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WO2021097667A1 - Revêtement à base de polymère de surface de matériau biomédical - Google Patents

Revêtement à base de polymère de surface de matériau biomédical Download PDF

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Publication number
WO2021097667A1
WO2021097667A1 PCT/CN2019/119454 CN2019119454W WO2021097667A1 WO 2021097667 A1 WO2021097667 A1 WO 2021097667A1 CN 2019119454 W CN2019119454 W CN 2019119454W WO 2021097667 A1 WO2021097667 A1 WO 2021097667A1
Authority
WO
WIPO (PCT)
Prior art keywords
parts
nano
titanium dioxide
based coating
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2019/119454
Other languages
English (en)
Chinese (zh)
Inventor
李玉光
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanjing Advanced Biological Materials & Process Equipment Institute Co Ltd
Original Assignee
Nanjing Advanced Biological Materials & Process Equipment Institute Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanjing Advanced Biological Materials & Process Equipment Institute Co Ltd filed Critical Nanjing Advanced Biological Materials & Process Equipment Institute Co Ltd
Priority to PCT/CN2019/119454 priority Critical patent/WO2021097667A1/fr
Publication of WO2021097667A1 publication Critical patent/WO2021097667A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D1/00—Coating compositions, e.g. paints, varnishes or lacquers, based on inorganic substances
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D183/00—Coating compositions based on macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon only; Coating compositions based on derivatives of such polymers
    • C09D183/02—Polysilicates
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D183/00—Coating compositions based on macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon only; Coating compositions based on derivatives of such polymers
    • C09D183/04—Polysiloxanes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D183/00—Coating compositions based on macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon only; Coating compositions based on derivatives of such polymers
    • C09D183/04—Polysiloxanes
    • C09D183/06—Polysiloxanes containing silicon bound to oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
    • C09D5/14—Paints containing biocides, e.g. fungicides, insecticides or pesticides

Definitions

  • the invention relates to the technical field of polymer materials, in particular to a polymer-based coating on the surface of biomedical materials.
  • the medical surface coating material is a medical surface composite material composed of a group material as a matrix and a layer of homogenous or heterogeneous film formed on its surface by a certain process technology. Its function is to improve the biological properties of the substrate surface, or to block the dissolution and diffusion of substrate ions to the surrounding tissues, or to improve the physical and chemical properties such as wear resistance and insulation of the substrate surface.
  • the most widely used is to add to the civil metal material substrate.
  • plasma spraying, vapor deposition, ion sputtering, immersion, sintering, electrophoresis and pyrolysis can be used for coating preparation. The first two methods are most suitable.
  • Coating materials are mainly used to manufacture artificial bones, joint sockets, joint heads, artificial tooth roots, artificial heart valves, etc.; it can also be used as an insulating layer for wires of electrical implant devices and surface coatings for guiding wires of cardiovascular catheters.
  • Existing coating materials generally only have a single performance, such as protection, antibacterial, and anticoagulant properties, and cannot have multiple properties at the same time to improve the performance of medical materials. Therefore, there is a need to provide a polymer-based coating on the surface of biomedical materials.
  • the present invention is realized through the following schemes:
  • a polymer-based coating on the surface of biomedical materials, in parts by mass, the base coating includes 2-5 parts of ethyl orthosilicate, 40-60 parts of pure water, 0.5-2 parts of glacial acetic acid, and silane coupling 0.5-2 parts of coupling agent, 0.1-0.5 parts of nano titanium dioxide, 0.5-1 parts of nano silver.
  • the nano titanium dioxide is prepared by a method including the following steps:
  • the average particle size of the nano titanium dioxide is 5-15 nm, and the specific surface area is 80-115 m 2 /g.
  • the average particle size of the nano silver is 20-30 nm, and the specific surface area is 70-90 m 2 /g.
  • the polymer-based coating on the surface of a biomedical material of the present invention uses nano-silver.
  • nano-silver particles have a large specific surface area and high surface energy, so that they have strong surface activity and super adsorption ability, so it is helpful
  • Corrupted oxygen atoms, oxygen free radicals, alkane molecules, etc. have a strong capture ability, which can effectively protect materials from bacteria.
  • silver ions react with the organic matter in bacteria to effectively kill bacteria, thereby Achieve antibacterial and bactericidal effects.
  • the polymer-based coating on the surface of a biomedical material of the present invention adopts nano-titanium dioxide to form a deadly protective layer on the surface of medical materials, which can effectively prevent the penetration of corrosive media and provide good protection for medical materials, thereby achieving protection The role of anti-corrosion.
  • a polymer-based coating on the surface of a biomedical material, in parts by mass, the base coating includes 2-5 parts of ethyl orthosilicate, 40-60 parts of pure water, 0.5-2 parts of glacial acetic acid, and silane coupling 0.5-2 parts of coupling agent, 0.1-0.5 parts of nano titanium dioxide, 0.5-1 parts of nano silver.
  • the nano titanium dioxide is prepared by a method including the following steps:
  • the average particle size of the nano titanium dioxide is 5-15 nm, and the specific surface area is 80-115 m 2 /g.
  • the average particle size of the nano silver is 20-30 nm, and the specific surface area is 70-90 m 2 /g.
  • a polymer-based coating on the surface of a biomedical material, in parts by mass, the base coating includes 3.5 parts of ethyl orthosilicate, 50 parts of pure water, 1 part of glacial acetic acid, 1 part of silane coupling agent, nanometer 0.1 part of titanium dioxide and 0 part of nano-silver.
  • a polymer-based coating on the surface of a biomedical material, in parts by mass, the base coating includes 3.5 parts of ethyl orthosilicate, 50 parts of pure water, 1 part of glacial acetic acid, 1 part of silane coupling agent, nanometer 0 parts of titanium dioxide and 0.5 parts of nano-silver.
  • a polymer-based coating on the surface of a biomedical material, in parts by mass, the base coating includes 3.5 parts of ethyl orthosilicate, 50 parts of pure water, 1 part of glacial acetic acid, 1 part of silane coupling agent, nanometer 0.1 part of titanium dioxide and 0.5 part of nano-silver.
  • the nano titanium dioxide is prepared by a method including the following steps:
  • the average particle size of the nano titanium dioxide is 10 nm, and the specific surface area is 85 m 2 /g.
  • the average particle size of the nano silver is 25 nm, and the specific surface area is 75 m 2 /g.
  • a polymer-based coating on the surface of a biomedical material, in parts by mass, the base coating includes 3.5 parts of ethyl orthosilicate, 50 parts of pure water, 1 part of glacial acetic acid, 1 part of silane coupling agent, nanometer 0.3 parts of titanium dioxide and 0.7 parts of nano-silver.
  • a polymer-based coating on the surface of a biomedical material, in parts by mass, the base coating includes 3.5 parts of ethyl orthosilicate, 50 parts of pure water, 1 part of glacial acetic acid, 1 part of silane coupling agent, nanometer 0.5 part of titanium dioxide and 1.0 part of nano-silver.
  • Example 1 to Example 3 and the coating prepared in Comparative Example 1 to Example 2 were magnetically stirred for 8 days to form a sol; the aluminum alloy test piece of the same size was polished with sandpaper until there were no obvious scratches. Then use alkaline washing-water washing-acid washing-water washing-alcohol washing-blow-drying; respectively immerse the processed aluminum sheet in each sol for 45 minutes, and carry out coating coverage by pulling method, and then carry out the corresponding test; Carrier quantitative sterilization test method to detect the killing effect on Staphylococcus aureus
  • the above test data shows that with the change in the mass fraction of nano-TiO2 in the base coating, the corrosion potential and impact strength of the aluminum sheet gradually increase, indicating that the coating has good protection and anti-corrosion properties; at the same time, with the quality of nano-silver in the coating As the score changes, the sterilization rate of the aluminum sheet gradually increases, indicating that the coating has a stable antibacterial effect.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Plant Pathology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Est divulgué un revêtement à base de polymère de surface de matériau biomédical, comprenant les constituants suivants en parties en masse : 2 à 5 parties de tétraéthoxysilane, 40 à 60 parties d'eau pure, 0,5 à 2 parties d'acide acétique glacial, 0,5 à 2 parties d'agent de couplage au silane, 0,1 à 0,5 partie de dioxyde de titane nanométrique, et 0,5 à 1 partie d'argent nanométrique. Grâce à l'ajout de dioxyde de titane nanométrique et d'argent nanométrique, le revêtement présente de bonnes propriétés antibactériennes et protectrices.
PCT/CN2019/119454 2019-11-19 2019-11-19 Revêtement à base de polymère de surface de matériau biomédical Ceased WO2021097667A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2019/119454 WO2021097667A1 (fr) 2019-11-19 2019-11-19 Revêtement à base de polymère de surface de matériau biomédical

