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WO2021080535A2 - Mélange d'huiles essentielles renforçant la mémoire - Google Patents

Mélange d'huiles essentielles renforçant la mémoire Download PDF

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Publication number
WO2021080535A2
WO2021080535A2 PCT/TR2020/050913 TR2020050913W WO2021080535A2 WO 2021080535 A2 WO2021080535 A2 WO 2021080535A2 TR 2020050913 W TR2020050913 W TR 2020050913W WO 2021080535 A2 WO2021080535 A2 WO 2021080535A2
Authority
WO
WIPO (PCT)
Prior art keywords
oil
weight
aetheroleum
essential oil
essential
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/TR2020/050913
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English (en)
Other versions
WO2021080535A3 (fr
Inventor
Muhammed Halis ERTAŞ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Talya Bitkisel Ueruenler Ticaret Ve Sanayi AS
Original Assignee
Talya Bitkisel Ueruenler Ticaret Ve Sanayi AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Talya Bitkisel Ueruenler Ticaret Ve Sanayi AS filed Critical Talya Bitkisel Ueruenler Ticaret Ve Sanayi AS
Publication of WO2021080535A2 publication Critical patent/WO2021080535A2/fr
Publication of WO2021080535A3 publication Critical patent/WO2021080535A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes

Definitions

  • the invention relates to a essential oil and mixture thereof comprising Orange Oil (Aurantii dulcis aetheroleum), Lemon Oil (Citrus aetheroleum), Lavender Oil (Lavandulae aetheroleum), Sage Oil (Salvia triloba aetheroleum) and Rosemary Oil (Rosmarini aetheroleum).
  • Essential oils are well-known natural ingredients and are used by means of extraction to provide odor to various preparations and formulations including perfumes, cosmetics, and foods. In topical preparations, various essential oils are used such as menthol, eucalyptus oil, camphor, peppermint for the purpose of relieving pain. Vapors from some essential oils are believed to be advantageous to remove multiple conditions, when inhaled, as in "aromatherapy".
  • the usage of essential oils for cosmetic products known from the prior art has the principle of providing odor or flavor to the products rather than any direct effect or benefit from the essential oil itself.
  • Aromatherapy can enhance the quality of life and it can even function as a complementary treatment to reduce the negative effects of various conditions such as stress, pain, and depression.
  • CN109805409 has suggested a mixture of soy lecithin, walnut oil, perilla oil, linseed oil, almond oil, sunflower seed oil, safflower oil, acerola oil, shasnong seed oil and peony seed oil as a memory booster.
  • CN109602010 has referred to a nutritious mixture comprising phosphatidylserine, krill oil and galangal plants with sharp leaves.
  • CN109497537 has suggested a mixture of water-soluble flax powder, royal jelly, cysteamine and in addition acid grain flour, vitamin Bl, vitamin B12, ferrous salt, dextrin, antioxidants to enhance brain functions and to ease down brain atrophy and reprieve aging.
  • CN108902937 has disclosed a composition comprising, flax seed kernel, Tianma, longan, Yuanzhi, Yizhiren, Ginkgo biloba extract, grape seed extract, selenium yeast, zinc yeast, magnesium lactate, vitamin B and acetylcholine for treating senile dementia and Alzheimer's disease.
  • US2019083564 disclosed the use of a mixture of essential oils such as Vetiver, Black Pepper, Ginger, Ylang Ylang, Sandalwood, Patchouli, Cedarwood, Myrrh, Frankincense, Lavender for neurological disorders such as seizures, migraines, anxiety, and tremors.
  • the proposed mixture to improve cognitive functions may also contain Coffee, Vanilla, Cinnamon Bark, Cloves, Dalmatian Sage, Rosemary, Blood Orange, Lemon, Grapefruit, Peppermint, Lime, Clementine, Spearmint or coconut oil.
  • the composition is specified to be administered by aromatherapy, it is essentially applied to the skin.
  • CN104800774 A (Xia) relates to a mixture containing 2-8 moiety lavender essential oil, 2-8 moiety tulip essential oil, 1-5 moiety rosemary essential oil and 1-5 moiety jasmine essential oil, which improves sleep quality.
  • US2007031343 discloses a large number of fragrance oils that can be used in inhalant formulations containing an active substance, carrier agent, and effective amounts of fragrance.
  • US20160279358 (Singer) relates to an inhalation rod comprising at least two essential oils.
  • essential oil mixtures which are especially applied by way of inhalation, that are used in strengthening the memory, improving mental capacity, facilitating daily life, increasing focus and concentration, and treating dementia and Alzheimer's disease.
  • the invention is related to an essential oil mixture comprising Orange Oil (Aurantii dulcis aetheroleum), Lemon Oil (Citrus aetheroleum), Lavender Oil (Lavandulae aetheroleum), Sage Oil (Salvia triloba aetheroleum) and Rosemary Oil (Rosmarini aetheroleum), and to the use of this mixture in strengthening memory, improving mental capacity, facilitating daily life, improving focus and concentration, and treating dementia and Alzheimer’s.
  • Orange Oil Amantii dulcis aetheroleum
  • Lemon Oil Cis aetheroleum
  • Lavender Oil Liavandulae aetheroleum
  • Sage Oil Salvia triloba aetheroleum
  • Rosemary Oil Rosmarini aetheroleum
  • the invention is an essential oil mixture; comprising Orange Oil (Aurantii dulcis aetheroleum), Lemon Oil (Citrus aetheroleum), Lavender Oil (Lavandulae aetheroleum), Sage Oil (Salvia triloba aetheroleum) and Rosemary Oil (Rosmarini aetheroleum).
  • Orange Oil Amantii dulcis aetheroleum
  • Lemon Oil Cis ae aetheroleum
  • Lavender Oil Liavandulae aetheroleum
  • Sage Oil Salvia triloba aetheroleum
  • Rosemary Oil Rosmarini aetheroleum
