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WO2021097667A1 - 一种生物医用材料表面高分子基涂层 - Google Patents

一种生物医用材料表面高分子基涂层 Download PDF

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WO2021097667A1
WO2021097667A1 PCT/CN2019/119454 CN2019119454W WO2021097667A1 WO 2021097667 A1 WO2021097667 A1 WO 2021097667A1 CN 2019119454 W CN2019119454 W CN 2019119454W WO 2021097667 A1 WO2021097667 A1 WO 2021097667A1
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parts
nano
titanium dioxide
based coating
polymer
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李玉光
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Nanjing Advanced Biological Materials & Process Equipment Institute Co Ltd
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Nanjing Advanced Biological Materials & Process Equipment Institute Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D1/00—Coating compositions, e.g. paints, varnishes or lacquers, based on inorganic substances
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D183/00—Coating compositions based on macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon only; Coating compositions based on derivatives of such polymers
    • C09D183/02—Polysilicates
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D183/00—Coating compositions based on macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon only; Coating compositions based on derivatives of such polymers
    • C09D183/04—Polysiloxanes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D183/00—Coating compositions based on macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon only; Coating compositions based on derivatives of such polymers
    • C09D183/04—Polysiloxanes
    • C09D183/06—Polysiloxanes containing silicon bound to oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
    • C09D5/14—Paints containing biocides, e.g. fungicides, insecticides or pesticides