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2019/119454 WO2021097667A1 (fr) 2019-11-19 2019-11-19 Revêtement à base de polymère de surface de matériau biomédical

Publications (1)

Publication Number Publication Date
WO2021097667A1 true WO2021097667A1 (fr) 2021-05-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2019/119454 Ceased WO2021097667A1 (fr) 2019-11-19 2019-11-19 Revêtement à base de polymère de surface de matériau biomédical

Country Status (1)

Country Link
WO (1) WO2021097667A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102921049A (zh) * 2012-09-28 2013-02-13 深圳清华大学研究院 抗菌医用导管及其制备方法
CN103948973A (zh) * 2014-04-21 2014-07-30 蒋旭宏 一种具有安全高效抗菌性能的医用气管导管
CN104194424A (zh) * 2014-09-19 2014-12-10 沈阳沃鑫源商贸有限公司 一种医用医疗器械金属抗菌涂层的制备方法
US20190269709A1 (en) * 2018-02-16 2019-09-05 American Nano, LLC. Topical compositions incorporating silica fibers

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102921049A (zh) * 2012-09-28 2013-02-13 深圳清华大学研究院 抗菌医用导管及其制备方法
CN103948973A (zh) * 2014-04-21 2014-07-30 蒋旭宏 一种具有安全高效抗菌性能的医用气管导管
CN104194424A (zh) * 2014-09-19 2014-12-10 沈阳沃鑫源商贸有限公司 一种医用医疗器械金属抗菌涂层的制备方法
US20190269709A1 (en) * 2018-02-16 2019-09-05 American Nano, LLC. Topical compositions incorporating silica fibers

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JALALI S.A.H.; ALLAFCHIAN A.R.; BANIFATEMI S.S.; ASHRAFI TAMAI I.: "The antibacterial properties of Ag/TiO2nanoparticles embedded in silane sol–gel matrix", JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS, ELSEVIER, AMSTERDAM, NL, vol. 66, 24 June 2016 (2016-06-24), AMSTERDAM, NL, pages 357 - 362, XP029681153, ISSN: 1876-1070, DOI: 10.1016/j.jtice.2016.06.011 *

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