  • the essential oil mixture comprising Orange Oil (Aurantii dulcis aetheroleum), Lemon Oil (Citrus aetheroleum), Lavender Oil (Lavandulae aetheroleum), Sage Oil (Salvia triloba aetheroleum) and Rosemary Oil (Rosmarini aetheroleum) is used for strengthening the memory, improving mental capacity, facilitating daily life, increasing focus and concentration, and treating dementia and Alzheimer's disease.
  • Orange oil and lemon oil used in the mixture of the present invention can be obtained by compressing fresh fruit peel; lavender oil, sage oil, and rosemary oil steam distillation.
  • Orange oil is a liquid with a specific weight of 0.8-1.05 g/cm and a refractive index of 1.46546- 1.47037. It contains at least 90% by weight d-limonene.
  • Lemon oil is a liquid with a specific weight of 0.8-1.05 g/cm and a refractive index of 1.46546-1.47037. Lemon oil is obtained from the fresh peel of the fruit. It contains citral, d-limonene, pinene, campen, b-felandren and g- terpinen as terpenic compounds.
  • Lavender oil is a yellow liquid with a specific weight of 0.878-
  • the essential oils in the essential oil mixture of the present invention may preferably be in the proportions given below.
  • the value stated in the invention as by weight is defined as the weight of the essential substance/the weight of the total mixture.
  • Essential oil mixture contains preferably 60-75% by weight, more preferably 65-70% by weight, most preferably 68% by weight Orange Oil (Aurantii dulcis aetheroleum).
  • Essential oil mixture contains preferably 20-40% by weight, more preferably 25-35% by weight, most preferably 30% by weight Lemon Oil (Citrus aetheroleum).
  • Essential oil mixture contains preferably 0,5-3% by weight, more preferably 0,5-2% by weight, most preferably 1% by weight Lavender Oil (Lavandulae aetheroleum).
  • Essential oil mixture contains preferably 0,25-2% by weight, more preferably 0,25-1% by weight, most preferably 0,5% by weight Sage Oil (Salvia triloba aetheroleum).
  • Essential oil mixture contains preferably 0,25-2% by weight, more preferably 0,25-1% by weight, most preferably 0,5% by weight Rosemary Oil (Rosmarini aetheroleum).
  • the essential oil mixture contains 65-70% by weight Orange Oil (Aurantii dulcis aetheroleum), 25-35% by weight Lemon Oil (Citrus aetheroleum), 0,5-2% by weight Lavender Oil (Lavandulae aetheroleum), 0,25-1% by weight Sage Oil (Salvia triloba aetheroleum), 0,25-1% of Rosemary Oil (Rosmarini aetheroleum).
  • the essential oil mixture contains 68% by weight Orange Oil (Aurantii dulcis aetheroleum), 30% by weight Lemon Oil (Citrus aetheroleum), 1% by weight Lavender Oil (Lavandulae aetheroleum), 0,5% by weight Sage Oil (Salvia triloba aetheroleum), 0,5% of Rosemary Oil (Rosmarini aetheroleum).
  • Essential oil mixtures in all embodiments of the invention can be used to strengthen memory, improve mental capacity, facilitate daily life, improve focus and concentration, treat dementia and Alzheimer’s.
  • the inventive essential oil mixture can be in the form of a solution, aerosol, spray, flavor or nasal inhaler.
  • the inventive essential oil mixture can be applied by inhalation orally and/or nasally. It can be applied directly through the nasal route or by sniffing a napkin that is damp with the mixture that is placed on an item such as a pillow, or through inhalation. Specifically, the essential oil mixture can be dripped on the person’s dress, for example on the collar and can be applied through sniffing. Application is preferably performed 3 or 4 times a day.
  • the essential oil mixture according to the present invention may have a refractive index of 1.4679 - 1.4704 at 25°C, a specific weight of 0,850-1,05 g/cm3 at 25°C.
  • Essential oils can comprise various compounds in their terpene structure.
  • the inventive essential oil mixture that comprises Orange Oil, Lemon Oil, Lavander Oil, Sage Oil, and Rosemary Oil can comprise Limonene, a-Pinene, b-pinene, Sabinene, b-Myrcene, jfTcrpincnc, Cymene, Linalool, Valencene from the terpene class compounds.
  • the amount of Limonene is preferably at least 80% by weight, more preferably at least 85% by weight, most preferably at least 90% by weight.
  • the amount of each a-Pinene, b-pinene, b-Myrcene, y 1 Terpinene compounds is at least 0,25% by weight, preferably at least 0,5% by weight, most preferably at least 0,1% by weight.
  • the amount of each Sabinene, Cymene, Linalool, Valencene compounds is at least 0,25% by weight.
  • the analysis of the inventive mixture is carried out by GC/GC-MS.
  • Gas chromatography (Agilent 7890A)- mass detector (Agilent 5975C) device or capillary column (HP InnowaxCapillary; 60.0 m x 0.25 mm x 0.25 pm) with an equivalent device or equivalent column is used.
  • the samples are diluted with hexane with a ratio of 1:100 for analysis.
  • helium having a 0,8 ml/min flow rate is used as a carrier gas.
  • the samples are injected into the device in 1 pi with a 40:1 split ratio.
  • the temperature of the injector is maintained at 250°C, column temperature program is adjusted to be 60°C (10 minutes), from 60°C to 220°C, 4°C/minutes and 220°C (10 minutes). In this temperature program, the total analysis time is about 60 minutes.
  • scan range (m/z) 35-450 atomic mass unit and electron bombardment ionization 70 eV are used.
  • the data of WILEY and OIL ADAMS libraries have been taken into account. Component percentages of the results have been carried out with the FID detector, and identification of components have been conducted with the MS detector. Tests:
  • Control group Scopolamine (Sco, 0.7 mg/kg body weight, i.p.) were given by inhalation in essential oil mixture (MO) (1% MO + Sco and 3% MO + Sco). ⁇ MO treatment groups (1% MO and 3% MO)
  • the effect of MO on the development of short-term memory could not be attributed to locomotor activity as explained in the number of maze arm entries, since no significant difference was found between the groups ( Figure 2).
  • Figure 1 Percentage of spontaneous change of the essential oil sample (MO) given to rats via inhalation at a rate of 1% and 3% by Y-maze test