Definitions

  • the invention relates to the technical field of polymer materials, in particular to a polymer-based coating on the surface of biomedical materials.
  • the medical surface coating material is a medical surface composite material composed of a group material as a matrix and a layer of homogenous or heterogeneous film formed on its surface by a certain process technology. Its function is to improve the biological properties of the substrate surface, or to block the dissolution and diffusion of substrate ions to the surrounding tissues, or to improve the physical and chemical properties such as wear resistance and insulation of the substrate surface.
  • the most widely used is to add to the civil metal material substrate.
  • plasma spraying, vapor deposition, ion sputtering, immersion, sintering, electrophoresis and pyrolysis can be used for coating preparation. The first two methods are most suitable.
  • Coating materials are mainly used to manufacture artificial bones, joint sockets, joint heads, artificial tooth roots, artificial heart valves, etc.; it can also be used as an insulating layer for wires of electrical implant devices and surface coatings for guiding wires of cardiovascular catheters.
  • Existing coating materials generally only have a single performance, such as protection, antibacterial, and anticoagulant properties, and cannot have multiple properties at the same time to improve the performance of medical materials. Therefore, there is a need to provide a polymer-based coating on the surface of biomedical materials.
  • the present invention is realized through the following schemes:
  • a polymer-based coating on the surface of biomedical materials, in parts by mass, the base coating includes 2-5 parts of ethyl orthosilicate, 40-60 parts of pure water, 0.5-2 parts of glacial acetic acid, and silane coupling 0.5-2 parts of coupling agent, 0.1-0.5 parts of nano titanium dioxide, 0.5-1 parts of nano silver.
  • the nano titanium dioxide is prepared by a method including the following steps:
  • the average particle size of the nano titanium dioxide is 5-15 nm, and the specific surface area is 80-115 m 2 /g.
  • the average particle size of the nano silver is 20-30 nm, and the specific surface area is 70-90 m 2 /g.
  • the polymer-based coating on the surface of a biomedical material of the present invention uses nano-silver.
  • nano-silver particles have a large specific surface area and high surface energy, so that they have strong surface activity and super adsorption ability, so it is helpful
  • Corrupted oxygen atoms, oxygen free radicals, alkane molecules, etc. have a strong capture ability, which can effectively protect materials from bacteria.
  • silver ions react with the organic matter in bacteria to effectively kill bacteria, thereby Achieve antibacterial and bactericidal effects.
  • the polymer-based coating on the surface of a biomedical material of the present invention adopts nano-titanium dioxide to form a deadly protective layer on the surface of medical materials, which can effectively prevent the penetration of corrosive media and provide good protection for medical materials, thereby achieving protection The role of anti-corrosion.
  • a polymer-based coating on the surface of a biomedical material, in parts by mass, the base coating includes 2-5 parts of ethyl orthosilicate, 40-60 parts of pure water, 0.5-2 parts of glacial acetic acid, and silane coupling 0.5-2 parts of coupling agent, 0.1-0.5 parts of nano titanium dioxide, 0.5-1 parts of nano silver.
  • the nano titanium dioxide is prepared by a method including the following steps:
  • the average particle size of the nano titanium dioxide is 5-15 nm, and the specific surface area is 80-115 m 2 /g.
  • the average particle size of the nano silver is 20-30 nm, and the specific surface area is 70-90 m 2 /g.
  • a polymer-based coating on the surface of a biomedical material, in parts by mass, the base coating includes 3.5 parts of ethyl orthosilicate, 50 parts of pure water, 1 part of glacial acetic acid, 1 part of silane coupling agent, nanometer 0.1 part of titanium dioxide and 0 part of nano-silver.
  • a polymer-based coating on the surface of a biomedical material, in parts by mass, the base coating includes 3.5 parts of ethyl orthosilicate, 50 parts of pure water, 1 part of glacial acetic acid, 1 part of silane coupling agent, nanometer 0 parts of titanium dioxide and 0.5 parts of nano-silver.
  • a polymer-based coating on the surface of a biomedical material, in parts by mass, the base coating includes 3.5 parts of ethyl orthosilicate, 50 parts of pure water, 1 part of glacial acetic acid, 1 part of silane coupling agent, nanometer 0.1 part of titanium dioxide and 0.5 part of nano-silver.
  • the nano titanium dioxide is prepared by a method including the following steps:
  • the average particle size of the nano titanium dioxide is 10 nm, and the specific surface area is 85 m 2 /g.
  • the average particle size of the nano silver is 25 nm, and the specific surface area is 75 m 2 /g.
  • a polymer-based coating on the surface of a biomedical material, in parts by mass, the base coating includes 3.5 parts of ethyl orthosilicate, 50 parts of pure water, 1 part of glacial acetic acid, 1 part of silane coupling agent, nanometer 0.3 parts of titanium dioxide and 0.7 parts of nano-silver.
  • a polymer-based coating on the surface of a biomedical material, in parts by mass, the base coating includes 3.5 parts of ethyl orthosilicate, 50 parts of pure water, 1 part of glacial acetic acid, 1 part of silane coupling agent, nanometer 0.5 part of titanium dioxide and 1.0 part of nano-silver.
  • Example 1 to Example 3 and the coating prepared in Comparative Example 1 to Example 2 were magnetically stirred for 8 days to form a sol; the aluminum alloy test piece of the same size was polished with sandpaper until there were no obvious scratches. Then use alkaline washing-water washing-acid washing-water washing-alcohol washing-blow-drying; respectively immerse the processed aluminum sheet in each sol for 45 minutes, and carry out coating coverage by pulling method, and then carry out the corresponding test; Carrier quantitative sterilization test method to detect the killing effect on Staphylococcus aureus
  • the above test data shows that with the change in the mass fraction of nano-TiO2 in the base coating, the corrosion potential and impact strength of the aluminum sheet gradually increase, indicating that the coating has good protection and anti-corrosion properties; at the same time, with the quality of nano-silver in the coating As the score changes, the sterilization rate of the aluminum sheet gradually increases, indicating that the coating has a stable antibacterial effect.

