure (Pa02) and oxygen saturation (Sa02) levels will be evaluated during routine blood count and the parameters will be reflected on the screen of the wristband that the patient is wearing. With the help of this device, both the patient and the physician will be able to intervene instantly as well as saving time, and the disability and mortality caused by the disease will decrease.
LIST OF FIGURES
1 . Device's Perspective View Correspondence of Numbers Shown in Figure
1. Micro needle electrodes
2. Electronic components
3. Battery
DETAILED DESCRIPTION OF THE INVENTION
The invention has been characterized by micro needle electrodes (1), electronic components (2) and battery (3). As a result of detailed researches, it is necessary to take a blood sample from the patient's artery for blood gas measurements. In addition, it is necessary to take arterial blood repeatedly for blood gas measurement at certain intervals deemed appropriate by the physician for the follow-up of the patient. It was seen that these blood samples were sent to the laboratory and studied on a blood gas analyzer, and a device that provides rapid and easy measurement, which takes continuous measurement at the same time without need of taking blood from the patient over and over, has been introduced.
The device has lab-on-a-chip technology developed with biosensor infrastructure. In this system, potentiometric measurements based on the determination of the potential transformation occurring as a result of the chemical reaction on the electrode surface will be taken with the help of micro-needle electrodes (1), which provide specific binding to the analyte that they want to measure on the electrode surface. In the system, Ag / AgCI electrode is used both as a pH measurement and as a reference electrode.
Carbon dioxide and bicarbonate measurement is made by bidirectional reaction of carbonic anhydrase enzyme immobilized on the working electrode surface. Oxygen measurement is made with the help of an oxygen electrode. After the blood gases are measured, data are transferred to the electronic components (2) unit. The transferred data are calculated by means of software embedded on the electronic components (2) and the partial pressure and percentages are calculated and transmitted to the wristband screen, the user phone and the following physician phone for display purposes using at least one of the communication protocols.
The device will be worn on the wrist. The micro-needle electrodes (1) inside the device, which are designed not to cause pain, pierce the skin only once, and the potential change of blood gas parameters (pH, PaC02, HC03, Pa02 and Sa02) is read by the sensors and the blood gas parameters are based on the process of determining the gas parameters. Thus, pH, PaC02, HC03, Pa02 and Sa02 levels, which are checked during routine blood count, are evaluated and the parameters are reflected on the screen of the wristband worn by the patient.
The values measured by the chip and wristband attached to the headset will be updated to the phones with an appropriate software, and the attention of the patient and / or his relatives will be tried to be drawn with a warning alarm in values outside the normal limits given in Table 1. In addition, these records will be transferred to the phone of the physician who follows the patient simultaneously. Thanks to the light battery (3), the device is applied in suitable parts of the body for the measurement of arterial blood pressure.
Figure imgf000005_0001
Table 1. Normal values for blood gases.

Claims

1. A blood gas measuring device characterized by micro-needle electrodes (1) designed not to cause pain applied in appropriate parts of the body for the measurement of arterial blood pressure, sensors that read potential changes as a result of reactions on the surface of micro electrodes (1 ), electronic components to which data is transferred (2), electronic components that process data (2) and an embedded software.
PCT/TR2020/051492 2020-02-04 2020-12-31 Blood gas measuring device Ceased WO2021158193A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR202001677 2020-02-04
TR2020/01677 2020-02-04

Publications (1)

Publication Number Publication Date
WO2021158193A1 true WO2021158193A1 (en) 2021-08-12

Family

ID=77199583

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2020/051492 Ceased WO2021158193A1 (en) 2020-02-04 2020-12-31 Blood gas measuring device

Country Status (1)

Country Link
WO (1) WO2021158193A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100204556A1 (en) * 2009-02-12 2010-08-12 Keimar, Inc. Physiological parameter sensors
US20150257685A1 (en) * 2014-03-13 2015-09-17 Sano Intelligence, Inc. System for monitoring body chemistry
US20190223770A1 (en) * 2018-01-24 2019-07-25 Bela Malik Biological sample extraction and detection system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100204556A1 (en) * 2009-02-12 2010-08-12 Keimar, Inc. Physiological parameter sensors
US20150257685A1 (en) * 2014-03-13 2015-09-17 Sano Intelligence, Inc. System for monitoring body chemistry
US20190223770A1 (en) * 2018-01-24 2019-07-25 Bela Malik Biological sample extraction and detection system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
C. H. AHN ET AL.: "Disposable smart lab on a chip for point-of-care clinical diagnostics", PROCEEDINGS OF THE IEEE, vol. 92, no. 1, 2004, pages 154 - 173, XP011105296, DOI: 10.1109/JPROC.2003.820548 *

Similar Documents

Publication Publication Date Title
Yang et al. Wearable and flexible electronics for continuous molecular monitoring
Jarvis et al. Low cost carbon monoxide monitors in smoking assessment
JP4611372B2 (en) Metabolic monitoring, method and apparatus for displaying conditions related to the health of a subject
US10368811B1 (en) Methods and devices for circadian rhythm monitoring
Khandpur Compendium of biomedical instrumentation, 3 volume set
WO2006025055A2 (en) Device and method for measuring physiological parameters
JP6035163B2 (en) Skin gas measuring device and skin gas measuring method
EP3731742A1 (en) System and method for analyzing biochemical sensor data
Bernet-Buettiker et al. Evaluation of a new combined transcutaneous measurement of PCO2/pulse oximetry oxygen saturation ear sensor in newborn patients
CN108175415A (en) A kind of application of wearable micro-fluidic chip in life monitoring field
Hutter et al. Point-of-care and self-testing for potassium: Recent advances
Saggio Are sensors and data processing paving the way to completely non-invasive and not-painful medical tests for widespread screening and diagnosis purposes?
Coskun et al. From population-based to personalized laboratory medicine: continuous monitoring of individual laboratory data with wearable biosensors
WO2021158193A1 (en) Blood gas measuring device
US11266378B1 (en) Energy coupling material for wearable ultrasound devices
Raymond et al. Wearable Electrochemical Sensors for Real-Time Biomarkers Detection
Schachter et al. Transcutaneous oxygen and carbon dioxide monitoring: Use in adult surgical patients in an intensive care unit
JP2023508989A (en) Systems and methods for sepsis risk assessment
Fan et al. Wearable sensors in critical care medicine
Mitsubayashi et al. Cavitas bio/chemical sensors for Internet of Things in healthcare
AU2020228375B2 (en) System for non-invasive examination of blood environment parameters
KOTYK AFFORDABLE DIABETES TREATMENT: STRATEGIES FOR THE DEVELOPMENT OF COST-EFFECTIVE NON-INVASIVE GLUCOSE MONITORING SYSTEMS
Domeracki et al. Telemedicine devices in internal medicine and neurology
Nogueira et al. A review between consumer and medical-grade biofeedback devices for quality of life studies
KR20250089198A (en) Wristband measuring device for transcutaneous pCO2 measurement and controlling method for the same

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20917630

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 20917630

Country of ref document: EP

Kind code of ref document: A1