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne un mélange d'huiles essentielles comprenant de l'huile d'orange (Aurantii dulcis aetheroleum), de l'huile de citron (Citrus aetheroleum), de l'huile de lavande (Lavandulae aetheroleum), de l'huile de sauge (Salvia triloba aetheroleum) et de l'huile de romarin (Rosmarini aetheroleum), ainsi que l'utilisation de ce mélange pour renforcer la mémoire, améliorer les capacités mentales, faciliter la vie quotidienne, améliorer l'attention et la concentration, et traiter la démence et la maladie d'Alzheimer.
PCT/TR2020/050913 2019-10-21 2020-10-06 Mélange d'huiles essentielles renforçant la mémoire Ceased WO2021080535A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2019/16207 2019-10-21
TR2019/16207A TR201916207A2 (tr) 2019-10-21 2019-10-21 Hafiza güçlendi̇ri̇ci̇ uçucu yağ karişimi

Publications (2)

Publication Number Publication Date
WO2021080535A2 true WO2021080535A2 (fr) 2021-04-29
WO2021080535A3 WO2021080535A3 (fr) 2021-10-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2020/050913 Ceased WO2021080535A2 (fr) 2019-10-21 2020-10-06 Mélange d'huiles essentielles renforçant la mémoire

Country Status (2)

Country Link
TR (1) TR201916207A2 (fr)
WO (1) WO2021080535A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022272114A1 (fr) * 2021-06-25 2022-12-29 The Coca-Cola Company Composition consommable par voie orale comprenant un extrait végétal
CN119632053A (zh) * 2024-11-29 2025-03-18 广东工业大学 一种植物精油组合物及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030061763A (ko) * 2003-06-23 2003-07-22 김은석 아로마 머드팩 조성물
KR20040055713A (ko) * 2003-12-26 2004-06-26 김남희 피부미용과 함께 정신적건강에 도움을 주는아로마테라피용 에센셜 오일 블렌드를 함유하는 화장품의조성물과 그의 제조방법.
KR100843692B1 (ko) * 2007-02-06 2008-07-04 (주)휴스콘건설 정서안정용 향료조성물 및 이를 이용한 고형향료조성물
CA2792018A1 (fr) * 2010-05-10 2011-11-17 Segetis, Inc. Formulations parfumees, leurs procedes de fabrication et articles en contenant
US10245295B1 (en) * 2017-09-21 2019-04-02 Laura Harris Smith Neurological essential oil composition and methods

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022272114A1 (fr) * 2021-06-25 2022-12-29 The Coca-Cola Company Composition consommable par voie orale comprenant un extrait végétal
CN119632053A (zh) * 2024-11-29 2025-03-18 广东工业大学 一种植物精油组合物及其应用

Also Published As

Publication number Publication date
TR201916207A2 (tr) 2021-05-21
WO2021080535A3 (fr) 2021-10-21

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