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  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
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Abstract

本发明公开了一种生物医用材料表面高分子基涂层，以质量份数计，所述基涂层包括正硅酸乙酯2-5份，纯水40-60份，冰乙酸0.5-2份，硅烷偶联剂0.5-2份，纳米二氧化钛0.1-0.5份，纳米银0.5-1份。本发明的基涂层通过添加纳米二氧化钛和纳米银，使其具备良好的抗菌、防护性能。

Description

一种生物医用材料表面高分子基涂层 技术领域
本发明涉及高分子材料技术领域，尤其是一种生物医用材料表面高分子基涂层。
背景技术
医用表面涂层材料以团体材料为基体，利用某种工艺技术在其表面形成一层同质或异质薄膜而构成的医用表面复合材料。其作用为增进基体表面的生物学性质，或阻隔基材离子向周围组织溶出扩散，或提高基体表面的耐磨性、绝缘性等物理化学性质、应用最广泛的是在民用金属材料基体上加涂生物陶瓷涂层，涂层制备可采用等离子喷涂、气相沉积、离子溅射、浸渍、烧结、电泳和热解等，最为适用的是前两种方法。涂层材料主要用于制造人工骨、关节臼、关节头、人工牙根、人工心瓣膜等；也可用作电学植人装置导线的绝缘层及心血管导管引导钢丝的表面涂层等。现有涂层材料一般只具有单一的性能，比如防护性、抗菌性、抗凝血性等，不能同时具备多种性能以提高医用材料的性能。因此，需要提供一种生物医用材料表面高分子基涂层。
发明内容
为了克服现有技术中的缺陷，提供一种生物医用材料表面高分子基涂层。
本发明通过下述方案实现：
一种生物医用材料表面高分子基涂层，以质量份数计，所述基涂层包括正硅酸乙酯2-5份，纯水40-60份，冰乙酸0.5-2份，硅烷偶联剂0.5-2份，纳米二氧化钛0.1-0.5份，纳米银0.5-1份。
所述纳米二氧化钛通过包含如下步骤的方法制备得到：
原料称取：按如下重量份配比称取原料，钛酸丁酯4-6份，无水乙醇10-30份，冰醋酸0.5-2份，超纯水0.5-2份，浓硝酸1-3份；
制备溶液a：在15-25℃下，将钛酸丁酯以40-60滴/min匀速滴入10-20份无水乙醇中，再加入0.5-2份的冰醋酸，得到溶液a；
制备溶液b：将0.5-2份的超纯水和5-10份无水乙醇混合均匀，再逐渐加入浓硝酸，得到pH＝2-3的溶液b；
制备：将所述溶液a以30-50滴/min匀速滴入溶液b中，匀速搅拌0.5-1h至出现透明的凝胶，烘干后放入马弗炉中升温至300-600℃焙烧0.5-1h，研磨即得所述纳米二氧化钛。
所述纳米二氧化钛的平均粒径为5-15nm，比表面积为80-115m 2/g。
所述纳米银的平均粒径为20-30nm，比表面积为70-90m 2/g。
本发明的有益效果为：
1.本发明一种生物医用材料表面高分子基涂层选用纳米银，一方面纳米银粒子比表面积大和表面能高，使其具有很强的表面活性与超强吸附的能力，因此对促使物质腐败的氧原子、氧自由基、烷烃类分子等均有极强的抓俘能力，能 有效保护材料不受细菌侵扰；另一方面银离子与细菌中的有机物反应，能有效杀灭细菌，从而达到抑菌、杀菌的作用。
2.本发明一种生物医用材料表面高分子基涂层采用纳米二氧化钛能在医用材料表面形成致命的保护层，能够有效阻止腐蚀性介质的渗透，对医用材料起到良好的防护，从而达到防护防腐的作用。
具体实施方式
下面结合具体实施例对本发明进一步说明：
一种生物医用材料表面高分子基涂层，以质量份数计，所述基涂层包括正硅酸乙酯2-5份，纯水40-60份，冰乙酸0.5-2份，硅烷偶联剂0.5-2份，纳米二氧化钛0.1-0.5份，纳米银0.5-1份。
所述纳米二氧化钛通过包含如下步骤的方法制备得到：
原料称取：按如下重量份配比称取原料，钛酸丁酯4-6份，无水乙醇10-30份，冰醋酸0.5-2份，超纯水0.5-2份，浓硝酸1-3份；
制备溶液a：在15-25℃下，将钛酸丁酯以40-60滴/min匀速滴入10-20份无水乙醇中，再加入0.5-2份的冰醋酸，得到溶液a；
制备溶液b：将0.5-2份的超纯水和5-10份无水乙醇混合均匀，再逐渐加入浓硝酸，得到pH＝2-3的溶液b；
制备：将所述溶液a以30-50滴/min匀速滴入溶液b中，匀速搅拌0.5-1h至出现透明的凝胶，烘干后放入马弗炉中升温至300-600℃焙烧0.5-1h，研磨即得所述纳米二氧化钛。
所述纳米二氧化钛的平均粒径为5-15nm，比表面积为80-115m 2/g。
所述纳米银的平均粒径为20-30nm，比表面积为70-90m 2/g。
下面结合具体实施例对本申请做进一步阐述。
对比例1
一种生物医用材料表面高分子基涂层，以质量份数计，所述基涂层包括正硅酸乙酯3.5份，纯水50份，冰乙酸1份，硅烷偶联剂1份，纳米二氧化钛0.1份，纳米银0份。
对比例2
一种生物医用材料表面高分子基涂层，以质量份数计，所述基涂层包括正硅酸乙酯3.5份，纯水50份，冰乙酸1份，硅烷偶联剂1份，纳米二氧化钛0份，纳米银0.5份。
实施例1
一种生物医用材料表面高分子基涂层，以质量份数计，所述基涂层包括正硅酸乙酯3.5份，纯水50份，冰乙酸1份，硅烷偶联剂1份，纳米二氧化钛0.1份，纳米银0.5份。
所述纳米二氧化钛通过包含如下步骤的方法制备得到：
原料称取：按如下重量份配比称取原料，钛酸丁酯5份，无水乙醇20份，冰醋酸1份，超纯水1份，浓硝酸1.5份；
制备溶液a：在18℃下，将钛酸丁酯以45滴/min匀速滴入15份无水乙醇中，再加入1份的冰醋酸，得到溶液a；
制备溶液b：将1份的超纯水和5份无水乙醇混合均匀，再逐渐加入浓硝酸，得到pH＝2-3的溶液b；
制备：将所述溶液a以40滴/min匀速滴入溶液b中，匀速搅拌0.5h至出现透明的凝胶，烘干后放入马弗炉中升温至400℃焙烧1h，研磨即得所述纳米二氧化钛。
所述纳米二氧化钛的平均粒径为10nm，比表面积为85m 2/g。
所述纳米银的平均粒径为25nm，比表面积为75m 2/g。
实施例2
本实施例与实施例一存在诸多相同之处，其相同之处不再赘述，将不同之处简述如下：
一种生物医用材料表面高分子基涂层，以质量份数计，所述基涂层包括正硅酸乙酯3.5份，纯水50份，冰乙酸1份，硅烷偶联剂1份，纳米二氧化钛0.3份，纳米银0.7份。
实施例3
本实施例与实施例一存在诸多相同之处，其相同之处不再赘述，将不同之处简述如下：
一种生物医用材料表面高分子基涂层，以质量份数计，所述基涂层包括正硅酸乙酯3.5份，纯水50份，冰乙酸1份，硅烷偶联剂1份，纳米二氧化钛0.5份，纳米银1.0份。
将实施例1～实施例3制备的涂层和对比例1～实施例2制备的涂层，磁力 搅拌8d制成溶胶状；将同样大小的铝合金试片用砂纸打磨至无明显划痕，再依次用碱洗-水洗-酸洗-水洗-酒精洗-吹干；将处理好的铝片分别浸入各溶胶中45分钟，通过提拉法进行涂层的覆盖，然后进行相应的测试；按载体定量杀菌试验法，检测对金黄色葡萄球菌的杀灭效果
表1 不同配比的涂层制成铝片的性能参数一览表
样品编号 腐蚀电位V 冲击强度kJ/m 2 24h平均杀菌率(％)
对比例1 -0.612 6.2 67.3
对比例2 -0.708 5.3 86.1
实施例1 -0.543 7.5 88.3
实施例2 -0.503 7.9 91.2
实施例3 -0.472 8.1 94.6
从上述试验数据显示，随着基涂层中纳米二氧化钛质量分数的变化，铝片的腐蚀电位和冲击强度逐渐增强，说明涂层具有良好的防护、防腐性能；同时随着涂层中纳米银质量分数的变化，铝片的杀菌率逐渐增强，说明涂层具有稳定的抗菌效果。
尽管已经对本发明的技术方案做了较为详细的阐述和列举，应当理解，对于本领域技术人员来说，对上述实施例做出修改或者采用等同的替代方案，这对本领域的技术人员而言是显而易见，在不偏离本发明精神的基础上所做的这些修改或改进，均属于本发明要求保护的范围。

Claims (4)

  1. 一种生物医用材料表面高分子基涂层，其特征在于：以质量份数计，所述基涂层包括正硅酸乙酯2-5份，纯水40-60份，冰乙酸0.5-2份，硅烷偶联剂0.5-2份，纳米二氧化钛0.1-0.5份，纳米银0.5-1份。
  2. 根据权利要求1所述的一种生物医用材料表面高分子基涂层，其特征在于：所述纳米二氧化钛通过包含如下步骤的方法制备得到：
    原料称取：按如下重量份配比称取原料，钛酸丁酯4-6份，无水乙醇10-30份，冰醋酸0.5-2份，超纯水0.5-2份，浓硝酸1-3份；
    制备溶液a：在15-25℃下，将钛酸丁酯以40-60滴/min匀速滴入10-20份无水乙醇中，再加入0.5-2份的冰醋酸，得到溶液a；
    制备溶液b：将0.5-2份的超纯水和5-10份无水乙醇混合均匀，再逐渐加入浓硝酸，得到pH＝2-3的溶液b；
    制备：将所述溶液a以30-50滴/min匀速滴入溶液b中，匀速搅拌0.5-1h至出现透明的凝胶，烘干后放入马弗炉中升温至300-600℃焙烧0.5-1h，研磨即得所述纳米二氧化钛。
  3. 根据权利要求1所述的一种生物医用材料表面高分子基涂层，其特征在于：所述纳米二氧化钛的平均粒径为5-15nm，比表面积为80-115m 2/g。
  4. 根据权利要求1所述的一种生物医用材料表面高分子基涂层，其特征在于：所述纳米银的平均粒径为20-30nm，比表面积为70-90m 2/g。
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102921049A (zh) * 2012-09-28 2013-02-13 深圳清华大学研究院 抗菌医用导管及其制备方法
CN103948973A (zh) * 2014-04-21 2014-07-30 蒋旭宏 一种具有安全高效抗菌性能的医用气管导管
CN104194424A (zh) * 2014-09-19 2014-12-10 沈阳沃鑫源商贸有限公司 一种医用医疗器械金属抗菌涂层的制备方法
US20190269709A1 (en) * 2018-02-16 2019-09-05 American Nano, LLC. Topical compositions incorporating silica fibers

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102921049A (zh) * 2012-09-28 2013-02-13 深圳清华大学研究院 抗菌医用导管及其制备方法
CN103948973A (zh) * 2014-04-21 2014-07-30 蒋旭宏 一种具有安全高效抗菌性能的医用气管导管
CN104194424A (zh) * 2014-09-19 2014-12-10 沈阳沃鑫源商贸有限公司 一种医用医疗器械金属抗菌涂层的制备方法
US20190269709A1 (en) * 2018-02-16 2019-09-05 American Nano, LLC. Topical compositions incorporating silica fibers

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JALALI S.A.H.; ALLAFCHIAN A.R.; BANIFATEMI S.S.; ASHRAFI TAMAI I.: "The antibacterial properties of Ag/TiO2nanoparticles embedded in silane sol–gel matrix", JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS, ELSEVIER, AMSTERDAM, NL, vol. 66, 24 June 2016 (2016-06-24), AMSTERDAM, NL, pages 357 - 362, XP029681153, ISSN: 1876-1070, DOI: 10.1016/j.jtice.2016.06.011 *

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